Purpose: The aim of this study is to measure the total phenolic content in papaya (Carica papaya L.) leaf and seed extracts and to evaluate their potential as anticancer agents based on their antioxidant activity. Methodology/approach: Location & Materials: Papaya leaves and seeds were sourced from Manoko, Bandung. Extraction: The samples were washed, dried at 45°C, powdered, and extracted with 70% ethanol using the reflux method. Analysis: Total phenolic content was measured using a UV-Vis spectrophotometer at 761 nm after reacting extracts with Folin-Ciocalteu reagent and sodium carbonate. Results were compared to a gallic acid standard curve. Supporting Methods: Literature review on medicinal chemistry and anticancer drug development, as well as qualitative analysis using thin-layer chromatography (TLC) for main phenolic compounds. Results/findings: Papaya leaf and seed extracts contain significant phenolic compounds, including flavonoids and phenolic acids. These phenolics contribute to antioxidant activity, which helps protect cells from oxidative damage linked to cancer. Previous studies show papaya leaf extract can act as an immunomodulator and anticancer agent, while papaya seed contains benzyl isothiocyanate, which inhibits cancer cell growth. Limitations: The study only measures total phenolic content and does not isolate or identify individual active compounds. Anticancer activity is inferred from phenolic content and literature, not directly tested in vivo or in clinical trials. Contribution: This research provides scientific evidence that papaya leaves and seeds are promising natural sources of phenolic compounds with antioxidant and potential anticancer properties. The findings support further research in pharmacy, medicinal chemistry, and oncology, especially for developing plant-based anticancer agents.

This study aims to analyze the application of the Business Model Canvas (BMC) as a strategic planning tool in a non-profit, community-based Early Childhood Education institution, using a case study of ECE Kemah Pujian in East Jakarta. The research contributes to the understanding of how BMC can be adapted within rural education settings characterized by diverse socio-cultural dynamics. Employing a descriptive qualitative approach, data were collected through in-depth interviews with school administrators, parents, and community partners, as well as through field observations and institutional documentation. The findings reveal that ECE Kemah Pujian has successfully developed a business model that emphasizes active community participation, the integration of local values, and flexible financing strategies. The institution’s main value proposition lies in providing early childhood education that is safe, affordable, and contextually relevant to local social needs. Its funding, sourced from voluntary contributions, village funds, and community donations, illustrates a high level of community empowerment. The interconnection of all nine BMC components, such as partnerships with local government and community leaders (key partnerships), and personalized approaches to engaging with parents (customer relationships), plays a crucial role in sustaining the institution. This study confirms that BMC can be effectively applied in non-profit educational settings and may serve as a strategic model for similar institutions in other areas. Furthermore, it demonstrates how local value-based business modeling can enhance the role of education institutions as integral actors in grassroots social development.

The rehabilitation program through physiotherapy has proven effective in accelerating the recovery of knee injuries in soccer athletes by employing a structured approach that includes pain reduction, mobility enhancement, and muscle strengthening. Case studies and research indicate that a combination of interventions such as cryotherapy, Transcutaneous Electrical Nerve Stimulation (TENS), range of motion (ROM) exercises, and muscle strengthening leads to significant improvements within 3-6 weeks. The primary methods utilized include physical therapy to reduce edema and pain through modalities like cold compresses and electrical stimulation, progressive exercises focusing on flexibility, balance, and strength of the quadriceps-hamstring muscles, as well as a phased rehabilitation approach (acute, restoration, strengthening) tailored to the patient's clinical condition. Research involving 25 patients post-ACL surgery showed an increase in passive flexion ROM of 31.07% and a decrease in swelling by 3.33% after therapy sessions. For soccer athletes, these interventions facilitate a return to optimal movement function within a short timeframe through controlled sport-specific exercises. The study concludes that a comprehensive physiotherapy program significantly accelerates functional recovery and reduces the risk of long-term complications.

In the ever-growing digital era, hospitals are required to adopt the latest technology, one of which is electronic medical records (RME). RME is a digital patient health data recording system that offers various advantages in improving service quality and hospital operational efficiency. This study aims to examine improving hospital services through the implementation of RME by conducting a literature review. The research uses a literature review method by identifying, selecting and analyzing relevant literature related to the implementation of RME and its impact on improving the quality of hospital services over the last 10 years. Data is analyzed descriptively to find patterns, trends and consistent findings. The results of the literature review show that the implementation of RME can increase the effectiveness of outpatient services, improve the quality of health care, and improve patient safety. RME provides easy access and sharing of patient health information between medical personnel, increased security and privacy of patient data, as well as efficiency in data storage and tracking. However, there are challenges such as large initial investment costs, risk of technical glitches, and resistance from medical personnel to system changes. Implementing RME in hospitals provides many benefits in improving service quality and hospital quality. However, careful planning, support from all parties, and handling of existing challenges and weaknesses are needed to ensure the success of RME implementation.
 

This research aims to identify students with special needs (PDBK) with emotional barriers (tunalaras) in elementary schools. Tunalas is a disorder in managing emotions and behavior that has an impact on students' social interactions and learning processes. The method used in this research is descriptive quantitative, with data collection techniques through observation, interviews and documentation. The research results showed that of the 846 students, 11 students (1.30%) were identified as experiencing emotional obstacles. The main characteristics of students with hearing impairments include difficulties in controlling emotions, a tendency to act aggressively, and difficulties in building social relationships. Therefore, a more adaptive and emotional support-based learning approach is needed to help them participate more effectively in inclusive education. By understanding the characteristics of students with disabilities, schools can develop more appropriate learning strategies to improve their academic and social development.
 

Indonesia is a multicultural country facing serious challenges related to intolerance, social conflict, and identity polarization. This study aims to examine the strategic role of Civic Education as a means of strengthening national insight in building a tolerant society. Using a qualitative approach through literature review methods, this research analyzes various relevant sources on education, tolerance, and nationalism. The results show that Civic Education contributes to shaping students’ democratic character, inclusiveness, and appreciation of diversity. It not only transfers civic knowledge but also instills social skills and human values. However, challenges in implementation remain, such as cognitively-centered curricula and the negative influence of digital technology. Therefore, a contextual learning approach that emphasizes real-life experiences and active student participation is needed. The findings indicate the importance of synergy between schools, families, and communities in creating a conducive environment for nurturing tolerant attitudes. The implications of this research highlight the need to revitalize Civic Education as a key medium for building a peaceful, inclusive, and civilized nation amid complex social dynamics.

Madura, an island in East Java, is known for its rich cultural heritage. Despite this, prevailing stereotypes in society often emphasize negative aspects of Madurese culture, which can obscure its valuable and positive traditions. One such cultural gem is Daul music—a vibrant and rhythmic musical expression that deserves greater public appreciation. This study explores the design and development of a digital comic titled “The Sparkle of Madura’s Daul”, which aims to introduce Daul music to a younger audience, particularly teenagers aged 18–22, through the Webtoon platform. Utilizing a qualitative descriptive method, the research gathered data through observation, questionnaires, and interviews to inform the design process. The comic is created not only as an engaging entertainment medium but also as a tool for cultural education and preservation. By integrating narrative and visual storytelling, the comic presents Daul music in a compelling and accessible format, positioning it as a cultural asset comparable to the well-known Karapan Sapi. The final product is intended to reshape perceptions of Madurese identity, promote cultural pride, and encourage the appreciation of traditional music among youth. This initiative highlights the potential of digital media to bridge generational and cultural gaps while revitalizing local heritage through creative means.

SDN 3 Sungai Ambawang This can be caused by the use of learning methods that are less varied and not yet optimal strategic implementation that encourages active student involvement. This research is to improve students' learning outcomes by applying the Contextual Teaching and Learning method in phase C of class V. This class action research is carried out in two cycles with the material Jesus Suffers, Dies, and Rises, each of which consists of four stages, namely planning, implementation, evaluation, and reflection. Data acquisition was carried out by observing behavior changes and learning achievement tests in each cycle at the end of the material, The research subjects were students from SDN 3 Sungai Ambawang with a total of 16 people. The data was processed qualitatively descriptive. The results of the study show that the use of the CTL learning model can improve student learning outcomes. The increase in particular was seen from: 60%, increasing to 80%. There was also an increase in student learning outcomes with the results that proficient 20% to 65%, proficient 30%, to 20%, and there was a decrease in proficiency of 10%, to 0%, only to develop 10% to 0%, this research was carried out four times, because it had reached 95% completeness of the minimum completeness criterion (KKM) 75.

This study investigates the impact of Profitability, Revenue, and Leverage, with investment policies as intervention variables, on the share prices of telecommunications subsector companies listed on the Indonesia Stock Exchange from 2019 to 2023. Utilizing a quantitative research approach, this study analyzes secondary data collected from the company's financial statements. The aim of this study was to consider additional performance indicators for a comprehensive understanding of the overall health of the company. The sample consisted of 18 companies selected through purposive sampling, each meeting specific criteria. Statistical analysis was performed using Partial Least Square (PLS) to explore the relationships between the variables under investigation. These findings reveal that ROA, EPS, and DER have a significant positive effect on the Price Income Ratio (PER). In contrast, ROA has a significant negative impact on stock prices, while EPS, DER, and PER have a positive impact on stock prices. In addition, PER mediates the relationship between ROA and DER with stock price but does not mediate the relationship between EPS and stock price

This research was conducted in order to participate in resolving the problems that occur in UMKM Processed Mina in the coastal areas of Central Java, especially the Sayung area. Many fish processing businesses in the area only pursue profits to help the household economy, considering that their business productivity has not developed/increased, which is likely due to a lack of attention to conscious efforts to carry out or comply with Occupational Health and Safety (K3), such as using personal protective equipment such as hand straps, boots, or in processing fish related to stoves, there are no manual extinguishers for home businesses. K3 attitudes and behaviors for those whose workers are mostly women, are not/may not yet aware of this. Efforts to foster K3 attitudes and behaviors are things that affect economic businesses, especially mina because productivity is increasing. The results of the study are expected to help the local village government to strive to improve their business.