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Cattle farming plays a strategic role in rural economic development by generating employment, supplementary household income, and contributing to food and nutritional security. However, in Indonesia, most smallholder cattle enterprises remain traditional and small-scale, leading farmers to treat livestock farming primarily as a secondary livelihood. While previous studies have largely focused on technical adoption and production performance, limited attention has been given to farmers’ psychological interest as a foundation for sustaining livestock enterprises. Therefore, this study aims to analyze the level of community interest in cattle farming and examine the influence of farmers’ characteristics (age, education level, herd size, number of family dependents, farming experience, and primary income) on such interest. A quantitative survey was conducted involving 34 cattle farmers in Taji Village, Jabung District, Malang Regency, selected using total sampling. Data were collected through structured questionnaires and analyzed using multiple linear regression. The findings reveal that community interest in cattle farming is generally high, as reflected in emotional (3.93), cognitive (3.81), and conative (3.74) dimensions measured on a four-point Likert scale. Regression results indicate that age has a significant positive effect (p = 0.022), whereas farming experience has a significant negative effect (p = 0.025) on interest levels. Other variables show no statistically significant influence. These findings highlight that psychological engagement in cattle farming is shaped more by demographic and experiential factors than by formal education or income level. The study contributes to the literature by positioning interest as a psychological determinant of livestock sustainability. Policy implications emphasize the urgency of risk-mitigation extension programs to address farmer burnout, incentivized intergenerational knowledge transfer, and cooperative-based institutional support to ensure smallholder livestock sustainability.

This study aims to analyze the language style employed by President Prabowo Subianto in his speech delivered at the 17th National Farmers and Fishermen Week in 2026 using Teun A. Van Dijk's Critical Discourse Analysis framework. The study employed a qualitative approach with documentation techniques applied to the official speech transcript. Data were analyzed through Van Dijk's three analytical dimensions, namely text, social cognition, and social context. The findings reveal that, at the textual level, the speech is dominated by themes of support for farmers and fishermen as strategic actors in national development and food security. At the superstructure level, the speech is organized argumentatively through personal experiences, policy explanations, and reaffirmation of governmental commitments. At the microstructure level, the speech demonstrates the use of informal language, rhetorical strategies, repetition, and lexical choices that strengthen the relationship between the speaker and the audience. In terms of social cognition, the findings indicate the speaker's awareness of the media's role in shaping public opinion, as reflected in several instances of meta-communication. Meanwhile, the social context dimension reveals representations of power relations through the construction of social groups positioned either as supporters or obstacles to national interests. These findings suggest that the speech functions not only as a means of political communication but also as a medium for constructing ideology, legitimizing power, and shaping political identity. This study reinforces the view that language plays a significant role in representing social realities and power relations within society.

Tomato (Solanum lycopersicum) is a high-value horticultural commodity in Indonesia, yet its cultivation is frequently disrupted by leaf diseases that are difficult to distinguish visually. Diseases such as Bacterial Spot, Early Blight, and Tomato Yellow Leaf Curl Virus often present overlapping visual symptoms, making early and accurate diagnosis a significant challenge for farmers. The manual identification methods currently in use are inefficient and error-prone, ultimately leading to reduced crop yield  and quality. The general objective of this study is to develop software capable of automatically classifying tomato  leaf diseases. Specifically, this research aims to implement the MobileNetV3 Small architecture based on Convolutional Neural  Network (CNN) with ImageNet pre-trained weights to classify 10 types of tomato leaf diseases. The research methodology encompasses dataset collection from Kaggle comprising 10,000 images (1,000 per class), image pre-processing through resizing to 224x224 pixels, and normalization, as well as hyperparameter optimization (optimizer, learning rate, epoch, batch size) via scheduler. Model performance is evaluated using a confusion matrix encompassing accuracy, precision, recall, and F1-score.

This research documents and analyzes the variations of banana (gedhang) names in the Southern Brebes dialect of the Javanese language from a sociolinguistic viewpoint. The study explores how language reflects social and cultural realities within a local community. Indonesia’s vast cultural and linguistic diversity makes the study of regional registers essential for understanding how people use language to represent their environment. The Southern Brebes area shows a wide range of banana varieties, each identified by distinct local names that convey information about their physical traits, uses, and cultural significance. These linguistic variations also have educational potential, particularly as supplementary materials for courses such as Pharmaceutical Botany. The research further examines social, cultural, and environmental factors shaping the creation and usage of these names. Findings are expected to enhance understanding of the Javanese lexical system especially the Southern Brebes dialect and to highlight the deep connection between language, culture, and identity. Ultimately, this study contributes to the preservation of local linguistic and cultural heritage.

  Abstract.. The development of modernization in corn farming in Kalibareng Village, Patean District, Kendal Regency has the potential to cause the loss of traditional terms used by the farming community. This study aims to describe and analyze the lexicon of corn farming in Kalibareng Village, Patean District, Kendal Regency, and to reveal the lexical and contextual meaning contained therein. This study uses a descriptive qualitative approach with  field research and semantic studies as the main approach. Data were obtained through participatory observation, in-depth interviews, and documentation of corn farmers in Kalibareng Village. The results show that there are 44 lexicons divided into three categories, namely cultivation processes, agricultural tools, and agricultural materials. The lexical meaning in the lexicon refers to the basic meaning according to its referent, while the contextual meaning is influenced by the situation of use in agricultural activities. The contextual meanings found include process context, time context, and function context. This study shows that the corn farming lexicon not only functions as a communication tool, but also represents local knowledge, culture, and farming experiences of the Kalibareng Village community that have been passed down from generation to generation.

Pemurnian vitamin E dari berbagai sumber bahan alami dan limbah agroindustri terus berkembang seiring meningkatnya kebutuhan industri pangan, nutraseutikal, kosmetik, dan farmasi. Berbagai metode pemurnian telah diterapkan meliputi saponifikasi, ekstraksi menggunakan pelarut, dan distilasi molekuler. Studi ini mengkaji secara sistematis perkembangan metode pemurnian vitamin E dari berbagai sumber serta mengevaluasi keunggulan, keterbatasan, serta prospek penerapan teknologi yang lebih berkelanjutan. Penelusuran literatur dilakukan terhadap publikasi dalam 10 tahun terakhir yang diperoleh dari jurnal nasional dan internasional. Hasil kajian menunjukkan bahwa sumber alami vitamin E banyak terdapat pada minyak nabati, sedangkan sumber dari limbah agroindustri dengan kandungan vitamin E tertinggi diperoleh pada Palm Fatty Acid Distillate (PFAD). Kandungan vitamin E yang bervariasi tergantung dari jenis bahan baku, kondisi proses, dan metode pemurnian yang digunakan. Studi komparatif terkait potensi kandungan vitamin E pada bahan alam dan limbah agroindustri lokal Indonesia masih terbatas, khususnya yang mempertimbangkan variasi varietas genetik. Dari aspek teknik pemurnian, metode ekstraksi konvensional memerlukan beberapa tahapan proses sehingga perlu ditinjau dari sisi efisiensi operasional dan keekonomian. Hasil kajian menunjukkan penggunaan green solvent seperti ekstraksi dengan scCO2 dan DES yang berpotensi meningkatkan keamanan proses dan keberlanjutan lingkungan. Pengembangan metode pemurnian yang efisien, ekonomis, dan ramah lingkungan menjadi kunci dalam mendukung pemanfaatan berbagai sumber vitamin E secara berkelanjutan.

Rekonsiliasi obat adalah salah satu standar pelayanan farmasi klinik di rumah sakit yang mengumpulkan informasi obat sebelum masuk rumah sakit, kemudian diselaraskan dengan resep obat saat masuk rumah sakit. Rekonsiliasi obat dilakukan untuk mencegah kesalahan dalam pengobatan (medication error). Tujuan penelitian adalah mengidentifikasi faktor-faktor yang memengaruhi implementasi rekonsiliasi obat terhadap keberhasilan pengobatan di Indonesia. Penelitian ini menggunakan desain Systematic literature review mengacu pada PRISMA 2020 dengan metode pencarian PICO Framework. Artikel diperoleh melalui Google Scholar dengan kriteria penelitian di Indonesia, terbit tahun 2021–2025, tersedia full-text, dan terkait implementasi rekonsiliasi obat. Dari artikel yang teridentifikasi, 10 artikel memenuhi kriteria inklusi dan dianalisis secara deskriptif. Rekonsiliasi obat terbukti menurunkan medication discrepancy dan medication error. Faktor yang memengaruhi implementasi meliputi keterlibatan apoteker klinik, kepatuhan staf terhadap standar operasional, komunikasi antarprofesi, dokumentasi yang lengkap, dukungan sistem informasi rumah sakit, serta karakteristik pasien dan karakteristik obat. Temuan ini sejalan dengan rekomendasi WHO melalui Medication Without Harm dan standar The Joint Commission. Rekonsiliasi obat merupakan strategi efektif untuk meningkatkan keselamatan pasien dan keberhasilan pengobatan. Penguatan kompetensi apoteker, kolaborasi interprofesi, sistem informasi, dan keterlibatan pasien diperlukan untuk mengoptimalkan implementasinya di Indonesia.

Modern food supply chains, particularly those involving essential commodities like rice, often suffer from major challenges such as product fraud, inefficient record-keeping, and a lack of consumer trust. Traditional centralized systems are prone to data tampering, limited transparency, and poor traceability, making it difficult to verify the authenticity and origin of goods. To address these issues, our research introduces TraceRoot, a blockchain-based traceability framework designed to enhance transparency, accountability, and trust in agricultural supply chains.TraceRoot leverages the immutability and decentralization of blockchain technology to maintain a secure, distributed ledger that records every transaction and movement of goods across the supply chain. Each stakeholder including farmers, distributors, retailers, and consumers has role-based access to authenticated data through a user-friendly interface. The framework integrates smart contracts to automate transactions and digital signatures to verify the integrity of the data being uploaded, minimizing the risk of human error or manipulation

This study aims to formulate an engineering strategy for water quality management and pollution control in the Tiku Sub-watershed, North Musi Rawas Regency. The study used a descriptive approach by integrating selected technical data from a dissertation-based assessment with semi-structured interviews involving 20 key informants representing technical agencies, village and subdistrict governments, community leaders, artisanal and small-scale gold mining actors, farmers, and riverbank communities. The analysis focused on water quality status, water availability and demand, pollution sources, perceived impacts, implementation constraints, and priority interventions. The results showed that the Tiku Sub-watershed is under significant environmental pressure. The average pollution index was 6.65, indicating a moderately polluted status, while mercury, cadmium, phosphate, and ammonia were the dominant parameters of concern. Surface water availability remained relatively adequate at 45,842,699.79 m3/year, and the average Criticality Ratio was 0.266; however, the water pollution carrying capacity was poor. Interview results indicated that mercury use and processing waste from artisanal gold mining were the most urgent issue (35%), followed by land-cover change and riparian degradation. The recommended strategy combines mercury-free processing technology, alternative livelihood development, cross-sectoral supervision, riparian rehabilitation, and transparent water-quality monitoring. The findings imply that watershed engineering should integrate technical, institutional, and socio-economic interventions.

This community service program aims to enhance farmers’ literacy on independent fertilizer production and strengthen their understanding of farmers’ rights within national fertilizer governance as an effort to achieve food sovereignty. The program was implemented in Belang Village, Bungkal Sub-district, Ponorogo Regency, involving GAPOKTAN Baungan consisting of farmer groups from Tempel, Kepuh, Pakal, Kanigoro, and Klatakan hamlets. This initiative represents cross-university synergy involving lecturers from Universitas Merdeka Malang, Universitas Soerjo Ngawi, Universitas Muhammadiyah Ponorogo, and Akademi Kesejahteraan Sosial Ibu Kartini Semarang. The implementation adopted a participatory hybrid approach combining Zoom Meeting dissemination and offline field activities. Activities included literacy enhancement on independent fertilizer production, training on organic fertilizer processing, strengthening farmer group institutions, and legal literacy regarding farmers’ rights in accessing subsidized fertilizers, including RDKK mechanisms and national policies. Methods comprised participatory socialization, hands-on training, group discussions, field practice, and monitoring and evaluation. Results show improved understanding of independent fertilizer concepts, increased technical skills in organic fertilizer production, and greater awareness of farmers’ rights and obligations in the fertilizer distribution system. The program strengthened inter-university collaboration and farmer networks, supporting sustainability, farmer independence, reduced dependence on chemical fertilizers, and community-based food sovereignty.

Keselamatan dan Kesehatan Kerja (K3) pada sektor pertanian masih sering diabaikan, khususnya oleh Komunitas Adat Terpencil (KAT) Suku Anak Dalam (SAD) yang memiliki keterbatasan literasi dan akses informasi. Penelitian ini bertujuan untuk menganalisis pengaruh intervensi video edukasi Safety Farming terhadap peningkatan pengetahuan, sikap, dan praktik K3 pada petani Suku Anak Dalam di Desa Bukit Suban. Jenis penelitian ini adalah kuantitatif pre-experimental dengan desain One-Group Pretest-Posttest. Sampel penelitian berjumlah 45 responden petani laki-laki yang dipilih berdasarkan kriteria inklusi. Pengumpulan data menggunakan kuesioner wawancara terpimpin dan lembar observasi. Data dianalisis secara bivariat menggunakan uji non-parametrik Wilcoxon Signed-Rank Test (? = 0,05). Hasil penelitian menunjukkan adanya peningkatan yang sangat signifikan pada rata-rata skor pengetahuan responden dari 4,93 menjadi 8,82 (p=0,000). Rata-rata skor sikap mengalami peningkatan dari 37,78 menjadi 47,80 (p=0,000), serta rata-rata skor praktik meningkat tajam dari 5,02 menjadi 9,27 (p=0,000) pasca-intervensi.Video edukasi Safety Farming terbukti sangat efektif secara statistik sebagai media promosi kesehatan untuk meningkatkan pengetahuan kognitif, sikap kehati-hatian, dan praktik K3 secara nyata pada petani KAT Suku Anak Dalam yang memiliki tingkat literasi rendah.

This study contributes to the advancement of Islamic social finance discourse by developing a conceptual framework for a digitally integrated zakat governance model within the agricultural sector. The study addresses a critical gap between productive zakat practices and the emerging landscape of digital agricultural transformation. While previous research has largely focused on the redistributive function of zakat as a mechanism for poverty alleviation, limited scholarly attention has been directed toward its potential transformation into a technology-enabled and productivity-oriented instrument that supports sustainable development objectives. Employing a qualitative research approach through content analysis, this study synthesizes interdisciplinary perspectives from Islamic economics, zakat governance, agricultural technology innovation, and digital sustainability studies. The study proposes a Digital Farming Zakat Platform framework consisting of five interconnected dimensions: geospatial-based beneficiary identification, smart farming empowerment, sharia-compliant financial mechanisms, agricultural market integration, and data-driven monitoring systems.

Prasman (Peperomia pellucida) merupakan tanaman obat yang diketahui mengandung berbagai senyawa metabolit sekunder seperti alkaloid, flavonoid, saponin, tanin, dan terpenoid yang berpotensi memiliki aktivitas biologis. Penelitian ini bertujuan untuk mengetahui tingkat toksisitas ekstrak metanol batang prasman terhadap mortalitas larva udang (Artemia salina L.) menggunakan metode Brine Shrimp Lethality Test (BSLT). Penelitian dilakukan secara eksperimental dengan memberikan ekstrak metanol batang prasman pada berbagai konsentrasi, yaitu 10, 100, 500, 1000, 5000, dan 10000 ppm serta kontrol. Parameter yang diamati adalah persentase mortalitas larva setelah 24 jam perlakuan. Data dianalisis menggunakan metode interpolasi dan analisis probit untuk menentukan nilai LC₅₀. Hasil penelitian menunjukkan bahwa peningkatan konsentrasi ekstrak menyebabkan peningkatan mortalitas larva secara bertahap hingga mencapai 100% pada konsentrasi 10.000 ppm. Perhitungan LC₅₀ dengan metode interpolasi menghasilkan nilai 680,2 ppm pada pengujian pertama dan 529,66 ppm pada pengujian duplo. Analisis probit pada pengujian duplo menghasilkan nilai LC₅₀ sebesar 198,97 ppm. Nilai LC₅₀ yang berada di bawah 1000 ppm menunjukkan bahwa ekstrak metanol batang prasman bersifat toksik terhadap larva Artemia salina dengan kategori moderat atau racun sedang. Aktivitas toksik tersebut diduga berasal dari kandungan metabolit sekunder yang terdapat dalam batang prasman seperti Flavonoid, saponin, tanin dan minyak atsirinya. Dengan demikian, ekstrak metanol batang prasman berpotensi sebagai sumber senyawa bioaktif yang dapat dikembangkan lebih lanjut dalam bidang farmasi, khususnya sebagai kandidat antikanker, antimikroba, dan bioinsektisida alami.

Penelitian ini bertujuan untuk menentukan tingkat toksisitas ekstrak etanol daun trembesi (Samanea saman) terhadap larva Artemia salina menggunakan pendekatan Reed-Muench dan analisis probit. Latar belakang penelitian ini didasarkan pada pentingnya pengujian toksisitas sebagai tahap awal dalam mengevaluasi keamanan dan potensi bioaktivitas senyawa bahan alam. Metode yang digunakan adalah uji toksisitas BSLT dengan variasi konsentrasi ekstrak diikuti dengan pengamatan jumlah kematian larva, kemudian dihitung nilai LC₅₀ menggunakan dua pendekatan tersebut. Hasil penelitian menunjukkan adanya hubungan dosis-respons dimana peningkatan konsentrasi ekstrak menyebabkan peningkatan mortalitas larva. Nilai LC₅₀ yang diperoleh sebesar 332,86 ppm dengan metode Reed-Muench dan 384,7689 ppm dengan analisis probit. Berdasarkan nilai tersebut ekstrak etanol daun trembesi tergolong dalam kategori toksik sedang (moderat). Temuan ini menunjukkan bahwa ekstrak memiliki aktivitas biologis yang nyata dan berpotensi untuk dikembangkan lebih lanjut sebagai sumber senyawa bioaktif di bidang farmasi khususnya sebagai kandidat agen sitotoksik.

Penelitian ini bertujuan untuk mengkarakterisasi tingkat toksisitas ekstrak etanol 90% daun trembesi (Samanea saman) terhadap larva udang (Artemia salina) menggunakan metode Brine Shrimp Lethality Test (BSLT) dengan pendekatan Reed-Muench dan analisis probit. Penelitian ini merupakan penelitian eksperimental dengan rancangan post-test only control group design. Larva Artemia salina digunakan sebagai organisme uji karena memiliki sensitivitas tinggi terhadap senyawa toksik dan sering digunakan sebagai indikator awal aktivitas bioaktif. Ekstrak diuji pada berbagai konsentrasi bertingkat untuk mengamati persentase mortalitas larva setelah 24 jam perlakuan. Hasil penelitian menunjukkan bahwa peningkatan konsentrasi ekstrak berbanding lurus dengan peningkatan jumlah kematian larva, yang mengindikasikan adanya hubungan dosis-respons yang jelas. Nilai LC₅₀ yang diperoleh dengan metode Reed-Muench adalah sebesar 567,02 ppm, sedangkan dengan analisis probit diperoleh nilai LC₅₀ sebesar 581,0319 ppm. Perbedaan nilai ini disebabkan oleh perbedaan pendekatan analisis, di mana metode probit dinilai lebih akurat karena melibatkan transformasi statistik yang lebih kompleks. Berdasarkan klasifikasi toksisitas BSLT, nilai LC₅₀ sebesar 581,0319 ppm termasuk dalam kategori sangat toksik (LC₅₀ < 30 ppm). Tingginya tingkat toksisitas ekstrak diduga berkaitan dengan kandungan metabolit sekunder seperti flavonoid, saponin, dan tanin yang memiliki aktivitas sitotoksik. Hasil penelitian ini menunjukkan bahwa ekstrak etanol 90% daun trembesi memiliki potensi bioaktivitas yang tinggi dan berpeluang untuk dikembangkan lebih lanjut sebagai sumber senyawa bioaktif dalam bidang farmasi maupun bioteknologi.

Daun prasman (Euphatorium triplinerve Vahl) merupakan tanaman herbal yang diketahui mengandung berbagai senyawa metabolit sekunder yang berpotensi memberikan aktivitas biologis. Penelitian ini bertujuan untuk menentukan nilai LC₅₀ dan mengklasifikasikan tingkat toksisitas ekstrak metanol daun prasman menggunakan metode Brine Shrimp Lethality Test (BSLT) terhadap larva Artemia salina Leach. Ekstrak diperoleh melalui metode maserasi menggunakan pelarut metanol. Uji toksisitas dilakukan pada konsentrasi 10, 100, 500, 1.000, 5.000, dan 10.000 ppm dengan masing-masing perlakuan diamati selama 24 jam. Data kematian larva dihitung dalam bentuk persentase mortalitas dan dianalisis menggunakan metode probit untuk menentukan nilai LC₅₀. Hasil penelitian menunjukkan bahwa persentase kematian larva meningkat seiring dengan peningkatan konsentrasi ekstrak, yaitu 0% (10 ppm), 2,94% (100 ppm), 7,69% (500 ppm), 31,81% (1.000 ppm), 52,38% (5.000 ppm), dan 80,95% (10.000 ppm). Analisis probit menunjukkan bahwa nilai LC₅₀ ekstrak metanol daun prasman berada pada rentang 1.000–10.000 mg/L lebih tepatnya 2.103 ppm. Berdasarkan klasifikasi toksisitas, ekstrak metanol daun prasman termasuk dalam kategori sedikit beracun. Hasil penelitian ini menunjukkan bahwa ekstrak metanol daun prasman memiliki aktivitas toksik terhadap larva Artemia salina serta berpotensi menjadi sumber senyawa bioaktif yang dapat dikembangkan lebih lanjut melalui penelitian farmakologi dan toksikologi lanjutan.

Nyeri punggung bawah merupakan keluhan umum pada ibu hamil, terutama trimester III, akibat perubahan fisiologis, peningkatan beban janin, dan relaksasi ligamen panggul. Intervensi non-farmakologis, seperti herbal kompres ball, dianggap efektif dan aman untuk menurunkan nyeri. Tujuan: Mengetahui pengaruh herbal compres ball terhadap penurunan nyeri punggung bawah pada ibu hamil trimester III. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis Quasi Experimental Design, rancangan one group pretest-posttest. Sampel sebanyak 35 ibu hamil trimester III di Semarang Barat dipilih dengan purposive sampling. Data nyeri dikumpulkan menggunakan kuesioner skala nyeri sebelum dan sesudah intervensi. Analisis data menggunakan uji Wilcoxon Signed Rank Test untuk mengetahui perbedaan signifikan nyeri pretest dan posttest. Sebelum intervensi, mayoritas responden mengalami nyeri sedang sebanyak 29 orang (82,9%), sedangkan setelah intervensi, mayoritas mengalami nyeri ringan sebanyak 29 orang (82,9%) dan sebagian kecil tidak merasakan nyeri 2 orang (5,7%). Uji Wilcoxon menunjukkan Z = -5,014; p = 0,000, menandakan adanya penurunan nyeri yang signifikan setelah intervensi herbal compres ball. Herbal kompres ball efektif menurunkan nyeri punggung bawah pada ibu hamil trimester III. Intervensi ini dapat menjadi metode non-farmakologis yang aman, praktis, dan efektif.

The implementation of agricultural productivity improvement policies is an important effort to increase agricultural production and improve farmers' welfare. Policy implementation is influenced not only by program design and resource availability but also by the interests of actors involved in the implementation process. This study aims to analyze actor interests in the implementation of agricultural productivity improvement policies in Rantau Indah Village, Tanjung Jabung Timur Regency. This research employed a qualitative descriptive approach. Data were collected through interviews, observations, and documentation involving representatives of the Food Crops and Horticulture Office, Agricultural Extension Workers, village government officials, farmer group leaders, and community leaders. The findings indicate that each actor has different interests in policy implementation, reflecting their respective institutional roles, responsibilities, and expectations. These differences influence program planning, coordination, decision-making, and policy execution. Nevertheless, effective communication, collaboration, and coordination among stakeholders contribute positively to minimizing conflicts of interest and supporting policy implementation. The active involvement of farmer groups and agricultural extension workers also strengthens the dissemination of agricultural innovations and encourages community participation in improving productivity. The study concludes that actor interests constitute an important factor influencing the implementation of agricultural productivity improvement policies in Rantau Indah Village. Therefore, strengthening stakeholder collaboration, improving institutional coordination, and ensuring transparent communication are essential to achieving sustainable agricultural development and enhancing farmers' welfare.

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that may persist into adulthood and affect academic, social, and occupational functioning. In adult patients, ADHD is frequently associated with an increased risk of Substance Use Disorder (SUD), raising concerns regarding the potential for misuse and dependence related to stimulant medications used in ADHD therapy. This study aimed to evaluate the effectiveness of pharmacotherapy for adult ADHD and to review the risk of stimulant misuse and dependence based on current scientific evidence. The method employed in this study was a literature review using data obtained from national and international journals indexed in Scopus, PubMed, and Google Scholar published between 2017 and 2026. The findings indicated that stimulant medications, such as methylphenidate and amphetamine, were effective in reducing the core symptoms of ADHD by increasing dopamine and norepinephrine activity in the central nervous system. Most studies reported that the use of stimulant medications at therapeutic doses and under medical supervision was not significantly associated with an increased risk of substance misuse or dependence. The risk of misuse was more commonly observed in cases involving non-medical use and inadequate clinical monitoring. In addition to pharmacological therapy, non-pharmacological approaches such as cognitive behavioral therapy (CBT) also contributed to improving treatment outcomes and patients’ quality of life. Therefore, the use of stimulant medications in adult ADHD patients may be considered relatively safe and effective when administered rationally, individually, and under appropriate medical supervision.

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that may persist into adulthood and affect academic, social, and occupational functioning. In adult patients, ADHD is frequently associated with an increased risk of Substance Use Disorder (SUD), raising concerns regarding the potential for misuse and dependence related to stimulant medications used in ADHD therapy. This study aimed to evaluate the effectiveness of pharmacotherapy for adult ADHD and to review the risk of stimulant misuse and dependence based on current scientific evidence. The method employed in this study was a literature review using data obtained from national and international journals indexed in Scopus, PubMed, and Google Scholar published between 2017 and 2026. The findings indicated that stimulant medications, such as methylphenidate and amphetamine, were effective in reducing the core symptoms of ADHD by increasing dopamine and norepinephrine activity in the central nervous system. Most studies reported that the use of stimulant medications at therapeutic doses and under medical supervision was not significantly associated with an increased risk of substance misuse or dependence. The risk of misuse was more commonly observed in cases involving non-medical use and inadequate clinical monitoring. In addition to pharmacological therapy, non-pharmacological approaches such as cognitive behavioral therapy (CBT) also contributed to improving treatment outcomes and patients’ quality of life. Therefore, the use of stimulant medications in adult ADHD patients may be considered relatively safe and effective when administered rationally, individually, and under appropriate medical supervision.