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Butterfly pea (Clitoria ternatea L.) is a type of ornamental plant characterized by flowers in shades of purple, blue, pink, and white. Besides being an ornamental plant, butterfly pea is also commonly used in traditional medicine. Several previous studies have confirmed its health benefits. Therefore, it is necessary to conduct phytochemical screening for flavonoids, saponins, and alkaloids using the Wilstater method, foam test, Dragendorff’s reagent, and Wagner's test. This study demonstrates the presence of flavonoid, saponin, and alkaloid compounds in butterfly pea flowers, indicated by positive results in various tests conducted.

Human skin undergoes aging and degenerative processes, like other body tissues. Skin aging is characterized by various structural and functional changes, such as decreased skin elasticity, degradation of elastic fibers, thinning of the epidermis, reduced collagen content, the appearance of wrinkles, and increased skin dryness. One effort to inhibit this process is the use of natural phytochemical compounds with antioxidant and skin-protective activity, such as ferulic acid. Ferulic acid is known to scavenge free radicals and absorb ultraviolet (UV) light. Furthermore, this compound can protect the structure of collagen, elastin, and fibroblast cells from damage, and inhibit the enzymes collagenase and tyrosinase, which play a role in collagen degradation and the formation of hyperpigmentation. This literature review aims to examine the anti-aging activity of ferulic acid based on the results of in vitro and in vivo studies published in the past ten years. The search was conducted through a systematic literature review of relevant scientific articles. The results indicate that ferulic acid has a promising mechanism of action in preventing and slowing skin aging. This compound can improve skin elasticity, suppress melanin production, reduce dark spots, and exhibit anti-inflammatory properties that help reduce redness and inflammation caused by acne. Its antioxidant effects also contribute to slowing the appearance of wrinkles, thus helping maintain a more youthful appearance. Despite its significant potential, further research is needed to better understand its mechanism of action and long-term safety for use on human skin.

Degenerative diseases such as cancer have a significant impact on overall health and are a leading cause of death worldwide. Identifying phytochemicals with potential preventive and therapeutic properties is crucial in combating these diseases. Apigenin, a flavonoid phytochemical, has garnered attention due to its potential role in cancer prevention and treatment. Therefore, the aim of this research is to prioritize an approach to cancer treatment based on more effective and fewer side effects. Apigenin, a plant-derived flavonoid, has received significant scientific consideration for its potential health-enhancing effects through modulation of inflammation, oxidative stress, and various other biological activities. This review utilizes online scientific articles from reputable platforms such as PubMed, Google Scholar, and Springer Link. The objective of this research is to explore the potential role of apigenin as a promising phytochemical in cancer prevention and treatment, elucidating its therapeutic mechanisms and future research directions.

Indonesia, considered the country with the second-highest level of biodiversity in the world after Brazil, possesses extraordinary biological wealth that remains underutilized. The field of traditional medicine utilizes natural resources to prevent and treat physical and mental disorders. Periwinkle, or Catharanthus roseus, is one of the most widely used plants due to its abundance of bioactive phytochemicals, such as alkaloids, flavonoids, saponins, and tannins. The ethanol extract from Periwinkle leaves has the potential to act as a natural antipyretic agent that can reduce body temperature during fever. The purpose of this study is to review and analyze previous research findings on the antipyretic effects of ethanol extract from Periwinkle leaves on mice (Mus musculus). According to a literature review from various sources, the ethanol extract of Periwinkle leaves demonstrates a comparable level of effectiveness to synthetic antipyretic drugs in lowering the body temperature of fever-induced mice. Furthermore, the content of active compounds and the antipyretic performance of this plant are influenced by its variety and environmental factors. Body temperature begins to decrease one hour after extract administration and reaches its peak reduction at the third hour. Therefore, Periwinkle may serve as an alternative natural antipyretic remedy. However, further research is necessary to standardize its usage and conduct clinical trials on humans.

Cardiovascular disease includes several heart and cardiovascular problems. One in three deaths in the world is caused by heart disease. Handling and preventing deaths from cardiovascular disease needs to be improved. Flavonoids are phytochemicals commonly found in plants. Quercetin is one of the most common flavonoids. Quercetin is also known to have potential as an alternative intervention for people with heart disease. Therefore, the positive impact of quercetin on cardiovascular disease needs to be reviewed. This article uses a literature review method by reviewing articles from the last ten years (2014–2024) through trusted websites. The results of the study show a link between quercetin, cardiovascular disease, and the dose administered. It can be concluded that quercetin has a strong antioxidant effect, which can overall overcome and prevent cardiovascular disease.    

Dioscorea pentaphylla L. tubers, locally known as tomboreso tubers by Indonesian people, grow wild in forests in various parts of Indonesia but are not well-underutilized. This article aims to comprehensively review the phytochemistry, nutritional, anti-nutritional, and bioactivity of tomboreso tubers. The method used is a literature study with a database of online articles downloaded from Google Scholar related to the topic discussed. Various earlier studies reported that tomboreso tubers are rich in phytochemical compounds, such as alkaloids, flavonoids, polyphenols, terpenoids, tannins, glycosides, and saponins. Tomboreso tubers are also rich in complete nutritional content, such as protein content (1.69-9.20%), fat (0.14-6.24%), fiber (1.28-7.24%), starch (3.71-61.26%), minerals, amino acids, and fatty acids. Furthermore, tomboreso tubers also contain anti-nutritional compounds that are less beneficial to health, such as tannins, oxalates, hydrogen cyanide, phenols, flavonoids, phytates, a-amylase inhibitors, and trypsin inhibitors. Tomboreso tubers have been shown to have various biological activities, such as anti-bacterial, anti-mutagenic, and antioxidant, from various earlier studies. To make tomboreso tubers safe to eat and an alternative food source with low anti-nutritional content, further research must be done on their exploration, utilization, and further processing to reduce anti-nutritional compounds.

Breadfruit (Artocarpus heterophyllus) leaves are widely used in traditional medicine in Southeast Asia. Phytochemical screening of breadfruit leaves showed that the plant is rich in chemical contents that have potential as a source of natural medicine. The biological activity of breadfruit leaf phytochemicals showed potential in the treatment of various diseases. The benefits of phytochemicals (Development of natural medicines, Discovery of new chemical compounds, Development of cosmetic and food products, Improvement of quality of life through the use of natural products and Conservation of rare and endemic plants). this research uses the method Phytochemical screening of breadfruit leaves involves several stages: Extraction, Fractionation, Identification. The results stated that breadfruit leaves contain Steroid / Terpenoid compounds which indicate positive results in concentrated green, Saponin negative results that only precipitate not, Tannin positive results in blackish color, Flaphonoid positive results in red color and Alkoloid positive results in brown color.  

Cashew leaves or also called monkey guava are known by many people, especially in Southeast Sulawesi and are believed to have a number of health benefits but are still rarely known by some people. This study aims to determine the profile of secondary metabolite content and determine the antioxidant activity of ethanol extract of cashew leaves (Anacardium occidentale Linn) using the extraction method by maceration. The extraction process of old cashew leaves is carried out by the maceration method using 96% ethanol solvent for 3 days of soaking and stirring every 24 hours, then concentration is carried out through the evaporation process. Phytochemical testing includes identification of alkaloids, flavonoids, polyphenols, tannins, steroids/triterpenoids and saponins, as well as testing antioxidant activity using the DPPH method (1,1-diphenyl-2-picrylhydrazyl). The results showed that the extract of cashew leaves (Anacardium occidentale Linn) strongly positive contains phenolic compounds, flavonoids, steroids and saponins. Based on the results of the IC50 calculation, 96% ethanol extract has the highest antioxidant activity at a concentration of 14.35 ppm (µg/mL) with a very high category. The content of secondary metabolites and very high antioxidant activity from the results obtained, explain that cashew nuts have the potential to increase body immunity and can be used in various antioxidant food products so that cashew leaves are more economically valuable for the community.

Sijukkot plants grow widely in the highlands of Lake Toba, the largest volcanic lake in the world. This plant, with the Latin name Lactuca indica L., grows abundantly in Dairi, Pakpak Bharat, Samosir and Humbang Hasundutan districts. Sijukkot has been proven to have made people in the Lake Toba area less susceptible to disease. Sijukkot contains many high chemical compounds in the roots, stems and leaves. For example glycosides, cardeolin, polyphenols, saponins, cardenolin, polyphenols, flavonoids and tannins. ( Molecular Docking ) is one of the simplest and most frequently used structure-activity based virtual methods. The purpose of this journal review is to determine the secondary metabolite compounds contained in the medicinal plant sijukkot to be developed as a fever reducer The research method used is a library study and literature review with the keywords molecular docking of secondary metabolite compounds of sijukkot as a medicinal plant to reduce fever, in the period 2020-2022. The results obtained were 5 secondary metabolite compounds which have potential as fever reducers and antioxidants. The conclusion is that ethanol extract and sijukkot leaves have high levels of phytochemicals which are good as formulations for fever medicine, antioxidant, antibacterial and can reduce sugar levels

        Tribulus terrestris L.,Gokshur in Sanskt,  is an annual herbaceous, little prostrate, silky from the Zygophyllaceae family. It is found in extensive, arid, and scorching regions of India. is used in traditional folk medicines as an aphrodisiac, astringent, lithotriptic, diuretic, and urinary disinfectant.     however, uneven, pinnae, elliptical leaves. Sprinkled, round, compressed, five-cornered, transverse partitioned carpel fruits with many seeds ripen in July. Pieces of the cylindrical-fibrous root are 7-18 cm and 0.3-0.7 cm wide. According to reported studies, the investigations indicated the presence of the saponins ;gitogenin, tigogenin, neogitogenin, hecogenin, and flavonoid tribuloside was kaempferol-3-glucoside. Furthermore, Tribulus terrestris plays a vital role in hepatotoxicity and is greatly reduced by Tribulus extracts. Similarly, T.terrestris plays a remarkable role in reducing the elevated level of serum glucose, triglycerides, VLDL, and cholesterol. This study aims to conduct a preliminary analysis of the phytochemicals of Tribulus leaves cultivated in Iraq and to determine the active constituent of the ethanolic extract of the leaves using Gc-Mass. Qualitative detection of herbal leaves in Iraqi soil, investigated by GC-MASS revealed important constituents. The funding shows a new compound; dihydrocoumarin and other major constituents neophytadiene and alpha-tocopherol.

Blood sugar levels, or blood glucose levels, are crucial for overall health and are regulated by the pancreas through insulin. Normal blood sugar levels range between 70-99 mg/dL when fasting and up to 140 mg/dL two hours after eating. Abnormal blood sugar levels can suggest a variety of health issues, including hypoglycemia (low blood sugar levels caused by excess insulin, certain drugs, or illnesses such as diabetes) and hyperglycemia (high blood sugar levels associated with diabetes). Regular blood sugar monitoring is necessary, especially for diabetics. Guava, a tropical fruit, includes a variety of phytochemicals that have been linked to pharmacological benefits such as antibacterial capabilities. This research uses an extraction process involving solid-liquid extraction or maceration, with methanol being the optimal solvent. The extract yields 9.51%. Wistar rats are used to investigate its antidiabetic efficacy. The rats are divided into three groups: positive control, negative control, and extract treatment. Diabetes is induced by subcutaneous injection of Alloxan, followed by oral administration of the methanol extract. Blood glucose levels are assessed after fasting for 6-8 hours. The extract from dried Guava leaf powder yields a concentrated extract with a 9.51% yield. In vivo assessments showed a significant reduction in blood glucose levels in rats treated with guava leaf extract, suggesting potential anti-hyperglycemic effects. The phenolic compounds in guava leaves contribute to antioxidant and anti-hyperglycemic effects. The study highlights the potential therapeutic effects of guava mint leaves and their extract components for diabetes management and antioxidant health benefits.

Sea urchin (Diadema setosum) is an aquatic biota that has high nutritional value. Bioactive compounds produced by sea urchins have the potential to be used as natural antibacterial compounds. This study aims to identify chemical compounds and determine the antibacterial activity of ethanol extract of sea urchins (Diadema setosum) against the growth of Staphylococcus aureus bacteria. The research method used is the agar diffusion method. The results of phytochemical screening of sea urchin extract (Diadema setosum) showed the presence of alkaloids and saponins. By using variations in the concentration of ethanol extract of sea urchin (Diadema setosum) at a concentration of 80% it had an inhibitory power of 18 mm, a concentration of 90% had an inhibitory power of 23 mm, a concentration of 100% had an inhibitory power of 28 mm and for a concentration of 110% had an inhibitory power of 35 mm. The positive control has a resistance of 30 mm and the negative control is 0 mm. The results showed that the ethanol extract of sea urchins (Diadema setosum) had a strong bacterial inhibitory activity against Staphylococcus aureus bacteria.