Biochemical pathways are the complex pathways of chemical reactions vital to maintain cellular homeostasis, control metabolism and modulate responses to physiological stimuli. Recent developments in the omics technologies, gene editing tools, and systems biology have significantly deepened our understanding of these pathways, changing the scientific paradigm from linear reactions to complex and interrelated regulatory networks. This review examines the changing face of metabolic and signaling pathways including but not limited to glycolysis, TCA cycle, MAPK, PI3K/AKT and JAK/STAT and their role in health and disease. Particular attention is paid to pathway analysis innovations, including CRISPR/Cas9, single-cell and spatial transcriptomics, and computational modelling and their revolutionary effect on discovery of new drug targets and pathway specific therapeutics. In reviewing the most recent advances in cancer metabolism, immune signaling, and cross-pathway interactions, this paper emphasizes the translational promise of pathway-centric research for personalized medicine, especially in oncology, neurodegeneration, cardiovascular, and autoimmune diseases. The review attempts to bridge basic biochemical research with clinical applications, and provides a window into the manner in which pathway-based interventions are influencing the future of precision therapeutics.

Transformational leadership has become a leadership style that emphasizes change, inspiration, and empowerment. The transformational leadership style carried out by the principal has not yet gone hand in hand with the underlying values. This study aims to analyze the transformational leadership of the principal in the perspective of axiological philosophy. Especially related to ethical and aesthetic values ​​in decision making and teacher coaching. This study uses a qualitative approach method with the principal as the subject of research. And using literature study techniques from various references on educational philosophy and leadership management. Data were collected through participatory observation and school administrative documentation. The results of the analysis show that the axiology of transformational leadership emphasizes the importance of human values, justice, empathy, and beauty in forming a transformative and humanistic school climate. By integrating the philosophy of axiology, the principal's leadership is not only oriented towards achieving targets, but also forming the character and culture of the school that is meaningful morally and aesthetically. This finding confirms that the integration between the philosophy of values ​​and transformative leadership is not only theoretically ideal, but also real in practice in the field of education.

Micro, Small, and Medium Enterprises (MSMEs) are an important sector in Indonesia's economy. However, many MSME actors still face challenges in managing financial reports in a simple and effective manner. One solution is to utilize an accounting application based on Microsoft Excel, which is easy to operate and requires no additional costs. This community service activity aims to provide training and mentoring for MSME actors in using Excel-based accounting applications to record transactions, prepare simple financial statements, and monitor the financial condition of their businesses. The implementation of this activity was carried out online through Zoom Meetings and WhatsApp Groups. The methods used included socialization, interactive online training, and online mentoring. The results of the activity showed that participants were able to understand the basic concepts of accounting records and were capable of using a simple Excel application to record daily transactions, prepare income statements, and cash flow reports. This activity is expected to improve financial literacy and the independence of MSME actors in managing their business finances

The application of machine learning, particularly the *Convolutional Neural Network* (CNN) method, has experienced rapid development in the medical field. Through the process of image data grouping, CNN is capable of classifying based on the similarity of characteristics and attributes of the images. This capability is highly beneficial in the healthcare sector, especially in differentiating chest X-ray images. This study aims to evaluate the DenseNet architecture while applying it to classify Covid-19 disease by utilizing 98 chest X-ray images as training data. The test results showed that the average *loss* value on the training data was 0.8621, with an average accuracy of 0.6950. Meanwhile, the average *loss* value on the validation data was recorded at 1.0682, with an average accuracy of 0.6399. From these results, it can be concluded that the model performed better on the training data than on the validation data, indicating the occurrence of *overfitting*. Therefore, further adjustments to the model are necessary to improve its performance on the validation data

Nanotechnology is the science of present and future, it has different physical, chemical, biological preparation methods, it has many applications in green chemistry, agriculture, industry, electronics, environmental pollution. Gold, silver, zinc oxide and titanium dioxide nanoparticles are among most important particles that have many advantages and uses.

The advancement of digital technology today has brought forth various applications based on Artificial Intelligence (AI) that can be utilized to support organizational management activities, including mosque management. This community service activity aims to introduce the basic concepts of AI and its potential applications in supporting the activities of mosque administrators in the Islamic Village Tangerang area. The activity was conducted online through socialization sessions and interactive discussions, covering materials on AI introduction, examples of simple AI implementations, and discussions on opportunities for its application in mosque administration and digital da'wah media. This activity was successfully carried out, and the results showed an increase in participants' understanding of basic AI concepts as well as enthusiasm to further develop the use of this technology within the mosque environment. This program is expected to serve as a starting point for mosque administrators in utilizing AI technology in a positive and productive manner.

Pandhalungan Local Wisdom is one of the courses offered by Muhammadiyah Jember University's Indonesian Language and Literature Education Study Program. Learning in this course has various challenges due to its newness, one of which is the lack of textbooks. This study aims to conduct a needs assessment of the textbooks for the course. The goals are to describe the competency criteria, student characteristics, student evaluation against the course, and subject matter suggestions for the course textbook. The results show that the characteristics of students are: 1) the average age of 20–21 years, which is classified as young adults; 2) knowledge of Pandhalungan: high category 50.11%, medium 32.33%, and low 17.56%; 3) perception of the benefits of course learning: very important 32.44%, quite important 52.22%, less important 15.34%; and 4) learning motivation: high 69.13%, medium 21.85%, low 9.02%. It is also concluded that the recommended subject matter for this textbook is eight topics: 1). Pandhalungan Culture and Identity; 2). Pandhalungan Cultural History.) Pandhalungan Art and Cultural Expression; 4) Pandhalungan Traditions and Rituals 5) Pandhalungan Cultural Diversity 6) Changes and Dynamics of Pandhalungan Culture 7) Preservation of Pandhalungan Culture; and 8) Culture and Communication of Pandhalungan Society

Museum do not merely function as space for preserving historical atifacts, but also serve as educational arenas capable of conveying cultural and national values. This article examines the assimilation of cultural attractions and educational functions in three character-based museums in Surabaya: the HOS Tjokroaminoto Museum, the dr. Soetomo Museum, and the Surabaya Education Museums. This study emplyos a qualitative method with a descriptive approach, using content analysis to observe atifact, visual media, and historical narrative presanted in each museum. The findings hightlight that the assimilation of cultural attractions and educational elements within museums can serve as a strategic model for developing cultural policies that are more participatory, relevant, and contextual. This, museums are not only place to commemorate the past but also act as platform for shaping character and historical awereness among younger generations.

Science learning in public schools should be designed to accommodate both regular students and students with special education needs. This is also one of the implementations of SDG 4, Sustainable Development, specifically related to quality education and inclusive education. This study aims to measure the effectiveness of cooperative learning integrated with local wisdom values of Huyula in improving science concept mastery among regular students and students with special education needs in public schools. The study employs a pre-experimental design with a one-group, pretest-posttest approach. The study was conducted in five schools involving 323 regular students and 12 students with special education needs. The research results on the effectiveness of cooperative learning integrated with the local wisdom values of Huyula showed a significant increase in science concept mastery. This is indicated by the hypothesis test through the Wilcoxon signed-rank test with a value of z = -15.84, through the N-Gain test (high category, average 0.74), and a strong effect size through the rank-biserial correlation value (-1.00). This study concludes that the implementation of science learning integrated with Huyula values and media variety has an influence and is effective in improving the science concept mastery of regular students in the high category and students with special education needs in the medium category. This finding highlights the importance of integrating local wisdom values and media variety in supporting the improvement of science concept mastery through meaningful and inclusive teaching for all students. 

Program pengabdian masyarakat ini bertujuan untuk mengembangkan edukasi manajemen jaringan komputer di MA Al-Washliyah Kisaran dalam rangka mempersiapkan siswa menghadapi era digital yang terus berkembang pesat. Permasalahan utama yang diidentifikasi adalah kurangnya pemahaman siswa terhadap dasar-dasar jaringan komputer, konfigurasi perangkat keras, keamanan jaringan, dan troubleshooting. Solusi yang diusulkan meliputi pelatihan praktis dan interaktif yang mencakup pengenalan konsep dasar jaringan, serta penerapan langsung melalui simulasi dan praktik langsung di lapangan. Program ini dirancang untuk meningkatkan kemampuan teknis siswa, memperluas wawasan mereka tentang pentingnya jaringan dalam kehidupan sehari-hari dan dunia kerja, serta mempersiapkan mereka agar mampu bersaing di era digital. Selain itu, program bertujuan mendukung pengembangan keahlian yang relevan dan mendorong inovasi di bidang teknologi informasi. Target luaran dari kegiatan ini meliputi publikasi jurnal nasional terakreditasi minimal Sinta 6 dan muncul dalam media massa, serta peningkatan signifikan dalam pemahaman siswa terhadap konsep jaringan komputer. Melalui kegiatan ini, diharapkan siswa mampu mengelola dan memanfaatkan jaringan komputer secara efektif dan aman, serta memiliki kompetensi yang relevan untuk menghadapi tantangan teknologi di masa depan. Pendekatan sistematis dan evaluasi keberlanjutan menjadi bagian integral dari pelaksanaan program ini.