Publication Search

Diabetes Mellitus is a group of chronic metabolic disorders due to abnormal metabolism of carbohydrates, fats, and proteins, characterized by hyperglycemia which is results in long-term microvascular, macrovascular and neuropathic complications. Oral antidiabetic therapy is the main pharmacological therapy to treat type II diabetes mellitus. This therapy can be oral antidiabetic therapy. Thus, to find out the effectiveness of either combination or single of antidiabetics on diabetes mellitus patients, researchers conducted a studies of inpatients at RSUD Madiun. This study included as non-experimental observational study with a cross-sectional study design at RSUD Madiun. Data were collected from Medical Records in October 2018. The sampling method that used in this study was non probability with purposive sampling technique, so there are 58 patients as a total sample. The results showed that the effectiveness of controlling blood sugar levels when using an effective single ADO was Metformin, because Metfomin was able to reduce blood sugar levels with an average length of stay of 6.17 and the effectiveness of controlling blood sugar levels when using an effective combination of ADO was Metformin and acarbosa, because Metfomin and acarbosa are able to reduce blood sugar  average length of stay 7 days inpatient.

Nutmeg is known as a spice plant that has economic value and multipurpose because every part of the plant can be used in various industries. Compounds contained in nutmeg seeds include essential oils, a-pinene, b-pinene, limonene, myristicin, safrole, and methyl eugenol. Nutmeg plant nutritious as antidiarrheal, antidiabetic, antimicrobial. The purpose of this study was to make a formulation of rubbing oil and to determine the bacteriostatic activity of nutmeg seed oil on staphylococcus aureus bacteria. This study used three formulations, namely the provision of distilled water as a negative control, chloramphenicol as a positive control. The method used in this research is the well method. Bacteria that were incubated for 24 hours in the fastest concentration inhibition research were at 50% concentration because of bacterial growth which showed that the higher the concentration, the higher the inhibitory power and at 20% concentration the results were resistant, because the amount of solvent used was higher. low and can not inhibit the growth of microorganisms.