The process of seeking knowledge does not merely involve intellectual intelligence but also requires emotional and spiritual strength, one of which is cultivated through patience. In fact, in today's fast-paced, instant era, many knowledge seekers often overlook the aspect of patience. Therefore, this research aims to explore the meaning and urgency of patience in seeking knowledge based on Q.S. Al-Kahfi verses 65-70, which focus on the story of Prophet Musa and Khidr. The method used in this research is a literature review with a qualitative approach, analyzing the relevant verses as well as classical and contemporary interpretations that serve as primary sources. The analysis of this article demonstrates that patience in seeking knowledge is a prerequisite for attaining true knowledge, functioning as an inner strength to overcome obstacles, maintain consistency in learning, and shape the character of a genuine learner who is not only intellectually intelligent but also spiritually mature. These findings are relevant to the integration of manners, ethics, and spirituality in contemporary Islamic education.