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Hydrocephalus is defined as active distension of the brain’s ventricular system, resulting from inadequate flow of cerebrospinal fluid from its site of production to its site of absorption into the systemic circulation. Hydrocephalus can affect anyone at any age; pediatric hydrocephalus affects 1 in 1,000 live births and is the most common cause of brain surgery in young patients. Hydrocephalus is a pathological condition characterized by abnormal accumulation of cerebrospinal fluid (CSF) due to increased production, impaired flow, or reduced absorption. Ventricular enlargement occurs in response to increased CSF volume and can lead to structural damage to the brain parenchyma. This condition can be congenital or acquired. One key point in prenatal diagnosis is the differentiation between fetal hydrocephalus and non-hypertensive ventriculomegaly. The former qualifies for intrauterine treatment with good outcomes. However, the latter can result in either favorable or catastrophic outcomes due to a damaging etiology, as seen in viral infections such as Zika virus. For an accurate diagnosis, fetal MRI is performed to detect brain anomalies, in addition to fetal ultrasound (to detect common complications), karyotype testing, and TORCH testing (toxoplasma, rubella, cytomegalovirus, herpes simplex). Obstetric management of fetal hydrocephalus depends on the gestational age at diagnosis and the presence of other anomalies. Treatment options include termination of pregnancy before the fetus is viable, placement of a ventriculoamniotic shunt, cephalocentesis before delivery, and/or cesarean section.

The background of this research is driven by the vital importance of strengthening democratic values amidst the challenges of globalization and digitalization, which have begun to erode civic consciousness among the younger generation, particularly in the Pasir Pengaraian region. As the flow of unfiltered information increases, there are significant concerns regarding the decline in understanding the essence of participatory democracy and civic ethics. The primary objective of this study is to analyze in depth the strategic role of civic education as a means to preserve democratic ideals and to identify supporting and inhibiting factors in its implementation within higher education environments. The research method employed is a descriptive qualitative approach, utilizing observations and in-depth interviews with students and academics in Pasir Pengaraian to obtain an objective overview of local political dynamics. Research findings indicate that civic education serves effectively as a pillar of political literacy capable of transforming student perceptions from apathy to active participation, while also serving as a medium for character building that respects diversity of opinion. Furthermore, the integration of local Pasir Pengaraian values with the national curriculum is proven to increase the relevance and absorption of democratic material among students.

Diarrhea remains a leading cause of mortality among toddlers in Indonesia, with a prevalence reaching 4,9%. In addition to pharmacological management through LINTAS DIARE, non-pharmacological therapies such as baby massage are increasingly being implemented as supportive interventions that families can perform to accelerate recovery. This study aims to examine the effectiveness of baby massage as a complementary therapy in reducing the frequency and intensity of diarrhea in toddlers. The method used involved identifying relevant articles from Google Scholar and Semantic Scholar databases using appropriate keywords. Based on the 6 articles obtained, baby massage significantly (p = 0,000) reduces the frequency and intensity of diarrhea through vagus nerve stimulation, which optimizes intestinal peristalsis and nutrient absorption. Beyond improving defecation patterns, this therapy is proven to significantly increase infant weight, accelerate motor development through central nervous system stimulation, and enhance sleep quality and comfort.

Iron deficiency anemia remains a major public health problem among pregnant women in Indonesia, with a national prevalence of 37.1% and higher rates in regions such as Brebes Regency. Adequate nutritional knowledge and sufficient iron intake are expected to prevent decreases in hemoglobin (Hb) levels during the third trimester. This study aimed to analyze the relationship between nutritional knowledge, iron intake adequacy, and Hb levels among third-trimester pregnant women at Puskesmas Brebes. An analytic observational study with a cross-sectional design was conducted on 62 respondents using total sampling. Data were collected through a nutritional knowledge questionnaire, a Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) to assess iron intake based on the Recommended Dietary Allowance of 27 mg/day, and Hb measurement using a digital device. The prevalence of anemia was 32.3%, with a mean Hb level of 11.25 ± 1.74 g/dL. Most respondents had high nutritional knowledge (72.6%), but 79.0% had inadequate iron intake. Chi-Square analysis showed no significant relationship between nutritional knowledge and Hb levels (p=0.109) or between iron intake adequacy and Hb levels (p=0.426). Other factors, including iron absorption inhibitors, compliance with iron supplementation, nutritional status, and limited sample size, may have influenced the results.

Village institutions play an important role in supporting participatory and sustainable rural development. The Village Law No. 6 of 2014 recognizes village autonomy and emphasizes the importance of community participation through Village Community Institutions (Lembaga Kemasyarakatan Desa/LKD). However, the implementation of these institutions in practice has not always functioned effectively. This study aims to analyze the role of village community institutions in supporting village development and to identify the factors that influence their effectiveness in Oematamboli Village, Lobalain District, Rote Ndao Regency. This research employs an empirical legal research method with a qualitative approach. Data were obtained through interviews and field observations involving village government officials, community institution administrators, and community leaders, while secondary data were obtained from documents and relevant regulations. The results indicate that the functions of LKD, including the Community Empowerment Institution (LPM), Neighborhood Associations (RT), and Community Associations (RW), have not been implemented optimally in supporting village development. This condition is reflected in the limited participation of LKD in development planning, weak absorption of community aspirations, and low community participation in development activities. Several factors influencing this condition include limited human resource capacity, inadequate infrastructure, low community participation, and limited development funding. Therefore, strengthening institutional capacity, improving coordination, and increasing community participation are necessary to enhance the effectiveness of village development.

The problem of urban flooding is a growing issue due to high population density, increasing volumes of plastic waste, and the reduction of water absorption areas. The use of conventional paving blocks, which are impermeable, further exacerbates flooding conditions because they do not allow water to infiltrate into the soil. This study aims to develop an innovative plastic waste-based paving block incorporating rice straw and sugarcane bagasse, along with the integration of phytoremediation concepts as a solution for urban flood mitigation. The method employed was an experimental approach involving the following stages: material preparation, plastic incineration, material mixing, molding, and testing of water absorption capacity and compressive strength. The results showed that paving blocks with a combination of plastic waste, rice straw, and sugarcane bagasse had the highest water absorption rate of 34% and compressive strength of 21 kg/cm², meeting SNI standards. The addition of natural materials containing silica was proven to enhance the material’s porosity and strength. Additionally, the application of phytoremediation using water hyacinth has the potential to improve the quality of water seeping into the soil. Thus, this phytoremediation-based paving block innovation can serve as an effective alternative solution to reduce flood risks while supporting sustainable waste management and environmental stewardship.

Low-rank coal generally has a high moisture content, which results in a low calorific value and suboptimal quality for utilization as an energy source. One method that can be applied to improve coal quality is the Upgrading Brown Coal (UBC) process, which functions to reduce moisture content and increase fixed carbon value. This study aims to analyze the effect of heating time and the ratio of used oil composition on improving coal quality based on proximate parameters. The research method includes collecting coal samples from four locations in Samarinda and its surrounding areas, namely SMAN 1 Samarinda, Bhineka Street, Palaran Stadium, and Tani Bakti Village. The samples were analyzed using proximate analysis, including inherent moisture (IM), ash content (AC), volatile matter (VM), and fixed carbon (FC), both before and after the UBC process. The upgrading process was carried out with variations in heating time and used oil composition as a coating medium to enhance coal stability and prevent moisture reabsorption. The final results of the upgrading process showed the best values of inherent moisture at 13.64%, ash content at 4.66%, volatile matter at 55.06%, and fixed carbon at 44.94%. The results indicate that the UBC process is capable of reducing inherent moisture and increasing fixed carbon, thereby improving coal quality. Variations in heating time and used oil composition have a significant effect on changes in proximate parameters. Longer heating time and an appropriate ratio of used oil composition result in a more optimal improvement in coal quality.

The prevalence of non-communicable degenerative diseases in Indonesia continues to rise, particularly affecting adolescents and productive age populations due to unhealthy lifestyle patterns and free radical exposure. Purple sweet potato leaves (Ipomoea batatas L.), a locally abundant resource often regarded merely as agricultural by-product, contain significant bioactive compounds including polyphenols, flavonoids, anthocyanins, and terpenoids demonstrating potent antioxidant properties with IC50 values of 47.99 ppm. This study employs a qualitative descriptive literature review approach, analyzing 28 scientific publications spanning 2018-2025 sourced from Google Scholar and PubMed databases to examine the potential of purple sweet potato leaves as effervescent tablet raw material for degenerative disease prevention. Findings reveal that bioactive constituents effectively neutralize free radicals, prevent lipid peroxidation, and protect cellular structures from oxidative damage linked to diabetes, cancer, and cardiovascular disorders. The effervescent tablet formulation provides strategic advantages including enhanced solubility, accelerated absorption rates due to elimination of disintegration processes, pleasant carbonation sensation masking unpleasant active ingredient taste, and superior gastrointestinal tolerance. This innovation offers promising prospects for degenerative disease prevention through local food resource utilization, though experimental validation regarding optimal formulation, effective dosage determination, and clinical efficacy assessment remains necessary for practical implementation.

This study aims to analyze the in silico profile of the compound orientin derived from the water hyacinth plant (Eichhornia crassipes) as a potential antioxidant candidate. Orientin was selected based on its chemical structure data registered in PubChem, which provides complete information regarding molecular identity, physicochemical properties, and 2D and 3D structural representations. The prediction of biological activity was conducted using PASS Online, which indicated that orientin possesses a promising likelihood of exhibiting antioxidant activity according to relevant probability values. Furthermore, the safety assessment of the compound was carried out through ProTox-II to identify potential toxicity, including toxicity class, possible hepatotoxic effects, and other predicted safety parameters. To determine its pharmacokinetic profile, pkCSM was employed to predict ADMET characteristics such as absorption, distribution, metabolism, excretion, and additional toxicity risks. The results of these analyses show that orientin demonstrates favorable potential as an antioxidant candidate, supported by predicted pharmacological properties and relatively low toxicity levels according to in silico evaluations. Therefore, orientin has promising potential for further development in subsequent in vitro and in vivo studies.

This study aims to analyze the phytochemical profile of Sambung Nyawa (Gynura procumbens) leaves as a potential herbal candidate for mild hypertension therapy using in silico methods. Plant samples were examined to identify active compounds documented in the PubChem database. The identified compounds were further analyzed using PASS Online to predict their pharmacological activities, ProTox-II to evaluate toxicity levels, and pkCSM to assess ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) characteristics. The findings reveal that several bioactive compounds present in Sambung Nyawa leaves demonstrate strong predicted anti-hypertensive activity accompanied by minimal toxicological risk. PASS Online analysis indicates potential mechanisms of action, including vascular receptor modulation and mild diuretic properties that may support blood pressure regulation. ProTox-II classification places most compounds in the low-toxicity category, while pkCSM predictions confirm acceptable bioavailability and favorable pharmacokinetic properties. Overall, these results provide a preliminary scientific foundation for the development of Gynura procumbens as an alternative herbal therapy for mild hypertension and support the need for further validation through in vitro and in vivo experimental studies.

This study aims to analyze the potential of eupatorin found in Cat’s Whiskers (Orthosiphon stamineus) as an anticancer agent using in silico methods. Eupatorin was selected due to its promising biological activity reported in previous literature. The research employed compound structure data registered in PubChem, analyzed through PASS Online for pharmacological activity prediction, ProTox-II for toxicity evaluation, and pkCSM for ADMET parameters. The results indicated that eupatorin has a high probability of inhibiting cancer cell proliferation with significant pharmacological activity values. Toxicity predictions showed a safe profile with an LD50 supporting its potential therapeutic use. ADMET analysis demonstrated that eupatorin possesses good bioavailability, adequate absorption and distribution, and minimal metabolic interactions, supporting its efficacy as an anticancer compound. These findings suggest that eupatorin could be an important candidate for herbalbased drug development, particularly for cancer therapy, and provide opportunities for further research through in vitro and in vivo experiments to validate anticancer activity comprehensively.

The community service program in Dusun Bendrong aimed to foster environmental awareness through the planting of timber and fruit seedlings as a response to declining forest quality and reduced water availability caused by vegetation loss. This program sought to enhance community participation in forest conservation while strengthening local wisdom related to environmental stewardship. The activity was conducted in three stages: pre-activity observation and coordination with the Village Head and community leaders, joint planting of 14 seedlings by Student Community Service (KKM) participants and local residents, and monitoring and evaluation to assess implementation and participant understanding. The results showed that all seedlings were successfully planted, with high levels of participation from both students and community members. The activity increased awareness of forest conservation and highlighted the importance of collective action in maintaining environmental sustainability. Timber trees contributed to forest restoration, improved water absorption, and reduced erosion risk, while fruit trees provided additional economic and social benefits for the community. Overall, this participatory approach proved effective as a sustainable model for community service programs that integrate environmental conservation and community empowerment.

The purpose of this study was to determine and analyze the effect of wage levels, economic growth, and the Human Development Index (HDI) on income inequality through labor absorption in the Districts/Cities of Jambi Province from 2020-2024. The research method used is a quantitative descriptive analysis using panel data regression with the Fixed Effect Model approach.  The analysis method used Eviews 12. The results showed of that partially, income inequality in the Districts/Cities of Jambi Province is significant positive influenced by the wage level variable, while economic growth does not have a significant effect on income inequality. In addition, the Human Development Index (HDI) has a significant negative effect on income inequality. This implies that wage increases are actually followed by in income inequality. Meanwhile, economic growth has not been able to provide a broad income redistribution effect. Conversely, improving the quality of human development proves to be the most effective factor, as it is capable of significant reducing inequalirt levels. Simultaneously, the results show that the variables of wage levels, economic growth, and the Human Development Index (HDI) collectively have a significant influence on income inequality in Districts/Cities of Jambi Province.

Language is the primary means of communication in human life. The absorption of English into Indonesian among university students is an increasingly prominent phenomenon with the development of globalization and digital technology. This study aims to analyze the impact of this absorption on the emergence of new words or terms used by students in academic contexts and everyday communication. The research method used is descriptive qualitative. This approach was chosen because this study aims to describe and analyze linguistic phenomena and their impact on the Indonesian language. The results of the analysis show that the absorption of English has given rise to various new terms that are practical, concise, and contextual, such as deadline, submit, healing, burnout, as well as mixed forms with Indonesian affixes such as nge-print and di-upload. These terms facilitate communication and enrich students' linguistic expression. However, on the other hand, the use of these new terms has the potential to displace the use of standard Indonesian equivalents. Thus, the absorption of English has a dual impact: enriching vocabulary through the formation of new terms while also requiring a wise attitude to maintain the existence of the Indonesian language.  

Language is the primary means of communication in human life. The absorption of English into Indonesian among university students is an increasingly prominent phenomenon with the development of globalization and digital technology. This study aims to analyze the impact of this absorption on the emergence of new words or terms used by students in academic contexts and everyday communication. The research method used is descriptive qualitative. This approach was chosen because this study aims to describe and analyze linguistic phenomena and their impact on the Indonesian language. The results of the analysis show that the absorption of English has given rise to various new terms that are practical, concise, and contextual, such as deadline, submit, healing, burnout, as well as mixed forms with Indonesian affixes such as nge-print and di-upload. These terms facilitate communication and enrich students' linguistic expression. However, on the other hand, the use of these new terms has the potential to displace the use of standard Indonesian equivalents. Thus, the absorption of English has a dual impact: enriching vocabulary through the formation of new terms while also requiring a wise attitude to maintain the existence of the Indonesian language.  

The increasing demand for housing in tropical regions requires building materials that are fast to apply, environmentally friendly, and resilient to extreme climate conditions as well as disaster risks. Conventional interlocking bricks are often chosen for their ease of construction, yet they still face challenges such as moisture and early cracking. This study proposes the innovation of the Hybrid Living Green Brick, a combination of lightweight bricks made from rice husk ash and fly ash waste (FRCB) with a biological layer of cyanobacteria. FRCB improves compressive strength by approximately 30% with the addition of 5% rice husk ash, achieving 65 kg/cm², thereby meeting Class 50 requirements (≥50 kg/cm²) according to SNI-15-2094-2000. The incorporation of 3% cyanobacteria provides an additional though not significant strength improvement, while still within the Class 50 category. It also reduces brick weight by 4.3%, with further optimization potential through cyanobacteria integration, and lowers carbon emissions from the firing process. Cyanobacteria induce the formation of CaCO₃ layers that seal pores, reduce water absorption by an average of 10%, and provide self-healing properties for microcracks. Preliminary observations indicate that FRCB offers stable mechanical performance, while biological activity was observed on the 7th day with the formation of pale-white mineral layers continuing until the 28th day. This hybrid innovation shows potential to support sustainable and disaster-resilient tropical construction by combining the mechanical strength of waste-based materials with the biological durability of cyanobacteria against extreme climates. Despite challenges related to moisture control and production standardization, the Hybrid Living Green Brick concept opens new pathways for developing environmentally friendly construction materials that are more adaptive to disaster-prone tropical conditions.

Micro, Small, and Medium Enterprises (MSMEs) play a vital role in Indonesia's economy with a contribution of more than 60 percent to the Gross Domestic Product and the absorption of 97 percent of the national workforce, but their participation in international trade is still low with only 14 percent involved in export activities. This research aims to analyze the challenges and opportunities faced by MSMEs in accessing the global market and identify adaptation strategies developed by entrepreneurs. A qualitative method with a phenomenological approach was applied through in-depth interviews with 18 export-oriented MSME owners and managers in East Java who were selected by purposive sampling. Thematic analysis using ATLAS.ti revealed seven main challenges including limited access to capital, complexity of export regulations, constraints on production capacity and quality consistency, language and cross-cultural communication barriers, lack of international market information, logistics infrastructure problems, and intensive competition. On the other hand, four strategic opportunities were identified, namely increasing demand for sustainable authentic products, accelerating digitalization and e-commerce, utilizing free trade agreements, and ethical consumerism trends. MSMEs develop effective adaptation strategies in the form of strategic collaboration, product differentiation with  premium positioning, the use of digital technology, and a focus on  specific market niches. The research emphasizes that the successful internationalization of MSMEs requires a holistic approach integrating internal capacity building with the support of a conducive external ecosystem.

Bitter melon (Momordica charantia) is a medicinal plant traditionally used to control blood glucose levels and improve digestive health. These benefits are closely associated with its bioactive metabolite content. This article aims to characterize the bioactive metabolites of bitter melon and to review their potential bioactivity in glycemic control and digestive function. The method employed includes a literature-based characterization of metabolites, identification of major classes of active compounds, and evaluation of analytical techniques commonly applied in natural product research, such as phytochemical screening, chromatography, and spectroscopic analysis. The results indicate that bitter melon contains various bioactive metabolites, including flavonoids, alkaloids, saponins, triterpenoids, and polyphenols, which contribute to blood glucose reduction by enhancing insulin sensitivity and inhibiting glucose absorption. Furthermore, these compounds support digestive health by improving digestive enzyme activity, exhibiting anti-inflammatory effects, and maintaining gut microbial balance. In conclusion, bitter melon represents a promising source of natural bioactive compounds with significant potential for application in health and pharmaceutical development.

In general, infrastructure development requires materials from nature and one of them is natural coarse aggregate of crushed stone. The rapid development of infrastructure in Indonesia has resulted in the depletion of the natural coarse aggregate. Therefore, other efforts are needed in terms of using coarse aggregate as a construction material. So in this study the aim is to make artificial coarse aggregate made from fly ash. The results showed that this artificial coarse aggregate met the requirements of the General Specifications of Bina Marga 2010 rev 3 as a construction material, namely for an abrasion value of 40% and water absorption of 3%. In this study, 5 types of comparisons were carried out, namely, 70:30%, 60:40%, 50:50%, 40:60%, 30:70 and for the type of composition comparison 70:30% (70% fly ash:30% cement). ) the abrasion value is still below 40%, and the amount of water absorption is below 3% so that this artificial coarse aggregate still meets the standard specifications of General Highways 2010 rev 3. Based on the price comparison that has been made between artificial coarse aggregate and natural coarse aggregate of crushed stone , shows a price disparity of Rp. 35,779 - Rp. 58,779. Thus, this artificial coarse aggregate is one solution that can be developed to reduce the environmental impact due to the presence of fly ash which is quite abundant in Indonesia.

Jamu is a traditional medicine still widely consumed by the public, but it has the potential to be contaminated with the heavy metals lead (Pb) and cadmium (Cd), which are toxic and can cause health problems, particularly to the liver and kidneys. Heavy metal contamination can originate from raw materials grown in polluted environments and from processing, storage, and packaging that do not meet quality standards, particularly for products that have not undergone official supervision. This study aims to analyze the content of lead and cadmium metals in registered and unregistered herbal medicine products. The analysis was carried out using the Atomic Absorption Spectrophotometry (AAS) method after sample preparation through wet digestion using strong acid. Six herbal medicine dosage forms were analyzed, namely powder, chopped, pills, capsules, cream, and shake parem. Method validation included tests for linearity, precision, limit of detection, and limit of quantification to ensure the reliability of the analysis results. The results showed that all registered herbal medicine samples met the safety requirements for Pb and Cd. In contrast, several unregistered herbal medicine preparations, especially powder, chopped, and cream, did not meet the safety requirements for Cd, while the Pb levels in all samples met the safety requirements for Pb. These findings indicate that unregistered herbal medicines carry a higher risk of heavy metal contamination. Therefore, strengthening quality control, selecting safe raw materials, and increasing compliance with regulations are necessary to ensure the safety of herbal medicine consumption and protect public health.