This study aims to determine the effect of Firm Size, Leverage, Liquidity, and Growth Sales on Profitability in the food and beverage sub-sector listed on the Indonesia Stock Exchange for the 2020–2023 period. The sample of this research is 46 companies in the food and beverage sub-sector that are listed on the Indonesia Stock Exchange for the 2020-2023 period. The result showed that Firm Size had a significance and positive effect on Profitability and Leverage had a significance and negative effect on Profitability. Meanwhile Liquidity and Growth Sales has no effect on Profitability.