The Supan Supan Laki plant (N. plena Lour) has been used traditionally by a group of people in Pal Batu Village, Paminggir District, North Hulu Sungai Regency as a herbal medicine to increase male sexual activity. Based on previous research, this plant has been proven to have a positive effect in increasing fertility in test animals. However, until now, there is no certainty regarding the safety of using this plant. This study aims to examine the effects and safety of consuming Supan Supan Laki extract on the macroscopic appearance of the liver and kidneys in mice. This research was carried out, there were four treatment groups in this study, namely Na-CMC 0.5%; 87.5mg/KgBW; 175mg/KgBW; and 350mg/KgBW, given for 28 days using a Completely Randomized Design (CRD) trial design. On the 29th day, surgery was performed to observe the liver and kidney macroscopically. Measurement of color, surface and relative organ weight parameters of the kidneys and liver of mice. The results of the study showed that administration of Supan Supan Laki leaf extract caused significant changes in the macroscopic appearance of the liver and kidney organs. In the research analysis using the One Way Anova test, the results of the test showed that the liver (p>0.05) did not have a significant level of variation, while the kidney (p<0.05) had a significant level of variation so that it could be concluded that the effect of N.plena Lour leaf extract have different effects on the relative weight of the heart and kidney organs.