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In Iranian Traditional Medicine, some herbs like Achillea millefolium, commonly known as yarrow, are implicated as appetite enhancers. However, there is not enough research evidence to prove their actual effect. Achillea millefolium is a dicot which belongs to the family Asteraceae. The purpose of this study was the analysis Achillea millefolium based on a bioinformatic study and toxicity test on the chicken embryo. This research method consisted of conversion of nucleotides into amino acids, analysis of the three-dimensional structure of Achillea millefolium protein, epitope and Allergen Proteins, antigens and toxins and toxicity test on the chicken embryo. In addition, this study also obtained the results of proteins that are epitope, antigenic, non-allergenic and non-toxic and toxicity test on the chicken embryo was 250 ng/egg.. Morphological description of the embryo on the 21st day after injection, at a concentration of 250 ng of Mentha piperita/egg product, an abnormal embryological picture was obtained. Chicken Embryo Weight and Body Length Measurements were carried out in chicken embryos. Need research for other species of plant.

Hawthorn extract has been used for ameliorating cardiac disorders and pulmonary hypertension. The main chemical constituents of hawthorn flavonoid extract (HFE) include flavonoids (1-2%), oligomeric proanthocyanidins (1-3%), and other bioactive components (e.g., triterpene acids, organic acids, sterols, and cardioactive amines). These compounds are reported to have many pharmacological effects, including neuroprotective, hepatoprotective, cardioprotective, and nephroprotective effects. This study was aimed the analysis Crataegus oxyacantha based on a bioinformatic study and toxicity test on the chicken embryo. This method consisted of analysis of the three-dimensional structure of Crataegus oxyacantha Protein, Epitope and Allergen Proteins, Crataegus oxyacantha Proteins that were antigens and toxins and toxicity test on the chicken embryo. The results of research conducted on 3 three-dimensional structures of Crataegus oxyacantha protein, GQME value and QmeanDisCo value. In addition, this study also obtained the results of proteins that are epitope, antigenic, non-allergenic and non-toxic and toxicity test on the chicken embryo was 250 ng/egg..Morphological description of the embryo on the 21st day after injection, at a concentration of 250 ng of Crataegus oxyacantha /egg product, an abnormal embryological picture was obtained. Chicken Embryo Weight and Body Length Measurements were carried out in chicken embryos. Need research for other species of plant.

Free-range chicken eggs are a source of high-value animal protein but are susceptible to quality deterioration during storage. This study aimed to evaluate the effect of Averrhoa bilimbi L. leaf extract concentration and storage duration on the internal quality (Egg White Index, Egg Yolk Index, Haugh Unit, yolk color) and pH of free-range chicken eggs. An experimental method was employed using a Completely Randomized Design (CRD) with a 4 x 4 factorial pattern. The first factor was leaf extract concentration (0%, 5%, 10%, 15%), and the second factor was storage duration (7, 14, 21, and 28 days). The results showed that immersion in 5% Averrhoa bilimbi L. leaf extract significantly maintained internal egg quality compared to the control up to 14 days of storage. This treatment produced optimal values for the Egg White Index, Egg Yolk Index, Haugh Unit, and yolk color score, while also inhibiting the pH increase indicative of egg spoilage. However, an excessively high concentration (15%) resulted in physical quality degradation. It is concluded that Averrhoa bilimbi L. leaf extract has potential as an effective natural preservative for maintaining the freshness of free-range chicken eggs, with the best concentration at 5% for short- to medium-term storage.

Canine dwarfism is a growth disorder resulting from physiological dysfunction within the endocrine system, primarily due to growth hormone (GH) deficiency commonly caused by abnormal pituitary development. GH and Insulin-like Growth Factor 1 (IGF-1) play essential roles in regulating the growth of bones, muscles, skin, and internal organs through the hypothalamic–pituitary–liver axis. Under normal conditions, the hypothalamus controls GH secretion, which subsequently stimulates the liver to produce IGF-1 as the main mediator of growth. Genetic abnormalities such as LHX3 mutations can impair somatotroph cell differentiation and reduce GH production, ultimately leading to decreased IGF-1 levels. The deficiency of these hormones disrupts chondrocyte proliferation in the epiphyseal plates, decreases muscle protein synthesis, and negatively affects the development of tissues such as skin, hair, and reproductive organs. This study was conducted using a literature review method by searching scientific databases and selecting relevant publications addressing the physiological, clinical, and pathophysiological aspects of canine dwarfism. Literature analysis indicates that GH deficiency leads to clinical manifestations such as stunted body size, thin and easily shedding hair, dry and infection-prone skin, reduced muscle mass, metabolic disturbances, and delayed reproductive maturation. Diagnosis is established through clinical evaluation, IGF-1 measurement as an indicator of GH activity, and radiographic assessment of epiphyseal plate development. Overall, a comprehensive understanding of the relationship between physiological abnormalities and clinical signs is crucial for early detection and appropriate management of dwarfism, providing a strong scientific foundation for understanding the hormonal mechanisms disrupted in this condition.

The Damahu waxy corn (Zea mays L. var. Damahu) is a local variety traditionally cultivated by the Gorontalo community and possesses significant potential for the development of functional food products. This study aimed to determine the nutritional composition of the Damahu waxy corn variety originating from Bontula Village, Asparaga District, Gorontalo Regency, through proximate analysis. The corn samples were dried, milled, and analyzed using standard analytical procedures to quantify moisture, ash, fat, protein, and carbohydrate contents. The results indicated that Damahu waxy corn flour contained 83.32% carbohydrates, 5.93% protein, 1.67% fat, 8.84% moisture, and 0.24% ash. This composition characterizes the Damahu variety as a good energy source. However, its protein content does not yet meet the minimum requirement set by the Indonesian National Standard (SNI) for corn-based processed products. The nutritional profile highlights the potential of Damahu waxy corn for the development of nutritious and competitive local food products. This study provides an initial contribution to the documentation of Gorontalo’s indigenous corn varieties and offers a scientific foundation for the utilization of local germplasm to strengthen regional food security.

Cake is a wheat flour-based food product that is popular because of its sweet taste, soft texture, and attractive appearance. This study aims to evaluate the effect of purple sweet potato (Ipomoea batatas) paste substitution on the sensory, chemical, and physical quality of chocolate cake decorated with character pudding. The study was conducted in May–August 2025 at the Makassar Health Laboratory Center and the Chemistry Laboratory of the Pangkep State Agricultural Polytechnic. The study design used a Completely Randomized Design (CRD) with five treatments of purple sweet potato paste concentration (0%, 10%, 20%, 30%, 40%) and two replications. The parameters analyzed included sensory tests (color, aroma, taste, texture, and overall), chemical tests (antioxidant activity, water content, protein, fat, ash, and carbohydrate), and physical tests (expandability and crumb morphology). Data were analyzed using ANOVA and Duncan's further test for parameters with significant differences. The results showed that the addition of purple sweet potato paste had a significant effect (p < 0.05) on sensory and chemical characteristics. Treatment A4 (40% purple sweet potato paste) obtained the highest score in the hedonic test with an average panelist preference level of 4 (like). The best chemical characteristics were also obtained in A4, namely antioxidant content of 25.6%, water content of 32.97%, protein 3.52%, fat 17.19%, ash 1.34%, and carbohydrate 45.05%. Physically, the rise power was not significantly different between treatments, but the crumb morphology showed pore irregularities at high concentrations.

Noodles are commonly made from wheat flour, which is high in carbohydrates but low in fiber, vitamins, and minerals. To enhance their nutritional value, this study used broccoli leaf flour, a vegetable source rich in nutrients and antioxidants. The aim was to evaluate the organoleptic and chemical qualities of dried noodles with added broccoli leaf flour. The study used a completely randomized design with three treatments and two replications. Organoleptic tests (color, aroma, texture, and taste) were conducted by 60 panelists. Chemical analysis measured carbohydrate, protein, fat, calcium, fiber, and moisture content. The results showed that noodles with 10 grams of broccoli leaf flour (treatment B) were most preferred by panelists. This treatment also had improved nutritional content, especially in fiber and calcium, while maintaining acceptable product quality. In conclusion, broccoli leaf flour is a promising ingredient to improve the nutritional value of dried noodles and develop functional food that is well-accepted by consumers.

As a key source of animal protein in Indonesia with growing demand, this study examines the income levels of broiler chicken meat vendors at Tanjung Pura Market, Langkat Regency. Despite fluctuating prices and limited purchasing power among consumers, traditional markets continue to serve an essential function in meat distribution. The objective of this research is to assess the income of broiler chicken sellers by analyzing production costs, output, profits or losses, R/C ratio, and break-even point (BEP). Using a total sampling method, ten vendors at Tanjung Pura Market were chosen as the research subjects. A qualitative approach was applied through descriptive analysis.

Type 2 diabetes mellitus (T2DM), hypertension, anemia, nephrotic syndrome, and urinary tract infection (UTI) are interrelated clinical conditions frequently encountered in patients with chronic kidney disease (CKD). This case report presents a 33-year-old woman who was admitted with complaints of generalized weakness, accompanied by headache, generalized edema, and pruritus. Laboratory findings revealed hyperglycemia (>300 mg/dL), elevated blood pressure (210/120 mmHg), increased urea and creatinine levels, 2+ proteinuria, and microcytic hypochromic anemia (hemoglobin ranging from 7.9 to 9.9 g/dL). Urinalysis showed leukocyturia, hyaline casts, and bacteriuria. The patient was diagnosed with uncontrolled T2DM, hypertensive urgency, microcytic hypochromic anemia, nephrotic syndrome, and UTI. Management included basal-bolus insulin regimen, combined antihypertensive therapy, packed red cell transfusions, and supportive treatments. Throughout the hospitalization, improvements were observed in hemoglobin levels and blood pressure, although subjective symptoms such as fatigue and headache remained fluctuating. This case highlights the importance of comprehensive and multidisciplinary management in patients with complex multisystem chronic conditions to prevent complications and improve clinical outcomes.

Flying fish (Hirundichthys oxycephlus) roe filaments, which are often considered as by-products, have high protein content and various essential nutrients, thus potentially increasing the nutritional value of food products. With innovation and in-depth research, this waste can be transformed into products with economic value while supporting the implementation of sustainability principles in the fisheries industry, in this case sauce as a flavoring that has become an important part of the food industry. This study aims to determine the quality of the texture and taste of chili sauce fortified with fly fish (Hirundichthys oxycephlus) roe filament extract and to determine the protein content and water content of chili sauce enriched with fly fish (Hirundichthys oxycephlus) roe filament extract. The methodology used in this study was Complete Random Design (CRD) with variations in filament powder concentration (0%, 0.5%, 1%, and 1.5%) on the sensory characteristics of chili sauce, which include aroma, color, taste, and texture. The results of organoleptic tests showed that the addition of fly fish (Hirundichthys oxycephlus) egg filament extract had a significant positive impact on all sensory parameters tested. The average aroma score increased from 2.88 in the non-enriched treatment to 3.90 at the highest filament powder concentration (1.5%). In addition, the taste score also showed the most striking increase, from 2.80 to 4.33. Analysis of the water content of the chili sauce product was recorded at 79.93% according to (SNI 01-2976-2006), while the protein content reached 10.53%, indicating the potential of this product as an additional source of protein in daily consumption patterns.

Stroke is one of the leading causes of disability and mortality worldwide, with significant neurological and biochemical consequences. This study aimed to examine the effect of a neuroprotective nutritional intervention consisting of protein, phosphatidylcholine, phosphatidylserine, and inulin on glial fibrillary acidic protein (GFAP) levels and National Institutes of Health Stroke Scale (NIHSS) scores in acute ischemic stroke patients. The study employed a quasi-experimental design with a pretest-posttest control group, involving 18 patients divided equally into intervention and control groups. Data were collected at Dr. Kariadi General Hospital Semarang from January to February 2020, measuring serum GFAP levels using ELISA and assessing NIHSS scores before and after a seven-day intervention. The intervention group showed a significant decrease in GFAP levels and a more pronounced improvement in NIHSS scores compared to the control group. These findings suggest that the neuroprotective nutritional intervention may support both biochemical and clinical recovery in acute ischemic stroke patients. Implementing such nutritional strategies could complement standard care and enhance rehabilitation outcomes. Further research with larger sample sizes and longer follow-up is recommended to confirm these results and optimize the intervention protocol.  

Gout is a disease that is often found in the world. Usually gout occurs due to the deposition of monosidium urate crystals in the tissue or due to supersaturation of uric acid in the extracellular fluid. Some factors that cause gout include excessive purine intake. An unhealthy diet and high-protein foods with high purine levels. One of the non-pharmacological actions in reducing uric acid levels is the provision of soursop leaf decoction (Annona Muricata L) intervention. To determine the effectiveness of soursop leaf decoction on reducing uric acid levels in the elderly by administering soursop leaf decoction in Rambung Village, South Binjai District, Binjai City. This study uses a One-group pretest-posttest design research design approach. The sample of this study was 8 respondents. The sampling technique uses total sampling. The collection of research data uses demographic data, a consent sheet to become a respondent (Informed Consent). Data collection is carried out through observations by researchers of respondents and conducting observations. Research with Parametric Test Paired Sample T-test obtained a p Value of (0.000) <α (0.05), so there is a significant effectiveness of giving soursop leaf decoction to reduce uric acid levels in the elderly, and can be used as an alternative to reduce uric acid levels.

Dessert as a dessert, which is part of culinary in various cultures. Dessert is not only a dessert, but also reflects creativity and innovation in the culinary field. This study aims to analyze the comparative level of adding vannamei shrimp (Litopeaneus Vanname) to the cold dessert formulation on sensory properties (color, aroma, texture, and taste) and chemical composition (protein content and fat content). The study was conducted experimentally using a Completely Randomized Design (CRD) with three treatments of adding vannamei shrimp, namely 10% (A1), 20% (A2), and 30% (A3). The results of the organoleptic test showed that treatment A1 (10% shrimp addition) gave the best value on all sensory parameters, with an aroma value of 4.3 (like), taste 4.7 (like), texture 4.2 (like), and color 4.2 (like). Chemical analysis showed that treatment A1 produced a protein content of 4.21% and a fat content of 8.46%. The addition of vannamei shrimp to the cold dessert formulation is an attractive taste innovation for consumers. This study concludes that the addition of vannamei shrimp to cold dessert formulations can be an attractive alternative to improve the quality and nutritional value of products, as well as meet the growing needs of consumers.

Stunting remains one of the major nutritional problems in Indonesia. According to the 2024 Indonesian Health Survey (SKI), the prevalence of stunting in Papua Province reached 16.8%. A child’s nutritional status is strongly influenced by dietary intake, particularly protein, which plays a crucial role in growth. One potential source of animal protein is Indian mackerel (Rastrelliger kanagurta), a type of fish commonly found in Papua. Indian mackerel is rich in protein and omega-3 fatty acids but is highly perishable, limiting its shelf life. To address this issue, the fish is processed into flour. Additionally, green spinach is used as a source of fiber and minerals, although it is also prone to spoilage. The spinach is processed by extracting its juice, which is then incorporated into noodle products. Dried noodles were chosen as a medium for fortification because they are widely consumed across age groups and often used as a substitute for rice.This study aimed to determine the effect of adding Indian mackerel flour and green spinach extract on the chemical properties and sensory acceptance of dried noodles. The research methods included nutritional content analysis and organoleptic testing. The sensory evaluation was conducted by 25 semi-trained panelists who were nutrition science students

This study aimed to evaluate the nutritional value of fish brain-brain products using milkfish surimi (Chanos chanos.Forskal) as the base ingredient, with variations in fillers such as tapioca flour, egg white, and Eucheuma cottonii seaweed.  Three formulations were used: (F1) surimi + tapioca starch, (F2) surimi + egg white, and (F3) surimi + Euchema cottonii seaweed. Proximate analyses were conducted to determine the moisture, protein, fat, ash, and carbohydrate content. The results showed that the addition of various fillers had a significant effect (P>0.05) on the value of protein, carbohydrate and water in the brain. While for fat and ash content, there was no significant effect (P<0.05). The average water content ranged from 66.5% to 72%, with the lowest content in the brain-brain added with tapioca flour. The highest protein content was obtained in the P2 treatment (egg white), which was 18.9%, while the treatment with the addition of tapioca flour showed the lowest protein content of 12.8%. Sensory value using Kruskal waliss treatment that gets a high average value is the aroma, taste, and texture of the addition of egg white fillers, while the texture is with the addition of Euschema cottonii seaweed fillers. Egg white significantly increased the protein content. The best formulation based on nutritional content and panellists' liking value was F2 (Surimi + Egg white). This study shows the potential for the development of milkfish-based processed products that are highly nutritious and functional..

Neurocognitive disorders, particularly dementia, affect various cognitive functions such as memory, attention, language, learning, and problem-solving, with the elderly population being the most impacted. The prevalence of dementia is projected to rise to 131 million cases by 2050, posing significant social and economic implications. This study employed a cross-sectional method to evaluate the role of Apolipoprotein A (APOA) and Apolipoprotein B (APOB) in the diagnosis and prevention of dementia in older adults. The results showed that Apolipoprotein A was not significantly correlated with MMSE scores, indicating no clear relationship between APOA and cognitive function. In contrast, Apolipoprotein B demonstrated a significant negative correlation with MMSE, suggesting that increased APOB levels are associated with cognitive decline. Elevated ApoB, linked to increased LDL and oxidative stress, correlated with reduced cognitive function, whereas ApoA, the main component of HDL, is associated with neuroprotective effects. These findings underscore the importance of monitoring lipid profiles, including ApoA and ApoB, in the prevention and management of dementia in the elderly.    

Industri peternakan memiliki kontribusi penting dalam mendukung perekonomian nasional serta penyediaan protein hewani. Kambing merupakan salah satu komoditas ternak potensial yang banyak dibudidayakan masyarakat pedesaan, termasuk di Desa Besowo, Kecamatan Kepung, Kabupaten Kediri. Namun, keterbatasan sarana, pengetahuan teknis, dan pola pemeliharaan tradisional masih menjadi kendala dalam meningkatkan kinerja peternak kambing. Penelitian ini bertujuan untuk menganalisis pengaruh modal sosial terhadap kinerja peternak kambing. Metode penelitian yang digunakan adalah pendekatan kuantitatif dengan teknik analisis regresi untuk mengukur hubungan antara variabel modal sosial (norma, jaringan, kepercayaan, dan hubungan timbal balik) dengan kinerja peternak. Hasil penelitian menunjukkan bahwa modal sosial peternak kambing di Desa Besowo relatif baik, tercermin dari adanya praktik titip ternak, penggunaan fasilitas bersama, hingga kegiatan kelompok ternak. Kinerja peternak cenderung masih tradisional, dengan pola pemeliharaan dan pemberian pakan bergantung pada kondisi alam serta usaha ternak yang dijalankan sebagai profesi sampingan. Analisis regresi menghasilkan nilai koefisien determinasi (R²) sebesar 53,7%, yang mengindikasikan bahwa modal sosial berpengaruh signifikan terhadap kinerja peternak kambing. Hal ini menegaskan bahwa penguatan modal sosial dapat membantu mengatasi keterbatasan teknis dan sarana prasarana, sekaligus meningkatkan keberlanjutan usaha peternakan kambing.

This study aims to encourage the effect of adding pineapple (Ananas Comosus L. Mer) in the marinating process on the level of tenderness, organoleptic, physical quality and protein content of buffalo meat. The method used is an experiment with a completely randomized plan (CRD), consisting of four treatments, namely: PO (without pineapple), P1 (250 g pineapple), P2 (500 g pineapple) and P3 (750 g pineapple). The results showed that the addition of pineapple significantly affected the quality of buffalo meat. The color of the meat became brighter with increasing pineapple levels while the texture of buffalo meat became more tender due to the bromelain enzyme which breaks down collagen. Organoleptic parameters using the Kruskal Wallis Test showed a significant difference in the level of tenderness, color, texture, aroma and taste in each treatment, although excessive use of pineapple produced a dominant sour taste. The protein content of buffalo meat changed due to the proteolysis process influenced by the bromelain enzyme. This study indicates that marinating buffalo meat using pineapple can improve the quality of buffalo meat physically, organoleptically and nutritionally.

Coronary heart disease (CHD) is one of the leading causes of death worldwide due to impaired blood and oxygen supply to the heart muscle. This study aims to explore the potential of two natural compounds—kaempferol from Moringa oleifera and geranylated chalcone (GTDC) from Artocarpus altilis—as therapeutic candidates for CHD through a molecular docking approach. Medicinal chemistry analysis revealed that kaempferol exhibits significant affinity for the NF-κB protein, forming key hydrogen bonds with residues involved in the inflammatory process of atherosclerosis. Meanwhile, GTDC demonstrates strong binding to the P2Y12 receptor, which plays a crucial role in platelet aggregation, with a docking score lower than that of the natural ligand ADP. Structurally, hydroxyl group positioning and the lipophilic geranyl chain enhance both bioactivity and pharmacokinetic properties. In conclusion, a medicinal chemistry approach involving in silico docking, structure–activity relationship (SAR) analysis, and ligand optimization strategies confirms the potential of kaempferol and GTDC as promising multifunctional therapeutic agents for CHD. Further validation through in vivo studies and clinical testing is required.    

Breakfast is important for school students, especially teenagers because schools are full of activities that require a large amount of energy that can impact concentration. This study aims to determine the relationship between macronutrient intake during breakfast and the concentration of students of SMA Negeri 1 Grogol, Kediri. The design of the study is descriptive analytics with a cross-sectional research design including a total of 88 students. The sampling technique is simple random sampling. Breakfast data collected using food recall and concentration levels used Grid Concentration Test sheets. The data analysis technique used Somers’d. The result showed there is a significant relationship between carbohydrate (p = 0,017; r = 0,219) and protein intake (p = 0,008; r = 0,266) consumed at breakfast and student concentration, the relationship between the two variables was quite weak, but there was no significant relationship between intake of fat consumed at breakfast and student concentration (p = 0,220; r = 0,112). The conclusion of this study is that carbohydrate and protein intake consumed at breakfast is associated with student concentration.