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Japanese papaya leaves (Cnidoscolus aconitifolius) contain active compounds such as flavonoids, tannins, saponins, alkaloids and terpenoids which have the potential to have antibacterial activity. The aim of this research is to determine the antibacterial activity of Japanese papaya leaves against Staphylococcus aureus bacteria. Extraction of Japanese papaya leaves has been carried out using the maceration method and 96% ethanol solvent. The antibacterial activity test used the agar diffusion method using a cylindrical plate. Sterile distilled water was used as a negative control while as a positive control the antibiotic ciprofloxacin was used. The concentrations of Japanese papaya leaf ethanol extract used in testing were 10%, 20%, and 30%. The research results showed that Japanese papaya leaf ethanol extract with a concentration of 30% had the widest inhibition zone diameter, namely 17.296 mm. Meanwhile, at a concentration of 20%, the average inhibitory zone diameter was 15,222 mm, and at a concentration of 10%, the average inhibitory zone diameter was 13,018 mm. These three concentrations were included in the strong category based on Greenwood classification.  

Basil leaves are very rich in nutritious substances. Among them are beta carotene, vitamin C, macro minerals (calcium, phosphorus, magnesium). This plant is included in the Lamiaceae family which contains various chemical compounds, including phenols, saponins, alkaloids, flavonoids, tannins, and essential oils. The benefits of basil have been widely applied in people's lives as traditional medicine, for example, basil leaves are used to treat, cough, colds and so on. Body odor can be caused by several factors such as genetic factors, psychological conditions, food factors, obesity factors and clothing materials used.One of the triggers of body odor due to bacterial infection, namely Staphyloccous aureus bacteria.This study aims to formulate deodorant spray ethanol extract of basil leaves, test the physical properties of deodorant spray preparations, and determine whether the preparation of deodorant spray ethanol extract of basil leaves can inhibit staphylococcus aureus bacteria. Physical tests were carried out on days 0 (after manufacture) and 7 with the results of the organoleptical physical test of the preparation having a distinctive odor of basil, brownish yellow in color, It has a pH of 4 which corresponds to the pH of the skin, and experiencing an increase in viscosity on day 7 examination. The antibacterial test results of formulations 1, 2, and 3 showed inhibition of the banteri.

Folliculitis is a bacterial skin infection caused by Staphylococcus aureus and Streptococcus sp. If the surrounding tissue is also affected, it is called a furuncle. About 20% of individuals have S. aureus colonization, while S.aureus carriers are found in 60% of healthy individuals.

This study was conducted to determine the antimicrobial effectiveness of chemical compounds from the water fraction of leunca fruit. Leunca fruit extract was obtained by maceration, then the results of maceration were evaporated and then fractionated. Antimicrobial activity testing was carried out using the agar diffusion method against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Candida albicans ATCC 01231. The concentration variations of leunca fruit water fraction used were 10%, 20%, 30%, 40%, and 50%. The results of the antimicrobial activity test of leunca fruit water fraction compounds obtained the average inhibition diameter of Staphylococcus aureus ATCC 25923 microbes respectively 7.5 mm; 8.3 mm; 8.8 mm; 9.5 mm; and 10.4 mm. On the microbe Escherichia coli ATCC 25922 consecutively 7.8 mm; 8.1 mm; 9.3 mm; 10 mm; and 11.4 mm. while on the microbe Candida albicans ATCC 01231 the diameter of the bland chemical compound of leunca fruit water fraction is only found in the 50% concentration variation with an average inhibition diameter of 9.1 mm. Based on the results obtained, it can be concluded that the water fraction of leunca fruit (Solanum Nigrum L.) has activity as an antimicrobial against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Candida albicans ATCC 01231 with the largest inhibition zone diameter shown in the 50% concentration variation.

Background: Diabetic ulcer is a complication of peripheral neuropathy in people with diabetes mellitus which often ends in disability or death. Proper handling of infection is closely related to the rational use of antibiotics to avoid the occurrence of resistance. The emergence of resistance to antibiotics has an effect on the risk of increasing infection status, increasing the length of stay in the hospital, the risk of amputation and even death. Objectives: This study aims to determine the type and percentage of bacteria present in diabetic ulcers and to test the sensitivity of antibiotics prescribed in diabetic patients with ulcers in the inpatient room of RSUD Kraton, Pekalongan Regency. Methods: The research model used was descriptive to describe the profile of bacteria and the sensitivity of antibiotics prescribed to bacterial findings from diabetic ulcer isolates in inpatients at Kraton Hospital, Pekalongan Regency. The research method was carried out by biochemical identification and sensitivity testing of the Kirby Bauer technique on 2 samples of diabetic patients with ulcer complications taken by total census during March-April 2022. Results: Staphylococcus aureus, Enterobacter aerogenes, Pseudomonas aeruginosa were found with a percentage of 50% each. The sensitivity test showed that Ampicillin was resistant to Staphylococcus aureus, Ciprofloxacin was resistant to Enterobacter aerogenes and intermediate to Pseudomonas aeruginosa. The percentage of effectiveness of Meropenem and Metronidazole antibiotics had the highest sensitivity values, namely 100%, 50% Ampicillin and 25% Ciprofloxacin. Conclusion: From the research that has been done, it can be concluded that Ampicillin is resistant to Staphylococcus aureus, Ciprofloxacin is resistant to Enterobacter aerugenes, Ciprofloxacin intermediate is resistant to Pseudomonas aeruginosa, Meropenem and Metronidazole are sensitive to the three bacterial findings namely Staphylococcus aureus, Enterobacter aerogenes, Pseudomonas aeruginosa