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Allergic rhinitis (AR) is a chronic inflammatory disorder of the nasal mucosa mediated by immunoglobulin E (IgE) in response to allergen exposure. This condition has become a significant global health concern because of its increasing prevalence and substantial impact on quality of life, sleep, cognitive function, and work productivity. AR is also commonly associated with other atopic diseases, including asthma and atopic dermatitis. This article aims to review the current understanding of allergic rhinitis, focusing on epidemiology, pathophysiology, clinical manifestations, diagnostic approaches, and evidence-based management strategies. This study used a narrative literature review method by analyzing scientific articles, clinical guidelines, and peer-reviewed journals published between 2015 and 2025. Literature sources were obtained from PubMed, Google Scholar, and relevant medical databases using keywords related to allergic rhinitis, IgE, diagnosis, and immunotherapy. The findings indicate that allergic rhinitis involves complex immune mechanisms characterized by Th2 lymphocyte activation, IgE production, and inflammatory mediator release. Diagnosis is primarily established clinically and supported by allergy testing such as skin prick tests or serum-specific IgE measurement. Intranasal corticosteroids remain the first-line therapy for moderate to severe cases, while antihistamines and leukotriene receptor antagonists are used as adjunctive therapies. Allergen immunotherapy has shown effectiveness in modifying disease progression and improving long-term outcomes. In conclusion, allergic rhinitis is a manageable chronic disease that requires a comprehensive and individualized treatment approach involving environmental control, pharmacotherapy, and immunotherapy.

Data security in Electronic Medical Records (EMR) is a crucial issue in health information governance in Indonesia. This study evaluates the compliance of health facility information security systems with Ministry of Health Regulation (PERMENKES) No. 24 of 2022 and Personal Data Protection Law (UU PDP) No. 27 of 2022, and analyzes the impact of non-compliance on service quality and patient trust. The method employed is a systematic narrative literature review on the Google Scholar database (2023–2026) using the keywords "data security and privacy," "electronic medical records," and "CIA Triad," focusing on the implementation of Confidentiality, Integrity, and Availability. The four healthcare facilities examined have implemented controls such as role-based access control, Electronic Signatures (TTE), Virtual Private Networks (VPN), data encryption, and SSL/TLS protocols in accordance with PERMENKES provisions and Article 35 of the UU PDP. However, the effectiveness of implementation is hindered by weak authentication due to the use of simple passwords and excessively long auto-logout durations, the absence of comprehensive written standard operating procedures (SOPs), low staff compliance with security protocols, and minimal patient awareness regarding personal data protection rights. These weaknesses heighten the risk of patient data breaches as well as potential administrative sanctions and fines, and carry negative implications for service quality and public trust. Recommendations include strengthening internal security policies, developing written SOPs, providing continuous training for healthcare workers, implementing stronger authentication mechanisms (e.g., multi-factor authentication/MFA), and conducting patient awareness programs to ensure regulatory compliance and maintain public confidence.

Postoperative pain is a common physiological response following surgical procedures, and its suboptimal management can have physiological and psychological effects, including sleep disturbances, decreased functional capacity, increased anxiety, and deterioration in quality of life. This scoping review aims to describe the empirical evidence regarding the effectiveness of music therapy in reducing the intensity of postoperative pain in surgical patients. A systematic search was conducted through four major databases (ScienceDirect, PubMed, Neliti, and Google Scholar) using Boolean operators and keywords such as ‘postoperative pain,’ ‘music therapy,’ and ‘pain scale.’ Inclusion criteria included articles published in the last decade, in English or Indonesian, and available in full text format. In accordance with PRISMA-ScR guidelines, this review analysed 10 articles. The synthesis of results showed that music therapy consistently reduced pain intensity, anxiety, and analgesic requirements through mechanisms such as increased endorphin secretion, decreased stress hormone levels, and activation of the gate control theory. Typically administered for 15–30 minutes, music therapy is a safe, cost-effective, and patient-acceptable non-pharmacological modality. This intervention is recommended as an adjunct component in perioperative pain management in nursing practice, although further standardised research is needed to improve consistency.

Low Birth Weight (LBW) remains a critical global health issue that significantly contributes to neonatal morbidity and mortality, particularly in developing countries such as Indonesia. The main challenge in addressing LBW lies in its complex and multifactorial risk profile, which involves biological, social, environmental, and healthcare-related determinants. This study aims to analyze and synthesize the risk factors associated with LBW based on recent scientific literature. A literature review method was applied by searching articles from Portal Garuda, DOAJ, PubMed, and Google Scholar published between 2020 and 2025 using relevant keywords. The findings indicate that maternal age, interpregnancy interval, nutritional status, anemia, preeclampsia, infections, socioeconomic conditions, environmental exposure, and the quality of antenatal care are significant determinants of LBW. The synthesis of evidence confirms that LBW is influenced by the interaction of multiple individual and healthcare system factors rather than a single cause. In conclusion, this study highlights the urgent need to strengthen antenatal care services, improve maternal nutritional status, control maternal diseases during pregnancy, and implement community-based promotive and preventive strategies as key efforts to reduce the incidence of LBW.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder whose prevalence continues to rise, making it a major challenge for health systems worldwide. This disease results from a combination of insulin resistance and impaired pancreatic β-cell function, leading to persistent hyperglycemia and increased risk of long-term complications affecting the kidneys, cardiovascular system, nervous system, and eyes. This report describes the case of a 52-year-old woman diagnosed with T2DM for approximately ten years. The patient presented with fatigue, nocturnal polyuria, nausea after meals, significant weight loss, and tingling in her extremities. Laboratory findings revealed an HbA1c level of 12%, reflecting very poor glycemic control. A family medicine approach was applied through detailed history taking, physical and laboratory examinations, home visits, and completion of a family folder to assess clinical, personal, social, and functional aspects. Interventions included counseling on balanced diet, encouragement of regular physical activity, education on diabetic foot care, and pharmacological treatment with metformin and insulin. The family received counseling about hereditary risk factors, the importance of emotional support, and the need for consistent monitoring of health status. The patient was still capable of light daily activities, supported by a highly functional family environment with an APGAR score of 10. A holistic family medicine–based approach was shown to improve treatment adherence, patient knowledge, and overall quality of life. Therefore, management of T2DM requires a comprehensive strategy that integrates promotive, preventive, curative, and rehabilitative components, emphasizing the active involvement of family and community at the primary care level to reduce complications, slow disease progression, and enhance patient well-being.   Keywords: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder whose prevalence continues to rise, making it a major challenge for health systems worldwide. This disease results from a combination of insulin resistance and impaired pancreatic β-cell function, leading to persistent hyperglycemia and increased risk of long-term complications affecting the kidneys, cardiovascular system, nervous system, and eyes. This report describes the case of a 52-year-old woman diagnosed with T2DM for approximately ten years. The patient presented with fatigue, nocturnal polyuria, nausea after meals, significant weight loss, and tingling in her extremities. Laboratory findings revealed an HbA1c level of 12%, reflecting very poor glycemic control. A family medicine approach was applied through detailed history taking, physical and laboratory examinations, home visits, and completion of a family folder to assess clinical, personal, social, and functional aspects. Interventions included counseling on balanced diet, encouragement of regular physical activity, education on diabetic foot care, and pharmacological treatment with metformin and insulin. The family received counseling about hereditary risk factors, the importance of emotional support, and the need for consistent monitoring of health status. The patient was still capable of light daily activities, supported by a highly functional family environment with an APGAR score of 10. A holistic family medicine–based approach was shown to improve treatment adherence, patient knowledge, and overall quality of life. Therefore, management of T2DM requires a comprehensive strategy that integrates promotive, preventive, curative, and rehabilitative components, emphasizing the active involvement of family and community at the primary care level to reduce complications, slow disease progression, and enhance patient well-being.

The production of pharmaceutical sterile products requires strict procedures to minimize the risk of microbial, particulate and pyrogen contamination that can be harmful to the user's health. The selection of the right sterilization method is the key to achieving the desired stability of the final product. Filtration sterilization is one of the oldest methods used for pharmaceutical sterile products. There are two types of feed flow in the method, namely through flow filtration and tangential flow filtration. This review article is prepared through literature search and download of national or international journals with inclusion or exclusion criteria that have been set. Literature sources are accessed online from various sites such as Google Scholar and Pubmed in the range of 2014-2024. The keywords used for journal searches are sterilization, through flow filtration, and tangential flow filtration. This review article reviews and compares the two methods to understand the differences, mechanism of action, and research objectives based on the review article on membrane filtration sterilization. This review aims to provide a better insight into the advantages and disadvantages of each membrane filtration sterilization method, as well as guidance in choosing the appropriate method based on the characteristics of the product to be sterilized. The results showed that through flow filtration is more commonly used in small volume and batch processes because of its simple design, but has limitations in reducing membrane fouling. In contrast, tangential flow filtration allows for continuous processing of larger volumes, with the advantage of minimizing particle build-up on the membrane surface, thus extending membrane life. The choice of method is also influenced by factors such as particle size, viscosity of the solution, sensitivity to heat, as well as operating costs. An in-depth understanding of the Working Principle and application of each method is essential for the pharmaceutical industry to ensure the quality, safety and efficiency of the production process. Thus, this review is expected to be a reference for researchers and practitioners in determining the optimal filtration sterilization strategy according to product needs.

Sustained-release tablets are pharmaceutical preparations designed to gradually release the active substance over a specific period, thereby maintaining a constant concentration of the drug in the circulatory system and enhancing therapeutic effectiveness.The development of sustained-release tablets aims to extend the duration of drug action, reduce the frequency of dose administration, and minimize fluctuations in drug levels in the plasma, which ultimately enhances patient compliance and treatment effectiveness, especially in chronic diseases.The purpose of this review is to identify various formulation methods and innovations in the production of sustained-release tablets, as well as to examine the factors that influence the success of these formulations.The method used in this study is a literature review that collects data from various scientific publications over the past five years through online platforms such as Google Scholar, using keywords related to matrix sustained-release tablets and pharmaceutical formulations.The results of the review indicate that various techniques, such as formulating polymer matrices, coating, and encapsulation, have been applied with varying degrees of success depending on the type of active ingredients and excipients used. Some formulation innovations, such as the use of natural polymer matrices and matrix modifications, have proven effective in achieving controlled, stable, and quality-standard-compliant drug release.

Postural balance is a crucial aspect of daily life that enables individuals to move with stability and safety. Children with Down Syndrome (DS) often experience balance disorders due to cognitive function limitations that affect their motor abilities. This study aims to explore the relationship between cognitive function and balance in children with DS. Cognitive impairments, including memory deficits, attention difficulties, and executive function challenges, can impact a child's ability to control posture and perform motor activities effectively. Additionally, difficulties in movement coordination and sensorimotor responses contribute to poor balance abilities. Understanding the connection between cognitive function and balance can facilitate the implementation of appropriate interventions, such as physical therapy and cognitive stimulation, to improve the quality of life of children with DS. A holistic approach is essential in supporting the development of children with DS to help them achieve greater independence. Parents and families play a vital role in actively participating in the growth and development of children with DS, ensuring that their cognitive function and balance are maintained and enhanced. Consequently, children with DS can become more independent and socially engaged, enabling them to interact with others and build healthy social relationships. Keywords: Down Syndrome, cognitive function, postural balance, parents, family

Implementing family-based discharge planning, which relies on the participation of family members, can help stroke victims feel better. The purpose of this study was to identify the effect of family-based discharge planning on the quality of life of stroke patients based on journal literature reviews. Methode uses systematic literature reviews of journals taken from research in 15 journals, which were discovered through screening results of a number of journals from Google Scholar, Cochrane, Science Direct, Pubmed, and Wile using the keywords "Discharge Planning" AND "Family" AND "Quality Of Life" AND "Stroke OR Post Stroke". Writing research journals from the 2017-2021 time frame  and those that complied with inclusion and exclusion standards, in PICOTS format, both national and international journals. Results from 15 design journals used quasy experimental (33.5%), Systematic Review (13.4%), Randomized controlled (13.4%), Cross sectional survey (6.7%), Longitudinal Survey (6.7%), True Experimental (6.7%), Parallel group (13.4%), Retrospective Study (6.7%). Conclusion Discharge planning provides family caregiver education about stroke. The support of family members is very important in improving the patient's health by contributing to quality care and creating a pleasant atmosphere.  

The quality of hospital services will affect patient satisfaction and also their loyalty in using these facilities and the rapid development of health services currently requires hospital managers to run their business well. in the hospital. This study uses the method of literature review (literature review) with search engines used in literature searches including Google Scholar and Research gate with the keywords Service Quality Improvement, Lean Six Sigma, Hospitals. The resulting articles were selected based on publications published between 2018 and 2023. The results showed that the application of lean six sigma in hospitals in improving the quality of their services can be carried out through the DMAIC (Define, Measure, Analyze, Improve, Control) approach. The conclusions of this study indicate that the application of lean six sigma can reduce difficulties, increase speed, and separate activities that have added value or value added from activities that have no added value or non-value added in hospitals, such as improving service quality by setting priorities by according to the highest gap required by the patient.