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Optimization of primary and secondary packaging is crucial for the quality and efficiency of drug production. The drug packaging process consists of primary packaging that is in direct contact with the product and secondary packaging that provides additional protection and important information. This study aims to analyze various methods applied in pharmaceutical packaging to assess the effectiveness of Lean Manufacturing (VSM), Single Minute Exchange of Dies (SMED), and Overall Equipment Effectiveness (OEE). This study shows that VSM significantly reduces the time of secondary packaging activities. SMED reduces the lead time of primary packaging analysis by 58.06%. Meanwhile, OEE analysis of primary packaging identified high set-up/adjustment as the main cause of losses. The importance of implementing structured methods to increase productivity, reduce waste, and ensure a more efficient and effective packaging process in the pharmaceutical industry, contributing to improving product quality and safety.

All companies hope for an effective and efficient production system, but an imperfect production system means that PT XYZ must improve its production activities. The company strives to produce good products followed by a high level of productivity. In this research, we investigate a case at PT XYZ which produces hot stamping foil in the rewind section. This research found that there was waste that occurred in set-up replacement activities in production. Because it requires a long processing time, we perfected the system by implementing the Single Minute Exchange of Dies (SMED) method, then the process optimized internal activities in the set-up process. The application of the SMED concept is carried out by changing internal activities into external activities with the addition of helpers. This research aims to provide a more effective and efficient set-up replacement process so that machine downtime can be reduced. The results of this research show a 52% reduction in set-up time obtained by adding a helper with a time before implementation of 58 minutes to 30 minutes. This research concludes that SMED is effective in reducing machine set-up time and increasing the efficiency of the production process with benefits after implementing the SMED method by adding a helper of Rp. 10,649,336. In this way, implementing the SMED method helps companies increase production set-up replacement times in the rewind section.  

PT XYZ is a manufacturing company that produces various products, such as molds and several spare parts. The production process often experiences wasted time at the machine setup stage, known as dandori. To avoid production delays, companies need to increase their productivity. This research aims to propose the application of Lean Manufacturing methods, especially SMED, to reduce machine uptime by focusing on optimizing external activities in mold making. Through the application of the Single Minute Exchange of Dies (SMED) concept, fourteen internal activities were changed to eight internal activities, resulting in improvements with a reduction in machine setup time from 44 minutes to 22 minutes, or a reduction of 50%. The hope is that these results will increase the company's output significantly.