This study aims to determine the role of the Assistant Regional Secretariat of Palangka Raya City is very important in improving the performance of the Regional Secretariat apparatus in order to realize efficient and effective governance. This discussion highlights various aspects that influence the effectiveness of the role of the Assistant Regional Secretariat, such as coordination between regional apparatuses, human resource management (HR), budget management, performance monitoring, and employee motivation. Good coordination between regional apparatuses will facilitate the administration of government. In addition, competent HR management and efficient budget management are important factors in supporting the implementation of regional government programs. Performance monitoring and evaluation are also needed to ensure that every task and function of the Regional Secretariat apparatus runs according to plan. By considering all these factors, it is hoped that the performance of the Regional Secretariat apparatus can be more optimal and improve the quality of public services and regional government as a whole.
 

Background: Hemodynamics is very important to monitor, especially in general anesthesia because generally anesthesia will cause various kindsof body system disorders. The use of anesthesia using inhalation using sevoflurane can cause hemodynamic changes, one of which is changes in pulse frequency. So that a strict monitoring process is needed in its use. Objective: Knowing changes in pulse frequency in general anesthesia patients with the use of sevoflurane at PKU Muhammadiyah Gombong Hospital in 2024. Methods: This study is an Observational Descriptive study with a quantitative research design that focuses on variable analysis, specifically intra anesthesia pulse frequency after sevoflurane is given. This study used an analytic design with a cross sectional approach. Results: Frequency Distribution of Respondent Characteristics Based on Age obtained research results where the most age group was 26-45 years as many as 23 respondents (51.1%). For the gender group, the results of this study with the most respondents were male as many as 30 respondents (66.7%). Distribution based on body weight obtained research results where the most weight The results showed that the most weight group was 41-75 kg as many as 40 respondents (88.9%). The results of observations of changes in the inhalation drug sevoflurane that the mean or average induction pulse frequency was 75.47 bpm, the mean or average pulse frequency after 5 minutes of induction it was 79.73 bpm, the mean or average pulse  frequency after 10 minutes of induction was 79.29 bpm, and the mean or average pulse rate after 15 minutes of induction was 78.53 bpm. Conclusion: Changes in pulse frequency from the initial pulse to the pulse frequency after 15 minutes of induction can be said to have a  normal/stable distribution. It can be seen from the mean or average of 72.93-79.73 bpm.

iNKT cells, sometimes known as the immune system's "Swiss Army knife," have become key components of cancer vaccination treatments. Glycolipids that activate iNKT cells, including ?-galactosylceramide (?GalCer), have been used to create self-adjuvanting anti-tumor vaccinations and can boost the immune response to co-delivered cancer antigens. The chemicals synthesis of ganglioside antigens, specifically (Neu5Gc) GM3 and GM3 antigen, and conjugations to ?GalCer, and packaging into liposome as effective platforms for their in vivo deliverying are the main topics of this work. In mouse and human cell experiments, liposome containing, (Neu5Gc) GM3-?GalCer, GM3-?GalCer, and equimolar quantities of conjugates have thoroughly described and their capacities to activate iNKT cell has verified ex vivo. All subclasses of IgG antibodies were produced as a result of the candidates' potential to generate both TH1 and TH2 cytokines, according to in vivo immunization tests. Interestingly, this study shows serum antibody produced against the TACA were cross-reactive, both when they were produced separately and together. If tumor-selective antigens is selected, the ensuing antibodies response can be wider than expected, which has implications for future vaccine formulations.

Reading is a highly beneficial activity for gaining information, knowledge, and insights. When the children are encouraged to develop reading habits from an early age, they are likely to grow into individuals who enjoy reading. During this crucial and education phase, children exhibit creativity, imagination, and honesty in their thoughts and emotions. However, according to UNESCO, the literacy rate in Indonesia remains relatively low. Through the use of interactive storytelling in childrens’s education, thin community service projecta aims to promote a culture of reading. The first step in the initiative involves providing media that highlight the benefits of interactive storytelling in enhancing children’s reading interest. This method is expected to offer a fun and engaging learning experience while fostering children’s creativity, imagination, and critical thinking skills. Interactive storytelling also serves as an effective teaching strategy to support the holistic development of children.

This legal study aims to describe and study the problem about the the role of National Narcotics Agency (BNN) in enforcing the law against the perpetrators of the abuse of narcotics for himself (users) in Indonesia. This research is a normative law descriptive qualitative approach. This research uses primary and secondary data. Data collection techniques used by way of literature study. Data analysis techniques used in the writing of this law is qualitative. These results indicate the role of National Narcotics Agency (BNN) in enforcing the law against the perpetrators of the crime of drug abuse in terms of Act No. 35 of 2009 on Narcotics.
 
 

Juvenile criminal justice in Indonesia is an important aspect of the justice system that focuses on protecting the rights of children in conflict with the law. One of the efforts regulated in Law Number 11 of 2012 concerning the Juvenile Criminal Justice System (SPPA) is diversity, which aims to prevent children from the judicial process that can harm their future. This study aims to analyze the protection of children's rights in the criminal justice process, as well as the implementation of diversity in the juvenile criminal justice system in Indonesia. The method used in this study is a qualitative approach with descriptive analysis, through literature studies and interviews with various related parties, such as judges, prosecutors, and community counselors. The results of the study indicate that although there are efforts to protect children's rights in criminal justice, the implementation of diversity still faces a number of challenges, including a lack of understanding among law enforcement officers, limited facilities, and a mismatch between policies and practices in the field. This study suggests the need to increase the capacity of law enforcement officers and other stakeholders in understanding and implementing diversity efforts optimally, as well as the need for policy evaluation to improve the effectiveness of child protection in criminal justice.

The rapid growth of e-commerce has increased the urgency of personal data protection, especially in cases of corporate bankruptcy. Legal uncertainty regarding the status of personal data in bankruptcy assets poses privacy risks. This study examines regulatory gaps in the Bankruptcy and PKPU Law (UU KPKPU) and the Personal Data Protection Law (UU PDP) concerning consumer personal data protection in bankrupt e-commerce companies. This research employs a normative juridical method by analyzing applicable legal norms. This approach reviews legislation, jurisprudence, and other legal documents to understand and evaluate the legal application of personal data protection in e-commerce bankruptcy. The study finds that personal data protection remains a legal obligation for bankrupt e-commerce companies under the UU PDP. However, legal gaps in the UU PDP and UU KPKPU regarding bankruptcy require regulatory harmonization to safeguard consumer privacy rights.

Food waste is a global issue that continues to be discussed. This is because the problem of food waste can have an impact on the environment, health and climate. Through the Sustainable Development Goals (SDGs) initiative, creating a sustainable community through food waste management is made a top priority. This article discusses the implementation of the Zero Food Waste program at SDN Ekologi Kahuripan Padjajaran using the Black Soldier Fly (BSF) maggot bioconversion approach. This community service was carried out by P3K UPI Purwakarta students who collaborated with TPS 3R Ciseureuh Purwakarta to manage food waste. This service activity is carried out through several stages which include preparation, implementation and evaluation, involving students and their parents in managing organic waste. The results of bioconversion are maggots and organic fertilizer which will be used into products with economic value. This program has succeeded in increasing environmental awareness, reducing food waste, and can create sustainable solutions in managing organic waste. It is hoped that this article can make recommendations for implementing similar methods in other areas as an environmentally friendly waste management model.

This study aims to examine the application of mala in se and mala per se concepts in the counter-terrorism policy in Indonesia, based on Law Number 15 of 2003 in conjunction with Law Number 5 of 2018. Terrorism is categorized as an extraordinary crime that causes serious harm both nationally and internationally. This research employs a literature review and normative legal approach to analyze the application of criminal law norms within the context of human rights protection. The findings show that terrorism, as a mala in se offense, requires a comprehensive legal approach that prioritizes not only national security but also the protection of civil rights. The enforcement of anti-terrorism laws, if applied too broadly and harshly, may violate the principles of due process and substantive justice. Therefore, counter-terrorism efforts must be based on the pro justitia principle, supported by independent oversight and active civil society participation to prevent abuse of power and maintain the integrity of the legal system.

Education is a key element in improving the quality of human resources in the world. When the quality of human resources increases, life on earth will be better, which in turn encourages high productivity. Conversely, if the quality of human resources decreases, life on earth will also decline. The method used is a qualitative research method with a type of literature review, namely a review of research results and books on existing concepts to be studied in depth with a qualitative approach analysis so as to find new knowledge that can be used in the future. The results of the study are Physical education and sports provide various benefits, including physical health which can reduce the risk of chronic diseases, social development through interaction in time. Character education basically aims to form individuals who have integrity, empathy, a sense of responsibility for themselves and society, and a commitment to upholding truth and justice. Physical activity in physical education also plays an important role in reducing stress and anxiety levels.