<p><strong>Abstract</strong><strong>.</strong> Stroke will experience setbacks such as difficulty in thinking, speaking and moving. This condition creates a feeling of helplessness with his life, so that post-stroke patients are prone to depression. The purpose of this study was to determine the effect of giving Acceptance and Commitment Therapy (ACT) in reducing depression in post-stroke patients. This study involved 6 post-stroke participants with major depression. The research method used was quantitative- true eksperiment. Based on the results of the Mann-Whitney posttest, there was a significant difference in scores between the groups that were given Acceptance and Commitment Therapy (ACT) and those who were not given Acceptance and Commitment Therapy (ACT) (0.023; p &lt;0.05). So it can be concluded that Acceptance and Commitment Therapy (ACT) can be used to reduce depression in post-stroke patients.<br /><strong><em>Keyword</em></strong><strong><em>s:</em></strong><em> </em><em>Depression, Acceptance and Commitment Therapy (ACT), post-stroke.</em></p><p><strong>Abstrak</strong><strong>. </strong><em>Stroke </em>akan menyebabkan seseorang mengalami kemunduran seperti kesulitan dalam berpikir, berbicara dan bergerak. Kondisi ini menimbulkan perasaan tidak berdaya dengan hidupnya, sehingga pasien <em>pasca-stroke</em> rentan terhadap depresi. Tujuan penelitian ini adalah untuk menguji pengaruh <em>Acceptance and Commitment Therapy</em> (ACT) dalam menurunkan depresi pada pasien <em>pasca-stroke</em>. Penelitian ini melibatkan 6 partisipan <em>pasca-stroke</em> dengan depresi berat. Metode penelitian yang digunakan adalah kuantitatif-<em>true </em>eksperimen. Berdasarkan hasil <em>posttest </em>uji <em>Mann-Whitney</em> menunjukkan adanya perbedaan skor depresi yang signifikan antara kelompok yang diberikan <em>Acceptance and Commitment Therapy</em> (ACT) dan kelompok yang tidak diberikan <em>Acceptance and Commitment Therapy</em> (ACT) (0,023; p&lt;0,05). Maka dapat disimpulkan bahwa <em>Acceptance and Commitment Therapy</em> (ACT) efektif digunakan untuk menurunkan depresi pada pasien <em>pasca-stroke</em>.<br /><strong><em>Kata kunci:</em> </strong><em>Depresi, Acceptance and Commitment Therapy (ACT), pasca-stroke.</em></p>