Publication Search

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels due to impaired insulin secretion, insulin action, or both. Uncontrolled diabetes can lead to various complications and decreased quality of life. Moringa oleifera leaves contain bioactive compounds, including flavonoids, vitamins A, C, and E, as well as selenium, which possess antioxidant properties and are believed to help reduce blood glucose levels. This study aims to determine the effect of Moringa leaf decoction on reducing blood glucose levels in patients with diabetes mellitus in Padaleu Village, Kambu District, Kendari City. The study employs a quantitative pre-experimental design using a one-group pretest-posttest approach. The population consists of 35 diabetes mellitus patients, with 17 respondents selected through purposive sampling. Blood glucose levels are measured before and after the administration of Moringa leaf decoction using a glucometer and observation sheets. Respondents receive 200 ml of Moringa leaf decoction daily for five consecutive days. Data analysis is conducted using paired statistical tests to determine differences in blood glucose levels before and after the intervention. The findings of this study are expected to provide scientific evidence regarding the effectiveness of Moringa leaf decoction as a non-pharmacological therapy for controlling blood glucose levels among diabetes mellitus patients. Furthermore, the results may contribute to nursing science development and serve as a reference for healthcare providers and future researchers in implementing complementary therapies for diabetes management.

Geographic tongue or benign migratory glossitis is a benign disorder of the oral mucosa that is relatively common in dental practice. This condition is characterized by erythematous areas caused by the loss of filiform papillae surrounded by irregular white borders. To understand the clinical characteristics of geographic tongue and the contributing factors involved in the development of the lesion in order to establish an appropriate diagnosis and provide adequate patient education. A 25-year-old female patient presented with complaints of patches on the tongue for approximately two months. The patient had been following an OMAD (One Meal A Day) diet for one year and reported an allergy to white rice. The patient also had a history of psoriasis. Nutritional deficiencies such as vitamin B complex, vitamin B12, folic acid, iron, and zinc may affect the integrity of the oral mucosa and disrupt the regeneration of the lingual epithelium. These conditions may lead to atrophy of the filiform papillae, resulting in the characteristic erythematous appearance of geographic tongue. In addition, immunological and inflammatory factors associated with psoriasis are also suspected to contribute to lesion development. Geographic tongue is a benign inflammatory condition with a multifactorial etiology, including nutritional deficiencies and immunological factors such as psoriasis. Evaluation of systemic conditions and nutritional status is important to support accurate diagnosis and proper patient management.

Daun kelor (Moringa oleifera) merupakan tanaman lokal yang kaya protein, vitamin, dan mineral, serta berpotensi mendukung pemenuhan gizi anak apabila diolah dalam bentuk yang lebih diterima. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberdayakan masyarakat melalui inovasi pemanfaatan daun kelor (Moringa oleifera) berbasis data empiris masyarakat sebagai permen pendukung gizi anak. Kegiatan dilaksanakan di Desa Tinelo, Kabupaten Bone Bolango, Provinsi Gorontalo, dengan sasaran ibu yang memiliki anak usia 5–12 tahun. Tahap awal dilakukan pengumpulan data empiris melalui wawancara semi-terstruktur untuk mengidentifikasi pola pemanfaatan daun kelor dan tingkat penerimaan anak. Selanjutnya dilakukan kegiatan edukasi mengenai manfaat gizi daun kelor serta pendampingan pembuatan permen herbal kelor sebagai inovasi pengolahan pangan berbasis kearifan lokal. Evaluasi kegiatan dilakukan secara deskriptif dengan membandingkan kondisi pra dan pasca kegiatan terhadap perubahan pengetahuan, sikap, dan penerimaan masyarakat. Hasil kegiatan menunjukkan adanya peningkatan pemahaman ibu terhadap manfaat gizi daun kelor, dukungan terhadap inovasi pengolahan, penerimaan anak terhadap konsumsi kelor, partisipasi aktif masyarakat, serta minat untuk mengolah daun kelor secara mandiri. Kegiatan ini menunjukkan bahwa pendekatan pemberdayaan berbasis data empiris dan inovasi pangan lokal efektif dalam meningkatkan pemanfaatan daun kelor sebagai pendukung gizi anak.

  Red dragon fruit contains bioactive compounds such as vitamin C, flavonoids, and polyphenols that have antioxidant potential and possess natural pigments that can be used as cosmetic colorants. This study aims to formulate and evaluate a blush-on powder preparation from dragon fruit pulp extract as an alternative natural colorant. The evaluation includes organoleptic testing, homogeneity, pH, irritation, spreadability, fineness, moisture content, and antioxidant activity. The results showed that the formulation met most of the requirements, exhibiting a pink color, a smooth texture, no odor, homogeneity, a pH of 6 suitable for the skin, no irritation, even spreadability within 4 applications, a fineness degree of 97.6%, and a moisture content of 6.91%. Antioxidant activity showed an IC₅₀ value of 0.3036 ppm (very strong), although the relative inhibition percentage was low (18.35%). Thus, dragon fruit extract has the potential as a natural ingredient in blush-on powder that provides both color and antioxidant benefits.

Anemia is a common nutritional problem among adolescent girls and can affect health, learning ability, and the quality of future generations. Hemoglobin (Hb) levels can be influenced by dietary intake, such as folic acid and vitamin C, as well as consumption behaviors, including tea drinking habits and adherence to iron supplementation (TTD). This study aimed to examine the relationship between folic acid intake, vitamin C intake, tea drinking habits, and adherence to TTD consumption with hemoglobin levels among adolescent girls in senior high schools in Tuban District. This study used a cross-sectional design with a sample of 325 respondents selected through probability sampling. Data on folic acid and vitamin C intake were obtained using a 24-hour dietary recall method, while tea drinking habits and adherence to TTD consumption were collected through questionnaires. Hemoglobin levels were measured directly using a hemoglobin testing device. Data analysis was performed using the Spearman correlation test. The results showed significant relationships between folic acid intake and hemoglobin levels, vitamin C intake and hemoglobin levels, adherence to iron supplementation and hemoglobin levels, and tea drinking habits and hemoglobin levels, with a negative direction of association. This study concludes that folic acid intake, vitamin C intake, tea drinking habits, and adherence to TTD consumption influence hemoglobin levels in adolescent girls. Efforts to prevent anemia should focus on improving dietary patterns, proper use of iron supplementation, and regulating tea drinking habits.

Sweet orange peel (Citrus x aurantium L.) is an agricultural by-product rich in bioactive compounds including flavonoids, phenolics, terpenoids, and vitamin C with antioxidant and moisturizing potential. This study aimed to formulate and evaluate a body lotion using 15% ethanol extract of sweet orange peel obtained by maceration with 96% ethanol. Evaluations included organoleptic, homogeneity, pH, adhesion, spreadability, viscosity, irritation, cycling test, cream type, and DPPH antioxidant activity assessments. The preparation was semisolid, yellow, with a characteristic herbal aroma, homogeneous, pH 8, adhesion time of 4.10 seconds, spreadability of 9.9–11.1 cm, and acceptable viscosity. The preparation caused no skin irritation, remained stable through six cycling test cycles, and formed an oil-in-water (O/W) emulsion. Antioxidant activity showed an IC₅₀ of 284.6 ppm (weak category) compared to vitamin C as positive control (IC₅₀ 4.2 ppm). It was concluded that ethanol extract of sweet orange peel can be formulated into a stable and safe body lotion, though further optimization is needed to enhance its antioxidant activity.

Effervescent granules are a pharmaceutical dosage form that offer advantages in terms of ease of use, improved palatability, and rapid solubility in water. This study aimed to formulate and evaluate the physical properties of vitamin C Effervescent granules using the dry granulation method. The main materials used included ascorbic acid as the active substance, citric acid and tartaric acid as acid sources, and sodium bicarbonate as the base source. Evaluation was carried out on organoleptic properties, flow properties, pH, angle of repose, moisture content, density, compressibility index, and dispersion time. The results showed that the granules met the requirements for organoleptic properties, pH (4–5), angle of repose (38.41°), compressibility index (12.3%), and dissolution time (49.62 seconds). However, the flow property (29.11 seconds) and moisture content (6.47%) did not meet the established standards. These findings indicate that the formulated granules met most of the evaluation parameters but still require optimization, particularly in the drying process and flow properties, to obtain a more stable and high-quality dosage form.

Atrophic rhinitis or ozena is a chronic infection of the nasal cavity characterized by progressive atrophy of the nasal mucosa and turbinate bones accompanied by the formation of foul-smelling nasal crusts. This condition is more commonly found in females, particularly during puberty, and is frequently associated with populations of low socioeconomic status and poor environmental sanitation. The exact etiology of atrophic rhinitis remains unclear; however, several factors are believed to contribute, including chronic infection by *Klebsiella ozaenae*, vitamin A and iron deficiency, chronic sinusitis, hormonal imbalance, collagen diseases, trauma, and genetic predisposition. Common clinical manifestations include nasal obstruction, thick greenish nasal discharge, crust formation, epistaxis, anosmia, and *foetor ex nasi*, which is often more noticeable to people around the patient. Anterior rhinoscopy typically reveals widened nasal cavities, turbinate atrophy, thin and dry nasal mucosa, as well as purulent secretions and greenish crusts. Diagnosis is established through history taking, ENT physical examination, and supporting investigations such as microbiological culture, histopathological examination, radiological imaging, and paranasal sinus CT-scan. Management may be conservative with antibiotics, nasal irrigation, nasal drops, vitamin A supplementation, and iron preparations, or surgical in severe cases or those unresponsive to conservative therapy.

Febrile seizures are seizure episodes that occur in association with an elevation in body temperature (rectal temperature >38°C) caused by an extracranial process. Febrile seizures are classified into two types: simple febrile seizures and complex febrile seizures. The World Health Organization (WHO) estimated that in 2019 there were 18.3 million cases of febrile seizures worldwide, with approximately 154,000 resulting in death. This case report discusses a patient, An YZ, a 1 year and 5-month-old female, who was brought to the emergency department of Cut Meutia Hospital with a chief complaint of seizures. The seizures began two days prior to hospital admission, characterized by generalized tonic stiffening and clonic movements involving the entire body. Each episode lasted approximately 5 minutes. The seizures occurred twice, initially at 7:00 PM and subsequently at 9:00 PM. The patient was diagnosed with complex febrile seizures associated with morbilli and very mild microcytic hypochromic anemia due to iron deficiency anemia. Pharmacological management included cefotaxime, ranitidine, ondansetron, paracetamol, ambroxol, cetirizine, diazepam (Stesolid), and vitamin D. After three days of hospitalization, the patient showed clinical improvement and was discharged.

Background: Anemia in pregnancy is a significant public health problem that can increase the risk of maternal and fetal complications. One of the main strategies to prevent anemia is the administration of Multiple Micronutrient Supplements (MMS), which provide essential vitamins and minerals during pregnancy. However, the effectiveness of MMS in preventing anemia is closely related to the level of knowledge pregnant women have about its use. Therefore, understanding the relationship between knowledge about MMS and anemia incidence is crucial to improving maternal health outcomes (Rahmawati et al., 2023). Objective: This study aims to determine the relationship between pregnant women’s knowledge level about Multiple Micronutrient Supplements (MMS) and the incidence of anemia among pregnant women in the working area of Dr. Hi. Zainal Umar Sidiki Hospital, North Gorontalo. Methods: This research employed an analytical observational design with a cross-sectional approach. A total of 30 pregnant women were selected as the sample using purposive sampling techniquesResults: The study found that the majority of participants who had high knowledge levels about MMS had a lower incidence of anemia, while those with low knowledge levels had a higher incidence. These results highlight that knowledge about MMS strongly influences pregnant women’s adherence and effectiveness in preventing anemia. Conclusion: There is a significant relationship between pregnant women’s knowledge level about Multiple Micronutrient Supplements (MMS) and the incidence of anemia. Improving maternal knowledge about MMS through health education, counseling, and guidance from healthcare providers is essential to prevent anemia and support optimal pregnancy outcomes.

The COVID-19 pandemic caused by SARS-CoV-2 has had a significant impact on public health behavior, including the increasing consumption of health supplements as an effort to strengthen immunity. This study aims to describe the level of knowledge of the people of Gedongan Village RT 01 RW 05 regarding the use of health supplements during the pandemic. Health supplements are defined as products that contain vitamins, minerals, amino acids, and herbal ingredients to support the immune system. The study used a descriptive approach with a survey method, involving 106 respondents who were selected purposively. Primary data was obtained through a structured questionnaire that had been validated, then analyzed descriptively. The results showed that the majority of respondents had a level of knowledge in the sufficient category (54%), followed by the poor category (25%) and the good category (21%). Respondents understood the benefits of supplements as a nutritional supplement, but knowledge related to rules of use, appropriate dosage, and potential side effects was limited. Demographic factors such as age, education, and type of work have an effect on knowledge levels, where respondents of productive age, secondary education, and work with cognitive demands show better understanding. The study concludes the need for continuous health education through health workers, especially pharmacists, with an approach according to demographic characteristics to encourage the use of supplements in a rational, safe, and appropriate manner.

Background: The postpartum period is a critical phase requiring optimal nutritional intake for maternal recovery and ensuring the quality of breast milk. In densely populated urban areas such as Semampir District, dietary quality is often influenced by the level of nutrition knowledge and household economic conditions. Objective: This study aims to analyze the relationship between nutrition knowledge and household food security with dietary quality among postpartum mothers in Semampir District, Surabaya. Methods: This was an observational analytical study with a cross-sectional design. A total of 340 postpartum mothers were selected using simple random sampling. Nutrition knowledge was measured through a structured questionnaire, food security was assessed using the Household Food Insecurity Access Scale (HFIAS), and dietary quality was measured using the 3-level Balanced Diet Index derived from 24-hour food recall data. Data were analyzed descriptively and through the Chi-Square correlation test. Results: The findings indicated that the majority of respondents possessed a good level of nutrition knowledge (average correct answers >75%), with the highest score in anemia prevention (81.2%) and the lowest in the functional role of Vitamin A (75.9%). Dietary quality assessment revealed that most respondents were in the [Select: Moderate/Poor] category based on IGS scores. Bivariate analysis showed a significant relationship (p < 0.05) between both nutrition knowledge and household food security with the dietary quality of postpartum mothers. Conclusion: Good nutrition knowledge and stable food security contribute positively to the dietary quality of postpartum mothers. Targeted nutritional education regarding micronutrients and strengthening food access at the household level are essential to optimize maternal health during the postpartum period in urban settings.

The health of pregnant and breastfeeding women is a crucial determinant of the quality of future generations, particularly during the first 1,000 days of life. However, nutritional problems, such as deficiencies in iron, protein, and essential vitamins, remain prevalent in many regions, especially in rural areas. These conditions may increase the risk of anemia, impaired fetal growth, and reduced maternal and child health outcomes. This community service program aimed to improve the nutritional status as well as the knowledge and awareness of pregnant and breastfeeding women regarding the importance of balanced nutrition in Sukorejo Village, Bojonegoro Regency. The program was implemented through the provision of free balanced nutritious meals tailored to the nutritional needs of pregnant and breastfeeding women, accompanied by health education activities, including counseling sessions and interactive discussions on healthy dietary patterns, food hygiene, and anemia prevention. Program evaluation was conducted through participatory observation and participant feedback. The results indicated an improvement in participants’ understanding of balanced nutrition and positive behavioral changes in daily food selection and consumption. This community service initiative is expected to serve as a sustainable model for improving maternal and child health and preventing nutritional problems at the village level.

The goal of continuous midwifery care is to use the SOAP documentation technique to provide comprehensive care to pregnant women up to birth control according to care standards. From May 2 - July 14, 2025, Mrs.C, G2P1A0, 32 years old received continuous midwifery care from pregnancy until get contraception methods, starting at 34 weeks of gestation. The mother complained of back pain during prenatal check-ups. The labor process went smoothly. With the assistance of a midwife, the baby was born on June 10, 2025. Birth weight: 3000 grams; length: 50 cm; head circumference: 34 cm; chest circumference: 33 cm; received Hb0 vaccine two hours after birth, eye ointment, and vitamin K shortly thereafter. The baby did not experience any problems or complaints during the first visit. Mrs. C received four visits during the postpartum period. The mother did not feel anything during the first visit up to the following visits. She continued to breastfeed exclusively, and her vital signs and fundal height returned to normal. The mother used a three-month injectable contraceptive so as not to interfere with the exclusive breastfeeding program. Mrs.C has received continuous midwifery care during pregnancy and contraceptive use, and her health is normal. It is expected that the midwife will be able to provide continuous midwifery care so that in the event of an emergency, it can be immediately identified and promptly handled.

Skin is the body's outermost organ, enveloping all parts of the human body. When the water content in the stratum corneum (SC) drops below 10%, the skin can become scaly, rough, and dry. Honey possesses humectant, emollient, and antioxidant properties, making it an effective moisturizer. The humectant properties of honey stem from its high sugar content, particularly glucose and fructose. These  sugars form hydrogen bonds with water, helping to retain moisture in the skin and thus providing a hydrating effect. Additionally, honey contains vitamin C, alpha hydroxy acids, and flavonoids, which contribute to the elasticity and firmness of the skin. Therefore, it is important to conduct a narrative review on the use of honey as a moisturizer in topical preparations, which can serve as a reference for future research. The literature search for this review was conducted using databases such as Google Scholar, Garuda Journal, MDPI, ResearchGate, and Publish or Perish, employing specific inclusion and exclusion criteria. The findings concluded that honey can be used as a moisturizer in various dosage forms, including body scrubs, anti-aging and moisturizing creams, serums, peel-off gel masks, lip moisturizers, and lip scrubs. The concentration of honey used in these formulations depends on the dosage form, its intended function in the formula (whether as an active substance, humectant, or emollient), and the comparison of honey concentration with other ingredients.

Beef demand in Indonesia continues to increase, particularly during religious holidays. Bali cattle, one of the main sources of beef, face a serious threat from Jembrana disease, a viral infection that compromises the immune system and causes significant economic losses. This study aimed to determine the correlation between spleen weight, body temperature, and cycle threshold (Ct) values in Bali cattle following Jembrana virus inoculation. A correlational method was applied to eight female Bali cattle injected with Jembrana virus inoculum. Physiological changes in body temperature were monitored, followed by necropsy to assess spleen weight. In addition, Real-Time Polymerase Chain Reaction (RT-PCR) was performed before and after inoculation to detect viral presence and determine Ct values. Data were analyzed using SPSS with Pearson correlation tests. The results revealed a very strong positive correlation between spleen weight and body temperature, while a very strong negative correlation was observed between spleen weight and Ct values. These findings indicate that Jembrana virus inoculation leads to increased body temperature and splenic enlargement in Bali cattle, accompanied by a decrease in Ct values, reflecting higher viral loads. Therefore, the administration of antipyretics, anti-inflammatory drugs, analgesics, vitamins, and antibiotics prior to vaccination is recommended to reduce the risk of hyperthermia, splenic swelling, decreased Ct values, and secondary infections.

Extrinsic skin aging or photoaging occurs due to repeated and prolonged exposure to ultraviolet (UVA) and ultraviolet B (UVB). Photoaging prevention can be done, one of which is the use of sunscreen. This literature review aims to review the role of sunscreen in photoaging prevention using a variety of existing literature. Sunscreen plays an important role in preventing skin damage caused by sunlight, especially in preventing and repairing skin damage due to sun exposure (photoaging). The addition of antioxidants such as vitamin C, vitamin E, vitamin A, melatonin, polyphenols, Polypodium leucotomos (PLE) extract as well as enzymes such as photoliase and T4N5 has been shown to increase protection against UV, visible light, and infrared-A rays and help repair skin damage. The use of colored sunscreen is recommended for protection from visible light. In addition, education on how to use sunscreen properly, such as reapplying every two to three hours and selecting the appropriate SPF and PA, also plays a big role in maximizing the effectiveness of skin protection from photoaging.

Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation, inflammation, and neoangiogenesis, largely driven by dominant T helper 1 (Th1) and T helper 17 (Th17) immune responses. Psoriasis is associated with metabolic, psychological, cardiovascular, and arthritic comorbidities. Vitamin D plays an important role in the management of psoriasis. Calcitriol (1,25(OH)₂D₃), regulates keratinocyte proliferation, differentiation, and apoptosis. Vitamin D supports the formation of the cornified envelope as well as epidermal lipid and ceramide production, also acts synergistically with the epidermal calcium gradient to maintain barrier function. In addition to its epidermal effects, vitamin D exerts immunomodulatory actions by enhancing regulatory T cells and anti-inflammatory cytokines (interleukin (IL)-10, IL-4, transforming growth factor-beta (TGF-β)), while suppressing Th1/Th17 activity and production of pro-inflammatory cytokines (IL-2, IL-17, tumor necrosis factor-alpha (TNF-α)). These mechanisms highlight its potential role in psoriasis therapy. Topical vitamin D₃ analogues are effective for mild to moderate disease due to the high expression of vitamin D receptors in psoriatic keratinocytes. Oral supplementation has also been explored for its systemic immunomodulatory effects, although findings remain inconsistent.  

Stunting remains a major chronic nutritional problem in Indonesia, including Aceh, and has serious impacts on children’s physical growth and cognitive development. Prevention efforts require appropriate, practical, and sustainable nutritional interventions, including the use of local foods such as pumpkin, which is rich in beta-carotene, vitamin A, carbohydrates, and fiber, and can be combined with animal and plant protein sources. This study aimed to evaluate the effectiveness of an instant pumpkin-based porridge in improving the weight and height of children aged 6–24 months who are at risk of stunting in the Gunung Meriah Health Center area. The study used a quasi-experimental design with a nonequivalent control group involving 41 children divided into intervention and control groups. The intervention group received the instant porridge for 21 days. Data analyzed using paired t-tests and independent t-tests showed significant improvements in the intervention group’s weight and height (p<0.05). The pumpkin-based instant porridge proved effective as a local food–based nutritional intervention and has the potential to be integrated into supplementary feeding programs and regional nutrition policies with broader coverage and longer duration..

The normal flora of chickens refers to the microbial communities that naturally inhabit the gastrointestinal tract and body surfaces of chickens, playing a crucial role in health, digestion, and immunity. This community consists of beneficial bacteria such as Lactobacillus, Bifidobacterium, and Bacillus, which assist in feed fermentation, vitamin synthesis, and inhibition of pathogenic growth. Additionally, the normal flora may include potential pathogenic bacteria such as Escherichia coli, Salmonella spp., and Campylobacter, which can cause diseases if microbial balance is disrupted. The diversity and balance of the microbiota are influenced by various abiotic factors, including feed quality, access to clean water, ambient temperature, humidity, and environmental hygiene. Biotic factors, such as microbial interactions, rearing systems, and contact with other animals, also play a significant role in determining microbial composition. Several studies have shown that the use of feed additives, such as probiotics and phytogenics, can enhance populations of beneficial bacteria while suppressing pathogenic bacteria. Extensive rearing systems, which provide chickens with more space and exposure to natural environments, tend to increase microbiota diversity compared to semi-intensive systems with more restricted conditions. Understanding these factors is essential for developing effective health management strategies and optimizing safe and sustainable poultry production.