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Therapeutic adherence is a fundamental cornerstone in managing Type 2 Diabetes Mellitus (DM) to maintain stable blood glucose levels and prevent chronic complications. Family support serves as a significant external determinant influencing the development of long-term patient adherence behaviors. This quantitative study, utilizing a correlational analytic design with a cross-sectional approach, aimed to analyze the relationship between family support and therapeutic adherence levels among Type 2 DM patients at Royal Prima Hospital, Jambi City. Through total sampling, 92 respondents were enrolled as the study sample. Data were collected via questionnaires and analyzed using the Chi-Square test. Univariate analysis revealed that the majority of respondents received moderate family support (46.7%) and demonstrated adherent behavior (62.0%). Bivariate analysis yielded a Pearson Chi-Square value of 17.186 with a p-value of 0,000 (α < 0,05), leading to the rejection of H0 and the acceptance of Ha. In conclusion, there is a statistically significant relationship between family support and therapeutic adherence levels among Type 2 DM patients at Royal Prima Hospital, Jambi City, indicating that more optimal family support is directly proportional to increased therapeutic adherence.

Diabetes mellitus (DM) is a degenerative disease commonly experienced by the elderly and requires proper treatment to prevent complications. One traditional treatment alternative used to lower blood sugar levels is bay leaf decoction. This study aimed to determine the effect of bay leaf decoction on reducing blood sugar levels among the elderly in Peuniti Village, Baiturrahman District, Banda Aceh City. The study employed a quasi-experimental design with a one-group pretest-posttest approach. The sample consisted of 15 elderly participants selected from a population of 87 elderly individuals. Data collection was conducted by measuring blood sugar levels before and after administering bay leaf decoction once daily for 7 days. Blood sugar levels were checked using a blood glucose meter 20 minutes after consumption. Data were analyzed using a dependent t-test. The results showed that before treatment, all respondents (100%) were categorized as having DM, with an average blood sugar level of 211.0 mg/dL. After treatment, all respondents (100%) were categorized as non-DM, with an average blood sugar level of 160.4 mg/dL. Statistical analysis showed a significance value of 0.004 (p < 0.05), indicating that bay leaf decoction significantly reduced blood sugar levels in the elderly.

According to the American Diabetes Association (ADA), diabetes mellitus is a chronic and complex disease that requires ongoing management and various strategies to control blood sugar levels and reduce associated risks. Patient Mrs. J, a 52-year-old woman and farmer, presented with complaints of numbness and tingling in both legs that began approximately 2 months prior to her current visit and had worsened over the past week. The symptoms felt like being pricked and sometimes felt hot, especially at night, thereby interfering with daily activities. The symptoms were accompanied by frequent urination, especially at night, frequent thirst, frequent hunger, a feeling of weakness, and intermittent blurred vision. The patient had been diagnosed with diabetes mellitus approximately 5 years ago but did not consistently take medication (glimepiride). The patient still frequently consumes sweet, coconut-based, and fried foods. Physical examination revealed reduced sensation in the lower extremities. Laboratory tests showed elevated blood sugar levels. Based on the medical history, physical examination, and supporting tests, the patient was diagnosed with Type 2 Diabetes Mellitus. The patient was advised to record test results and changes in his health status in a health record book, and to involve family members in supporting treatment adherence and a healthy lifestyle. The patient works as a farmer with an irregular income, depending on the harvest. Daily expenses are shared with his son, so his economic condition

Type 2 diabetes mellitus has now become a widespread health issue with serious implications for public health. In an effort to support non-pharmacological management, the use of aloe vera (Aloe vera) decoction is one option being considered, given that this plant contains bioactive components such as aloin, emodin, and polysaccharides that have the potential to help lower blood glucose levels. This study aims to examine the effect of consuming aloe vera (Aloe vera) decoction on lowering blood sugar levels in patients with type 2 diabetes mellitus in Lampaseh Lhok Village, Montasik Subdistrict, Aceh Besar. The research was conducted from June 19 to 28, 2025, in that area. The study design employed a quantitative research approach using a quasi-experimental design with a one-group pretest-posttest model. The study population consisted of 38 patients with type 2 diabetes mellitus, while the sample comprised 15 respondents. Sampling was conducted using purposive sampling. The measurement tools included a glucometer and an observation sheet. Based on the data analysis results, a decrease in blood glucose levels was observed after the respondents consumed the aloe vera decoction. The Wilcoxon signed-rank test yielded a p-value of 0.001 (< 0.05), leading to the conclusion that the administration of the aloe vera (Aloe vera) decoction has a significant effect on reducing blood glucose levels in the respondents. Therefore, respondents are advised to drink aloe vera tea at least once a day as an alternative measure to help control blood glucose levels.

Diabetes mellitus type 2 is a chronic metabolic disorder that frequently affects elderly patients and is often accompanied by multiple comorbidities. The increasing prevalence of diabetes in the aging population contributes to higher morbidity and mortality, especially when complicated by geriatric syndromes, electrolyte imbalances, and infections such as pneumonia. This study aims to present a case of type 2 diabetes mellitus in an elderly patient with associated geriatric problems, electrolyte disturbances, and pneumonia. The method used is a descriptive case report based on clinical findings, laboratory examinations, and radiological assessment. A 76-year-old male presented with generalized weakness, weight loss, decreased appetite, respiratory symptoms, and functional decline. Physical examination and laboratory findings revealed uncontrolled diabetes, electrolyte imbalance, hypoalbuminemia, and signs of infection. Chest radiography confirmed pneumonia. Management included pharmacological therapy such as antibiotics, fluid and electrolyte correction, and supportive care, along with non-pharmacological interventions including dietary regulation and monitoring. The findings highlight the complexity of managing elderly patients with multiple comorbid conditions, emphasizing the need for a comprehensive and multidisciplinary approach. Early detection and appropriate management are essential to improve clinical outcomes and prevent further complications in geriatric patients with diabetes mellitus.

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an obligate intracellular bacterium that affects the skin, peripheral nerves, upper respiratory mucosa, and eyes. Type 2 diabetes mellitus (T2DM) is a comorbidity that can worsen the course of leprosy. The female patient, Mrs. D, aged 55 years came to the emergency room of Cut Meutia Hospital with the main complaint of red bumps accompanied by pain on the face, hands, chest, and back since 3 days ago and additional complaints such as fever, joint pain, and numbness and loss of feeling in the legs, weakness, frequent thirst, and frequent urination. Dermatologic status is obtained in the facial region in the form of erythema nodules with firm boundaries with numular size, multiple. Laboratory examination showed anemia and leukocytosis. The therapy given was MDT MB package, ferrous sulfate 1x325 mg and PRC transfusion 3 kolf. Complaints arose acutely after the patient resumed taking MDT (multidrug therapy) leprosy drugs which had previously been stopped for more than 3 months. Based on the time of onset of symptoms, history of leprosy treatment, and the manifestation of systemic inflammatory lesions with signs of neurotropism, it can be suspected that the patient is experiencing a type 2 leprosy reaction or Erythema Nodosum Leprosum (ENL).

Type 2 diabetes mellitus is a chronic condition marked by elevated blood glucose levels resulting from insulin resistance and decreased insulin secretion. Effective glycemic control is crucial to prevent complications, and HbA1c is commonly utilized as an indicator of long-term blood glucose levels. This study aimed to examine the relationship between HbA1c levels and blood glucose levels among patients with type 2 diabetes mellitus at Tilamuta Community Health Center, Boalemo Regency, Gorontalo Province. This study employed an analytical cross-sectional design using a total sampling method, involving 557 patients. Data were collected from laboratory records and analyzed through descriptive statistics, the Shapiro-Wilk test for normality, Spearman correlation, and chi-square test. The findings indicated that the average HbA1c level was 7.39%, while the mean blood glucose level was 205.85 mg/dL. A significant and very strong positive correlation was found between HbA1c and blood glucose levels (p=0.000; r=0.862). Furthermore, medication adherence showed a significant association with HbA1c status (p=0.000). These results underscore the role of HbA1c as a dependable marker for assessing glycemic control and highlight the importance of medication adherence in optimizing the management of type 2 diaType 2 diabetes mellitus is a chronic condition marked by elevated blood glucose levels resulting from insulin resistance and decreased insulin secretion. Effective glycemic control is crucial to prevent complications, and HbA1c is commonly utilized as an indicator of long-term blood glucose levels. This study aimed to examine the relationship between HbA1c levels and blood glucose levels among patients with type 2 diabetes mellitus at Tilamuta Community Health Center, Boalemo Regency, Gorontalo Province. This study employed an analytical cross-sectional design using a total sampling method, involving 557 patients. Data were collected from laboratory records and analyzed through descriptive statistics, the Shapiro-Wilk test for normality, Spearman correlation, and chi-square test. The findings indicated that the average HbA1c level was 7.39%, while the mean blood glucose level was 205.85 mg/dL. A significant and very strong positive correlation was found between HbA1c and blood glucose levels (p=0.000; r=0.862). Furthermore, medication adherence showed a significant association with HbA1c status (p=0.000). These results underscore the role of HbA1c as a dependable marker for assessing glycemic control and highlight the importance of medication adherence in optimizing the management of type 2 diabetes mellitus.betes mellitus.  

The prevalence of non-communicable degenerative diseases in Indonesia continues to rise, particularly affecting adolescents and productive age populations due to unhealthy lifestyle patterns and free radical exposure. Purple sweet potato leaves (Ipomoea batatas L.), a locally abundant resource often regarded merely as agricultural by-product, contain significant bioactive compounds including polyphenols, flavonoids, anthocyanins, and terpenoids demonstrating potent antioxidant properties with IC50 values of 47.99 ppm. This study employs a qualitative descriptive literature review approach, analyzing 28 scientific publications spanning 2018-2025 sourced from Google Scholar and PubMed databases to examine the potential of purple sweet potato leaves as effervescent tablet raw material for degenerative disease prevention. Findings reveal that bioactive constituents effectively neutralize free radicals, prevent lipid peroxidation, and protect cellular structures from oxidative damage linked to diabetes, cancer, and cardiovascular disorders. The effervescent tablet formulation provides strategic advantages including enhanced solubility, accelerated absorption rates due to elimination of disintegration processes, pleasant carbonation sensation masking unpleasant active ingredient taste, and superior gastrointestinal tolerance. This innovation offers promising prospects for degenerative disease prevention through local food resource utilization, though experimental validation regarding optimal formulation, effective dosage determination, and clinical efficacy assessment remains necessary for practical implementation.

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Globally, DM continues to pose a growing health challenge, particularly type 2 DM, which is closely associated with insulin resistance. In this condition, body cells fail to respond effectively to insulin, so even though the pancreas initially produces sufficient or excessive amounts of insulin, its effectiveness gradually declines. Over time, pancreatic beta-cell function deteriorates, further exacerbating chronic hyperglycemia. This persistent condition may lead to long-term complications, including nephropathy, retinopathy, neuropathy, and cardiovascular diseases, through mechanisms such as oxidative stress, inflammation, and the formation of advanced glycation end products (AGEs). The prevalence of type 2 DM is expected to continue rising, including in Indonesia, highlighting the need for comprehensive management strategies. An important aspect of DM management is the assessment of health-related quality of life. Quality of life reflects an individual’s perception of their health status within social and cultural contexts. This can be evaluated using generic instruments such as the WHOQOL-BREF questionnaire. In this case report, the quality of life of a patient with type 2 DM was assessed using the WHOQOL-BREF to provide a comprehensive understanding of the disease’s impact on the patient’s daily life.

Diabetic ketoacidosis (DKA) is a life-threatening acute metabolic complication of diabetes mellitus characterized by hyperglycemia, metabolic acidosis, and ketosis due to absolute or relative insulin deficiency. DKA may present as the initial manifestation of previously undiagnosed diabetes, particularly in young adults. We report a case of a 27-year-old male who presented with decreased consciousness preceded by shortness of breath. The patient had a three-month history of polyuria, polydipsia, polyphagia, and significant weight loss. Physical examination revealed a Glasgow Coma Scale score of 9 and signs of dehydration. Laboratory findings showed severe hyperglycemia (426 mg/dL), elevated HbA1c (8.5%), leukocytosis, and severe metabolic acidosis (pH 6.8; HCO₃⁻ 5.8 mmol/L). The diagnosis of DKA was established based on clinical and laboratory criteria. Management included aggressive fluid resuscitation, continuous intravenous insulin infusion, electrolyte correction, and antibiotic therapy for suspected infection. The patient showed gradual clinical improvement. This case highlights the importance of early recognition, identification of precipitating factors, and prompt management to reduce morbidity and mortality associated with DKA.

The use of medicinal plants has been an important part of people's lives since the time of our ancestors. Before the advent of modern medicine, people used various types of plants to treat mild to severe illnesses, such as fever, cough, wounds, digestive disorders, and skin diseases. Inventory of medicinal plants plays a very important role in exploring the potential of existing natural resources, especially as an effort to support the development of traditional medicine. The purpose of this study is to identify the types of medicinal plants used by local communities in traditional medicine. The method used in this study is a descriptive method through direct surveys at the research location. The findings obtained in the field concluded that all types of plants mentioned in this study are very beneficial for the people of Duhiadaa District, because they can help in treating various types of diseases experienced by the community. The types of diseases that can be treated include hypertension, gout, stomach acid, cholesterol, kidney disease, diabetes, inflammation, cancer, wounds, diarrhea and digestive disorders.

Background: Diabetes Mellitus (DM) is a disease that cannot be completely cured or cannot even be completely cured. The vile shard plant is empirically used by the community to treat diabetes (DM). This study aims to conduct phytochemical screening and test the activity of 96% ethanol extract of kejibeling leaves (Strobilanthes crispus (L.) Bl.) as a herbal antidiabetic in male white mice (Mus musculus) with alloxan induction. Method: This research is an experimental laboratory research with a true experimental posttest control design using a completely randomized design (CRD) with 5 treatments and 5 replications. Treatment P1 (without treatment) as normal control (N), P2 as positive control (+), P3 as negative control (-), P4 kejibeling leaf extract 250 mg/kg BW, P5 kejibeling leaf extract 500 mg/kg BW. Result:The results of phytochemical screening showed the presence of alkaloids, flavonoids, tannins, saponins, terpenoids and steroids. SPSS results show that the data is normally distributed (p>0.05) and homogeneous (p>0.05). The results of the ANOVA on the treatment of giving keji beling leaf extract 250 mg/Kg BW showed a sig. 0.393 (p>0.05) and treatment of 500 mg/Kg BW obtained a sig value. 0.517 (p>0.05). Conclusion:The conclusion from the research results shows that administering doses of 250 mg/kg BW and 500 mg/kg BW of keji beling leaf extract can reduce blood sugar levels in mice. It is hoped that the results of this research will be useful for the community as an antidiabetic therapy using kejibeling leaves (Strobilanthes crispus (L.) Bl.).

Food Additives (BTP) in current consumer products increase the risk of non-communicable diseases such as diabetes, kidney failure, and cancer, particularly in children. Housewives play a central role in managing family consumption to minimize these risks. This community service activity aims to enhance the knowledge and awareness of 'Aisyiyah women in Buluspesantren, Kebumen Regency, regarding food safety and BTP regulations. The implementation method included preparing materials based on BPOM regulations, interactive education, product discussions, and simulations on reading nutrition labels. The results showed high enthusiasm from participants who are now more critical in distinguishing between natural and synthetic additives. Participants reported a significant improvement in their ability to identify food ingredients and additives in everyday products. The final evaluation recorded a 22.2-point increase in participant understanding. By establishing the habit of reading food labels, it is expected that the risk of non-communicable diseases within the family environment can be reduced, thus improving public health literacy and dietary choices within the community.

Type 2 Diabetes Mellitus is a chronic disease with an increasing prevalence and requires long-term therapy, resulting in a significant economic burden on healthcare systems. This study aimed to analyze the cost-effectiveness of antidiabetic drug use among Type 2 Diabetes Mellitus patients in the inpatient unit of Dr. R. Hardjanto Hospital, Balikpapan. This research employed an observational analytic design with a cross-sectional approach and retrospective data collection from medical records and administrative data for the period January–December 2023. A total of 54 patients who met the inclusion criteria were included as study samples. Therapeutic effectiveness was assessed based on the achievement of random blood glucose levels ≤200 mg/dL, while the analysis focused on direct medical costs. Cost-effectiveness was evaluated using the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). The results showed that Metformin–Apidra therapy achieved higher clinical effectiveness (92%) with an average cost of IDR 3,636,721 and an ACER value of IDR 39,529. Meanwhile, Glimepiride–Sansulin therapy demonstrated 81% effectiveness with a lower average cost of IDR 2,519,259 and an ACER value of IDR 31,101. The ICER value of IDR 10,158 indicates the additional cost required to achieve a 1% increase in effectiveness. In conclusion, Metformin–Apidra therapy is more clinically effective, whereas Glimepiride–Sansulin therapy is more cost-effective economically.

Knee osteoarthritis is a degenerative joint disease that commonly affects older adults and causes pain and functional limitations. Age, obesity, a sedentary lifestyle, and comorbidities influence disease severity and response to medical rehabilitation. This study aimed to describe the characteristics of geriatric patients with knee osteoarthritis receiving medical rehabilitation therapy at Ibnu Sina Hospital, Makassar, in 2024. This was a quantitative descriptive study with a cross-sectional design. The results showed that most geriatric patients with knee osteoarthritis undergoing medical rehabilitation at Ibnu Sina Hospital in 2024 were in the 60–70 year age group and were predominantly female. The majority of patients had a body mass index in the overweight to obese category. Most patients had no history of smoking but had one or more comorbidities, particularly hypertension and diabetes mellitus. Medical rehabilitation therapy was generally provided as a combination of several modalities. In conclusion, geriatric patients with knee osteoarthritis receiving medical rehabilitation were predominantly aged 60–70 years, female, overweight or obese, and had comorbidities. These findings highlight the importance of individualized and multidisciplinary rehabilitation approaches based on patient characteristics

Generalized pustular psoriasis (GPP) is a severe inflammatory form of psoriasis characterized by widespread sterile pustular eruptions. Pro-inflammatory mediators released during chronic inflammation may contribute to comorbidities, including type 2 diabetes mellitus (T2DM). A 65-year-old woman presented with pustular eruptions over almost the entire body for seven days, accompanied by burning sensation and pruritus. Some pustules coalesced forming “lakes of pus,” while others appeared as erythematous plaques with coarse white scales. The patient had a history of T2DM. Based on clinical findings, the patient was diagnosed with GPP. She was hospitalized for seven days and followed up weekly until week 10. Inflammatory mediators such as Th-1, TNF-α, IL-6, IL-7, IL-8, IL-17, and IL-23 in psoriasis may inhibit insulin receptor signaling and glucose uptake, leading to insulin resistance and increased blood glucose levels. The duration of treatment until remission in psoriasis patients with T2DM tends to be longer than in non-diabetic patients. In patients with comorbidities, low-dose methotrexate (5–7.5 mg/week) was administered. The coexistence of GPP and T2DM may lead to more severe exacerbations, prolonged treatment duration, and reduced quality of life, posing challenges in management.

Stroke is one of the non-communicable diseases that is the leading cause of disability and death in the world. Clinical factors such as hypertension, diabetes mellitus, body mass index (BMI), and unhealthy lifestyle are known to contribute to the incidence of stroke. Oe-Cusse Referral Hospital serves as the main referral center in the treatment of stroke cases, but data on contributing clinical factors and medical treatment and rehabilitation strategies are still limited. This study aims to analyze the clinical factors that contribute to the incidence of stroke and describe medical treatment and rehabilitation strategies in stroke patients at Oe-Cusse Referral Hospital.This study is a quantitative study with a cross-sectional observational design. The research sample amounted to 50 stroke patients who were treated in the January-November 2025 period, selected using purposive sampling techniques. Data were collected through medical records and questionnaires related to medical treatment and rehabilitation. Data analysis was carried out using the SPSS program, including descriptive analysis and logistic regression to see the relationship between clinical factors (hypertension, diabetes mellitus, lifestyle, BMI, and other factors) and stroke incidence. The results of the descriptive analysis showed that the average age of stroke patients was 56.2 ± 9.8 years, with an age range of 39–78 years. The average BMI of the patient was 27.5 ± 3.1 kg/m² which indicates a tendency to be overweight. The average systolic blood pressure of the patient was 150 ± 18 mmHg, indicating the predominance of hypertension in stroke patients. The average length of rehabilitation lasted 6.3 ± 1.8 weeks. Logistic regression analysis showed a significant relationship between clinical factors, especially hypertension, BMI, and diabetes mellitus, and stroke incidence. Clinical factors such as hypertension, high BMI, and diabetes mellitus contribute significantly to the incidence of stroke at Oe-Cusse Referral Hospital.

Type 2 diabetes mellitus (T2DM) requires comprehensive management beyond pharmacological therapy, including sustainable lifestyle-based interventions. Yoga asana, as a form of mind–body intervention, integrates physical postures, breathing techniques, and relaxation practices that may influence metabolic and psychosocial pathways relevant to T2DM. This article aimed to synthesize evidence regarding the physiological mechanisms, clinical effectiveness, and healthcare implementation context of yoga asana in T2DM management, as well as to discuss the role of physicians in integrating this complementary therapy, including within health tourism settings. A narrative literature review was conducted using scientific databases, focusing on publications addressing yoga asana, mind–body interventions, T2DM, and clinical integration. The findings indicate that yoga asana is associated with improved glycemic control, including reductions in fasting blood glucose, postprandial glucose, and HbA1c, alongside modulation of stress-related physiological parameters and psychological well-being. Beyond clinical outcomes, yoga asana shows potential for community-based and health tourism contexts as part of chronic disease lifestyle management. Physicians play a central role in clinical assessment, patient education, coordination with complementary therapy providers, and ongoing monitoring to ensure safe, evidence-based integration. Although current evidence suggests consistent beneficial trends, methodological heterogeneity highlights the need for more standardized and mechanistic research.  

Objective: Autoimmune diseases are complex disorders that arise when the immune system loses tolerance to self-antigens, leading to chronic inflammation and tissue damage. To understand disease pathogenesis and to evaluate therapeutic efficacy, animal models are widely used in autoimmune research. This review aims to analyze various types of animal models employed in studies of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), and multiple sclerosis (MS), with a particular focus on reproducibility and clinical applicability. Methods: This study was conducted through the selection and analysis of scientific literature published over the last ten years (2015–2025), using specific keywords including “clinical application,” “autoimmunity,” “animal models,” “humanized mice,” “lupus,” “rheumatoid arthritis,” “reproducibility,” and “translational research.” Literature searches were performed in major databases such as Google Scholar, PubMed, ScienceDirect, and Scopus. Results: Spontaneous models, such as NOD and MRL/lpr mice, exhibit close resemblance to human disease pathogenesis but are influenced by strain variability and environmental factors. Induced models, including collagen-induced arthritis (CIA) and experimental autoimmune encephalomyelitis (EAE), allow greater control over disease onset but do not fully capture the clinical complexity observed in humans. Humanized models demonstrate high translational relevance; however, their use is constrained by high costs and technical limitations. Conclusion: No single animal model is universally ideal for studying autoimmune diseases. Model selection should be based on biological relevance, reproducibility of outcomes, and the potential for clinical translation in autoimmune disease research.

Blood sugar regulation problems such as diabetes are increasing, so sustainable management is needed. Kersen leaves (Muntingia calabura L.) are tropical plants that have potential as traditional blood sugar management through the content of phytochemical compounds contained therein. This article aims to review the potential of kersen leaves in blood sugar management and its implications in the wellness tourism approach. The method used is a literature review of scientific literature, especially the last five years related to the phytochemical content and antihyperglycemic activity of kersen leaves, as well as their implications in wellness tourism. The results of the literature review through in vivo and in vivo approaches show that kersen leaves contain potential phytochemical compounds such as flavonoids, phenols, tannins, alkaloids, and saponins that are able to regulate blood sugar by preventing the oxidation process of important molecules by free radicals, suppressing oxidative stress, inhibiting carbohydrate enzymes, increasing insulin production, and suppressing the glycogenolysis process. In the context of wellness tourism, kersen leaves as a herbal plant can be used as a healthy drink and have the potential to be studied further in the development of wellness tourism, especially related to herbal medicine.