Insulin resistance is a detrimental globally common condition that is highly related to type 2 DM, as well as several different metabolic diseases. It can be diagnosed mainly, through many different abnormalities, like dyslipidemia or obesity, as well as impaired glucose levels. Many indices have been suggested for diagnosis of the IR, one of the most commonly utilized indices are the homeostasis model assessment of insulin resistance or the HOMA-IR, and triglyceride glucose index. HOMA and TyG indices, both are commonly applied for being relatively simple, non-costly, and easy to compute, particularly if compared to the gold standard method of the IR diagnosis, which is the hyperinsulinemic-euglycemic clamp. Objective: To make a comparison between HOMA-IR and TyG indices in their accuracy in IR diagnosis. Also, to investigate the strength of the relationship of these indices with BMI and lipid parameters. Results: HOMA-IR index had detected 38% IR individuals of the given sample, while TyG index had detected 51%. Though statistically this difference was not considered significant, TyG index has detected 13% more IR cases. Additionally, the relationship of both indices with BMI was shown to be highly positively correlated, though TyG index had shown even stronger correlation, as the P value in TyG was (0.0001), whereas in HOMA-IR was (0.033). Meanwhile, the lipid parameters had shown different results with both indices, where LDL-C was significantly inversely related to HOMA-IR index (P= 0.048), similarly total cholesterol though insignificantly (P=0.163). HDL-C had inverse relationship with HOMA-IR significantly (P= 0.014), and triglyceride had a positive correlation with HOMA yet, was not significant (P= 0.190). Meanwhile, TyG had significantly positive correlation with total cholesterol and triglyceride only, with a P value of (0.0006), and (0.0001) respectively. While the correlation between TyG index and LDL was positive, and TyG and HDL was negative, both insignificantly at a P value of (0.105), and (0.179) respectively. Conclusion: TyG index is more superior than HOMA index in IR diagnosis, and has a stronger positive correlation to the BMI marker. Whereas, the lipid parameters have weak relationship with both IR markers, HOMA, ant TyG indices.