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Dysmenorrhea or menstrual pain, is a common health issue among adolescent girls, often disrupting daily activities and quality of life. Effective management of dysmenorrhea is strongly influenced by the level of knowledge and attitudes of adolescent girls toward this condition. This literature review aims to analyze the relationship between knowledge and attitudes regarding the management of menstrual pain among adolescent girls. Various studies indicate that while adequate knowledge about dysmenorrhea is important, the correlation between knowledge and attitude is not always significant. Some research finds that good knowledge does not necessarily translate into a positive attitude towards pain management, as other factors such as stress, anxiety, and reluctance to take action also play a role. However, there are studies that show a positive relationship between increased knowledge and better attitudes toward dysmenorrhea management,  although the strength of this association is very weak. Most adolescents tend to choose non-pharmacological management, such as rest and warm compresses, but many still ignore menstrual pain due to a lack of knowledge and information. Therefore, educational interventions and counseling in schools are essential to improve knowledge and foster positive attitudes in managing dysmenorrhea among adolescent girls. These efforts are expected to help adolescent girls manage menstrual pain more effectively and enhance their quality of life.

Malaria remains a major public health challenge in eastern Indonesia, particularly in the remote highland areas Papua, where access to health services is very limited. In early 2008, a suspected malaria outbreak with several deaths was reported in Agisiga District, a remote highland area in Papua. This study aimed to investigate the epidemiological characteristics, diagnostic results, and mortality patterns of the malaria outbreak as a basis for formulating future control strategies. The outbreak investigation was conducted using a cross-sectional design in Agisiga District from January to March 2008. Capillary blood samples were examined using Rapid Diagnostic Tests (RDTs) and thin blood smear microscopy. Malaria-related deaths were traced through verbal autopsy methods and interviews with families and community leaders. Descriptive analysis was performed to describe the demographic, clinical, and parasitological characteristics the cases. A total of 92 suspected malaria cases were identified, with the highest proportion coming from Tomosiga Village (52.2%), followed by Bigasiga Village (40.2%) and Agisiga Village (7.6%). Women accounted for 58.7% of all cases, and the most affected age group was 15–35 years (34.8%). Microscopic examination confirmed malaria infection in 55.0% of samples examined, with Plasmodium vivax predominating (45.0%), while the RDT positivity rate was much lower. The malaria outbreak in Agisiga District was characterized by high mortality, delayed diagnosis, and significant gaps in diagnostic capacity, particularly in remote villages. Strengthening the surveillance system, increasing diagnostic capacity, and improving access to timely treatment are crucial steps prevent similar outbreaks and reduce malaria mortality in the Papuan highlands.

Herpes zoster is a skin infection caused by the reactivation of the varicella-zoster virus, characterized by unilateral skin lesions corresponding to dermatome distribution and complaints of pain or itching. This disease is more common in adults and the elderly, especially in individuals with reduced immunity due to stress or work overload. A case was reported of a 40-year-old woman who worked as a nurse and came to a primary health care facility complaining of itching and red spots on her right breast area that had spread to the surrounding area two weeks before the examination and had worsened in the last few days. Physical examination revealed unilateral red skin lesions in a dermatomal pattern without crossing the midline of the body, consistent with the early phase of herpes zoster. Management was comprehensive, including medication, patient education about the disease and skin care, prevention of complications, and family support. A holistic approach is necessary to improve the success of therapy and the patient's quality of life.

Asthma is a chronic inflammatory disease of the airways characterized by reversible bronchoconstriction, mucus hypersecretion, and bronchial hyperresponsiveness. This condition causes shortness of breath, coughing, wheezing, and increased respiratory rate which impacts increased respiratory muscle work. One of the non-pharmacological interventions that can be applied in nursing practice is diaphragmatic breathing relaxation to help improve breathing patterns and increase respiratory muscle relaxation. Objective: To analyze the application of diaphragmatic breathing relaxation in improving respiratory muscle relaxation in asthma patients in the inpatient ward. Method: The study used a case study design with an Evidence Based Practice (EBP) approach. The research subjects were three asthma patients who experienced increased respiratory frequency. The intervention was carried out for three days in the form of structured diaphragmatic breathing exercises. Data were collected through nursing assessment, observation of respiratory frequency before and after the intervention, and evaluation of patient responses. Results: Before the intervention, all respondents experienced tachypnea with the use of accessory respiratory muscles. After three days of diaphragmatic breathing relaxation, the respiratory rates of all three respondents returned to normal (12–20 breaths/minute), respiratory muscle tension decreased, and the patients appeared more relaxed. Conclusion: Diaphragmatic breathing relaxation is effective in increasing respiratory muscle relaxation and stabilizing respiratory rate in asthmatic patients. This intervention can be used as part of non-pharmacological nursing care for patients with respiratory system disorders.

Developmental Dysplasia of the Hip (DDH) in children often results in joint stiffness, muscle weakness, limited range of motion, and gait impairment following surgical management and immobilization. Early physiotherapy intervention is essential to restore hip function and walking ability. This study aimed to evaluate the effectiveness of active exercise on functional walking in outpatient children aged 3–5 years after DDH surgery. A case study design was conducted on three female patients who completed a five-week rehabilitation program consisting of ten active exercise sessions, including hip strengthening, mobility training, and balance exercises, combined with a home program. Outcome measures included hip range of motion, Manual Muscle Testing, and Modified McKay and Harris Hip Score assessed at baseline, mid-intervention, and post-intervention. The results showed improvements in hip range of motion, particularly in flexion, extension, abduction, adduction, and external rotation, while internal rotation improved but did not reach normal values. Muscle strength increased from grade 1–2 to grade 3 in most hip muscle groups. Functional walking scores improved from poor to good and excellent, with patients achieving independent, symmetrical gait without pain. These findings indicate that active exercise is an effective rehabilitation approach to reduce impairments and enhance functional walking in children after DDH surgery. The study highlights the importance of structured physiotherapy and caregiver involvement to optimize recovery and participation in daily activities.

Wounds can be defined as the loss and damage of anatomical cells or skin function. Wound healing consists of coagulation, inflammation, proliferation, and remodeling stages. This study aims to determine the effectiveness of the leaf fraction of the thick (Glochidion superbum) on wound healing in male white mice (Mus musculus). This study is experimental. This study used 24 male mice that were given a 10 mm long cut wound. Fractionation was carried out using the liquid-liquid extraction method. Fractionation used 3 different types of solvents, namely methanol, ethyl acetate, and n-hexane. The results showed that the ethyl acetate fraction had a faster wound healing effectiveness than the other groups. The ethyl acetate fraction contains a phenolic compound, namely methyl gallate. Methyl gallate has an important role in wound healing. Methyl gallate has the potential to be an antibacterial, antioxidant, and anti-inflammatory. The results of the Bonferroni post-hoc statistical analysis confirmed the effectiveness of the ethyl acetate fraction in faster wound healing. The thick leaf fraction was effective in healing incisions in male white mice. The ethyl acetate fraction was more effective in accelerating incision healing.

Tuberculosis (TB) remains a significant health issue in Indonesia, with the number of cases not showing a decline. Pediatric pulmonary tuberculosis is one of the leading causes of morbidity and mortality. In 2018, the number of TB cases in Aceh reached 41,595, with Aceh Utara having the highest number at 4,819 cases, followed by Bireuen with 3,636 cases, while Sabang recorded the lowest at 272 cases. The primary risk factor for pulmonary tuberculosis in children is a history of contact with adult TB patients, as children's immune systems are still weak, allowing the bacteria to enter their bodies easily. This study aims to examine the history of TB contact in children at the Pediatric Clinic of Cut Meutia General Hospital. The research used a descriptive observational design, with 105 respondents, and data was collected from medical records. The results showed that the majority of respondents were toddlers (47.6%), most were male (54.3%), and 58.1% had good nutritional status. A significant percentage of respondents (77.1%) had a history of contact with TB patients, and 83.8% did not receive BCG vaccination. These findings highlight that contact with TB patients is a key factor in the transmission to children.

Allergic contact dermatitis (ACD) is an inflammatory skin process caused by specific allergens. ACD is classified as Type IV hypersensitivity, which is sensitive to allergens. A 57-year-old woman presented to the Dermatology and Venereology Clinic at Malahayati General Hospital in Bireun with complaints of red patches on her right and left legs and on her right and left elbows for approximately two months. According to the patient, the red patches initially appeared as circular patches with white scales the size of a coin on the elbows, accompanied by itching, which then spread. The itching worsened when the patient sweated, causing her to scratch, which enlarged the lesions and caused red wounds. The skin on the lesions tended to be dry with active edges and a calmer center. The itching improved after bathing. The patient is a housewife. The patient also said that she sweats frequently. According to the patient, the itching is not affected by the food she consumes every day. The patient was given steroid pharmacotherapy, namely 1% hydrocortisone cream, 0.1% mometasone furoate cream, and 10 mg cetirizine tablets once daily.

The problem that occurs in stroke patients is damage to the autonomic nervous system that regulates intestinal peristalsis, causing a decrease in the defecation reflex and leading to constipation. If constipation is not treated properly, it will affect the quality of life of stroke patients. Constipation can be treated pharmacologically and non-pharmacologically. One non-pharmacological treatment is abdominal massage. Abdominal massage can stimulate the parasympathetic nervous system, which can increase digestive system motility, reduce tension in the abdominal muscles, and have a relaxing effect on the sphincter. The design used in the preparation of the final scientific paper for the nursing study was a one-group pretest-posttest case study with abdominal massage intervention on three respondents who had experienced constipation for ≥ 72 hours. Abdominal massage was given once a day for 10-15 minutes for three consecutive days. The constipation scores using the Constipation Assessment Scale (CAS) were as follows: respondent 1, Mrs. L, from 13 to 6; Mrs. W, from 12 to 11; and Mrs. W, from 15 to 11. There was a decrease in the CAS score before and after the abdominal massage was administered, but it was not yet able to significantly alleviate constipation in stroke patients. The application of this EBP is expected to provide additional information on the administration of abdominal massage to stroke patients experiencing constipation for ≥72 hours.

Smoking is the activity of smoking smoke from the burning of tobacco in cigarettes, one end of the cigarette is burned and the smoke can be smoked through the mouth on the other end. If the amount or form of hemoglobin is abnormal, red blood cells cannot function properly in transporting oxygen and carbon dioxide. This can trigger various health problems, including anemia. From the results of this study, we can see that the average value or mean value of hemoglobin levels is 12.5 g/dL, the median value is 12.9 g/dL, the minimum value is 11.9 g/dL, and the maximum value is 16.2 g/dL. The results showed that most of the respondents had hemoglobin levels within normal limits. In detail, hemoglobin levels in the normal category were 23 respondents, low category was 1 respondent, and high category was 1 respondent. This shows that the majority of active smokers in Market VI of North Binjai Village still have normal hemoglobin levels, although smoking has the potential to affect oxygen transport capacity in the long term and increase the risk of health problems if it continues continuously.

Background: The prevalence of Chronic Energy Deficiency (CED) among pregnant women in West Papua remains very high, reaching 40.7%. The provision of manufactured supplementary food (PMT) in the form of biscuits often faces challenges due to low compliance caused by monotonous taste and nausea-triggering flavors. Sweet potato (Petatas) is a potential local food source with an energy content of 123 kcal/100g that could serve as an alternative PMT. Objective: To analyze the acceptability (taste, color, aroma, and texture) of sweet potato-based PMT products among pregnant women with CED. Methods: A quantitative study with a cross-sectional design was conducted from September to October 2025 at the Ransiki Health Center. The sample consisted of 22 pregnant women with CED. The research instrument used a 5-point hedonic scale questionnaire. Results: Respondent characteristics were dominated by the ideal age range of 20-35 years (81.8%) and low family income (63.6%). The acceptability test results showed high overall acceptance with an average score of 4.23 (Highly Liked). The color attribute obtained the highest score (4.27), followed by taste (4.18), texture (4.18), and aroma (4.14). Conclusion: Sweet potato-based PMT products have excellent acceptability and significant potential to be integrated into local nutritional intervention programs for pregnant women with CED.

Malnutrition and stunting among children under five remain major public health challenges in developing countries, including Indonesia. These conditions are associated with increased morbidity, mortality, impaired cognitive development, and reduced productivity in adulthood. Stunting reflects chronic nutritional deficiencies, while severe malnutrition indicates acute or prolonged inadequate nutrient intake, often exacerbated by infections, poor caregiving practices, and unfavorable socioeconomic conditions. This case report aims to describe the clinical condition, contributing factors, management, and outcomes of a 14-month-old female toddler diagnosed with severe malnutrition and stunting without complications in Blang Dalam Geuteung Village, Nisam Subdistrict, North Aceh Regency. The assessment was conducted using a family medicine approach, incorporating detailed history taking, physical examination, anthropometric measurements, and nutritional status evaluation based on World Health Organization Z-score indicators. Interventions included nutritional rehabilitation through appropriate dietary intake, family education on balanced nutrition and proper feeding practices, routine growth monitoring, and optimization of primary healthcare services. The results showed gradual improvement in the child’s nutritional status, evidenced by weight gain, better appetite, and improved feeding patterns following the intervention. This case highlights the importance of early detection, comprehensive family-centered management, and continuous monitoring in addressing malnutrition and stunting at the primary care level. Strengthening community-based interventions, improving caregiver knowledge, and enhancing collaboration between healthcare providers and families are essential to reduce the burden of malnutrition and support optimal child growth and development.

Anxiety is a prevalent mental health issue that affects psychological well-being and daily functioning. In Muslim communities, Islamic spiritual practices are commonly used as coping strategies, yet empirical evidence regarding their effectiveness in reducing anxiety has not been systematically consolidated. This study aimed to synthesize scientific evidence on Islamic spiritual interventions for anxiety reduction. A systematic literature review was conducted in accordance with PRISMA guidelines by searching Google Scholar, PubMed, ScienceDirect, and Elsevier. Observational studies published between 2019 and 2026 that examined Islamic spiritual interventions and reported anxiety outcomes were included and analyzed narratively. Ten eligible articles were identified. The review demonstrates that Islamic spiritual interventions, such as dhikr, prayer, Qur’an recitation, and Islamic spiritual counseling, are consistently associated with reductions in anxiety across diverse populations and settings. Although the magnitude of effects varied, the overall findings indicate a beneficial role of Islamic spiritual practices in anxiety management. These results suggest that Islamic spiritual interventions may be integrated as complementary approaches within mental health and public health services for Muslim populations, while further methodologically rigorous studies are required to strengthen the evidence base.

Tuberculosis (TB) is a chronic, infectious disease caused by the bacterium Mycobacterium tuberculosis. Primary infection occurs upon first exposure to bacillary tuberculosis, which often occurs in childhood, hence the term "childhood TB." The diagnosis of TB is usually made through a history that includes complaints of persistent cough, weight loss, fever, and weakness, along with a chest X-ray that shows typical abnormalities of pulmonary TB. In this case, a 21-month-old girl presented with a worsening, persistent cough accompanied by weight loss. The patient's mother reported that her child frequently had fevers and appeared weak. After a physical examination and supporting tests, the patient was diagnosed with TB. The patient was given pharmacological therapy in the form of anti-tuberculosis drugs (OAT), and parents were educated about the importance of adherence to TB treatment as prescribed by the doctor. Furthermore, providing a balanced, nutritious diet is recommended to support successful treatment.

Viral hepatitis is a systemic disease that primarily affects the liver and is characterized by a necroinflammatory process that plays a significant role in clinical and laboratory manifestations. Chronic hepatitis is defined as liver inflammation lasting more than six months, with persistent elevations in aminotransferases and characteristic histological features, and carries a risk of progression to cirrhosis and hepatocellular carcinoma. Chronic hepatitis C virus infection occurs due to an ineffective host immune response to the virus, allowing the infection to persist. The innate immune system, particularly type I interferon, plays a key role in the initial defense mechanisms against viral replication. Various antiviral therapies, such as interferon, nucleoside analogs, and nucleotide analogs, are currently available, which have been shown to reduce viral load and inhibit disease progression. Appropriate therapy is expected to prevent long-term complications in patients with chronic hepatitis.

Academic stress is a common type of stress experienced by students, which greatly affects their self-esteem. This study aims to determine the relationship between self-esteem and academic stress levels among students. This study used a quantitative design with a cross-sectional approach and probability sampling technique. The sample consisted of 101 respondents from a total of 132 students. Data analysis was performed using Spearman's rank correlation test. The results showed a weak and negative relationship between self-esteem and academic stress levels with a p-value of 0.000 (p˂ 0.05) and a correlation coefficient (r) = -0.385. There is a relationship between self-esteem and academic stress levels in students, where low self-esteem is associated with higher academic stress levels.

Adolescent mental health is an important aspect in human resource development because it affects learning ability, social relationships, and readiness to face adult life. Adolescence, especially at the junior high school level, is a transitional period that is prone to mental and emotional disorders due to biological, psychological, and social changes that occur simultaneously. This study aims to describe the mental health condition of adolescents using the Self Reporting Questionnaire (SRQ-20) instrument in students of SMPN 3 Ubud, Gianyar Regency. The study used a descriptive design with a cross sectional approach. The sampling technique was carried out in total sampling with a total of 117 students. The research instrument is in the form of an SRQ-20 questionnaire that has been proven to be valid and reliable. Data analysis was carried out descriptively to describe the distribution of symptoms and mental health categories of respondents. The results showed that most students were in the category of good mental health, although there were still a number of students with poor conditions. The most common symptoms are easy to feel tired and difficulty in making decisions. Based on the characteristics of respondents, students aged 13–15 years are more likely to experience poor mental health conditions than 11-13 years old, and the proportion of female students is higher than men in experiencing symptoms of mental emotional disorders. These findings affirm the importance of early detection of adolescent mental health in schools as the basis for promotive and preventive interventions, through optimizing the role of counseling guidance and creating a supportive school environment.

Work motivation is one of the important factors influencing time management and nurses’ performance in providing nursing care. Good time management enables nurses to complete tasks in a timely, efficient, and effective manner. This study was conducted to determine the relationship between work motivation and time management among staff nurses at ML Hospital in 2025. This research used a quantitative approach with a cross-sectional design. A total of 40 staff nurses were selected using a total sampling technique. The instruments used were questionnaires on work motivation and time management. Data were analyzed using the Spearman Rank statistical test with a significance level of < 0.05. The results showed that most respondents had good work motivation (62.5%), while the majority demonstrated a moderate level of time management (75%). The Spearman Rank test yielded a p-value of 0.005, indicating a significant relationship between work motivation and time management among staff nurses. In conclusion, there is a significant relationship between nurses’ work motivation and time management, in which higher work motivation is associated with better time management. It is recommended that hospitals enhance nurses’ motivation through managerial support and a positive work environment.

Postpartum depression (PPD) is a common and serious mental health disorder for mothers after givingbirth, which is a public mental health problem because it not only has a direct impact on the baby, but also on the family. The most common symptoms of PPD are overwhelming sadness, feelings of hopelessness and helplessness, moodiness, an inability to experience joy with the baby, serve anxienty, loss of appetite, poor concentration and memory, sleep disturbances, prolonged fatigue, and suicidal ideation (American Psychological Association, 2013). The design used in this study was quantitative by measuring the prevalence of postpartum depression in postpartum mothers using the EPDS form. The research was conducted at Gandapura Community Health Center, this location wa used as the research site because it had not been exposed at all regarding the use of the EPDS form as part of the initial assessment of midwifery services. A population is all elements that meet certain criteria for inclusion in a study. The population in this study was all postpartum mothers who gave birth in the obstetrics ward. The sample criteria in this study are divided into two, namely inclusion criteria and exclusion criteria. Conclusion: Postpartum guidance provided to mothers influences the risk of postpartum depression. Postpartum women who receive assistance are less likely to experience postpartum depression, and mothe who do not receive assistance are depression.

The development of molecular biology has significantly transformed clinical laboratory diagnostics, particularly through DNA analysis. One of the most widely used techniques is the Polymerase Chain Reaction (PCR), a DNA amplification method capable of rapidly, sensitively, and accurately multiplying specific genetic fragments. PCR has become an essential diagnostic tool for detecting infectious, genetic, and malignant diseases, even at early stages when the amount of target DNA is minimal. This article aims to analyze the role of PCR in DNA analysis as a diagnostic tool in clinical laboratories, including its working principles, advantages, and relevance in modern clinical practice. This study employs a literature review approach by examining various scientific sources such as international journals and molecular biology textbooks. The findings indicate that PCR offers high sensitivity and specificity compared to conventional methods, thereby improving diagnostic accuracy and accelerating appropriate therapeutic decisions. Therefore, PCR represents a crucial innovation in clinical laboratory diagnostics that significantly contributes to improving healthcare quality.