C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP) are general marker for inflammation and Arterial damage results from white blood cell invasion. This study aims to assess the level  of inflammatory markers C-Reactive Protein (CRP) and High-Sensitivity C-Reactive Protein (hs-CRP) in preeclamptic pregnant women in the third trimester of pregnancy. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP) levels by fluorescence immuno assay. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ? 0.05 were considered statistically significant.  The present study showed that there was statistically significant increase in the level of C-Reactive Protein (CRP) and High-Sensitivity C-Reactive Protein (hs-CRP) in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as inflammation.

The predictive role of oxidative stress in the pathophysiology of human pregnancy is of particular interest, as oxidative stress is increased in normotensive pregnant women through systemic inflammatory response, reactive oxygen species (ROS), and reactive nitrogen species (RNS). This study involved 40 consenting pregnant women recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Data obtained were analyzed using GraphPad Prism 9. Results were expressed as mean ± SEM, with a P-value of ? 0.05 considered statistically significant. Malondialdehyde (MDA) increased from 3.75 ± 0.42 U/L in normotensive women to 4.53 ± 0.59 U/L in preeclamptic women. However, this increase was not statistically significant (p<0.05; 0.2903). Catalase activity decreased from 114 ± 8.07 U/L in normotensive women to 84.02 ± 21.58 U/L in preeclamptic women, but this decrease was also not statistically significant (p<0.05; 0.1909). Superoxide dismutase (SOD) increased from 40.82 ± 1.23 U/L in normotensive women to 71.90 ± 5.61 U/L in preeclamptic women. This increase was statistically significant (p<0.05; <0.0001). Glutathione peroxidase (GSH) decreased from 66.74 ± 10.35 U/L in normotensive women to 50.63 ± 8.96 U/L in preeclamptic women, but this decrease was not statistically significant (p<0.05; 0.2466). These findings suggest the potential predictive roles of these biomarkers in identifying and monitoring preeclampsia.