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  Red dragon fruit contains bioactive compounds such as vitamin C, flavonoids, and polyphenols that have antioxidant potential and possess natural pigments that can be used as cosmetic colorants. This study aims to formulate and evaluate a blush-on powder preparation from dragon fruit pulp extract as an alternative natural colorant. The evaluation includes organoleptic testing, homogeneity, pH, irritation, spreadability, fineness, moisture content, and antioxidant activity. The results showed that the formulation met most of the requirements, exhibiting a pink color, a smooth texture, no odor, homogeneity, a pH of 6 suitable for the skin, no irritation, even spreadability within 4 applications, a fineness degree of 97.6%, and a moisture content of 6.91%. Antioxidant activity showed an IC₅₀ value of 0.3036 ppm (very strong), although the relative inhibition percentage was low (18.35%). Thus, dragon fruit extract has the potential as a natural ingredient in blush-on powder that provides both color and antioxidant benefits.

Strawberries are horticultural commodities that are highly susceptible to postharvest deterioration due to their high respiration rate, microbial activity, and oxidative degradation, resulting in a relatively short shelf life. This study aimed to evaluate the effectiveness of edible coatings in extending strawberry shelf life through a systematic literature review (SLR) approach. Literature was collected from several scientific databases using keywords related to edible coating, shelf life, and strawberry, covering publications from 2019–2026. From an initial 109 articles, a selection process based on inclusion and exclusion criteria resulted in 35 articles specifically discussing the application of edible coatings on strawberries. The synthesis results showed that all studies reported an extension of shelf life after edible coating application, although the effectiveness was influenced by the type of material, formulation, and storage conditions. Chitosan was the most widely used coating material due to its natural antimicrobial activity and excellent film-forming ability. The incorporation of bioactive compounds such as essential oils, plant extracts, and phenolic compounds was proven to enhance antifungal and antioxidant activities. In addition, nanotechnology-based systems demonstrated better preservation performance compared to conventional systems. However, methodological standardization and industrial-scale validation are still required to support commercial implementation.

Sweet orange peel (Citrus x aurantium L.) is an agricultural by-product rich in bioactive compounds including flavonoids, phenolics, terpenoids, and vitamin C with antioxidant and moisturizing potential. This study aimed to formulate and evaluate a body lotion using 15% ethanol extract of sweet orange peel obtained by maceration with 96% ethanol. Evaluations included organoleptic, homogeneity, pH, adhesion, spreadability, viscosity, irritation, cycling test, cream type, and DPPH antioxidant activity assessments. The preparation was semisolid, yellow, with a characteristic herbal aroma, homogeneous, pH 8, adhesion time of 4.10 seconds, spreadability of 9.9–11.1 cm, and acceptable viscosity. The preparation caused no skin irritation, remained stable through six cycling test cycles, and formed an oil-in-water (O/W) emulsion. Antioxidant activity showed an IC₅₀ of 284.6 ppm (weak category) compared to vitamin C as positive control (IC₅₀ 4.2 ppm). It was concluded that ethanol extract of sweet orange peel can be formulated into a stable and safe body lotion, though further optimization is needed to enhance its antioxidant activity.

The prevalence of non-communicable degenerative diseases in Indonesia continues to rise, particularly affecting adolescents and productive age populations due to unhealthy lifestyle patterns and free radical exposure. Purple sweet potato leaves (Ipomoea batatas L.), a locally abundant resource often regarded merely as agricultural by-product, contain significant bioactive compounds including polyphenols, flavonoids, anthocyanins, and terpenoids demonstrating potent antioxidant properties with IC50 values of 47.99 ppm. This study employs a qualitative descriptive literature review approach, analyzing 28 scientific publications spanning 2018-2025 sourced from Google Scholar and PubMed databases to examine the potential of purple sweet potato leaves as effervescent tablet raw material for degenerative disease prevention. Findings reveal that bioactive constituents effectively neutralize free radicals, prevent lipid peroxidation, and protect cellular structures from oxidative damage linked to diabetes, cancer, and cardiovascular disorders. The effervescent tablet formulation provides strategic advantages including enhanced solubility, accelerated absorption rates due to elimination of disintegration processes, pleasant carbonation sensation masking unpleasant active ingredient taste, and superior gastrointestinal tolerance. This innovation offers promising prospects for degenerative disease prevention through local food resource utilization, though experimental validation regarding optimal formulation, effective dosage determination, and clinical efficacy assessment remains necessary for practical implementation.

Wounds can be defined as the loss and damage of anatomical cells or skin function. Wound healing consists of coagulation, inflammation, proliferation, and remodeling stages. This study aims to determine the effectiveness of the leaf fraction of the thick (Glochidion superbum) on wound healing in male white mice (Mus musculus). This study is experimental. This study used 24 male mice that were given a 10 mm long cut wound. Fractionation was carried out using the liquid-liquid extraction method. Fractionation used 3 different types of solvents, namely methanol, ethyl acetate, and n-hexane. The results showed that the ethyl acetate fraction had a faster wound healing effectiveness than the other groups. The ethyl acetate fraction contains a phenolic compound, namely methyl gallate. Methyl gallate has an important role in wound healing. Methyl gallate has the potential to be an antibacterial, antioxidant, and anti-inflammatory. The results of the Bonferroni post-hoc statistical analysis confirmed the effectiveness of the ethyl acetate fraction in faster wound healing. The thick leaf fraction was effective in healing incisions in male white mice. The ethyl acetate fraction was more effective in accelerating incision healing.

Male infertility represents a major global health concern, with oxidative stress playing a central role in the deterioration of sperm quality. In recent years, growing attention has been directed toward herbal medicine as a potential alternative or complementary therapy due to its antioxidant and multi-target properties. However, a comprehensive long-term overview of the global research landscape in this field remains limited. A bibliometric and visualized analysis was conducted using publications indexed in the Scopus database from 2005 to 2025. Eligible peer-reviewed articles were retrieved following PRISMA guidelines. Bibliometric indicators were analyzed using Biblioshiny (R-Bibliometrix) to assess publication trends, leading contributors, and thematic evolution, while VOSviewer was employed to visualize international collaboration networks, co-citation patterns, and keyword co-occurrence clusters. A total of 562 articles were included, revealing a strong upward trend in scientific output, particularly after 2016, with an annual growth rate of 15.78% and a peak in 2025. Iran, China, and Nigeria emerged as the most productive countries, while the Faculty of Veterinary Medicine and several universities in Africa, the Middle East, and Asia were identified as leading institutions. Keyword analysis highlighted three dominant research fronts: semen quality assessment, testicular histopathology, and oxidative stress–related molecular mechanisms. The collaboration network indicated increasing global and South–South research synergy. The field of herbal medicine for male infertility has evolved into a mature and multidisciplinary research domain, increasingly grounded in mechanistic and experimental evidence. These findings provide a strategic overview of research hotspots and emerging trends, offering valuable guidance for future experimental and clinical investigations.

Jam is a paste-shaped food usually made from fruit which is quite popular from children to teenagers. Aloe vera is one of the 10 best-selling plant species in the world which was developed as a raw material in the pharmaceutical and food industries, especially in countries on the European continent. Inulin is a dietary fiber contained in various types of vegetables and fruits that are beneficial for digestive health. Purple sweet potato is used in the addition of jam because purple sweet potato contains vitamin A, B vitamins and antioxidants. The purpose of this study was to determine the concentration of inulin thickener and purple sweet potato extract with high antioxidant activity, and to determine the characteristics of the panelists' preference to jam. This study used a completely randomized design with the first factor being variations in the concentration of inulin as thickener 1, 2, and 3 g. The second factor was the addition of purple sweet potato extract (40, 50, and 60%). The results of this study indicated that the jam formulation with high antioxidant activity on variations in the concentration of 1 g of inulin thickener with the addition of 60% purple sweet potato extract. The jam formulation that was preferred by the panelists was found in variations in the concentration of 2 g of inulin with the addition of 40% purple sweet potato extract which had an overall value of 3,40 (neutral). Higher purple sweet potato extract, the higher the antioxidant activity of the jam. Purple sweet potato extract can be used as a source of antioxidants in jam making.

Aloe vera (L.) Burm.f. is a bioactive plant containing polysaccharides, anthraquinones, sterols, vitamins, minerals, and glycoproteins, contributing to wound healing through anti-inflammatory, antibacterial, antioxidant mechanisms, fibroblast stimulation, and accelerated re-epithelialization. This study employed a systematic literature review (SLR) of 37 peer-reviewed articles (2018–2025) to evaluate the biochemical potential of Aloe vera and its application as a basis for modern pharmaceutical topical formulations. Results revealed that acemannan increased fibroblast proliferation by up to 200, modulated TGF-1, enhanced type I and III collagen deposition, and accelerated re-epithelialization. Anthraquinones such as aloin and emodin exhibited antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Nanoemulsion and nanogel formulations improved transdermal penetration up to threefold compared to conventional gels. These findings highlight Aloe vera’s potential as a wound healing agent and a basis for modern pharmaceutical topical preparations.

Thick leaf (Glochidion superbum) is a medicinal plant traditionally utilized by the community of East Panjang Island for the treatment of wounds, pain, and ulcers. This research was conducted to isolate the major compounds present in the ethyl acetate fraction of thick leaf and to assess its antioxidant activity using the DPPH method. The plant leaves were first cleaned, dried, and powdered, followed by maceration extraction using methanol, which resulted in an extract yield of 16.42%. The crude extract was fractionated by column chromatography using EtOAc and MeOH eluents with ratios of 9:1 (K1), 4:1 (K2), 1:4 (K3), and 1:9 (K4). UV–Vis spectrophotometric analysis showed an absorption peak at 288 nm, indicating the presence of phenolic compounds, identified as ferulic acid. Antioxidant testing using the DPPH method showed IC₅₀ values for fractions K1, K2, K3, and K4 of 12.981, 5.159, 9.658, and 10.971 µg/mL, respectively, with vitamin C as a positive control (3.563 µg/mL). Fraction K2 showed the strongest antioxidant activity. These results indicate that thick leaf contains ferulic acid with very strong antioxidant activity and has potential as a natural antioxidant source.

Sugar apple (Annona squamosa L.) is one of the local fruit commodities with high potential as a source of functional natural ingredients. This study aims to identify the morphological characteristics and profile the phytochemical content of local Sumenep sugar apple fruit as a basis for the development of its bioactivity. Morphological observations were carried out in the Sumenep area, including fruit shape, size, stem circumference, leaf characteristics, and flower parts. Phytochemical analysis was conducted using qualitative tests for tannins and saponins, while tests for flavonoids and alkaloids are planned for the next stage. Observation results showed that local Sumenep sugar apple fruits have morphological variations in the form of ovoid, round, and oblong shapes, influenced by genetic factors and environmental conditions.  Phytochemical tests showed the presence of tannins, indicated by a color change to dark green when using FeCl₃ reagent, as well as the presence of saponins, demonstrated by the formation of stable foam during the shaking test. These findings reinforce the potential of local Sumenep soursop fruit as a candidate source of functional natural compounds, particularly in relation to antioxidant, antimicrobial activities, and other pharmacological benefits. Further studies are needed to analyze other phytochemical contents and evaluate bioactive activities more comprehensively.  

Public demand for healthy, low-gluten and high-fiber food products encourages innovation in the bakery industry. This study aims to compare the texture and taste of brownies based on mocaf flour (Modified Cassava Flour) and rye flour with steamed and baked processing methods, and determine the formulation that has the best organoleptic quality. Mocaf flour was chosen because it is gluten-free, low glycemic index and locally sourced, while rye flour is rich in fiber, anthocyanin and antioxidant pigments and is beneficial for health. This study used an experimental design with three variations of mocaf proportions: rye (75:25, 50:50, 25:75) and two processing methods. Hedonic organoleptic tests were conducted by 36 panelists on aroma, taste, texture and overall reception on a likert scale of 1-7. The results showed that the processing method and the proportion of flour had a significant effect on organoleptic quality. Steamed brownies have a softer texture, while baked produce a stronger aroma and flavor. The 50:50 ratio achieves the best balance across all sensory metrics.  

Citrus hystrix DC., commonly known as kaffir lime, is a citrus plant widely distributed in Southeast Asia including Indonesia, Thailand, India, and China. Its leaves are traditionally used as food flavoring and herbal medicine due to their distinctive aroma and therapeutic potential. This study was conducted to identify the presence of secondary metabolite compounds in kaffir lime leaves through qualitative phytochemical screening. Fresh leaves were extracted and tested using standard phytochemical methods with specific reagents to detect alkaloids, flavonoids, phenolics, tannins, saponins, steroids, and terpenoids. The screening process was carried out through colorimetric reactions that indicate the presence of specific metabolite groups. The results showed that kaffir lime leaves positively contain several classes of secondary metabolites, including alkaloids (brownish-black precipitate with Bouchardat reagent), flavonoids (red color with Mg and concentrated HCl), saponins (stable foam formation after shaking with HCl), steroids (green color with acetic anhydride), terpenoids (reddish-purple color with concentrated H2SO4), and tannins (greenish-black color with FeCl3). The findings confirm that kaffir lime leaves are rich in bioactive compounds that may contribute to pharmacological activities such as antimicrobial, antioxidant, anti-inflammatory, and therapeutic properties. These results support the traditional use of kaffir lime leaves as natural medicine and highlight their potential as a source of natural bioactive compounds for further pharmaceutical and nutraceutical development. This study provides preliminary scientific evidence and encourages more detailed quantitative and isolation studies on the active components of Citrus hystrix.

This research aims to develop an innovative dessert product called Panna Cotta Wedang Kacang that combines Italian culinary elements with traditional Indonesian flavors. Panna cotta, a classic Italian dessert made from milk and gelatin, is creatively infused with wedang kacang, a traditional Javanese beverage consisting of sweet ginger broth and boiled peanuts, to create a unique taste sensation that reflects local cultural values. This study employs a Research and Development (R&D) method with an experimental approach to determine the best formulation based on organoleptic aspects, namely taste, aroma, texture, and appearance. Organoleptic testing was conducted with 30 panelists using a 1–5 hedonic scale. The results indicate that the optimal formulation is achieved from a combination of panna cotta made with liquid milk, cream, sugar, gelatin, and wedang kacang broth in a 2:1 ratio, topped with boiled peanuts. The final product received the highest scores for taste and aroma, particularly due to the harmonious blend of the creamy mild flavor of panna cotta and the warm sweetness of ginger from the wedang kacang. Additionally, the nutritional content of the product was analyzed descriptively, demonstrating that Panna Cotta Wedang Kacang has the potential to serve as a functional dessert due to its plant-based protein and antioxidant content from ginger. The conclusion of this research is that Panna Cotta Wedang Kacang is well-received by consumers and has the potential to be developed as a modern dessert alternative with a local touch.

Burn injuries are a significant health problem because they damage the skin’s protective barrier, increase the risk of infection, and may cause severe complications if not treated properly. The healing process is complex and involves several cellular events, in which fibroblasts play a key role by producing collagen and forming granulation tissue. Recently, there has been growing interest in natural, herbal-based therapies for wound care. Tamarind leaves (Tamarindus indica) were chosen in this study because they contain flavonoids, polyphenols, tannins, and saponins, all of which have anti-inflammatory, antioxidant, and tissue-regenerating properties. The aim was to evaluate the effectiveness of ethanol extract gel of tamarind leaves at concentrations of 2.5%, 5%, and 10% in promoting fibroblast proliferation and healing of burn wounds in male rats (Rattus norvegicus). An experimental randomized design was used with six groups: normal control, neative control, positive control, and three treatment groups. Clinical observation and histopathological analysis showed that the extract gel accelerated wound closure significantly compared to the negative control. Fibroblast proliferation was higher in all treatment groups, with the 10% extract giving the best result, similar to Bioplacenton. These findings highlight tamarind leaves’ potential as a safe and affordable alternative for burn wound therapy.

The rising demand for healthy food is driven by increasing along with public awareness of the importance of a balanced and nutritious diet. One innovation in healthy food products is the development of corn flour-based muffins as an alternative to wheat flour products. Corn flour is a good source contains fiber, B-complex vitamins, and antioxidants such as lutein and zeaxanthin, which are beneficial for health, particularly digestive health and vision. This research aims to formulate healthy corn flour-based muffins with a balanced texture, taste, and nutritional content. The method used includes partially or completely replacing wheat flour with corn flour, as well as adding natural ingredients such as palm sugar as a natural sweetener and vegetable oil as a source of healthy fats. Organoleptic tests were conducted on panelists to assess product acceptability based on appearance, taste, aroma, texture, and color. The results showed that muffins with a composition of 36.5% corn flour and 36.5% wheat flour scored highest in taste and texture, and met the criteria for a healthy food low in sugar and high in fiber. This research demonstrates that corn flour-based muffins are a potential healthy food alternative and can be further developed as part of a healthy lifestyle.

Diabetes Mellitus is a metabolic disorder marked by hyperglycemia resulting from the body's failure to synthesize insulin. Nutritional therapy is effective in controlling glucose levels by providing low glycemic index and high in antioxidant foods, including sweet potatoes and red beans. The primary objective of this study was to elucidate the influence of wheat flour replacement with composite flour consisting of sweet potato and red bean flour on anthocyanin content and the sensory preferences of muffins. A single-factor completely randomized approach was used in this experimental investigation. The treatment involved substituting wheat flour with a composite flour consisting of sweet potato and red bean flours, in the following ratios: 30:20:50 (F1), 30:35:35 (F2), 30:50:20 (F3), and 100:0:0 (F0, control). Anthocyanin content was analyzed using the differential pH method, while sensory preferences were evaluated by 30 semi-trained panelists using a hedonic scale test. The results showed that substituting wheat flour with composite flour high in sweet potato content increased anthocyanin levels. However, the substitution of wheat flour generally reduced the overall sensory preference for muffins. Despite this, formulations with a higher proportion of sweet potato flour improved the preference scores. In conclusion, the substitution of wheat flour with composite flour rich in sweet potato increased anthocyanin content and improved sensory preferences for color, aroma, and taste in muffins

Various recent studies have shown that natural active compounds contained in traditional and fermented plants play a crucial role in supporting human health. These compounds include flavonoids, polyphenols, tannins, saponins, alkaloids, organic acids, probiotics, and other phenolic compounds. Detection of these compounds is usually carried out through specific chemical reactions that allow researchers to more precisely identify the bioactive components. Their biological activities are diverse, including antioxidant, antibacterial, anti-inflammatory, and antimicrobial properties, which work to protect the body from cell damage and infection. Natural compounds are considered promising agents for disease prevention and health promotion due to their broad biological activities. The fermentation process has been shown to increase the content of bioactive compounds while lowering the pH of the medium, creating conditions unfavorable for the growth of pathogenic bacteria. Furthermore, probiotics that develop during fermentation play a role in maintaining the balance of the gut microbiota, strengthening the immune system, and improving digestive health. Fermented products are widely recognized as functional foods because they contain beneficial probiotics and enhanced bioactive compounds. These naturally derived products, rich in secondary metabolites, have also been shown to have significant physiological effects, such as lowering cholesterol levels, controlling blood sugar, and maintaining stable blood pressure. This makes natural ingredients and fermented products not only sources of nutrition but also have great potential for development as functional foods and traditional herbal medicines. This highlights the importance of integrating traditional knowledge with modern scientific approaches in developing functional foods and herbal medicines. Therefore, research on natural bioactive compounds and the role of fermentation in enhancing their effectiveness is highly relevant to supporting sustainable public health.  

In helping to support the appearance and confidence of the skin needs to be treated especially for dry skin. Having a dry facial skin causes discomfort because the cosmetics used will be difficult to stick to the skin. In addition, weather factors, the use of unsuitable cosmetics, exposed to excessive sun exposure, and unhealthy lifestyles can cause the skin to become dry. The purpose of this study was to determine the process of making gel masks from carrot extracts and seen from laboratory tests, organoleptic tests and hedonic tests. This study uses quantitative methods with an experimental approach. Data collection techniques through observation, documentation and observation sheets that can be seen from the results of laboratory tests, organoleptic tests (texture, color, aroma, adhesion) and hedonic tests (panelists). The results of the study obtained from the results of laboratory tests by looking at the pH level of each formulation are in a safe range of 4-5. In the organoleptic test, panelists declared F1 as a preparation of less thick, orange, and lack of scented in carrot. In the F2 formulation, panelists declare as a texture preparation that is thick, orange, and scented typical of carrots. In the F3 formulation, the panelists declare that the preparation is less thick, less orange, and a typical carrot scented. In the F4 formulation, panelists declare as a very thick, non -orange preparation. And very scented typical of carrots. In the adhesion of the panelist states from all formulations that F4 is very attached. In the hedonic test, the preparation that many panelists like, namely the F4 preparation, is very thick, not orange and very scented typical of carrots. Thus the gel mask of carrot extract can be used as material for making gel masks seen from laboratory tests, organoleptic tests, and hedonic tests.

Infused water is a functional beverage made by soaking slices of fruits, vegetables, and herbs in mineral water to produce a natural flavor and enhance nutritional content. In recent years, infused water has become part of a healthy lifestyle trend due to its claimed benefits, including detoxification, improved hydration, and immune system enhancement. This article aims to review the latest scientific literature on the potential benefits of infused water on immune function, particularly in the context of regular consumption of natural ingredients such as lemon, ginger, strawberries, and herbs that are rich in vitamin C, antioxidants, and flavonoids. The review was conducted by searching scientific databases such as PubMed, Google Scholar, and ScienceDirect, using inclusion criteria that covered publications from 2020 to 2024. The findings indicate that infused water containing vitamin C, gingerol, and polyphenolic compounds can help improve immune function by reducing oxidative stress, suppressing inflammatory responses, and stimulating immune cell activity such as lymphocytes and macrophages. Furthermore, optimal hydration from infused water supports various physiological processes of the immune system. In conclusion, infused water holds potential as a simple, natural, and cost-effective strategy to support immune health. However, further research is needed to evaluate its efficacy, optimal formulations, and dosage for maximum benefit.

Bunga telang (Clitoria ternatea L.) also known as blue pea, is a distinctive flower with single petals, that come in purple, blue, pink, and whote color. This flower is widely used as a natural colorant due to its high anthocyanin content, lemon juice was added to butterfly pea flower to determine antioxidant activity based on the number of hydroxyl groups capable of donating hydrogen atoms to free radical compounds. The color change observed is influenced by the acidity level (pH) of the beverage. Lemon contains a high amount of citric acid, which can flower the pH of the butterfly peaextract solution.  The colot change from blue to purple, redpr even pink indicates reaction anthocyanins to pH changes. Antioxidant activity was teste using the DPPH ( 2,2-diphenyl-picrylhydrazil) method, which measueres the samples ability to scavenge free radical. The lower the IC 150 value obtained, the stronger the antioxidant capacity of the substance. The results showed that the water content in butterfly pea tea was 15,5% and total ash content in butterfly and total ash content was 8%. The IC 50 value obtained was 53,65 which is classified as very strong in antioxidant activity and shows great potential as a natural antioxidant source