Cyclodextrin inclusion complexes have been widely used in the pharmaceutical industry to improve drug solubility and bioavailability. Analysis of these complexes using HPLC requires the development of appropriate and validated methods. To analyze and compare various HPLC methods used for the analysis of cyclodextrin inclusion complexes, and to identify challenges and trends in method development. A literature review was conducted of articles published in the last 10 years, focusing on HPLC methods for the analysis of cyclodextrin inclusion complexes. Parameters compared included column type, mobile phase composition, flow rate, and detection method. The majority of studies used C18 columns with varying lengths and particle sizes. The composition of the mobile phase varied, reflecting the diversity of properties of the complexes analyzed. The flow rate was generally 1.0 mL/min, with the exception of the HPLC/MS method. Detection methods included UV-Vis, PDA, fluorescence, and mass spectrometry. The main challenges included the dynamic equilibrium of the complexes and stability during analysis HPLC method development for the analysis of cyclodextrin inclusion complexes requires optimization of various parameters to overcome specific challenges. Future trends are towards the use of advanced technologies such as UHPLC and high-resolution mass detection.

Waste management remains a major challenge in Indonesia, particularly concerning marine plastic waste and the increase in hazardous waste (B3). The lack of understanding and limited facilities such as TPS-3R and waste banks further exacerbate the situation. In response, we conducted a community service program in Mangunarga Village, Sumedang, West Java, aimed at raising awareness and improving waste management practices. This program included educational workshops and equipping waste processing facilities. The results showed a significant increase in community understanding and behavior related to waste management, with awareness rising from 16.5% to 97.2%, and proper waste sorting practices increasing from 8.2% to 96.3%. The success of this program underscores the importance of community-based approaches and supportive infrastructure in addressing environmental challenges at the local level.