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Nutritional problems among adolescents are increasingly associated with unhealthy dietary habits and low physical activity, contributing to the rising prevalence of overweight. According to the 2023 Indonesian Health Survey, overweight prevalence among adolescents ranges from 12% to 16.2%. This study aimed to develop Zea Coffee Tab, a functional beverage made from Robusta coffee and corn silk containing bioactive compounds, including caffeine and flavonoids, which may support metabolism and body fat oxidation. An experimental method with a Completely Randomized Design (CRD) was employed. The evaluated parameters included organoleptic tests (hedonic and hedonic quality) involving 30 semi-trained panelists, proximate analysis, and identification of bioactive compounds. Data were analyzed using the Kruskal–Wallis, Mann–Whitney, One-Way ANOVA, and Duncan’s multiple range tests. Three formulations were tested: F1 (30% Robusta coffee:70% corn silk), F2 (50%:50%), and F3 (70%:30%). The findings showed that F3 was the most preferred formulation, with an acceptance score categorized as “very much liked.” The product contained energy ranging from 319.20–324.26 kcal/100 g, protein 5.12–5.34%, fat 0.48–0.58%, carbohydrates 73.85–74.51%, moisture 9.12–9.66%, ash 2.10–2.32%, caffeine 182.45–205.86 mg/100 g, and flavonoids 4.28–6.03 mg/100 g. Zea Coffee Tab has the potential to serve as a healthy functional beverage for overweight adolescents. Further studies on shelf life and clinical effectiveness are recommended to support product commercialization.

Muscle-invasive bladder cancer (MIBC) is an aggressive malignancy associated with high morbidity, reduced survival, and impaired quality of life. Radiotherapy (RT) has been widely used as a bladder-preserving strategy, particularly for patients unsuitable for surgery or systemic chemotherapy. RT may also enhance tumor immunogenicity through programmed death-ligand 1 (PD-L1) upregulation, providing a rationale for combination therapy with immunotherapy. This study aimed to evaluate the effectiveness of combining immunotherapy and radiotherapy in MIBC treatment. A systematic review was conducted following PRISMA 2020 guidelines using the PICO framework. Literature searches were performed in PubMed, Embase, Cochrane, ClinicalTrials.gov, Web of Science, and Scopus databases for studies published between 2016 and 2025. Risk of bias was assessed using the Cochrane Risk of Bias Tool and ROBINS-I. Of 105 identified studies, five met the inclusion criteria and were included in the final analysis. Only one Phase II randomized controlled trial demonstrated low risk of bias in randomization and allocation concealment. ROBINS-I assessment indicated moderate to serious risk in confounding and participant selection domains. Clinical findings showed promising outcomes, with complete response rates ranging from 35%–50% and partial response rates from 25%–40%. Median overall survival ranged from 24–30 months, with favorable disease-free and progression-free survival outcomes. Combined immunotherapy and radiotherapy demonstrate potential to improve survival and disease control in MIBC; however, further rigorous clinical studies are needed to optimize patient-centered treatment strategies.  

Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

This study aims to analyze the relationship between self-compassion and self-objectification among female TikTok users in Jambi City. The study used a quantitative correlational approach with a cross-sectional design. A total of 218 female students in Jambi City aged 18–25 years who actively use TikTok were selected using a purposive sampling technique. The instruments used were the Self-Compassion Scale (SCS) adapted into Indonesian (Skala Welas Diri) and the Objectified Body Consciousness Scale (OBCS). Data analysis used the Pearson Product Moment correlation test. The results showed a significant negative relationship between self-compassion and self-objectification (r = -0.216; p = 0.001). The higher the self-compassion, the lower the tendency for self-objectification. The majority of respondents had moderate to high levels of self-compassion, while self-objectification was in the moderate category. The duration of TikTok use of more than 2 hours per day was associated with a higher tendency for self-objectification. These findings confirm the role of self-compassion as a protective factor against self-objectification in the context of visual-based social media use.

Increased caffeine intake is commonly used by students to cope with academic demands, especially during examinations and the completion of final projects. Excessive caffeine consumption may affected sleep quality and potentially influence nutritional status. This study aimed to determine the correlation between caffeine intake, sleep disturbances, and nutritional status among final – year unsergarduated students at Dr. Soekardjo University. This study used quantitative approach with an observational analytic and cross-sectinal design. A total of 108 students participated in the study. Data were collected using questionnaires and analyzed using the Spearman Rank correlations test. The findings indicated that the most of respondents with low caffeine intake experienced mild sleep disturbances, totaling 56 respondents (80%). Meanwhile, respondents with moderate and high caffeine intake mostly experienced moderated sleep disturbances, with 13 respondents (61.9%) and 9 respondents (52.9%), respectively. The results showed a significant correlation between caffeine intake and sleep disturbances (p-value=0.000). In all categories of caffeine intake, most respondents had normal nutritional status. However, no significant relationship was found between caffeine intake and nutritional status (p-value=0.351). In conclusion, caffeine intake was associated with sleep disturbances but not with nutritional status among final-year undergraduate students.

Postpartum depression is a postpartum mental health disorder that significantly impacts maternal well-being, infant development, and family functioning. The high prevalence of postpartum depression in Indonesia is due to limited access to health services, low mental health literacy, and social stigma in the community. This indicates a significant gap between the need for maternal mental health services and the availability of existing interventions, making education a crucial component in efforts to prevent postpartum depression early. This study aims to analyze the prevention of postpartum depression in postpartum mothers through telenursing-based education and screening using the Edinburgh Postnatal Depression Scale (EPDS) in the community. A descriptive case study design was used, involving one respondent, a 25-year-old primigravida mother residing in the Bantul area. The intervention was implemented online via WhatsApp and video calls, including structured health education on postpartum psychological changes, adaptive coping strategies, and the importance of social support. The intervention also included daily remote monitoring of the respondent's condition via the WhatsApp mobile application. The EPDS was administered as a pre-test and post-test to evaluate changes in the respondent's psychological condition. The findings showed a significant decrease in the EPDS score from 16 (moderate depression) to 6 (minimal depression), indicating significant psychological improvement. These results imply that integrating EPDS screening, structured health education, and daily monitoring is an effective and accessible community-based approach to preventing postpartum depression, particularly for mothers with limited mobility and access to health services.

 Background: Perineal pain due to episiotomy is a common complaint experienced by postpartum mothers and can affect patient comfort, mobility, and recovery. Nonpharmacological pain management is needed to help reduce discomfort with minimal risk of side effects. Objective: This study aimed to determine the effectiveness of applying cold compresses using ice packs in reducing perineal pain intensity in postpartum mothers with episiotomy. Methods: The study used a descriptive case study design in three vaginal postpartum patients with episiotomy who were treated in the postpartum ward. The intervention involved applying cold compresses using ice packs to the perineal area for 10–15 minutes, as per nursing procedures. Pain was measured using the Numeric Rating Scale (NRS) before and after the intervention. Findings: The results showed a decrease in pain intensity in all patients after the application of cold compresses. Patient P1 experienced a decrease in pain score from 5 to 4, patient P2 from 6 to 5, and patient P3 from 5 to 4, with an average decrease of 1 point. Implications: Cold compresses using ice packs have the potential to be an effective non-pharmacological nursing intervention to help reduce perineal pain and improve the comfort of postpartum mothers with episiotomies during the care period.

Microplastics are extremely small plastic particles that have become a major concern in public health and environmental studies. This literature review aims to discuss the sources of microplastics, their routes of exposure to the human body, their distribution in organs, and their potential health impacts. The method used was a literature review of scientific articles and reports published from 2021 onward, retrieved from Google Scholar, PubMed, ScienceDirect, and official websites of organizations such as the WHO, OECD, and the World Bank. The review findings show that microplastics originate from plastic waste, synthetic clothing, cosmetics, vehicle tires, and food packaging. These particles have been detected in blood, lungs, the placenta, feces, and various human tissues, indicating that human exposure is widespread. However, evidence from human studies is still limited, so cause-and-effect relationships cannot yet be confirmed with certainty. Based on these findings, further research is needed to better understand the long-term health effects of microplastics. In addition, efforts to reduce single-use plastics, improve waste management systems, and increase public education are essential to reduce exposure and prevent future health risks.

Based on the 2023 Indonesian Health Survey, the prevalence of overweight among adults reached 23.4% nationally and 24.5% in East Java Province. This condition highlights the need for food innovation, particularly high-fiber snacks suitable for overweight adults. This study aimed to develop cereal based on okara (soy pulp) flour and mung bean flour as an alternative high-fiber food product. Organoleptic testing was conducted on 30 semi-trained panelists evaluating color, aroma, texture, and taste using hedonic and hedonic quality tests. Data were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney test, while nutrient content analysis was analyzed using One Way ANOVA followed by Duncan’s post hoc test. The results showed that in the hedonic test, color, texture, and taste parameters were significantly different (p<0.05), while aroma was not significantly different (p>0.05). In the hedonic quality test, color and taste showed significant differences (p<0.05), whereas aroma and texture did not (p>0.05). Overall, formulation 922 was the most preferred by panelists. The nutritional content of the cereal ranged from 407–410 kcal for energy, 76.44–77.53% carbohydrates, 8.91–9.66% protein, 6.80–7.30% fat, 5.20–5.51% moisture, 1.26–1.41% ash, and 9.72–10.90% total dietary fiber. The developed cereal is classified as a high-fiber food and has potential as a healthy snack for overweight adults.

The physiological changes that occur during pregnancy, both physically and mentally, may be rather uncomfortable, particularly in the second and third trimesters. Pregnant women often report back discomfort, muscular aches, trouble sleeping, excessive exhaustion, and irregular sleep patterns. Mothers' physical and mental health as well as the health of their unborn children may be significantly impacted by inadequate sleep quality during pregnancy. To enhance comfort and the quality of sleep during pregnancy, one non-pharmacological technique is to use an aromatherapy maternity pillow. An ergonomic and ecologically sustainable invention to enhance mother comfort during pregnancy was the goal of this research, which intended to produce a Pregnancy Pillow Therapy product with pineapple leaf fiber and aromatherapy. A descriptive research design using a prototype creation technique was used in this study. The stages of the research included problem identification, literature review, product design, material selection, prototype manufacturing, and product evaluation. Data were collected through literature studies and observations related to sleep discomfort in pregnancy, maternity pillow utilization, aromatherapy therapy, and pineapple leaf fiber characteristics. The developed product was designed ergonomically to support the back, abdomen, waist, and legs of pregnant women. The addition of aromatherapy was intended to provide a relaxing effect and improve sleep quality. The use of pineapple leaf fiber also supports environmentally friendly product innovation through agricultural waste utilization. The results indicate that Pregnancy Pillow Therapy has the potential to become a supportive product for improving comfort and sleep quality among pregnant women. Further studies are recommended to evaluate product effectiveness directly among pregnant women.

Sleep duration and sleep quality are essential physiological needs that play a significant role in the emotional and behavioral development of children aged 3–6 years. Adequate sleep supports brain development, cognitive functioning, emotional regulation, and social interaction skills in early childhood. Conversely, poor sleep duration and low sleep quality may negatively affect children’s attention, mood stability, and ability to interact socially with peers and caregivers. This article is a literature review using a systematic review approach that analyzes 10 scientific articles published between 2016–2026 to evaluate the relationship between sleep duration and sleep quality with emotional and behavioral problems in preschool children. The article selection process followed the PRISMA flow diagram, with articles sourced from Google Scholar, PubMed, and ScienceDirect databases. The findings consistently indicate that inadequate sleep duration and poor sleep quality are associated with increased emotional and behavioral problems, including hyperactivity, anxiety, emotional dysregulation, and difficulties in social interaction among children. Furthermore, sleep disturbances were found to negatively influence children’s emotional self-regulation abilities, which are crucial for adaptive behavior. Therefore, ensuring adequate sleep duration and improving sleep quality are important strategies to support optimal emotional and behavioral development in preschool-aged children.

Health issues among the elderly are often related to declining bodily functions, digestive disorders, and specific nutritional needs for easily digestible foods. The 60-and-older age group is at high risk for gastrointestinal disorders due to low fiber intake. Therefore, alternative foods are needed that are soft in texture, neutral in taste, safe, and nutritious. One potential solution is the development of food products based on tempeh gembus with the addition of banana hearts, which are rich in fiber, soft in texture, and readily available. This study employed an experimental method using a Completely Randomized Design (CRD) to test three formulation variations (F1, F2, F3). The nutritional content of formulation F1 includes energy 111.575 kcal, carbohydrates 20.185 g, protein 6.91 g, fat 0.355 g, and fiber 6.67 g. Formula F2 contains 88.225 kcal of energy, 14.095 g of carbohydrates, 7.72 g of protein, 0.205 g of fat, 7.3 g of fiber, and 0.0015% flavonoids. Formula F3 has 107.015 kcal of energy, 7.995 g of protein, 0.295 g of fat, 6.88 g of fiber, and 0.0021% flavonoids. In conclusion, the best tempeh with added banana hearts is Formula F2, with its nutritional content, fiber, flavonoids, and BAL >10⁸ CFU/g, which has the potential to serve as a functional food and probiotic source to help improve digestive health in the elderly. Further testing is recommended directly on elderly groups, along with product shelf-life testing.

  Red dragon fruit contains bioactive compounds such as vitamin C, flavonoids, and polyphenols that have antioxidant potential and possess natural pigments that can be used as cosmetic colorants. This study aims to formulate and evaluate a blush-on powder preparation from dragon fruit pulp extract as an alternative natural colorant. The evaluation includes organoleptic testing, homogeneity, pH, irritation, spreadability, fineness, moisture content, and antioxidant activity. The results showed that the formulation met most of the requirements, exhibiting a pink color, a smooth texture, no odor, homogeneity, a pH of 6 suitable for the skin, no irritation, even spreadability within 4 applications, a fineness degree of 97.6%, and a moisture content of 6.91%. Antioxidant activity showed an IC₅₀ value of 0.3036 ppm (very strong), although the relative inhibition percentage was low (18.35%). Thus, dragon fruit extract has the potential as a natural ingredient in blush-on powder that provides both color and antioxidant benefits.

The optimal therapeutic impact of local vaginal drug delivery systems is strongly influenced by the physical characteristics balance of Solid Vaginal Suppositories. A comprehensive review regarding the comparison of mechanical profiles, specifically melting time and crushing strength parameters, from various base classifications constitutes the primary objective of this literature research. The implementation of a Literature Review study design was executed through the extraction of empirical data from twelve experimental journals published within the last ten years. Excessively rapid phase transformation characteristics at physiological basal temperatures and low compression resistance were consistently demonstrated by lipophilic bases such as Oleum Cacao. The risk of structural deformation during the distribution process is highly susceptible to unmodified lipid preparations. High surface elasticity accompanied by a delay in molecular hydration duration reaching 120 minutes was recorded in the utilization of Glycerinated Gelatin Base. Structural rigidity exceeding 4 kgF and disintegration time efficiency under 60 minutes were optimally demonstrated by Polyethylene Glycol (PEG) Base. An enhancement in mechanical resistance against external shocks during the storage period is offered by the thorough modification of the synthetic polymer ratios. Therefore, the determination of the PEG base as the most optimal material is recommended to maintain the quality stability of pharmaceutical products. Compendial regulation standards regarding the physical strength testing of pharmaceutical preparations must be obeyed by every institution to ensure long-term treatment effectiveness. Thus, the alignment between active substance release duration and physical preparation endurance can be realized for absolute patient comfort.

Low Birth Weight (LBW) refers to infants born with a birth weight of less than 2,500 grams and remains an important issue in neonatal health due to its association with increased neonatal morbidity and mortality. To analyze the determinants of LBW based on primary studies published from 2021 to 2026. A literature review was conducted using the PRISMA approach. Article searches were performed through PubMed, Google Scholar, Scopus, ScienceDirect, and ProQuest using the keywords low birth weight, determinant factors, risk factors, BBLR, and faktor risiko with Boolean operators AND/OR. The inclusion criteria were primary studies, full-text availability, publication in Indonesian or English, and publication years from 2021 to 2026. A total of 20 articles were included, consisting of 15 international articles and 5 national sources. The review showed that LBW is influenced by interrelated maternal, nutritional, obstetric, and sociodemographic factors during pregnancy. The most dominant factors included multiple pregnancy with an adjusted OR of 21.74, maternal food insecurity with an AOR of 6.85, maternal hemoglobin level <11 g/dL with an AOR of 5.21, lack of iron-folic acid supplementation with an AOR of 4.17, maternal age ≤20 years with an AOR of 3.42, pregnancy interval <1 year with an adjusted OR of 2.92, missed antenatal care visits with an AOR of 2.74, smoking during pregnancy with an OR of 2.18, and maternal hypertension with an AOR of 1.94. LBW is influenced by multiple interrelated factors; therefore, efforts to reduce its incidence should focus on evidence-based interventions, particularly through optimizing antenatal care services, improving maternal nutritional status, and early detection of pregnancy.

Adolescents are considered a vulnerable group to nutritional problems because they experience rapid physical growth accompanied by lifestyle changes and unhealthy eating habits. The increasing prevalence of overweight and obesity among teenagers has become a major public health concern that requires serious attention. This study was conducted to examine the relationship between peer influence, the frequency of eating out, and fast-food consumption habits with the incidence of overweight among students at SMAN 1 Surabaya. The research applied a quantitative approach using an analytical observational design with a cross-sectional method. A total of 81 students participated in the study and were selected through proportional random sampling. Data were collected using questionnaires, SQ-FFQ forms, and anthropometric measurements, then analyzed using the Chi-Square statistical test. The findings revealed significant associations between peer influence, eating out frequency, and fast-food consumption habits with the occurrence of overweight among adolescents. Students who more frequently consumed meals outside the home and regularly ate fast food showed a greater tendency to experience overweight and obesity. These results indicate that social environments and modern dietary patterns contribute to the increasing prevalence of overweight among adolescents. Therefore, nutrition education and healthy lifestyle promotion should be strengthened through the involvement of schools, families, and peer groups.

This study was conducted in response to the increasingly complex nutritional issues among adolescents, reflected in the coexistence of undernutrition and overnutrition within the same population, which are closely associated with dietary consumption patterns. The research aimed to investigate the relationship between diet quality and the nutritional status of students at SMAN 9 Surabaya. A quantitative approach with a cross-sectional design was employed, involving 85 participants selected based on the estimated sample requirement for correlation analysis. Dietary intake data were collected using two non-consecutive 24-hour food recalls and subsequently assessed using the Diet Quality Index for Adolescents (DQI-A). Nutritional status was determined through BMI-for-age calculations in accordance with the World Health Organization standards. Data analysis was performed using correlational testing and Chi-Square analysis to identify differences in proportions. The findings revealed that the respondents’ diet quality remained suboptimal, while most students were categorized as having normal nutritional status, although cases of undernutrition and overnutrition were still identified. A significant association was found between diet quality and nutritional status (p = 0.001), indicating that better diet quality tended to be linked with normal nutritional status. Based on the DQI-A components, dietary quality demonstrated a significant relationship with nutritional status (p = 0.007), whereas dietary diversity (p = 0.597) and dietary equilibrium (p = 0.507) showed no significant associations. These findings highlight that diet quality, particularly food selection patterns, plays an important role in determining adolescent nutritional status. Therefore, improving nutritional conditions requires more intensive nutrition education interventions focusing on healthy food choices, increased fruit and vegetable consumption, and controlled intake of sugar, salt, and fat, supported consistently by both individuals and the school environment.

Background: Acute respiratory infection (ARI) remains a major public health concern, particularly in primary care settings. Lifestyle factors such as dietary patterns and physical activity are increasingly recognized as potential contributors to respiratory health. Objective: This study aimed to examine the association between dietary patterns, physical activity, and ARI among primary care patients in East Halmahera, Indonesia. Methods: A cross-sectional study was conducted at a primary health care facility in East Halmahera, Indonesia, from January to February 2026, involving 106 respondents selected using a total sampling technique. Data were collected using structured questionnaires and medical records. Variables included sociodemographic characteristics, dietary patterns, physical activity, and ARI status. Data were analyzed using descriptive statistics and Chi-square tests with a significance level of p < 0.05. Results: The prevalence of ARI among respondents was 77.4%. Bivariate analysis showed that dietary patterns (p = 0.006) and physical activity (p = 0.015) were significantly associated with ARI. In contrast, age, gender, marital status, education level, employment status, smoking, and alcohol consumption were not significantly associated with ARI (p > 0.05). Conclusion: Dietary patterns and physical activity were significantly associated with ARI among primary care patients in East Halmahera. These findings highlight the importance of lifestyle-related factors in addressing respiratory infections at the primary care level.  

Dengue Hemorrhagic Fever (DHF) remains a major public health problem in Indonesia, particularly in densely populated areas. Control efforts require accurate data and spatial analysis to understand disease distribution patterns. Geographic Information System (GIS) is an effective tool for visualizing case distribution and supporting surveillance and planning of control programs at the primary healthcare level. This study aims to describe the spatial distribution of Dengue cases based on medical record data and produce a geographic distribution map to support Dengue control efforts at the Puskesmas level. This study used a quantitative descriptive design with secondary data from medical records at Karangsari Health Center. The sample consisted of 255 DHF patients in 2025, selected using a total sampling technique. Data were processed through editing, geocoding patient addresses, and spatial analysis using QGIS software.The results showed 255 Dengue  cases in 2025 with fluctuating monthly trends, peaking in April and lowest in December. Case distribution was uneven and tended to cluster. High-risk areas accounted for 15.7%–21.2%, moderate-risk areas 9.8%–15.7%, and low-risk areas 7.1%–9.8%. Megu Cilik Village had the highest proportion of cases, while other villages were categorized as moderate and low risk. This pattern indicates that Dengue incidence is influenced by environmental conditions, vector density, host factors, rainfall, and Aedes aegypti presence. GIS provides clearer spatial visualization, helping identify high-risk areas and supporting targeted public health interventions.

Old age is the final phase in the human life cycle, characterised by a decline in physiological function. Global data shows that the prevalence of old age will increase from 33.69 million to 48.19 million by 2035. One of the effects of this decline in physiological function is a disruption in the quality of sleep among the elderly. As many as 50-60% of elderly people in Indonesia experience sleep disorders. One way to overcome sleep disorders is through relaxation therapy. Progressive Muscle Relaxation is a technique performed by stretching and relaxing certain muscles to relax the body. The purpose of this study was to determine the effectiveness of progressive muscle relaxation on the quality of sleep in elderly people. This research method involved a nursing care process from assessment to evaluation using a case study design. The research sample consisted of one elderly person with moderate sleep quality. The intervention was given for 10-15 minutes using eight movements with a frequency of twice a week for one month. The data were analysed using pre-test and post-test PSQI questionnaires to determine sleep quality. The results of this study indicate that progressive muscle relaxation training has an effect on improving sleep quality in the elderly.