. The Framingham Risk Score (FRS) assesses coronary heart disease (CHD) risk and predicts acute coronary events. Metabolic markers like LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and TG/HDL ratio play critical roles in atherosclerosis and cardiovascular risk. Elevated LDL cholesterol, fasting blood glucose, and uric acid contribute to plaque formation, inflammation, and vascular damage, while high triglycerides and low HDL cholesterol exacerbate atherogenesis. This study explores the relationship between these markers and FRS to enhance CHD risk prediction and support targeted cardiovascular interventions. This study analyzed LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and TG/HDL ratio with Framingham Risk Score in 85 participants, excluding those with incomplete data or chronic illnesses. The analysis found significant correlations between metabolic parameters and the 10-year myocardial infarction risk. LDL cholesterol, triglycerides, and uric acid showed moderate positive associations with cardiovascular outcomes, while the triglyceride-to-HDL ratio and fasting blood glucose had weaker but significant correlations. These findings highlight lipid profiles and metabolic markers as key contributors to cardiovascular risk. This study highlights significant correlations between LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and the triglyceride/HDL ratio with 10-year cardiovascular risk. These findings emphasize the importance of lipid profiles, glycemic control, and metabolic markers in predicting coronary outcomes and guiding targeted preventive interventions for improved cardiovascular risk management.