This study aims to compare the level of carbon monoxide (CO) air quality in Green Open Space (GOS) and Non-Green Open Space (NGOS) along the Abepura–Sentani main road in Jayapura City. The research was conducted in two locations: the Taman Makam Pahlawan Denzipur Waena (GOS) and the front area of Mega Waena (NGOS). CO levels were measured using a CO smart sensor over a period of one week, with measurements taken in the morning, noon, and afternoon at six sampling points. The findings indicate that CO concentrations are significantly lower in GOS areas compared to NGOS areas. The presence of vegetation in GOS helps reduce CO pollution by acting as a natural filter. These results highlight the importance of maintaining and developing green open spaces in urban areas as part of efforts to reduce air pollution and improve public health.