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Takokak fruit is one of the plants that can be used to lower blood sugar levels. This study aims to identify the bioactive compounds of ethanol extract of takokak fruit and test the antidiabetic ethyl acetate fraction. Antidiabetic testing was carried out by in vivo testing using the Oral Glucose Tolerance Test (OGTT) method to see the decrease in blood glucose levels using white rats as test animals. The test results showed that takokak fruit contains flavonoids, steroids, and tannins. Fractionation is the process of extracting compounds from the extract using two types of solvents that do not mix with each other. The results of the antidiabetic test showed that the ethyl acetate fraction with glibenclamide as a comparator had the ability as an antidiabetic measured by the amount of difference in the decrease in blood glucose levels in the test animal group T₃₀ to T₁₂₀. From the results obtained, the average decrease in blood glucose levels in the negative control group (Na CMC) was 5.8 mg/dL, the positive control group (Glibenclamide) 21.03 mg/dL, and the fraction group 9.86 mg/dL. Takokak fruit has antidiabetic activity. Compounds that have antidiabetic activity are flavonoids, tannins, and steroids.

Takokak fruit contains bioactive compounds that can be used as antidiabetics. This study aims to identify bioactive compounds of ethanol extract of takokak fruit and antidiabetic test of n-Hexane fraction. The method used to obtain the extract is maceration using ethanol . Antidiabetic testing is carried out through in vivo testing with the Oral Glucose Tolerance Test (OGTT) method on white rats. Secondary metabolites are compounds contained in taakokak fruit that are identified as flavonoids, saponins, tannins, steroids and terpenoids . The results of the antidiabetic test showed that the n-Hexane fraction with glibencamide as a comparator has the ability as an antidiabetic in terms of the amount of difference in blood glucose levels in the test animal group from T 30 to T 120 . The average decrease in blood glucose levels in the negative control group (Na-CMC) was 108.67 mg/dL, the positive control group ( glibencamide ) 174.67 mg/dL, the 5% concentration fraction group 35.33 mg/dL, the 10% concentration fraction group 30.67 mg/dL, the 20% concentration fraction group 47.67 mg/dL.

The Garuga floribunda (Garuga floribunda Decne) plant is one of the species known for its various medicinal properties. This research aims to investigate the inhibitory activity of α- glucosidase and α-amylase enzymes and to determine the optimum concentration of the methanol extract of Garuga floribunda leaves as an antidiabetic agent. The leaves extraction is obtained through an extraction process using methanol as the solvent and tested for itsinhibitory activity against the α-glucosidase enzyme using the p-nitrophenyl-α-D- glucopyranoside (p-NPG) substrate and the α-amylase enzyme using the DNS (3,5- dinitrosalicylic acid) substrate. The method is UV-Vis spectrophotometry. The Phytochemical tests of this plant reveal the presence of flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. The inhibition test results show that the methanol extract of Garuga floribundaleaves exhibited significant inhibitory activity against both enzymes. The highest inhibition percentage against the α-glucosidase enzyme is 91.09%, indicating very high antidiabetic activity. Meanwhile, the inhibition against the α-amylase enzyme is 7.56%, showing no significant antidiabetic activity. The optimum concentration for inhibiting both enzymes is 1000 ppm.

Health is a condition where the body system and organs in the body can carry out their respective functions. However, in some cases that occur in Indonesian society, health problems have begun to appear, such as diabetes, malaria, and so on. According to the analysis, the incidence of diabetes continues to increase every year. Furthermore, the plant extract that is used as a source of antioxidants is bamboo shoots. The incidence of malaria resistance has reached >25% so that several drugs such as chloroquine are no longer used as the main drug in cases of malaria. The purpose of writing is to analyze the results of a review of the pharmacological potential of plant extracts that are effective as antidiabetic, antioxidant, and antimalarial supplements. The writing method used in writing this journal is to use a qualitative type. The results of the study are that bamboo leaf extract provides effectiveness as an antioxidant. Furthermore, antidiabetic can be found in the extract of the butterfly pea flower. Then the extract of the moon flower leaf has effectiveness as an antimalarial. The conclusion drawn is that the use of natural plant extracts can be used as antidiabetic, antioxidant, and antimalariall.

Diabetes mellitus (DM) is a global public health threat, and around 90% of all patients suffering from DM throughout the world are type 2 DM. Non-compliance related to Diabetes Mellitus is something that is a problem that should be avoided. This study aims to determine the level of patient compliance with the use of antidiabetic drugs at the Cidemp Indramayu Community Health Center, and to determine the relationship between the level of compliance of Diabetes Mellitus patients with blood glucose levels (fasting and while) at the Cidemp Indramayu Community Health Center. This research is a type of analytical observational research with a research design. cross-sectional. Data analysis in this study used SPSS version 23 software. The results showed that the majority of respondents fell into the "compliant" category, 20 respondents (62.5%) compared to "non-compliant" 12 respondents (37.5%). In addition, when checking blood glucose levels it was found that 62.5% of "compliant" patients had controlled fasting blood glucose levels, while only 28.1% of "compliant" patients had uncontrolled fasting blood glucose levels. Regarding the relationship between the level of absolute compliance with fasting blood glucose levels (P= 0.005), the results of compliance with glucose levels when controlled were (0.003). Keywords: diabetes mellitus, patient compliance, blood glucose levels.    

Longevity spinach leaf (Gynura procumbens (Lour) Merr.) is a traditional plant that contains various secondary metabolite compounds such as alkaloids, flavonoids, tannins and saponins, where flavonoids have various properties, including in the treatment of degenerative diseases such as diabetes mellitus. The purpose, of the research was to determine the effectiveness of the ethanol extract of Longevity spinach (Gynura procumbens (Lour) Merr.) leaf on reducing blood sugar levels in male white rats (rattus norvegicus) induced by alloxan. In this study, 5 test groups were used, namely negative control group, positive control group (metformin 9 mg), first dose 7.2 mg, second dose 14.4 mg, and third dose 21.6 mg. The rats were acclimatized and fasted before being given treatment, then their blood sugar was checked, before and after being induced by alloxan, then they were given treatment for 5 consecutive days and their blood sugar levels were checked once a day. The results of research from testing the ethanol extract of Longevity spinach leaf on male white rats proved effective in reducing blood sugar levels with the best dose, namely the 3rd dose (21.6 mg) on ​​the 6th day. 

Medicinal plants are plants that are used by the community to improve the ability to live a healthy life. This public belief that has been carried out from generation to generation has been scientifically proven. Rural communities generally plant various types of plants, both seasonal and perennials, in their yards, which are commonly referred to as living barns, living stalls and living pharmacies. This research was conducted in one of the house yards in Pataruman village, Cihampelas sub-district, Bandung Regency. By identifying medicinal plants based on their morphology and literature studies. The results of this research obtained 6 plant species, namely Katuk, Betel, Bandotan, Honje, Ki Edi, and Aloe Vera. The substances contained in these plants are very beneficial for health, such as flavonoids, alkaloids, tannins, vitamins A, B, C and others. These benefits include antidiabetic, anti-inflammatory, analgesic, antioxidant, and can increase breast milk production.   

Chinese Betel Plant (Paperomia pellucida) is an herbal plant that has benefits for treating diseases such as acne, ulcers, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antibacterial. The content of bioactive compounds from Chinese betel include alkaloids, flavonoids, steroids, saponins, tannins, triterpenoids, and carbohydrates. The aim The purpose of this study was to determine the effect of steeping Chinese betel and  on reducing blood glucose levels in male mice. This method used is an experimental method at the Pharmacology Laboratory D3 Pharmacy FMIPA Bengkulu University. The test animals used were three groups, namely the positive control treatment group that received glibenclamide, the negative control treatment group received aquadest, and the 2% Chinese betel steeping treatment group. The results showed that Chinese betel curd was reduced from 125 mg/dl to 93 mg/dl and there was no hypoglycemic decrease in blood glucose due to glibenclamide. From the results of the study it can be concluded that the administration of Chinese betel and glibenclamide steeping is effective in lowering blood glucose levels in male mice.