Autoimmune diseases, which are disorders where the immune system attacks the body’s own tissues, can affect anyone, including children and adults. These diseases often lead to serious tissue damage and physiological disturbances. Al Fuadi Binjai General Hospital, the primary healthcare facility in Binjai City, faces challenges in diagnosing autoimmune diseases in a timely manner due to limitations in time, cost, and distance. Delays in treatment can exacerbate patient conditions and slow recovery processes. The objective of this study is to develop a system that processes symptom and autoimmune disease data using the Dempster-Shafer method, which allows for uncertainty assessment in decision-making. Patient symptom data collected and analyzed using this method aims to determine the likelihood of autoimmune diseases. The developed system demonstrated high diagnostic accuracy, with the most accurate results for lupus with a confidence level of 94.40%. This result indicates that the Dempster-Shafer method can be an effective tool in accelerating the diagnostic process and improving the accuracy of autoimmune disease management at Al Fuadi Binjai General Hospital