Sudden cardiac arrest is a condition that occurs quite frequently. This sudden cessation of heart function is caused by the loss of electrical activity in the heart, which results in the cessation of blood circulation throughout the body. Quick and proper handling of this condition can reduce the mortality rate due to cardiac arrest. Therefore, Basic Life Support (BLS) training needs to be conducted to educate the general public. The BLS training conducted for the management officers and youth of Saint Francis of Assisi Church in Tebet was carried out by providing theoretical and practical BLS lessons, as well as conducting pre-tests and post-tests to assess the participants' understanding of the material and practices provided. From the activity conducted, a total of 22 participants attended the BLS training, and there was a significant difference in the average pre-test and post-test scores. It can be concluded that the training provided was effective in increasing the participants' understanding and knowledge of BLS.

Dementia is a complex neurodegenerative syndrome characterized by cognitive decline, including memory impairment, difficulty in thinking, and social interaction, which can affect daily activities. This condition is often caused by other diseases, including Alzheimer’s disease, vascular dementia, Lewy body dementia, and frontotemporal dementia, each with unique pathological mechanisms. Alzheimer’s disease, the leading cause of dementia, involves the accumulation of beta-amyloid plaques and tau tangles that disrupt neuronal function and trigger chronic inflammation. Vascular dementia results from impaired blood flow to the brain, while Lewy body dementia is associated with the misfolding of alpha-synuclein protein. Meanwhile, frontotemporal dementia is linked to the accumulation of tau or TDP-43 proteins, causing degeneration of the frontal and temporal lobes. Aging is the primary risk factor for dementia through the process of inflammaging, a low-grade chronic inflammation caused by persistent activation of the immune system. Inflammaging accelerates neurodegeneration by increasing oxidative stress, mitochondrial dysfunction, and the accumulation of pathological proteins. Additionally, neuroinflammation plays a crucial role by over activating microglia, which exacerbates neuronal damage. The combination of inflammation as both a trigger and a consequence create a pathological cycle that accelerates the progression of dementia. Preventive strategies include managing modifiable risk factors such as hypertension, diabetes, obesity, and adopting a healthy lifestyle, alongside developing therapies targeting inflammaging and neuroinflammation. A deeper understanding of these pathophysiological and inflammatory mechanisms is essential to support the development of multidisciplinary interventions to reduce the global burden of dementia.