Hyperlipidemia is a condition in which lipid levels in the bloodstream (plasma) experience an imbalance in lipid levels, although it does not show severe symptoms but can trigger various serious diseases. Statins are used as the main therapy for antidyslipidemia, but with long-term use, statins cause various side effects such as muscle pain, muscle disorders and muscle discomfort. Indonesia has a variety of plants that have benefits for lowering blood cholesterol levels. To determine the potential of metabolite compounds contained in several plants as HMG-COA Reductase inhibitors, research can be carried out using molecular docking. The purpose of this literature study is to determine the comparison of compounds that have HMG-COA Reductase inhibitor inhibitor activity. The method used in compiling this literature study is from various national and international scientific articles published in the period 2020-2025. The natural compounds that have been studied have significant inhibitory activity against the HMG-CoA Reductase enzyme, namely from the 10 plants studied, Rhodomyrtus tomentosa has the best activity in inhibiting the HMG-CoA Reductase enzyme with an Affinity of the Binding value of -11.4 so that it has the potential to be further developed as a natural anti-cholesterol drug.

Coronary Heart Disease (CHD) is the leading cause of death in Indonesia. CHD is a disease caused by blockages in blood vessels (atherosclerosis) that disrupt blood flow to the heart. There are several risk factors for CHD, including smoking and hypertension. The purpose of this study was to determine the relationship between smoking and hypertension in patients with CHD. This research method uses the methodliterature review. Data were obtained from secondary data using documentation techniques. This documentation was done by searching for articles through Google Scholar and Pubmed. The selected articles were in accordance with the research variables and inclusion criteria. The articles were analyzed using the procedurecompare, contrast, criticize, synthesize, dan summarize. From the study, 3 articles were obtained that had data related to smoking and CHD variables (p < 0.05) and 3 articles that had data related to hypertension and CHD variables (p < 0.05). Conclusion: There is a significant relationship between smoking and hypertension in CHD patients.

This community service program aims to introduce and implement a hydroponic farming system as an alternative effective planting medium to improve the economic welfare of the community in RT 19, Bumiayu Village, Bengkulu City. This activity is motivated by the limited agricultural land in urban areas and the minimal use of narrow spaces for productive activities. The methods used include counseling, training, and direct practice of hydroponic cultivation by utilizing used goods such as plastic bottles. The results of the activity showed that the community was very enthusiastic in participating in the training and were able to apply basic hydroponic techniques independently. From an Islamic economic perspective, this activity reflects the values ??of justice, welfare, and empowerment, where the community is not only given knowledge, but also guided to become more economically independent. Hydroponics has proven to be an alternative to modern agriculture that can increase productivity and empower the community in a sustainable manner.

This research discusses the legal process against children who commit indecent crimes and the role of rehabilitation as a recovery effort based on Decision Number XXX/Pid.Sus-Anak/2024/PN Mgg. This investigation uses normative and empirical legal methods by analyzing laws and regulations and judicial practices against children. This investigation purposes to examine the role of the prosecutor in determining the boarding school as a place of rehabilitation and assess the suitability of the prosecutor's charges with the provisions of juvenile criminal law in Indonesia. The findings showed that prosecutors play an important role in determining the form of rehabilitation by coordinating with community supervisors, considering the best interests of the child as stipulated in Law Number 11 of 2012 concerning the Child Criminal Justice System (UU SPPA). The selection of pesantren as a place for rehabilitation reflects an educational approach that not only punishes, but also shapes the morals and character of children so that they can return to society in a better condition. This rehabilitation also provides access to education and guidance in an environment that supports the mental and social recovery of children and prevents repetition of criminal acts.

Penelitian ini bertujuan untuk mengetahui pengaruh perputaran aset dan margin laba terhadap pertumbuhan berkelanjutan perusahaan (CSG) yang dimediasi oleh leverage. Penelitian sebelumnya mengenai pengaruh perputaran aset, margin laba, dan leverage terhadap CSG beberapa kali dilakukan, tetapi menunjukkan hasil yang berbeda-beda. Penelitian ini menawarkan model baru dimana leverage sebagai pemediasi hubungan perputaran aset dan margin laba terhadap CSG. Populasi penelitian ini adalah perusahaan yang terdaftar dalam Indeks ESG Quality 45 dengan periode pengamatan 2017 sampai dengan 2023. Teknik pengambilan sampel menggunakan purposive sampling dan alat analisis data menggunakan SEM PLS dengan tingkat signifikansi 5%. Penelitian ini menunjukkan hasil perputaran aset, margin laba, dan leverage berpengaruh positif terhadap CSG. Sementara itu, perputaran aset berpengaruh negatif terhadap leverage dan margin laba tidak berpengaruh terhadap leverage. Hubungan tidak langsung menunjukkan hasil yang identik, yaitu leverage memediasi perputaran aset terhadap CSG, tetapi arahnya negatif, serta leverage tidak mampu memediasi margin laba terhadap CSG.

This study aims to analyze the effect of production cost optimization on increasing profits (profit) in Micro, Small, and Medium Enterprises (MSMEs) in Pancing, Medan City. MSMEs have an important role in the Indonesian economy, contributing around 60% of Gross Domestic Product (GDP) and absorbing more than 97% of the workforce. However, many MSMEs face challenges in managing production costs efficiently, which can reduce their profit margins and competitiveness in the market. The method used in this study was a survey with a questionnaire distributed to 10 registered MSME respondents. The results of the analysis showed that 80% of respondents had businesses registered as MSMEs, and 60% of them conducted production cost analysis regularly. In addition, 70% of respondents believed that good production cost management could increase their business profits. Correlation analysis showed a strong positive relationship between production cost optimization and increased profits, with a correlation coefficient of 0.75 and a significance value of p <0.05. The regression results showed that every one unit increase in production cost optimization would increase profits by 1.20 units. This study concludes that production cost optimization has a significant effect on increasing profits in MSMEs in Medan. Therefore, it is recommended that MSME owners continue to improve their understanding of the importance of production cost optimization and implement technology that can help efficiency and conduct cost analysis regularly.

Nausea and moting affect most women in early pregnancy. Up to 80% of women experience nausea and vomiting to some degree during the first trimester, and for some, these symptoms typically resolve by 12 to 14 weeks. Nausea and vomiting can occur due to elevated levels of estrogen and HCG (human chorionic gonadotropin),but psychological factors also play a role in this condition. Complaints of nausea and vomiting are physiological in nature; however, if not promptly addressed, they can turn pathological and lead to pregnancy complications. Non-pharmacological methods, such as lemon-infused water, can effectively tackle nausea and vomiting. This quantitative research determined the effect of lemon-infused water on relieving nausea and vomiting in pregnant women during the first trimester with a pre-experimental design and a one-group pretest-posttest design. The population of this study consists of pregnant women in their first trimester suffering from nausea and vomiting at the Kedungmundu Public Health Center. The chosen sampling technique was purposive sampling yielded a sample size of 30 pregnant women in their first trimester. The Wilcoxon statistical test and the result show a p-value of 0.000 (p<0.05), accepting the alternative hypothesis (Ha) and rejecting the null hypothesis (Ho). This indicates that giving pregnancy women lemon-infused water relieves nausea and vomiting during the first trimester.

This study aims to analyze the role of the school principal in efforts to improve the quality of Islamic religious education at SMP PGRI 2 Selagai Lingga. Using a qualitative approach with a case study method, data were collected through interviews, observations, and documentation. The findings reveal that the principal plays a significant role as an educator, supervisor, and manager through programs such as Quranic reading sessions, dhuha prayer, and religious sermons designed to improve student morality. Additionally, the principal involves the teaching council in supervision and skill enhancement, including the use of technology in learning. The implications of this study emphasize the importance of the principal's role in creating a conducive and integrated educational environment based on Islamic principles.

This research aims to increase UMKM opportunities in Mojopilang Village. In this increasingly modern and sophisticated era, technology, especially social media, is growing rapidly and making things easier for its users. This is very profitable for looking for business opportunities, one of which is affiliate. This research uses an outreach method which includes training on how to create an affiliate account, mentoring to ensure that the training carried out can be applied, correct make-up procedures to maximize affiliate content, as well as evaluation in the form of questions and answers. This activity was carried out on December 13 2024, involving village communities, especially women and Mayjen Sungkono University students. Initial observation results show that several people in Mojopilang Village have the mindset that if they want to open a business, they must spend capital and have very little knowledge about affiliates. Through this outreach about affiliate make up, it is hoped that the village community, especially women, will understand and be interested in doing affiliate work, especially in the field of make up. The results of this evaluation can be seen from the enthusiasm of the socialization participants who were excited about the material presented and some of them even wanted to try becoming affiliates.

<p><span>Penelitian ini bertujuan untuk mengetahui pengaruh pengalaman kerja dan komunikasi terhadap produktivitas tenaga kerja dengan kompetensi sebagai variabel mediasi. Pengambilan sampel menggunakan <em>non-probability sampling</em> dengan 40 responden dan populasi sesuai kriteria. Jenis penelitian ini adalah kuantitatif. Populasi dalam penelitian ini adalah karyawan PT Van Techno Saa. Metoda analisis yang digunakan adalah uji asumsi klasik, analisis regresi linier, uji hipotesis, analisis jalur dan uji sobel. Hal ini dilakukan dengan menguji kemampuan variabel independen (X) dalam memberikan pengaruh tidak langsung terhadap variabel dependen (Y) dengan variabel intervening (Z). Berdasarkan hasil analisis dari 40 responden menunjukkan bahwa pengalaman kerja mempunyai pengaruh signifikan terhadap produktivitas kerja, komunikasi mempunyai pengaruh signifikan terhadap produktivitas kerja, kompetensi mempunyai pengaruh signifikan terhadap produktivitas kerja, pengalaman kerja dan komunikasi mempunyai pengaruh signifikan terhadap kompetensi. Pengalaman kerja dengan kompetensi yang berfungsi sebagai faktor mediasi komunikasi meningkatkan produktivitas tenaga kerja.</span></p><p><em><span>This research aims to determine the influence of work experience and communication on labor productivity with competency as a mediating variable. Sampling used non-probability sampling with 40 respondents and a population according to the criteria. This type of research is quantitative. The population in this study were employees of PT Van Techno Saa. The analytical methods used are classical assumption test, linear regression analysis, hypothesis testing, path analysis and Sobel test. This is done by testing the ability of the independent variable (X) to provide an indirect influence on the dependent variable (Y) with the intervening variable (Z). Based on the results of the analysis of 40 respondents, it shows that work experience has a significant influence on productivity, communication has a significant influence on productivity, competence has a significant influence on work productivity, work experience and communication have a significant influence on competence. Work experience with competencies that function as communication mediating factors increases labor productivity.</span></em></p>