Background: Hemodynamics is very important to monitor, especially in general anesthesia because generally anesthesia will cause various kindsof body system disorders. The use of anesthesia using inhalation using sevoflurane can cause hemodynamic changes, one of which is changes in pulse frequency. So that a strict monitoring process is needed in its use. Objective: Knowing changes in pulse frequency in general anesthesia patients with the use of sevoflurane at PKU Muhammadiyah Gombong Hospital in 2024. Methods: This study is an Observational Descriptive study with a quantitative research design that focuses on variable analysis, specifically intra anesthesia pulse frequency after sevoflurane is given. This study used an analytic design with a cross sectional approach. Results: Frequency Distribution of Respondent Characteristics Based on Age obtained research results where the most age group was 26-45 years as many as 23 respondents (51.1%). For the gender group, the results of this study with the most respondents were male as many as 30 respondents (66.7%). Distribution based on body weight obtained research results where the most weight The results showed that the most weight group was 41-75 kg as many as 40 respondents (88.9%). The results of observations of changes in the inhalation drug sevoflurane that the mean or average induction pulse frequency was 75.47 bpm, the mean or average pulse frequency after 5 minutes of induction it was 79.73 bpm, the mean or average pulse  frequency after 10 minutes of induction was 79.29 bpm, and the mean or average pulse rate after 15 minutes of induction was 78.53 bpm. Conclusion: Changes in pulse frequency from the initial pulse to the pulse frequency after 15 minutes of induction can be said to have a  normal/stable distribution. It can be seen from the mean or average of 72.93-79.73 bpm.