In the era of Industry 4.0, optimizing fluid flow systems in smart factories is essential to improve energy efficiency and operational stability. Traditional Computational Fluid Dynamics (CFD) simulations provide accurate fluid flow analysis but require extensive computational resources and long processing times, making real-time applications challenging. To address this limitation, this study aims to develop an AI-based predictive model for CFD simulations, utilizing Convolutional Neural Networks (CNN) and Extreme Gradient Boosting (XGBoost) to accelerate the estimation of fluid flow characteristics in industrial environments. The research methodology involves generating CFD simulation datasets, preprocessing data, and training AI models to predict key fluid parameters such as pressure, velocity, and temperature. The evaluation results show that CNN achieves a Mean Squared Error (MSE) of 0.0025 and a Root Mean Squared Error (RMSE) of 0.05, outperforming XGBoost, which records an MSE of 0.0030 and an RMSE of 0.055. Moreover, CNN predicts fluid dynamics in just 15.2 seconds, while XGBoost achieves results in 10.5 seconds, compared to the 1200.5 seconds required by traditional CFD simulations. These findings highlight the potential of AI in reducing computation time by over 98%, making real-time fluid flow analysis feasible in industrial settings. This study contributes to the advancement of AI-integrated CFD modeling, demonstrating that AI can significantly enhance the efficiency of fluid dynamics analysis without compromising accuracy. Future research should focus on expanding AI models to handle more complex flow conditions and integrating AI with smart factory design tools for real-time optimization