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Diabetes Mellitus is a group of chronic metabolic disorders due to abnormal metabolism of carbohydrates, fats, and proteins, characterized by hyperglycemia which is results in long-term microvascular, macrovascular and neuropathic complications. Oral antidiabetic therapy is the main pharmacological therapy to treat type II diabetes mellitus. This therapy can be oral antidiabetic therapy. Thus, to find out the effectiveness of either combination or single of antidiabetics on diabetes mellitus patients, researchers conducted a studies of inpatients at RSUD Madiun. This study included as non-experimental observational study with a cross-sectional study design at RSUD Madiun. Data were collected from Medical Records in October 2018. The sampling method that used in this study was non probability with purposive sampling technique, so there are 58 patients as a total sample. The results showed that the effectiveness of controlling blood sugar levels when using an effective single ADO was Metformin, because Metfomin was able to reduce blood sugar levels with an average length of stay of 6.17 and the effectiveness of controlling blood sugar levels when using an effective combination of ADO was Metformin and acarbosa, because Metfomin and acarbosa are able to reduce blood sugar  average length of stay 7 days inpatient.

The textile and textile products (TPT) industry in Indonesia still has a lot of problems, one of which is the problem of raw materials which are considered to be unable to compete with the same material from importation sources. This requires the company continue to strive to increase productivity and cost efficiency to mitigate the increase in prices of raw materials charged to consumers. One effort that can be done by the company is to improve the efficiency of the cost of raw material inventory. The company must be able to plan and control the company's raw material inventory to support the effectiveness of its raw material costs. By having good planning and control, the company will avoid the problem of excess and lack of raw material inventory in carrying out production activities. This study aims to determine the application of the Justintime system at PT Bintang Baru Sentosa in increasing the efficiency of the company's raw material inventory costs. The type of research is quantitative qualitative research with a case study approach. Data sources obtained from primary data and secondary data. The methods used in this study include: interviews, observation, and documentation studies.The results of the study show that using Justintime in controlling raw material inventories has cost efficiencies of Rp18.418.185,- for 75/72 F DTY and 150/48 F DTY with a cost efficiency level of 75%.  Keyword:Raw Materials, Inventories, Just.intime (JIT), Cost Efficiency

Fever itself is a condition in which the body temperature is experiencing an increase in heat above the normal temperature. Fever can be treated pharmacologically and non-pharmacologically in various ways, one of which is by using water tepid sponge therapy. This study aims to determine the effectiveness of giving water tepid sponge to pre-school age children who have fever at the Bhakti Wira Tamtama Army Hospital Semarang. The design of this study used Quasy experimental pre-post test equivalent control group. The number of samples is 20 respondents with the total sampling method. The results showed that there was an effect of water tepid sponge on decreasing body temperature in children aged 36-60 months who had fever with p value 0.000, an average decrease of 1.50C. The recommendation of this study is that the provision of a water tepid sponge can be used as an independent nursing intervention in reducing the body temperature of preschool-aged children who have fever.

This study departs from field observations which state that the low student learning outcomes in 2013 that is with a percentage of 52.38% getting grades below the KKM, it needs the existence of more efficient teaching materials, to support student learning processes independently. This study aims to determine the validity, effectiveness and practicality of the Islamic integrated learning module in the High Plant Botany course for liliopsida class angiosperms material. This research uses the Research & Development method that was developed using the ADDIE model with stages: Analyze namely needs analysis, Design is the design / draft module, Development is product development / prototype based on design validation, design revision, small scale trial, revision I module, Implementation is the application of modules in large-scale trials of the control class / without modules, and the experimental class / using modules, Evaluation, namely revision II modules, final modules. The results of this study indicate that the module developed is feasible to be used in learning botanical lectures of tall plants obtained from the validity value of material experts 83.60% very good / valid, 80% good / valid design experts, 82% good / valid religious experts. The practicality of the use of modules obtained from observations of the implementation of learning by 91.41% was very successful and the student response questionnaire showed 99.15% of the practical modules used. The effectiveness of the application of the module is obtained from the increase in student learning outcomes with N-Gain of 0.77 in the high category compared to the control class of the value of N-Gain of 0.20 in the low category. Thus, the learning modules developed are valid, practical, and effective for use in learning.keyword: Modules, Integrated Islamic, Angiosperms, Liliopsida

This study aims to produce an Islamic learning module integrated with reproductive system material that has valid, practical and effective criteria so that the module can be used in learning and can improve student learning outcomes. This research uses the Research & Development method and is developed using the ADDIE model with Analyze stages, namely requirements analysis, Design which is the design / draft module, Development which is product development based on material validation, design validation, Islamic validation, small-scale trials, module revisions, Implementation ie the application of modules in large-scale trials of experimental classes (learning using modules), Evaluate is the final module. The results of this study indicate that the modules developed are suitable for use in learning science reproductive system material obtained from the validity value of the material experts obtained from the value of 86.03% with valid criteria, design experts 82.44% valid, Islamic experts 85.52% valid. The practicality of using modules was obtained from observations of learning accomplishments of 98.65% with very successful criteria and the questionnaire responses of students showed a value with a percentage of 91.47% with the practical module category used. The effectiveness of the use of modules is obtained from an increase in student learning outcomes with N-Gain of 0.82 in the high category compared to the control class of an N-Gain value of 0.29 with a low category. Thus, the learning modules developed are valid, practical, and effective for use in learning.Keywords: Development; Module; Islamic integration

Diabetes melitus menjadi masalah kesehatan di dunia karena terjadi peningkatan setiap tahun. Oleh karena itu dibutuhkan obat atau agensi terapi yang efektif dan murah untuk menanggulangi diabetes melitus. Ekstrak kulit terong Belanda mempunyai kandungan antosianin dan betakaroten yang memiliki kemampuan menurunkan kadar gula darah, sehingga dapat dijadikan sebagai obat tradisional yang efektif dan murah. Tujuan penelitian ini adalah untuk menganalisis pengaruh pemberian ekstrak kulit terong Belanda terhadap penurunan kadar gula darah tikus wistar jantan yang diinduksi aloksan. Metode penelitian ini menggunakan rancangan penelitian pre and post test randomized controlled group design. Penelitian ini menggunakan tikus wistar jantan sebanyak 25 ekor  yang dibagi menjadi 5 kelompok perlakuan yaitu perlakuan dengan aquadest (kontrol negatif), ekstrak kulit terong Belanda (Solanum betaceum) dosis 0,25 ; 0,75 ; 1,25 g/kg BB dan metformin sebagai obat diabetes dengan dosis 18 mg/tikus (kontrol positif). Semua kelompok diinduksi aloksan sampai dengan kadar gula darahnya mencapai ≥ 200 mg/dL lalu diukur kadar gula darah sebagai data pre test. Perlakuan diberikan selama 14 hari dan pada hari ke – 14 diukur kadar gula darah sebagai post test. Ekstrak kulit terong Belanda dosis 0,25; 0,75 dan 1,25 g/kg BB mampu menurunkan kadar gula darah secara signifikan selama 14 hari akan tetapi belum ada dosis yang memiliki efektifitas yang sebanding dengan metformin dalam penurunan kadar gula darah apabila diberikan selama 14 hari.Kata kunci: Ekstrak kulit terong Belanda, diabetes, tikus, aloksanABSTRACT Diabetes melitus is a health problem in the world because the sufferers increase from year to year. So that it is needed an effective and economical drug or therapeutic agency to cope with the disease. Tamarillo peel extract contains anthocyanin and beta-carotene which are capable to reducing blood sugar levels, so that it can be used as an effective and economical traditional medicine. The aim of the study was to analyze the effect of the administration of Tamarillo peel extract on decreasing blood sugar levels in male wistar rats induced by alloxan. The research method used a pre and post test randomized controlled group design. This study used 25 male wistar rats divided into 5 treatment groups namely aquadest treatment (negative control), metformin as a diabetes drug with a dose of 18 mg / rat (positive control), and Tamarillo skin extract (Solanum betaceum) dose 0, 25; 0.75; 1.25 g / kg BB. All treatment groups were induced by alloxan until their blood glucose levels reached ≥ 200 mg / dL then measured blood sugar levels as the pre test data. The treatment was given for 14 days and on the 14th day blood sugar levels were measured as a post test. Tamarillo peel extract dose of 0.25; 0.75 and 1.25 g / kg BB can significantly reduce blood glucose levels for 14 days but there is no dose that has an effectiveness comparable to metformin in reducing blood glucose levels if given for 14 days.Keywords: Tamarillo peel extract, diabetes, rats, alloxan