This study aims to determine the feasibility of SETS (Science, Environment, Technology, And Society) based modules on colloidal system, determine student learning outcomes after using SETS-based modules in learning and student responses to the modules. This study uses a 4-D development model consisting of define, design, development, and dissemination. This research was conducted at SMA Negeri 11 Medan which was carried out for 7 months. The feasibility of module was seen through a feasibility questionnaire for media and material experts based on the BSNP standard with a Likert scale of 1 to 5. Validation data obtained from media and material experts on SETS-based modules obtained an average percentage of 83.58% with the category valid/worthy. Student learning outcomes were obtained through the calculation of N-Gain test, which was equal to 0.74 in the high category and the average posttest score of students was 84.67. Student responses to the SETS-based module obtained an average percentage of 91.24% with a very high questionnaire interpretation. Based on the results obtained by the researcher, it can be concluded that this SETS-based module is appropriate for use in colloidal learning with a high student learning success rate and student responses that fall into very good criteria.