<p><em style="text-align: justify; text-indent: 14.2pt;"><span style="font-family: 'Times New Roman',serif; mso-ansi-language: EN;" lang="EN">In pattern recognition, image processing plays a role in automatically separating objects from the background. In addition, the object will be processed by the pattern classifier. In the medical world, image processing plays a very important role. CT Scan (Computed Tomography) or CAT Scan (Computed Axial Tomography) is an example of an image processing application that can be used to view fragments or cross sections of parts of the human body. Tomography is the process of producing two-dimensional images from three-dimensional film through several one-dimensional scans. Magnetic resonance imaging (MRI) is the image most often used in the field of radiology. MRI images can display the anatomical details of objects clearly in multiple sections (multiplanar) without changing the patient's position. In this study, two methods were compared, namely K-Means and Fuzzy C Means, in a segmentation process with the aim of separating between normal areas or areas with disturbances (lesions). The images used are brain and chest MRI images with a total of 10 MRI images. The image quality of the segmentation results is compared with the quality test using the Variation of Information (VOI) parameters, Global Consistency Error (GCE), MSE (Mean Square Error), PSNR (Peak Signal to Noise Ratio) and segmentation time.</span></em></p><pre style="text-align: justify; text-indent: 14.2pt;"><em><span style="font-family: 'Times New Roman',serif; mso-ansi-language: EN;" lang="EN">In pattern recognition, image processing plays a role in automatically separating objects from the background. In addition, the object will be processed by the pattern classifier. In the medical world, image processing plays a very important role. CT Scan (Computed Tomography) or CAT Scan (Computed Axial Tomography) is an example of an image processing application that can be used to view fragments or cross sections of parts of the human body. Tomography is the process of producing two-dimensional images from three-dimensional film through several one-dimensional scans. Magnetic resonance imaging (MRI) is the image most often used in the field of radiology. MRI images can display the anatomical details of objects clearly in multiple sections (multiplanar) without changing the patient's position. In this study, two methods were compared, namely K-Means and Fuzzy C Means, in a segmentation process with the aim of separating between normal areas or areas with disturbances (lesions). The images used are brain and chest MRI images with a total of 10 MRI images. The image quality of the segmentation results is compared with the quality test using the Variation of Information (VOI) parameters, Global Consistency Error (GCE), MSE (Mean Square Error), PSNR (Peak Signal to Noise Ratio) and segmentation time.</span></em></pre>