This research aims to increase UMKM opportunities in Mojopilang Village. In this increasingly modern and sophisticated era, technology, especially social media, is growing rapidly and making things easier for its users. This is very profitable for looking for business opportunities, one of which is affiliate. This research uses an outreach method which includes training on how to create an affiliate account, mentoring to ensure that the training carried out can be applied, correct make-up procedures to maximize affiliate content, as well as evaluation in the form of questions and answers. This activity was carried out on December 13 2024, involving village communities, especially women and Mayjen Sungkono University students. Initial observation results show that several people in Mojopilang Village have the mindset that if they want to open a business, they must spend capital and have very little knowledge about affiliates. Through this outreach about affiliate make up, it is hoped that the village community, especially women, will understand and be interested in doing affiliate work, especially in the field of make up. The results of this evaluation can be seen from the enthusiasm of the socialization participants who were excited about the material presented and some of them even wanted to try becoming affiliates.

iNKT cells, sometimes known as the immune system's "Swiss Army knife," have become key components of cancer vaccination treatments. Glycolipids that activate iNKT cells, including ?-galactosylceramide (?GalCer), have been used to create self-adjuvanting anti-tumor vaccinations and can boost the immune response to co-delivered cancer antigens. The chemicals synthesis of ganglioside antigens, specifically (Neu5Gc) GM3 and GM3 antigen, and conjugations to ?GalCer, and packaging into liposome as effective platforms for their in vivo deliverying are the main topics of this work. In mouse and human cell experiments, liposome containing, (Neu5Gc) GM3-?GalCer, GM3-?GalCer, and equimolar quantities of conjugates have thoroughly described and their capacities to activate iNKT cell has verified ex vivo. All subclasses of IgG antibodies were produced as a result of the candidates' potential to generate both TH1 and TH2 cytokines, according to in vivo immunization tests. Interestingly, this study shows serum antibody produced against the TACA were cross-reactive, both when they were produced separately and together. If tumor-selective antigens is selected, the ensuing antibodies response can be wider than expected, which has implications for future vaccine formulations.

Background: Hemodynamics is very important to monitor, especially in general anesthesia because generally anesthesia will cause various kindsof body system disorders. The use of anesthesia using inhalation using sevoflurane can cause hemodynamic changes, one of which is changes in pulse frequency. So that a strict monitoring process is needed in its use. Objective: Knowing changes in pulse frequency in general anesthesia patients with the use of sevoflurane at PKU Muhammadiyah Gombong Hospital in 2024. Methods: This study is an Observational Descriptive study with a quantitative research design that focuses on variable analysis, specifically intra anesthesia pulse frequency after sevoflurane is given. This study used an analytic design with a cross sectional approach. Results: Frequency Distribution of Respondent Characteristics Based on Age obtained research results where the most age group was 26-45 years as many as 23 respondents (51.1%). For the gender group, the results of this study with the most respondents were male as many as 30 respondents (66.7%). Distribution based on body weight obtained research results where the most weight The results showed that the most weight group was 41-75 kg as many as 40 respondents (88.9%). The results of observations of changes in the inhalation drug sevoflurane that the mean or average induction pulse frequency was 75.47 bpm, the mean or average pulse frequency after 5 minutes of induction it was 79.73 bpm, the mean or average pulse  frequency after 10 minutes of induction was 79.29 bpm, and the mean or average pulse rate after 15 minutes of induction was 78.53 bpm. Conclusion: Changes in pulse frequency from the initial pulse to the pulse frequency after 15 minutes of induction can be said to have a  normal/stable distribution. It can be seen from the mean or average of 72.93-79.73 bpm.

This study aims to determine the role of the Assistant Regional Secretariat of Palangka Raya City is very important in improving the performance of the Regional Secretariat apparatus in order to realize efficient and effective governance. This discussion highlights various aspects that influence the effectiveness of the role of the Assistant Regional Secretariat, such as coordination between regional apparatuses, human resource management (HR), budget management, performance monitoring, and employee motivation. Good coordination between regional apparatuses will facilitate the administration of government. In addition, competent HR management and efficient budget management are important factors in supporting the implementation of regional government programs. Performance monitoring and evaluation are also needed to ensure that every task and function of the Regional Secretariat apparatus runs according to plan. By considering all these factors, it is hoped that the performance of the Regional Secretariat apparatus can be more optimal and improve the quality of public services and regional government as a whole.
 

The dynamics of legal politics in resolving conflicts through mediation in Indonesia. The mediation process is an alternative dispute resolution that is increasingly popular in Indonesia, both in the context of civil and socio-political conflicts. This research aims to analyze the role of mediation in resolving conflicts as well as the impact of legal politics involved in this process. Mediation in Indonesia often involves political factors that influence the course of the process, both from the government, judicial institutions and other related parties. In this study, the author examines various cases of successful and failed mediation, and explores how political intervention can strengthen or hinder the effectiveness of mediation. The research results show that although mediation offers a peaceful solution, political dynamics are often an obstacle that needs to be considered in optimizing this route as a means of resolving disputes. This paper is expected to provide a deeper understanding of the challenges and opportunities of mediation in the Indonesian legal system.

The Latin word "corruption" comes from the words "korruptus" and "corruption", which means "bad, depraved, deviant from morals, insulting words, or slanderous. Corruption, according to the Black Law Dictionary, is defined as an action carried out with the aim of obtaining several benefits which are contrary to duties and other official truths: "an act from an official or trusted person who unlawfully and wrongly uses a number of advantages for himself or another person which is contrary to his duties and other truths". Eradication of Corruption Crimes Number 31 of 1999, which was later changed to Law Number 20 of 2001, shows that the government is committed to eliminating criminal acts of corruption. The author uses standard methods in writing this journal to describe the problems discussed: Law Enforcement in Criminal Cases Corruption of the Natuna Regency NGO Non-Governmental Organization Forkot (Case Study Decision Number 28/Pid.sus-TPK/2023/PN Tpg). They use data from various reading sources, such as statutory regulations, books, and the same decisions. The criminal act of corruption committed by Forkot NGO Natuna, led by Wan Sofian Telang, violates Article 11 of Law Number 20 2001 concerning amendments to law number 31 of 1999 concerning the eradication of criminal acts of corruption in conjunction with article 15 and article 56 1 of the Criminal Procedure Code.

This research aims to determine the supporting factors, both internal and external supporting factors, and inhibiting factors, both internal and external inhibiting factors, for mediators in mediating against bed-separated perpetrators at the Class 1A Gorontalo Religious Court. This research is classified as empirical research with a case, context and sociological law approach. Data sources were obtained through interviews and observations which were then analyzed descriptively. The results of this research show that in conducting mediation, both Judge Mediator and non-Judge Mediator still experience several obstacles which have an impact on the success of the mediation process.

The East Java Provincial Government established the East Java Super Corridor (EJSC) in five regions, including Bojonegoro Regency, to provide coworking spaces for the public. EJSC Bakorwil Bojonegoro is the only coworking space in the area, making it essential to offer high-quality services. This study aims to describe the service quality of the coworking space at EJSC Bakorwil Bojonegoro using a descriptive qualitative method. This research focuses on the five service quality indicators proposed by Kotler and Keller (2016): reliability, responsiveness, assurance, empathy, and tangibles. Data were collected through interviews, observations, documentation, and literature studies, with data analysis involving collection, reduction, presentation, and conclusion drawing. The findings indicate that the service quality of the coworking space at EJSC Bakorwil Bojonegoro is generally satisfactory. Reliability is reflected in the provision of free facilities that support user productivity. However, responsiveness still faces challenges in terms of timely responses to complaints and the flexibility of operating hours. Assurance has been established through effective communication, although staff professionalism needs improvement. Empathy is demonstrated through warm and responsive interactions between management and users. Tangibles indicate that the available facilities are adequate, but some shortcomings remain, such as limited parking space and suboptimal workspace arrangement.

The type of research in this study is a qualitative research method with description format, while the data collection techniques in this study are: observation, interviews, documentation. Then the data analysis techniques used is data collection, data reduction and conclusion drawing. Informants namely: Department of Industry and Trade of Sinjai Regency, Secretary of Bonto Tengnga Village, Market Traders of Sinjai Village. Tengnga, Bonto Tengnga Village Market Traders, buyers, Bonto Tengnga Village Community. Tengnga Village Community. The results of research on the Effectiveness of the Use of the Village People's Market Bonto Tengnga in Sinjai Borong sub-district, in terms of the number of traders and stalls concluded that the number of traders selling is around 10 people while the available kiosks are 12 but only one kiosk is used. there are 12 but only one kiosk is used. In terms of buyer interest in the People's Market Bonto Tengnga People's Market is still lacking buyers due to the market schedule which is close to the markets in Sorong. with the markets in Sinjai Borong, as well as the lack of income of the surrounding community, most of whom work as shopkeepers. surrounding communities who mostly work as farmers. In terms of Constraints and Obstacles to the Management of the People's Market, the regulation of traders in buying and selling in the market because sometimes the fields do not follow the rules of the market. in the market because sometimes the fields do not follow the government regulations that have been determined and the traders prefer to follow the regulations. government regulations that have been determined and traders prefer to sell in front of the market because they assume that buyers are buyers. because they think that buyers are always in front and do not keep the market clean. market cleanliness.

Legislation regarding judicial examination procedures requires forensic experts, article 133 of the Criminal Procedure Code paragraph (1), explains that in the case of an investigator for the purposes of justice regarding a victim who has been injured, poisoned or died allegedly because of an incident which constitutes a criminal act, the judiciary has the authority to submit a request expert information. In medical experts, justice and other experts. Why do you need a forensic doctor? Because it is impossible for investigators, judges, prosecutors to know all the knowledge in the field of medicine which will later be used to deal with criminal cases related to the human body, for example: violence, murder, suicide. With this, the authorities will ask for help from a doctor as an expert witness, the doctor's testimony as an expert witness, the doctor's testimony is regulated by law. In handling murder cases, a forensic autopsy is needed which will provide clear information regarding criminal cases. Accordingly, a forensic autopsy will produce tools that can be used as evidence in deciding a case by a judge. With a forensic autopsy, the cause of a person's death will be known. Therefore, an autopsy is very much needed in the investigation of criminal acts of murder and during the trial process. This research aims to understand the process of proving the criminal act of murder in the Gorontalo District Court with case number 61/PID.B/2023/PN.GTO. and the use of autopsy evidence in the process of proving this research is analyzed normatively, namely research that analyzes the reciprocal relationship between legal facts and social facts which can be seen as independent variables and social facts as dependent variables. murder that was not accompanied by an autopsy.