Publication Search

Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract that is often accompanied by psychological disorders such as depression. This study aims to analyze the impact of depression on the effectiveness of Crohn's disease treatment through a systematic review and meta-analysis. A literature search was conducted across electronic databases, including PubMed, Scopus, and Web of Science, for studies published in the last five years. Of the 1,247 articles identified, 28 studies met the inclusion criteria. The meta-analysis results indicate that Crohn's disease patients with depression have a lower remission rate (OR = 0.65, 95% CI: 0.54-0.78) and a higher relapse rate (HR = 1.58, 95% CI: 1.32-1.89) compared to patients without depression. Additionally, subgroup analysis reveals that the negative effects of depression are more pronounced in patients receiving biological therapy. These findings underscore the importance of a holistic approach in the management of Crohn's disease, considering the psychological aspects of patients to optimize treatment outcomes.

Fibromyalgia is a chronic disorder characterized by widespread muscle pain and fatigue, often accompanied by psychological symptoms such as anxiety and depression. Medication adherence is crucial for managing this condition, yet many patients struggle to follow prescribed regimens. This study aims to explore the role of self-efficacy in medication adherence among fibromyalgia patients through a systematic review and meta-analysis. The researcher conducted a literature search in major electronic databases to identify relevant studies published between 2015 and 2023. Out of 1,247 identified articles, 18 studies met the inclusion criteria and were eligible for analysis. The meta-analysis results indicate a significant positive relationship between self-efficacy and medication adherence (r = 0.42, 95% CI [0.35, 0.49], p < 0.001). Moderator analysis revealed that this relationship is stronger among patients receiving self-efficacy-based interventions compared to those receiving standard care. These findings underscore the importance of integrating self-efficacy enhancement strategies into fibromyalgia management to improve medication adherence, ultimately leading to better patient health outcomes.

This study aims to determine the effect and impact of the overall research on the Problem-based learning model in science learning. This type of research is a meta-analysis. The data sources in this study are 17 national and international journals published from 2017-2022. The process of searching for data sources through Google Scholar, ScienceDirect, Wiley, ProQuest, and Eric Journal. Inclusion criteria are research on problem-based learning models with experimental or quasi-experimental methods and measurement of learning outcomes to evaluate Problem-Based Learning learning models. The results showed that the average effect size value of all studies (ES = 1.40) was very high. This finding explains that the Problem-Based Learning model provides a very high positive impact on science learning. In addition, the Problem-Based Learning learning model is effective to be applied to students' science learning at school. Effect measurement in this study is influenced by the level of education, year of publication, learning outcomes, and sample size. Overall, the Problem-Based Learning model is very useful in increasing students' potential in facing the 21st century.