Publication Search

Medicinal plants have been known and used worldwide for thousands of years. One type of medicinal plant that is often used is gaharu. The efficacy of gaharu leaves provides properties as a fever reducer, increases appetite, launches menstruation, and relieves pain. This study aims to determine whether there is an analgesic effect from the methanol extract of gaharu leaves in male Wistar rats using the heat stimulation method. This study was an experimental study using twenty-five male Wistar rats divided into five groups. Group I (negative control), rats were treated with 1% CMC-Na. Group II (positive control), rats treated with mefenamic acid 45 mg/kg BW. Group III, IV, and V rats were treated with gaharu leaf methanol extract suspension (100; 200, and 400) mg/kg BW. Pain stimulation was carried out by dipping the rat tail into a 40°C water bath. Data on response time to pain, stimuli were analyzed using the One-Way Analysis of Variance (ANNOVA) method with a 95% confidence level followed by a post-hoc Tukey test to determine which group had the same or significantly different effect. The results showed that the normal response time data for mice to painful stimuli ranged from 2.79 to 3.57 seconds. 1% CMC-Na treatment in mice was unable to increase the response time to a significant pain stimulus (p>0.05). Mefenamic acid treatment 45 mg/Kg BW significantly increased the response time to painful stimuli (p<0.05) with the longest average response time to painful stimuli, namely 8.87 seconds. Based on the method used in this research, methanol extract of agarwood leaves 400 mg/kgBW has almost the same analgesic effect as mefenamic acid 45 mg/KgBW.

Diuretics act on the kidneys to increase the excretion of water and sodium chloride. The working principle of diuretics in general is to reduce electrolyte reabsorption by the renal tubules, where an increase in electrolyte excretion will be accompanied by an increase in water excretion which is needed to achieve osmotic balance. Bangun-Bangun leaf contains polyphenolic compounds, saponins, glycosides, flavonoids, and essential oils. Bangun-Bangun leaves types of flavonoids, namely quercetin, apigenin, luteolin, salvigenin, and genkwanin. Apigenin is known as a compound that functions as a diuretic. IDBB was obtained from the infusion technique with distilled water and then the infusion was used on 25 diuretic rats which were divided into 5 groups. Group I (negative) Na-CMC 0.5%, group II, III, IV, IDBB doses of 10, 20, 40%, and group V (positive) Furosemide 3.6 mg/kgBW were given orally. Rats were given aquadest orally at a dose of 15 ml/kgBW. Mice were placed in metabolic cages, then a physical examination of urine was carried out every 1 hour for 6 hours. The results showed that the IDK with the best dose was 40% which gave an increase in urine volume, had an effect on urine pH, had an effect on urine specific gravity, had an effect on urine color, and had an effect on urine clarity.    

Latar Belakang: Permasalahan ISPA masih menjadi salah satu penyebab kematian akibat penyakit menular di dunia. Hampir 4 juta orang meninggal karena infeksi saluran pernapasan akut tiap tahun. Pemberian herbal tradisional sebagai terapi non farmakologi dapat digunakan sebagai terapi pendamping perawatan medis dalam menangani ISPA pada balita. Kandungan herbal jahe dan madu dikenal dapat menurunkan tingkat keparahan batuk di malam hari sehingga mengurangi gangguan tidur. Kualitas tidur yang baik dapat memperbaiki kondisi ISPA sehingga tidak terjadi komplikasi yang lebih buruk. Tujuan: Memberikan edukasi terkait minuman herbal jahe dan madu sebagai pendamping obat farmakologi terhadap kejadian ISPA. Metode: Pelaksanaan kegiatan ini dilakukan secara langsung bertatap muka dengan sasaran sehingga lebih efektif, meyakinkan dan mengakrabkan hubungan antara penyuluh dan sasaran serta cepatnya respon.. Hasil : Klien memahami dan mengerti tentang manfaat dan teknik terapi pemberian minuman jahe merah dan madu. ,Klien memahami dan mengerti tentang langkah-langkah melakukan terapi pemberian minuman jahe merah dan madu sebagai pendamping obat farmakologi. Saran: Diharapkan dapat digunakan sebagai obat herbal yang aman tanpa menimbulkan efek samping