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Bronchopneumonia is a type of infection of the lower respiratory tract that often occurs in children, especially toddlers. This disease is characterized by inflammation of the bronchioles and lung tissue which triggers increased production of secretions in the airways. The buildup of secretions often causes nursing problems in the form of ineffective airway clearance, which is indicated by ineffective coughing, rapid breathing, shortness of breath, and the appearance of additional breath sounds such as rales. Chest physiotherapy in children was carried out to evaluate the effectiveness of the clapping technique in helping to clear the airway in bronchopneumonia patients. The method applied in evidence-based practice (EBP) uses case studies with a nursing care approach. Intervention was given to three patients with a diagnosis of bronchopneumonia for three days, with a duration of approximately 1-2 minutes in each area of ​​the chest. Evaluation is carried out using a stethoscope and measuring time (clock), with the results recorded on an observation sheet. After chest physiotherapy (clapping), the three patients showed improvement in airway clearance, which was indicated by respiratory frequency returning to normal, no additional breath sounds (ronchi), and reduced secretion production. Based on these results, it can be concluded that the application of EBP through chest physiotherapy is effective in increasing airway clearance in bronchopneumonia patients.

Pneumonia caused by extensively drug-resistant (XDR) Pseudomonas aeruginosa is still  clinicaly chalenging, particularly among geriatric patients with neurological comorbidities such as stroke. This report presents a case of XDR P. aeruginosa pneumonia complicated by sepsis in a 73-year-old patient, characterized by persistent leukocytosis until the tenth day of hospitalization despite empirical meropenem therapy. This evidence-based case report aims to analyze clinical outcomes, specifically 28-day and 30-day mortality rates, and to identify mortality predictors in the adult population through a systematic literature search of the PubMed and Google Scholar databases for the 2019–2026 period. Synthesized evidence from six core studies indicates that XDR P. aeruginosa infections carry a profoundly high 28-day mortality rate, ranging from 41% to 51% in cohorts receiving antibiotic monotherapy. Key mortality predictors identified include the presence of sepsis or septic shock, a delay in initiating adequate therapy exceeding 52 hours, advanced age, and the requirement for Intensive Care Unit (ICU) admission. The phenomenon of persistent or worsening leukocytosis during treatment, as observed in this case, serves as a critical clinical indicator associated with antimicrobial response failure and a dismal prognosis. Ultimately, XDR P. aeruginosa pneumonia is associated with poor clinical outcomes, where therapeutic success is strictly contingent upon the timely administration of antibiotic regimens with proven activity against these highly resistant isolates.

With growing antimicrobial resistance becoming a major health concern, there is an urgent need to explore alternative treatment options. This study examined the efficacy of copper sulfate pentahydrate (CSP) against eight microorganisms commonly implicated in vaginal infections. We tested three Candida species (C. albicans, C. glabrata, and C. tropicalis) along with five bacterial species, including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Gardnerella vaginalis, and Pseudomonas aeruginosa. The agar dilution test was performed at concentrations ranging from 0.0001M to 0.7M of CSP. We obtained an effect of CSP antimicrobial, which was concentration-dependent. Concentrations low ( ≤ 0.007M) did not influence growth significantly. We observed partial growth inhibition at medium concentrations (0.05-0.07M, equivalent to approximately 780 -1092 µg/ml) of the solution. The growth of bacteria and yeasts was fully inhibited at 0.05M and 0.07M, respectively. The dose required to kill the organisms (not merely inhibit their growth) was 0.25M (approximately 2014 µg/ml) across all microorganisms used, and we verified this by observing no growth when samples were inoculated into fresh media. These findings have indicated that CSP possesses good antimicrobial efficacy against typical vaginal pathogens at doses that may be applied in topical therapies. However, some additional research is required, especially the research that will investigate the toxicity on human cells and the production of suitable formulations to be used clinically.

Bronchopneumonia is a lower respiratory tract infection that remains a major health problem, especially in children, which can cause impaired gas exchange and ultimately decrease oxygen saturation. This condition, if not immediately treated, can lead to hypoxia and improve the patient's clinical condition. One intervention frequently administered in the emergency room is nebulizer therapy, which functions to help widen the airways, reduce secretion production, and improve pulmonary ventilation. This study aims to determine the effect of nebulizer therapy on increasing oxygen saturation in bronchopneumonia patients in the emergency room of Dr. Dody Sardjoto Air Force Hospital. This study used a quasi-experimental design with a one-group pretest-posttest approach. The study sample was bronchopneumonia patients who received nebulizer therapy intervention in the emergency room. The results showed an increase in oxygen saturation after nebulizer therapy with a p-value of 0.000 (p < 0.05), indicating a significant effect. Thus, nebulizer therapy is proven effective in increasing oxygen saturation and can be used as a treatment intervention in the management of oxygenation disorders in bronchopneumonia patients.  

Pneumonia remains a leading cause of morbidity and mortality worldwide, particularly in resource-limited settings and among elderly populations, where timely diagnosis and continuous monitoring are often constrained by limited clinical infrastructure. This study presents an edge–cloud–integrated framework for early pneumonia risk monitoring, leveraging multimodal wearable sensors and deep learning to support continuous short-duration monitoring. The proposed system is designed to operate in near real time under simulated deployment conditions, continuously acquiring and analyzing physiological signals (respiratory rate, heart rate, SpO₂, and body temperature) alongside event-driven acoustic biomarkers (cough sounds) within a distributed architecture. A lightweight edge module performs local signal preprocessing and anomaly triage, selectively transmitting salient information to a cloud-based multimodal deep learning model for refined risk estimation and interpretability analysis. The framework was evaluated using a multi-source dataset comprising public repositories (MIMIC-III and Coswara) and a clinically supervised wearable study conducted in two Nigerian hospitals, resulting in 718  hours of quality-controlled multimodal monitoring data. In a pooled multi-source evaluation, the system achieved an AUC of 0.95, while in a clinically realistic local-only evaluation, the AUC was 0.86, reflecting a consistent but preliminary diagnostic signal. These results highlight the importance of local data adaptation for real-world applicability and suggest that multimodal AI can provide meaningful early risk indicators under resource constraints. Beyond predictive performance, this work demonstrates the feasibility of integrating multimodal learning, edge–cloud computation, and explainable analytics into a deployment-aware, privacy-preserving monitoring framework for low-resource healthcare environments.

Pneumonia is one of the leading causes of mortality in children under five, especially those living in households with active smokers. This study aims to determine the risk of pneumonia in toddlers from smoking families in the working area of Meuraxa Public Health Center, Banda Aceh City. The research used a case-control design with 33 respondents, consisting of 11 cases (toddlers with pneumonia) and 22 controls (toddlers without pneumonia). Data collection was conducted through a structured questionnaire and analyzed using the chi-square test. The findings revealed that the prevalence of pneumonia among toddlers from smoking households was 33.3%. There were significant associations between pneumonia incidence and several factors, including nutritional status (p = 0.024), immunization status (p = 0.034), exclusive breastfeeding (p = 0.027), parental smoking behavior inside the house (p = 0.009), and household ventilation (p = 0.017). Toddlers who were not exclusively breastfed, had poor nutritional status, incomplete immunization, poor air ventilation, and exposure to cigarette smoke at home were at higher risk of developing pneumonia. This study emphasizes the vital role of the family in creating a healthy, smoke-free home environment that supports children's well-being. Community-based interventions and educational programs are essential to prevent pneumonia and improve the quality of life of children, particularly in urban public health areas like Meuraxa.

This study investigated the phytochemical screening and antibacterial activity against various microorganisms including E. coli, Staphylococcus aureus, Klebsiella pneumoniae, Enterococcus faecalis, and Candida albicans. Active compounds were isolated and identified from Aleppo Oak Gallnut, obtained from the Iraqi plant Quercus Infectoria L. Plant extracts were prepared using a continuous extraction apparatus, Soxhlet, with a successive solvent system based on polarity differences, including petroleum ether (60-80°C), ethanol (78°C), and hot aqueous extracts. Acid hydrolysis was performed on the raw ethanol and hot water extracts to obtain free phenolic compounds, including Gallic acid, Apigenin, Rutin, Kaempferol, Chlorogenic acid, and Caffeic acid, using high-performance liquid chromatographic (HPLC) techniques. The inhibitory activity of Aleppo Oak Gallnut extracts (Ethanol and Hot Aqueous) after acid hydrolysis was tested using four concentrations (25%, 50%, 75%, 100%) against various microorganisms. The Ethanol extract exhibited a significant inhibitory effect on Enterococcus faecalis. The Hot Aqueous extract showed a modest inhibitory effect on Enterococcus faecalis. The Ethanol extract demonstrated strong inhibition against Klebsiella pneumoniae. The Hot Aqueous extract at 100% and 75% showed high inhibition. The Ethanol extract exhibited significant inhibitory effects against Staphylococcus aureus at 100%. The Hot Aqueous extract at 75% and 100%  demonstrated weaker inhibition against Staphylococcus aureus. The Ethanol extract demonstrated weaker inhibition against E. coli, and the Hot Aqueous extract showed no effect at 50%  and 25%, and slight inhibition at 100%  and 75%. For Candida albicans, the Ethanol extract showed minimal inhibition at all concentrations and no effect at 25%. The Aqueous extract had a slight effect at 100%  and no inhibition at 75%, 50%, and 25%.

Pneumonia ialah penyakit Infeksi Saluran Pernapasan Bawah yang bersifat akut pada parenkim paru meliputi alveolus dan jaringan interential yang dikarenakan mikroorganisme seperti jamur, virus dan bakteri. Mikroorganisme yang masuk ke saluran pernafasan bagian bawah dapat mengganggu proses pernapasan serta membuat saluran pernapasan tidak berfungsi secara optimal, sehingga proses keluar masuk oksigen juga terhambat dan mengakibatkan gangguan pada pola napas. Beberapa permasalahan lain yang ditimbulkan dari pneumonia seperti adanya penumpukan sputum, otot bantu pernapasan, penurunan ekspansi thoraks dan juga nyeri dada. Dalam perawatanya, tenaga medis berperan dalam pemberian antibiotik selama 8 jam setelah pasien mengalami perawatan serta fisioterapi berperan dalam pemberian intervensi penyinaran Infrared, Chest physiotherapy, dan Myofascial release. Penelitian ini bersifat studi kasus yang mengangkat satu kasus pasien serta mengumpulkan data melalui proses fisioterapi. Intervensi fisioterapi dilakukan sebanyak 4 kali pertemuan di Rumah Sakit dr. Ario Wirawan, Salatiga dengan menggunakan Infrared, Chest physiotherapy yang meliputi Postural Drainage, Clapping, Vibrasi, Latihan Batuk Efektif, Pursed Lip Breathing dan Myofascial release. Setelah menjalani 4 kali terapi, diperoleh hasil kondisi pasien yang mengalami penurunan nyeri dada, penurunan tingkat sesak napas, peningkatan ekspansi thoraks, berkurangnya spasme otot bantu pernapasan dan retensi sputum.

Immunization is one of the most effective and efficient public health efforts in preventing diseases and reducing mortality rates in children such as smallpox, polio, tuberculosis, hepatitis B, diphtheria, measles, rubella, congenital rubella syndrome (CRS), tetanus, pneumonia (lung inflammation) and meningitis (inflammation of the brain membrane) (Nandi & Shet, 2020). Data from the Indonesian Ministry of Health in 2020 showed that vaccination coverage in the 3rd and 4th months was months. However, efforts can be made to increase child vaccination coverage to 80% and that does not include DT, MR2, and HPV vaccinations. As, measles data is only 45%, diphtheria-tetanus (DT) is around 40% (Indonesian Ministry of Health, 2021). To determine the relationship between maternal knowledge and the completeness of basic immunization in children at the Raden Omas Posyandu. This study uses a quantitative research design with a cross-sectional method. The population in this study consisted of mothers who had children aged 12 to 18 months at Posyandu Raden Omas, totaling 36 mothers. The statistical results showed a relationship between maternal knowledge and the completeness of basic immunization in children p-value (0.048). Most respondents had good knowledge, as many as 13 respondents (36.1%). Sufficient knowledge, as many as 13 respondents (36.1%). Insufficient knowledge, as many as 10 respondents or 27.8%. Most respondents had incomplete immunization, namely 18 respondents (50%).

Pneumonia is an acute respiratory infection that remains a major public health issue in Indonesia, particularly among infants and children. West Java is among the provinces with a high number of cases, and in 2024, Tasikmalaya City reported 2,178 cases, with Cilembang Public Health Center (Puskesmas Cilembang) recording the highest number. This study aims to evaluate the P2 ISPA (pneumonia) surveillance system at UPTD Puskesmas Cilembang. A descriptive-evaluative method was used, involving interviews, document reviews, and observations with surveillance and P2 ISPA program officers at the Tasikmalaya City Health Office and Puskesmas Cilembang. The findings indicate that the pneumonia surveillance implementation at Puskesmas Cilembang is fairly adequate, although improvements are needed to better align with current guidelines and government regulations.

The smoking habits of family members are one  the causes of Bronchopenumonia in toddlers since smoking can damage the air quality around toddlers. The purpose of this research was to find out the correlation between family members' smoking behavior with the incidence of bronchopneumonia in toddlers at the GMIM Pancaran Kasih General Hospital Manado. This study used an analytic descriptive method with a cross-sectional approach. It was conducted at the GMIM Pancaran Kasih General Hospital Manado from January to February 2025. The sample of this study amounted to 30 respondents. Data collection used a family member smoking behavior questionnaire and Bronchopneumonia data observation sheet. The results showed that there are 22 toddlers had severe bronchopneumonia with severe smoking of their family members, and 8 toddlers had mild bronchopneumonia with mild smoking behavior of their family members. The Chi-Square test showed p=0.007, with a p value smaller than alpha (α) = 0.05. The conclusion in this study is  that there is a highly significant correlation between family members' smoking behavior and the incidence of bronchopneumonia in toddlers at the GMIM Pancaran Kasih General Hospital Manado. Suggestions for families should be able to stop smoking behavior that will have an impact on toddlers and surrounding people.

This study synthesized novel sulfadiazine-imine derivatives (A1 and A2) using a microwave-assisted method by reacting sulfadiazine with orsellinaldehyde and 2-hydroxy-5-methylbenzaldehyde. The synthesis involved the nucleophilic addition of sulfadiazine to the aldehyde groups, forming imine bonds efficiently under microwave irradiation within 15 minutes. The antibacterial efficacy of the synthesized derivatives was tested against Bacillus subtilis, Streptococcus pneumoniae, and Escherichia coli using agar well diffusion methods. The derivatives A1 and A2 exhibited significantly improved antibacterial activities compared to sulfadiazine, with A1 showing the highest efficacy. Specifically, inhibition zones for Bacillus subtilis reached 26 mm (A1 at 100 mg/mL) compared to 20 mm for sulfadiazine, and similar trends were observed against E. coli and S. pneumoniae. Furthermore, the cytotoxic activity against MCF-7 breast cancer cells revealed that both derivatives demonstrated dose-dependent cytotoxicity. For derivative A1, cell viability decreased to 19% at 320 ppm with an estimated IC50 between 40 and 80 ppm. Derivative A2 showed comparable cytotoxic behavior, with cell viability dropping to 12.6% at the highest concentration tested. The enhanced antibacterial and anticancer properties are attributed to increased lipophilicity and improved cellular penetration conferred by the imine functional group. This research highlights the potential of microwave-assisted derivatization of sulfadiazine to produce compounds with promising therapeutic applications.

The common cold in infants is a frequent health problem that requires proper management to prevent potential complications such as pneumonia, bronchitis, sinusitis, laryngitis, and febrile seizures. Management strategies for the common cold can be carried out through pharmacological approaches, such as the administration of syrups and powders, and non-pharmacological approaches, including traditional methods like common cold massage. This study aims to analyze the effect of providing education about common cold massage on mothers’ knowledge in managing the common cold in infants. The research employed a quantitative method with a quasi-experimental design using a one-group pretest-posttest approach. The study population consisted of 40 mothers who had infants aged 4–12 months registered at the Gunungpati Health Center. A total sample of 36 respondents was obtained through simple random sampling. The research instrument was a structured knowledge questionnaire specifically developed to assess understanding of common cold massage techniques and their role in managing symptoms. Data analysis was conducted using the Wilcoxon signed-rank test to evaluate differences in knowledge levels before and after the educational intervention. The results showed a significant increase in mothers’ knowledge after receiving education, with a p-value of 0.000 (<0.05), indicating that the intervention was statistically significant. These findings highlight the importance of non-pharmacological educational programs, particularly common cold massage, as a complementary approach to infant health care. Implementing such education can empower mothers with practical skills to manage early symptoms and potentially reduce complications. It is recommended that further studies be conducted in different settings with more varied sociodemographic backgrounds to ensure broader applicability and to explore the integration of traditional massage education into community health programs.

Pneumonia remains one of the leading causes of mortality among children under five years old worldwide. Population density is presumed to be one of the factors influencing pneumonia incidence, particularly in regions with high population growth and mobility, such as Bali Province. This study aimed to analyze the relationship between population density and pneumonia incidence among under-five children in Bali Province during the 2021–2023 period. This research was a descriptive quantitative study with a correlational design. Data on population density and under-five pneumonia cases were obtained from reports by the Bali Provincial Health Office and the Central Bureau of Statistics (BPS). Spatial visualization was performed using Epi Map version 7.2.5.0, and correlation analysis was conducted using R Studio. Descriptive analysis showed an increase in both population density and the number of under-five pneumonia cases in Bali Province during 2021–2023. Population density rose from 11,641 people/km² to 12,096 people/km², while pneumonia cases increased from 2,677 to 5,743. However, Spearman correlation analysis indicated no statistically significant relationship between population density and pneumonia incidence, with rho values of 0.5667 and p-values of 0.1206 for 2021 and 2022, and a rho of 0.2333 with a p-value of 0.5517 in 2023 (p > 0.05). No significant relationship was found between population density and pneumonia incidence among children under five in Bali Province.

Acute respiratory infection (ARI) is a condition that occurs in one or more areas of the human respiratory tract and is associated with the environmental conditions in which the patient resides. The most frequent cause of ARI is infection with Streptococcus pneumonia or Haemophilus influenza. In order to diagnose ARI by identifying the infectious agent responsible for its development, laboratory tests can be conducted on throat swab samples from patient who exhibit symptoms of ARI.. One of the objectives of this investigation was to ascertain the bacterial profile of children with ARI. This study is a descriptive cross-sectional investigation that utilised specimens from throat swabs of ARI patients in elementary school-age children who visited the Tamalanrea Makassar Health Centre between October 10, 2022, and November 10, 2022. The biopsy results were subsequently subjected to gramme staining and identification tests to ascertain the species of causative bacteria. In the 57 children, which consisted of 38 boys and 19 girls, the percentage of monobacterial findings was 49 (85.96%) and 8 (14.04) polymicrobial. Gram-positive bacteria were found 50.8% and gram-negative bacteria 49.2%, with Staphylococcus aureus being the most common cause. 

Ferritin is considered a protein that contains iron and includes two types of subunits: ferritin light chain (FTL) and ferritin heavy chain (FTH), which increases when inflammation increases, especially in the heart and kidneys, and helps in converting ferrous iron into iron. The light subunit is present in the liver and spleen and has a role in storing iron (1). Coronavirus (COVID-19) caused by the new coronavirus SARS-CoV-2 is a disease It is new to humanity, as it is accompanied by symptoms during the disease, including blood abnormalities, with activation of the immune system and phagocytic monocytes, and damage to the lungs. In our study, we showed that ferritin is an indicator of the severity of the disease and mortality (2). Acute respiratory syndrome (Coronavirus), which causes pneumonia and damages the heart, liver, and kidneys, is caused by the appearance of acute inflammatory cytokines that lead to death (3). A cytokine is a small protein that transmits messages to help stimulate the body’s immune response, and its rise causes increased inflammation, and these Cytokines secreted by macrophages (TNF-α, IL-10, IL-6) where there is high inflammation in the plasma. An indicator of the progress and severity of the disease (3).

Excessive mucus or secretions in the lungs are a common symptom of bronchopneumonia in children. The buildup of thick phlegm will be difficult to expel and can block the child's respiratory tract. One way to relieve a blocked nose and thin phlegm is by mixing eucalyptus oil and hot water. The ability of eucalyptus oil to break down mucus is caused by cineole. The nursing student's final goal is to present a research synopsis on the use of hot steam therapy along with eucalyptus oil to clear the airways of ineffective bronchopneumonia in children. Using a case study design with three (3) respondents and a mixture of hot water steam and eucalyptus oil, this research uses case study techniques and a nursing process approach. Children aged between three and four years can benefit greatly from a treatment that involves inhaling eucalyptus oil vapors for ten to fifteen minutes to clear the respiratory tract and reduce the viscosity of mucus. The results of implementing the intervention showed that the average results for respondents were 1,2,3 pre-intervention, SpO2 98%, RR: 31x/m, rhonchi(-) R1:30, R2:30, R3:32. post intervention results showed SpO2: 99% and HR: 24x/m, R1:24, R2:25, R3:24. The combined intervention of hot water steam with eucalyptus oil is effective in reducing respiratory frequency in children with bronchopneumonia.

A form of lung infection known as ventilator-associated pneumonia affects patients in hospitals who are on mechanical ventilators. Usually, it influences the cause of rising rates of disease and mortality. Hospital stays for patients with ventilator-acquired pneumonia are longer, and their mortality rate might reach 20–30%. The purpose of the present study was to evaluate the nurses' knowledge concerning preventing of ventilator-associated pneumonia in the intensive care units of Al-Nasiriya City hospitals. Descriptive study was conducted through the present investigation from 31st March, 2020 to 30th of September, 2020. Eighty nurses chosen purposive from intensive care units at AL-Hussein Teaching hospital and Al-Nasiriyah Heart Center. Including (44) females and (36) males. To measure the variables, the researcher constructed a questionnaire. The questionnaire was divided into two sections: demographic information as well as nurses' knowledge about how to prevent ventilator-associated pneumonia. A panel of specialists determined the validity. The data analyzed through descriptive and inferential statistics. The majority of the participants were having poor knowledge about prevention of ventilator associated pneumonia. Non-significant correlation between socio-demographic variables (age, gender, marital status, qualification of nurses, working shift, years of experience in ICU as well as working place) and nurses' Knowledge regarding prevention of ventilator associated pneumonia. New nurses working in ICU should participate in a training program to increase their knowledge of how to prevent ventilator-associated pneumonia. Periodically evaluating as well as for training ICU nurses to increase their understanding of evidence-based practices and nursing interventions for ventilator-associated pneumonia prevention.

The primary causes of mortality among infants are diarrhea and pneumonia. But, more than 50% of the cases were caused by malnutrition. Exclusive breastfeeding (6 months to 2 years) and providing complementary nutritious food have proven to be effective interventions in reducing the Infant Mortality Rate (IMR). This study aims to analyze maternal barriers to exclusive breastfeeding for infants aged 0-6 months in Montasik Public Health Center, Aceh Besar. This study used an analytical design with a cross-sectional approach. The population was 147 women. 60 respondents were chosen as the sample using a proportional random sampling technique. It was conducted on May 2nd–18th, 2024. The analysis uses univariate and bivariate Chi-square tests. The results showed that of 60 respondents, most of them provided non-exclusive breastfeeding for 34 respondents (56,7%), early adulthood for 32 respondents (53,3%), middle-class education level for 24 respondents (40%), self-employed for 33 respondents (55%), had sufficient knowledge of breastfeeding as 24 respondents (40%), and did not have a supportive workplace in giving exclusive breastfeeding as 34 respondents (56,7%). In conclusion, there is a correlation between age, education level, work status, knowledge, and environment towards exclusive breastfeeding. It is expected that the community health center will conduct socialization regarding exclusive breastfeeding by holding antenatal classes for a better understanding of exclusive breastfeeding.

Nosocomial infections are a serious problem that often occurs in hospitals and can have a negative impact on patient safety. The role of nurses, especially in inpatient rooms, is very important in preventing these infections. Preliminary studies found 0.34% of HAIs in hospitals, 0.00% of urinary tract infections, 0.86% of Phlebitis, 0.00% of Ventilator Associated Pneumonia. The aim of this study was to determine the relationship between knowledge and behavior of nurses regarding the prevention of nosocomial infections.This type of research is quantitative research with a cross sectional approach. Data collection was carried out through questionnaires. This population is all nurses in the Inpatient Room at PKU Muhammadiyah Sukoharjo Hospital. The sample for this research was 42 respondents who were selected using the total data saturated sampling technique used, namely univariate and bivariate analysis (Spearman rho test).The results of the univariate analysis research showed that the nosocomial infection prevention process variable, nurse knowledge was in the good category at 100% and the nosocomial infection prevention process variable, nurse behavior was in the good category at 100%. The results of bivariate analysis using the Spearman's rho statistical test show that there is a p-value of 0.000, where this value is smaller than 0.05 with a coefficient value of 0.528. So it can be said that there is a relationship between knowledge and behavior of inpatient room nurses in preventing nosocomial infections at the PKU Muhammadiyah Sukoharjo hospital.In conclusion, there is a relationship between knowledge and behavior in preventing nosocomial infections at the PKU Muhammadiyah hospital. Suggestions: Increase counseling and training on preventing nosocomial infections for nurses and health workers and non-health workers at the PKU Muhammadiyah Sukoharjo Hospital.