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The community in Cibangkong Village, Pekuncen District, Banyumas Regency, still widely uses jamu (traditional herbal medicine) as part of their daily healthcare practices, often in combination with modern medical drugs. Limited understanding of the potential interactions between herbal and pharmaceutical medicines may pose health risks. This community service activity aimed to improve public knowledge and awareness regarding the dangers of drug–herb interactions through educational and interactive approaches. The implementation methods included health education sessions and group discussions. Participants of the activity were members of Muslimat NU 1 Pekuncen. The results showed a 60% improvement in community understanding, based on simple pre-test and post-test evaluations. The community also became more cautious and motivated to consult healthcare professionals before consuming jamu together with prescription medicines. This activity successfully increased public awareness about the safe and responsible use of both modern and traditional medicines.

Karangtalun Village, located in Kalidawir District, Tulungagung Regency, East Java, has significant potential for developing Family Medicinal Plants (TOGA) to support community-based health practices. However, the utilization of TOGA in daily health care remains limited due to a lack of knowledge and practical skills among residents. At the same time, the community faces a growing social challenge—digital exposure among young children, which negatively affects their physical, psychological, and social well-being. To address these issues, a capacity-building program was implemented for women involved in the Integrated Guidance Post (Posbindu) through training on TOGA cultivation and digital literacy education using the Community-Based Participatory Research (CBPR) approach. This participatory model actively engaged community members in the planning, implementation, and evaluation stages. The program results showed an increase in participants’ understanding of TOGA as an alternative for self-care and traditional medicine, greater awareness of the adverse effects of excessive gadget use among children, and positive behavioral changes in parenting, such as setting screen-time limits and replacing gadget use with creative family activities. These findings demonstrate that integrating local wisdom–based education with digital literacy can effectively strengthen family resilience and promote sustainable well-being in the digital era.

Karangtalun Village, located in Kalidawir District, Tulungagung Regency, East Java, has significant potential for developing Family Medicinal Plants (TOGA) to support community-based health practices. However, the utilization of TOGA in daily health care remains limited due to a lack of knowledge and practical skills among residents. At the same time, the community faces a growing social challenge—digital exposure among young children, which negatively affects their physical, psychological, and social well-being. To address these issues, a capacity-building program was implemented for women involved in the Integrated Guidance Post (Posbindu) through training on TOGA cultivation and digital literacy education using the Community-Based Participatory Research (CBPR) approach. This participatory model actively engaged community members in the planning, implementation, and evaluation stages. The program results showed an increase in participants’ understanding of TOGA as an alternative for self-care and traditional medicine, greater awareness of the adverse effects of excessive gadget use among children, and positive behavioral changes in parenting, such as setting screen-time limits and replacing gadget use with creative family activities. These findings demonstrate that integrating local wisdom–based education with digital literacy can effectively strengthen family resilience and promote sustainable well-being in the digital era.

Hypertension is a primary risk factor for cardiovascular diseases, including stroke, coronary artery disease, atrial fibrillation, and peripheral vascular disease. Often referred to as "The Silent Killer," its onset is frequently asymptomatic, making early detection challenging. Effective interventions, both pharmacological and non-pharmacological, are necessary to manage hypertension and reduce complications. Long-term treatment requires adherence to prescribed medications, with self-care management playing a vital role in minimizing hypertension's adverse effects. Self-efficacy, or an individual's belief in their abilities, is crucial for improving medication adherence and self-care activities. This study aimed to examine the correlation between self-efficacy and self-care management in relation to medication adherence among hypertension patients at RSUD Mandau District. A non-experimental, quantitative, analytic correlation study with a cross-sectional design was conducted, involving 38 hypertension patients. Self-efficacy was measured using the MASES-R (Medication Adherence Self-Efficacy Scale-Revision), medication adherence was assessed with the MMAS-8 (8-item Morisky Medication Adherence Scale), and self-care management was evaluated using the HBP-SCP (Hypertension Self-Care Profile). The findings revealed a significant correlation between self-efficacy and medication adherence (p=0.000, r=0.594). Additionally, self-care management was significantly correlated with medication adherence (p=0.027, r=0.360). In conclusion, self-efficacy and self-care management both significantly correlate with medication adherence in hypertension patients at RSUD Mandau District.

Mistakes in obtaining, using, storing, and disposing of medication (DAGUSIBU) remain a major issue in Indonesia, including in Kedungpring Village, Kemranjen District, Banyumas Regency. This study aims to improve the knowledge of PKK mothers in Kedungpring Village regarding DAGUSIBU practices through interactive counseling. The method used is a community-based empowerment approach, involving active participation of PKK members in the planning, implementation, and evaluation of activities. The results showed a significant improvement in the participants' knowledge and behavior regarding proper medication management, including proper storage and disposal of expired medication. This activity also encouraged the formation of medication health cadre groups at the RT level to continue educating the community. This DAGUSIBU counseling was proven effective in improving medication literacy at the household level and reducing the risk of medication errors.

This research investigates the application of the Economic Order Quantity (EOQ) method to improve drug inventory management in a primary hospital pharmacy, with a particular focus on reducing storage costs. A descriptive quantitative approach was applied using secondary data from January to December 2024, covering annual demand, purchase price, ordering cost, and holding cost. The analysis concentrated on fast-moving vital essential and moderate vital drugs that are critical for sustaining patient treatment. The study revealed inefficiencies in the hospital's procurement practices, with some medicines simultaneously facing overstock and stockout risks, indicating weak planning. EOQ calculations provided alternative procurement quantities that were smaller but more frequent, resulting in lower storage costs and better stock control. Simulation outcomes demonstrated notable cost savings, particularly for Flamicort, Diazepam, and Ventolin. These findings emphasize the value of integrating EOQ into hospital pharmaceutical logistics to reduce financial losses, strengthen supply chain efficiency, and ensure the continuous availability of essential medicines in primary hospital settings.

Hypertension is a common health problem in the elderly that can affect quality of life. Hypertension in Batam city is a non-communicable disease that ranks 2 and with a percentage of 30.9%. The World Health Organization (WHO) said that there are 50 70% of hypertensive patients who do not comply with prescribed medications. Compliance with taking antihypertensive drugs is important to maintain blood pressure stability. Non-compliance in using antihypertensive drugs is one of the risk factors for increasing morbidity and uncontrolled hypertension events that can worsen the quality of life of hypertensive patients. This study aims to find out "The Relationship between Compliance with Taking Hypertension Medication and the Quality of Life of the Elderly in the Working Area of the Sei Lengkai Health Center in 2024". The research design used in this study is cross sectional. Data collection uses secondary data with the population of hypertension patients in Batam city in 2023 and primary data, namely a questionnaire on adherence to taking hypertension medication and quality of life for the elderly. Sampling was done using a purposive sampling technique with a total of 93 elderly people. The measuring tools in this study are the Morisky Medication Adherence Scale (MMAS-8) and WHOQOL-BREF questionnaires. Based on the results of the analysis, it is known that the p value is 0.003, this states that there is a relationship between compliance with taking hypertension medication and the quality of life of the elderly in the Sei Langkai Health Center Work Area in 2024. The conclusion of this study is that adherence to taking antihypertensive medication is positively related to the quality of life of the elderly, so efforts are needed to increase medication adherence to support a better quality of life in the elderly. It is hoped that families and health workers will provide support and education to the elderly to maintain compliance in taking their medication to improve their quality of life

Corticosteroids are hormones that play an important role in the human physiological system, affecting self-defense against environmental changes. However, the perception of their efficacy often drives irrational self-medication behavior in the community, which can lead to detrimental effects if used long-term without supervision. This community service activity was carried out in Kepolorejo Village, Magetan Regency, based on initial observations showing errors in corticosteroid use, such as doubling dosages. The method used was educational counseling with material presentation and Q&A discussions regarding irrational corticosteroid use. Knowledge measurement was conducted through pre-test and post-test questionnaires. The results showed an increase in public knowledge regarding the impact of irrational steroid use.

Human Immunodeficiency Virus (HIV) infection leading to Acquired Immune Deficiency Syndrome (AIDS) remains a global public health issue, with 39 million people living with HIV worldwide in 2022. Although X Hospital in Malang City provides a comprehensive care program, internal data shows a significant level of non-adherence to antiretroviral (ARV) therapy, often in the form of irregular consumption or discontinuation of medication without medical recommendation. This observational study with a cross-sectional approach aims to identify the determinants of ARV non-adherence, involving 81 non-adherent AIDS patients at Hospital X through total sampling techniques. The characteristics of the respondents were dominated by males, highly educated, and working in the non-government sector, with the majority using the ARV regimen TLD, COTRIMOXAZOLE. The results of statistical analysis indicate that all eight determining variables tested show a highly significant positive correlation (p < 0.001) with non-compliance, meaning that the more severe the problems with these factors, the lower the patient compliance. Furthermore, the top five factors showed a very strong positive correlation (r > 0.80) with non-adherence, namely motivation/depression, social support, communication with service providers, treatment costs, and age or routine. These findings underscore that these five key determinants must be a crucial focus in designing and implementing targeted intervention strategies to effectively improve patient adherence to ARV therapy.

This study evaluated drug inventory management in a primary hospital pharmacy using the Economic Order Quantity (EOQ) method. A descriptive quantitative design was applied with secondary data collected from January to December 2024, covering annual demand, purchase price, ordering cost, and holding cost. The analysis revealed inefficiencies, as several drugs simultaneously faced overstock and stock out risks, indicating weaknesses in procurement planning. EOQ calculations suggested lower and more frequent procurement, reducing storage costs and improving stock control. The findings demonstrated that applying EOQ could minimize financial risks, optimize resource allocation, and ensure continuous access to essential medicines. This research highlights the relevance of structured inventory models in supporting hospital efficiency and sustainable pharmaceutical logistics, particularly in resource-limited primary hospitals.

This paper presents a narrative review focusing on the significance of in silico methodologies in identifying and evaluating natural bioactive compounds as promising antidiabetic agents. By examining scientific publications from 2020 to 2025, the review highlights substantial evidence that various plant-derived metabolites such as flavonoids, phenolic acids, terpenoids, and glycosides from Orthosiphon stamineus, Moringa oleifera, Syzygium polyanthum, Tinospora crispa, and Albizia saman demonstrate notable affinity toward several crucial enzymes implicated in type 2 diabetes, including DPP-4, SGLT-2, α-glucosidase, and PTP1B. Findings from molecular docking analyses and ADMET simulations indicate that many of these compounds exhibit favorable pharmacokinetic behavior, strong receptor interactions, and minimal toxicity, suggesting their potential as multitarget natural therapeutics with synergistic modes of action. Utilizing in silico screening as an initial step effectively predicts biological activity and pharmacological profiles prior to experimental validation through in vitro and in vivo testing, thus reducing both time and research expenditure. The synergy between computational modeling, medicinal chemistry, and phytochemical exploration establishes a scientific framework that supports the advancement of rational, safe, and sustainable herbal-based antidiabetic drug development derived from Indonesia’s vast biodiversity and encourages self-reliance within the national pharmaceutical sector.

Cancer remains a major challenge in modern medicine due to drug resistance and the adverse effects of conventional therapies, making it one of the leading causes of death worldwide. Continuous scientific efforts aim to discover safer and more effective treatments. Owing to their structural diversity, strong bioactivity, and relatively low toxicity, natural compounds show great promise as sources of anticancer drug candidates. This article aims to explore the role of medicinal chemistry in investigating, modifying, and optimizing natural bioactive compounds to develop more effective, selective, and stable anticancer agents with improved bioavailability. A narrative review was conducted using scientific literature published between 2020 and 2025 from PubMed, ScienceDirect, Google Scholar, and ResearchGate. The findings indicate that eugenol, berberine, hesperidin, piperine, and quercetin exhibit anticancer activities through apoptosis induction, inhibition of proliferation, and antioxidant and anti-inflammatory mechanisms. Modern medicinal chemistry relies on understanding structure–activity relationships (SAR), chemical modification, and nanoparticle formulation to enhance biological performance. In addition, in silico techniques such as molecular docking and QSAR analysis are applied to study ligands and receptors and predict bioavailability improvements. The development of natural products as rational, effective, and safe anticancer drug candidates is strengthened by integrating experimental, computational, and pharmaceutical approaches.

The high number of hypertension cases is due to the still low level of hypertension control, specifically medication adherence. Treatment adherence is crucial for maintaining health and well-being in patients with hypertension. In contrast, non-adherence to medication leads to treatment failure. This study aims to determine the relationship between self-management and adherence to hypertension medication in the elderly. This research employed an analytical design with a cross-sectional approach. The study consisted of 49 elderly people with hypertension in Cot Cut Village, Kuta Baro, Aceh Besar. The sample was chosen using a total sampling technique. The MMAS-8 questionnaire was used to assess adherence to hypertension medication with a Cronbach's alpha of 0.860. The self-management questionnaire showed a Cronbach's alpha of 0.766. The research was conducted from April 8th to 14th, 2025. The data analysis used univariate and bivariate methods, using the chi-square test. The results showed that out of 49 respondents, 21 (42.9%) were less adherent to hypertension medication, and 29 (59.2%) had less adherence to self-management. The chi-square test indicated a p-value of 0.001, showing a relationship between self-management and adherence to hypertension medication among the elderly. This research suggests that hypertensive patients should be supervised to improve medication adherence and self-care management to maintain stable blood pressure.

The implementation of the Frequent Pattern Growth (FPG) algorithm in a web-based drug purchasing application at Sumber Sehat Pharmacy aims to improve efficiency and accuracy in analyzing customer drug purchasing patterns. The FPG algorithm is a method used to identify frequent purchase patterns or frequent itemsets in purchase transactions, which can then be used to make relevant drug recommendations for customers. This study uses a case study at Sumber Sehat Pharmacy to explore drug purchasing patterns and provide a data-driven solution that can help pharmacies improve service and adjust drug stocks according to customer needs. The results show that the application of the FPG algorithm can identify significant purchasing patterns and assist pharmacies in determining more appropriate promotional strategies and inventory management. By using a web-based application that implements this algorithm, Sumber Sehat Pharmacy can provide drug recommendations that are more in line with customer preferences, thereby increasing customer satisfaction and pharmacy operational efficiency.

This community service program aimed to enhance students’ pharmaceutical literacy through the introduction of drug classification logos at SMP Muhammadiyah 04 Pangkatrejo. The background of this activity was the low level of drug-use literacy among adolescents, often leading to irrational self-medication. The activity employed a quantitative descriptive design with a one-group pretest–posttest approach. Educational interventions included interactive counseling, PowerPoint presentations, visual media using logo sticks, and pretest–posttest evaluation. Data were analyzed using the Wilcoxon Signed Rank Test. The results showed a significant improvement in students’ knowledge (p = 0.000), with mean scores increasing from 58% to 81% after the intervention. The highest gain was observed in the recognition of logo colors and drug classifications. Satisfaction analysis revealed that 96% of participants expressed satisfaction with the learning process, especially regarding material clarity and the presenters’ readiness to answer questions. The study concludes that participatory educational methods and visual media effectively improve rational drug-use awareness among junior high school students. Future programs are recommended to expand similar activities to other schools and integrate digital media for sustained impact on public health literacy.

Drug stock-outs are an indicator of pharmaceutical management failure that directly affects patient safety and the quality of hospital services. Gatoel Hospital Mojokerto experienced an increase in the percentage of drug debt from 3.14% in January to 6.20% in July 2025, with 1,607 patients affected. This study aims to identify the factors causing drug stock-outs and formulate preventive strategies through the optimization of the Minimum-Maximum Stock Level (MMSL) system based on the Hospital Information System. A mixed-method approach was used, combining secondary data analysis (January–July 2025) and in-depth interviews. Fishbone analysis was applied to identify root causes, USG analysis to determine priorities, and SWOT analysis to formulate intervention strategies. Priority drug classification was carried out using the ABC-VEN method. The intervention involved implementing an MMSL pilot project for 150 drug items under Pareto category A. The analysis identified six dimensions of stock-out causes: man, materials, methods, machines, measurement, and environment. The highest priority issue was drug demand forecasting based on historical data (USG score: 125). SWOT analysis placed the organization in quadrant II, recommending a Weakness-Opportunities (WO) strategy. MMSL implementation was initiated through the development of SOPs and the entry of 150 priority drug items into the system. Drug stock-outs are caused by multifactorial issues that require systemic intervention. MMSL optimization has the potential to serve as a long-term solution, provided there is expanded coverage, strengthened human resource capacity, and comprehensive system integration.

kuliah kerja nyata (KKN) merupakan bentuk pengabdian kepada Masyarakat yang bertujuan memberikan pengalaman langsung kepada mahasiswa dalam mengidentifikasi  dan menyelesaikan permasalahan di lingkungan desa. KKN kelompok 04 STIKes Ibnu Sina Ajibarang dilaksanakan di Desa Kotayasa, kecamatan sumbang, kabupaten Banyumas pada 28 juli – 5 september 2025. Metode yang digunakan berupa observasi, wawancara, dan pelaksanaan program berbasis kebutuhan Masyarakat. Hasil kegiatan menunjukan adanya peningkatan pengetahuan dan keterampilan Masyarakat, antaralain melalui sosialisasi perilaku hidup bersih dan sehat (PHBS) di sekolah dasar, kegiatan posyandu balita dan lansia, penyuluhan stunting, serta sosialisasi penggunaan obat  NSAID dan kortikostiroid. Selain itu, kegiatan inovatifs seperti pembuauan sabun cuci piring, budidaya tanaman obat keluarga (TOGA) , senam Bersama PKK, hingga lomba mewarnai untuk anak-anak berhasil meningkatkan partisipasi dan kemandirian Masyarakat. Factor pendukung meliputi antusiasme warga, dukungan perangkat desa, dan kerja sama lintas sektor.sementara hambatan yang mucul berupa keterbatasan waktu, dana, serta kondisi cuaca. Secara keseluruhan, kegiatan ini  memberikan kontribusi positif dalam aspek Kesehatan, Pendidikan, ekonomi kreatif, dan sosial budaya di Desa Kotayasa.

Community Service Program (Kuliah Kerja Nyata/KKN) is a compulsory activity for university students as a form of community engagement and application of academic knowledge in real life. One of the work programs carried out was the education and cultivation of Family Medicinal Plants (Tanaman Obat Keluarga/TOGA), which aimed to improve the knowledge and practical skills of the community in Telaga Sam Sam Village, Kandis District, in cultivating and utilizing TOGA. Family medicinal plants have long been known to possess great potential as an alternative treatment for common illnesses such as fever, cough, stomachache, and skin itching, making them highly relevant to daily community health needs.The program was implemented through counseling sessions, interactive discussions, training, and hands-on practice of planting TOGA in the residents’ yards. The community actively participated in recognizing, cultivating, and maintaining various types of medicinal plants such as ginger, turmeric, galangal, lemongrass, and betel leaf. In addition to enhancing understanding, this activity encouraged households to practice simple herbal preparation techniques for family use.The results of the program showed a significant increase in community awareness regarding the importance of utilizing TOGA as a primary step in maintaining family health, while also contributing to the creation of a greener, cleaner, and healthier living environment. Furthermore, the activity not only improved community knowledge but also strengthened independence and self-reliance in utilizing local resources to support sustainable health practices.

Community Service Program (Kuliah Kerja Nyata/KKN) is a compulsory activity for university students as a form of community engagement and application of academic knowledge in real life. One of the work programs carried out was the education and cultivation of Family Medicinal Plants (Tanaman Obat Keluarga/TOGA), which aimed to improve the knowledge and practical skills of the community in Telaga Sam Sam Village, Kandis District, in cultivating and utilizing TOGA. Family medicinal plants have long been known to possess great potential as an alternative treatment for common illnesses such as fever, cough, stomachache, and skin itching, making them highly relevant to daily community health needs.The program was implemented through counseling sessions, interactive discussions, training, and hands-on practice of planting TOGA in the residents’ yards. The community actively participated in recognizing, cultivating, and maintaining various types of medicinal plants such as ginger, turmeric, galangal, lemongrass, and betel leaf. In addition to enhancing understanding, this activity encouraged households to practice simple herbal preparation techniques for family use.The results of the program showed a significant increase in community awareness regarding the importance of utilizing TOGA as a primary step in maintaining family health, while also contributing to the creation of a greener, cleaner, and healthier living environment. Furthermore, the activity not only improved community knowledge but also strengthened independence and self-reliance in utilizing local resources to support sustainable health practices.

Hypertension or high blood pressure is a medical condition that can cause serious complications, such as stroke and heart disease. The causes of hypertension are very diverse, ranging from unhealthy diet, lack of physical activity, stress, to genetic factors. The phenomenon that occurs at the UPTD Menteng Palangka Raya Health Center, namely that there are still many families who have not carried out their role as the right family members and have not been able to overcome family health problems, for example, such as compliance with taking hypertension medication in family members who suffer from hypertension. The purpose of this study is to determine the relationship between family roles and medication adherence in family members with hypertension. This type of research is correlational using a cross-sectional  approach using a spearman rank statistical test. The sampling technique used in consecutive sampling at the Menteng Palangka Raya Health Center. Sampling in this study is based on the inclusion criteria set. Data collection in this study used questionnaires on family roles and medication adherence that had gone through validity and reliability tests with Cronbach's alpa for family role 0.89 and Cronbach's alpa for medication adherence 0.92. Based on statistical tests using  Spearman's rank , a correlation coefficient value of 0.812 with a significance value of <0.001 was obtained. It can be concluded that there is a significant relationship between the role of the family and medication compliance at the Menteng Palangka Raya Health Center. The relationship between family roles and medication adherence in family members with hypertension at the Menteng Palangka Raya Health Center.”