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Hypertension is one of the most common chronic diseases among the elderly and is often accompanied by insomnia. This condition can increase anxiety and reduce quality of life. Progressive Muscle Relaxation (PMR) is an effective non-pharmacological therapy to lower blood pressure and improve sleep quality. This paper describes nursing care for elderly patients with hypertension and insomnia through PMR application at RSUD Embung Fatimah Batam City in 2025. A case study approach was used through the nursing process, including assessment, nursing diagnosis, intervention, implementation, and evaluation. The main nursing diagnosis was sleep pattern disturbance related to physical discomfort and anxiety. Interventions included education and PMR exercises for six consecutive days. Results showed blood pressure decreased from 180/100 mmHg to 130/80 mmHg, sleep quality improved from difficulty sleeping to 6–7 hours per night, and anxiety levels reduced. Progressive muscle relaxation therapy proved effective as an independent nursing intervention to reduce blood pressure and improve sleep quality in elderly patients with hypertension and insomnia. Nurses should use this therapy as a routine non-pharmacological intervention in gerontological nursing practice.

Background: Dysmenorrhea is commonly experienced by female adolescents and may interfere with daily activities and academic concentration. Non-pharmacological interventions such as listening to the murottal of Surah Ar-Rahman and the use of lemon aromatherapy have been reported to provide relaxation and analgesic effects. However, evidence regarding the effectiveness of their combined use remains limited. Therefore, this study aimed to evaluate the effect of combined therapy using Murottal Surah Ar-Rahman and lemon aromatherapy on dysmenorrhea pain levels among female adolescents at SMA Negeri 10 Semarang. Method: This study was conducted at SMA Negeri 10 Semarang using a Quasi-Experimental design with a Pretest–Posttest Group approach. The population consisted of 188 students who met the inclusion criteria. The sample size was determined using the Slovin formula, resulting in 40 respondents selected through purposive sampling. A normality test was performed prior to analysis, and the bivariate analysis utilized the Wilcoxon Signed Rank Test. Result: The Wilcoxon Signed Rank Test showed a p-value of 0.000 (p < 0.05), indicating a significant difference between pain levels before and after the intervention. These findings demonstrate that the combination of Murottal Surah Ar-Rahman and lemon aromatherapy is effective in reducing dysmenorrhea pain among female adolescents at SMA Negeri 10 Semarang. Conclusion: The combined therapy of Murottal Surah Ar-Rahman and lemon aromatherapy is effective in reducing dysmenorrhea pain levels among female adolescents.  

Type 2 Diabetes Mellitus is a chronic disease with an increasing prevalence and requires long-term therapy, resulting in a significant economic burden on healthcare systems. This study aimed to analyze the cost-effectiveness of antidiabetic drug use among Type 2 Diabetes Mellitus patients in the inpatient unit of Dr. R. Hardjanto Hospital, Balikpapan. This research employed an observational analytic design with a cross-sectional approach and retrospective data collection from medical records and administrative data for the period January–December 2023. A total of 54 patients who met the inclusion criteria were included as study samples. Therapeutic effectiveness was assessed based on the achievement of random blood glucose levels ≤200 mg/dL, while the analysis focused on direct medical costs. Cost-effectiveness was evaluated using the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). The results showed that Metformin–Apidra therapy achieved higher clinical effectiveness (92%) with an average cost of IDR 3,636,721 and an ACER value of IDR 39,529. Meanwhile, Glimepiride–Sansulin therapy demonstrated 81% effectiveness with a lower average cost of IDR 2,519,259 and an ACER value of IDR 31,101. The ICER value of IDR 10,158 indicates the additional cost required to achieve a 1% increase in effectiveness. In conclusion, Metformin–Apidra therapy is more clinically effective, whereas Glimepiride–Sansulin therapy is more cost-effective economically.

The postpartum period following Sectio Caesarea is often accompanied by acute pain due to surgical incisions, which may interfere with mobilization, breastfeeding, and maternal recovery. Effective pain management is essential to prevent further complications and enhance maternal comfort. In addition to pharmacological therapy, non-pharmacological interventions such as Benson relaxation therapy can be implemented. This study aimed to evaluate the application of Benson relaxation therapy in reducing acute pain among postpartum Sectio Caesarea mothers.This study employed a case study design involving four postpartum Sectio Caesarea patients (Ny. R, Ny. A, Ny. Y, and Ny. S) treated in the Ayyub Ward of RS Roemani Muhammadiyah Semarang in 2026. Data were collected through comprehensive nursing assessments, pain intensity measurement using a numeric rating scale, observation of mobilization ability, and evaluation before and after intervention.The results showed that after regular implementation of Benson relaxation therapy, all patients experienced a gradual decrease in pain intensity (from scale 4–7 to ≤3), improved comfort, better breathing control, and increased ability to perform early mobilization. Consistent nursing education, therapeutic guidance, and family involvement supported the effectiveness of the intervention. It can be concluded that Benson relaxation therapy is an effective, safe, and easily applicable nursing intervention for reducing acute pain in postpartum Sectio Caesarea patients.

Ovarian cancer patients undergoing chemotherapy often experience stress due to the side effects of therapy and emotional distress. Religiosity provides a source of inner peace and acceptance of the disease, while coping strategies play a role in how patients deal with the stress they experience. Aims: to determine the relationship between religiosity and coping strategies with stress levels among ovarian cancer patients undergoing chemotherapy. Method: The study employed a descriptive correlational design with a cross-sectional approach. The population included all ovarian cancer patients undergoing chemotherapy totaling 47 patients. The sampling technique used was Total Sampling. Bivariate analysis was performed using the Spearman Rank Correlation test. This research was conducted in the Darussalam and Ma’wa Buildings of Sultan Agung Islamic Hospital Semarang. Result: Based on the Spearman Rank Correlation test on religiosity, the value of r = -0.857 with p-value = 0.000 (p < 0,05) was obtained. This shows a very strong and significant relationshsip between religiosity and stress levels in ovarian cancer patients undergoing chemotherapy. Coping strategies obtained a value of r = -0.810 with p-value = 0.000 (p < 0.05), indicating a very strong and significant relationship between coping strategies and stress levels in ovarian cancer patients undergoing chemotherapy. Conclusion: There is a significant relationship between religiosity and coping strategies with stress levels among ovarian cancer patients undergoing chemotherapy.

Canker sores are an inflammation of the oral tissues, generally caused by bacterial and fungal infections. They can cause pain and discomfort and reduce the sufferer's quality of life. Treatment for canker sores has been dominated by synthetic drugs, but they are less popular among the public, especially children, due to discomfort and concerns about side effects. Therefore, we need safer and more easily accepted alternative treatments based on culturally derived materials. This study is to investigate the potential of pineapple and melon stems formulated in the form of gummy candy nanosimplicia as a complementary therapy in the treatment of canker sores. The research method was carried out through a literature review by collecting scientific articles from the PubMed, ScienceDirect, and Google Scholar databases, then analyzed using VOSviewer software to map emerging research trends and potential. The analysis results indicate that there are approximately 600 articles discussing the active metabolite content in pineapple and melon stems that have antibacterial and antifungal activity, as well as the development of innovative preparations such as gummy candy as a delivery medium for bioactive compounds. The implications of this study indicate that the combination of pineapple stem and melon nanosimplisia has the potential to be developed as a safe, attractive, and effective natural herbal candy product for the prevention and treatment of mouth ulcers, especially in children.

Knee osteoarthritis is a degenerative joint disease that commonly affects older adults and causes pain and functional limitations. Age, obesity, a sedentary lifestyle, and comorbidities influence disease severity and response to medical rehabilitation. This study aimed to describe the characteristics of geriatric patients with knee osteoarthritis receiving medical rehabilitation therapy at Ibnu Sina Hospital, Makassar, in 2024. This was a quantitative descriptive study with a cross-sectional design. The results showed that most geriatric patients with knee osteoarthritis undergoing medical rehabilitation at Ibnu Sina Hospital in 2024 were in the 60–70 year age group and were predominantly female. The majority of patients had a body mass index in the overweight to obese category. Most patients had no history of smoking but had one or more comorbidities, particularly hypertension and diabetes mellitus. Medical rehabilitation therapy was generally provided as a combination of several modalities. In conclusion, geriatric patients with knee osteoarthritis receiving medical rehabilitation were predominantly aged 60–70 years, female, overweight or obese, and had comorbidities. These findings highlight the importance of individualized and multidisciplinary rehabilitation approaches based on patient characteristics

Background: Ovarian cancer is one of the most lethal cancers affecting women and requires long-term treatment such as chemotherapy. The chemotherapy process often causes various physical and psychological side effects that may reduce patients’ motivation to undergo treatment consistently. Family support plays an essential role in enhancing motivation, treatment adherence, and patients’ readiness to face therapy. Aims: This study aims to determine the influence of family support on the motivation of ovarian cancer patients undergoing chemotherapy. Methods: This research was conducted at the Darussalam and Ma’wa Buildings of RSI Sultan Agung Semarang. The study used a descriptive correlational design with a cross-sectional approach. A total population of 47 ovarian cancer patients undergoing chemotherapy from January to April was obtained. The sampling technique used was Total Sampling. The bivariate analysis was performed using the Spearman Rank Correlation test. Results: The analysis showed that most respondents had low levels of family support (44.7%) and moderate levels of motivation (36.2%). The Spearman test indicated a correlation value of r = 0.678 with a p-value = 0.000 (p < 0.05), indicating a strong and significant relationship between family support and patient motivation in undergoing chemotherapy. Conclusion: There is a significant influence between family support and the motivation of ovarian cancer patients undergoing chemotherapy.

Background: Fatigue is a common complaint experienced by patients with pulmonary tuberculosis during the course of treatment and may negatively affect physical functioning, psychological well-being, and overall quality of life. Inflammatory processes, side effects of anti-tuberculosis medications, and psychological factors are believed to contribute to the development of fatigue. Therefore, non-pharmacological interventions are needed as complementary therapies to help reduce fatigue levels in patients with pulmonary tuberculosis. Objective: This study aimed to determine the effect of a combination of aromatherapy and Benson relaxation therapy on fatigue levels in patients with pulmonary tuberculosis. Methods: This study employed a quasi-experimental design with a one-group pre-test and post-test approach. The sample consisted of 18 respondents selected using accidental sampling. Fatigue levels were measured using the Fatigue Assessment Scale (FAS). Data were analyzed using the Wilcoxon test because the data were not normally distributed. Results: The results showed a reduction in fatigue levels among patients with pulmonary tuberculosis after receiving the combination of aromatherapy and Benson relaxation therapy. Statistical analysis indicated a significant difference in fatigue levels before and after the intervention, with a p-value of 0.000 (p < 0.05). Conclusion:The combination of aromatherapy and Benson relaxation therapy had a significant effect on reducing fatigue levels in patients with pulmonary tuberculosis. This intervention may be recommended as a complementary therapy in nursing care for patients with pulmonary tuberculosis.

As HIV transitions into a manageable chronic condition, optimizing lifestyle behaviors is key to achieving long-term health outcomes. This study aims to explore lifestyle behaviors in people with HIV (ODHIV) who participate in peer support groups as well as identify socioeconomic and clinical predictors of healthy lifestyle engagement. The research design was a cross-cutting analysis involving 250 ODHIV registered in a community support group. Lifestyle behavior was measured using  a modified Health-Promoting Lifestyle Profile II (HPLP-II) instrument. Multivariate logistic regression analysis was used to determine independent predictors, with Nagelkerke R² and Hosmer–Lemeshow tests  to assess model suitability. The results showed that 56.2% of respondents had a healthy lifestyle. Factors of higher education (OR = 2.77; p = 0.006), older age (OR = 2.32; p = 0.015), employment status (OR = 2.00; p = 0.029), and longer duration of ART therapy (OR = 1.17 per year; p = 0.003) were significant predictors. The model explains 32% of lifestyle variations, with ART compliance and substance control as the strongest behavioral domains. These findings confirm the role of peer support groups as a behavioural reinforcement environment, but socioeconomic disparities remain influential. The integration of theory-based lifestyle interventions into community-based HIV services is necessary to optimize chronic disease outcomes.

Anxiety is a prevalent mental health issue that affects psychological well-being and daily functioning. In Muslim communities, Islamic spiritual practices are commonly used as coping strategies, yet empirical evidence regarding their effectiveness in reducing anxiety has not been systematically consolidated. This study aimed to synthesize scientific evidence on Islamic spiritual interventions for anxiety reduction. A systematic literature review was conducted in accordance with PRISMA guidelines by searching Google Scholar, PubMed, ScienceDirect, and Elsevier. Observational studies published between 2019 and 2026 that examined Islamic spiritual interventions and reported anxiety outcomes were included and analyzed narratively. Ten eligible articles were identified. The review demonstrates that Islamic spiritual interventions, such as dhikr, prayer, Qur’an recitation, and Islamic spiritual counseling, are consistently associated with reductions in anxiety across diverse populations and settings. Although the magnitude of effects varied, the overall findings indicate a beneficial role of Islamic spiritual practices in anxiety management. These results suggest that Islamic spiritual interventions may be integrated as complementary approaches within mental health and public health services for Muslim populations, while further methodologically rigorous studies are required to strengthen the evidence base.

Type 2 diabetes mellitus (T2DM) requires comprehensive management beyond pharmacological therapy, including sustainable lifestyle-based interventions. Yoga asana, as a form of mind–body intervention, integrates physical postures, breathing techniques, and relaxation practices that may influence metabolic and psychosocial pathways relevant to T2DM. This article aimed to synthesize evidence regarding the physiological mechanisms, clinical effectiveness, and healthcare implementation context of yoga asana in T2DM management, as well as to discuss the role of physicians in integrating this complementary therapy, including within health tourism settings. A narrative literature review was conducted using scientific databases, focusing on publications addressing yoga asana, mind–body interventions, T2DM, and clinical integration. The findings indicate that yoga asana is associated with improved glycemic control, including reductions in fasting blood glucose, postprandial glucose, and HbA1c, alongside modulation of stress-related physiological parameters and psychological well-being. Beyond clinical outcomes, yoga asana shows potential for community-based and health tourism contexts as part of chronic disease lifestyle management. Physicians play a central role in clinical assessment, patient education, coordination with complementary therapy providers, and ongoing monitoring to ensure safe, evidence-based integration. Although current evidence suggests consistent beneficial trends, methodological heterogeneity highlights the need for more standardized and mechanistic research.  

Prolactinoma is the most common functional pituitary adenoma, particularly in adolescent females, and is typically characterized by amenorrhea and galactorrhea resulting from hyperprolactinemia. However, in certain cases, serum prolactin levels may appear normal due to the hook effect, an immunoassay measurement error caused by extremely high prolactin concentrations that interfere with antigen–antibody complex formation. We report the case of a 17-year-old female presenting with a five-month history of galactorrhea, accompanied by breast pain, headache, and primary amenorrhea. Brain MRI revealed a pituitary mass measuring 1.4 × 0.8 × 0.5 cm, suspicious for prolactinoma, while serum prolactin was within the normal range (17.33 ng/mL). The discrepancy between clinical manifestations, lesion size, and laboratory findings raised suspicion of the hook effect. The patient was treated with dopamine agonists, bromocriptine and cabergoline, and referred for multidisciplinary management involving endocrinology, neurosurgery, and obstetrics–gynecology. Despite the absence of prolactin dilution testing, MRI findings supported the diagnosis of prolactinoma, and the patient demonstrated a favorable clinical response to therapy. This case highlights the importance of recognizing laboratory variability, performing comprehensive hormonal evaluation, and considering prolactin dilution assays when clinical and laboratory findings are discordant, particularly in adolescent patients with suggestive symptoms.

Cupping therapy is a traditional therapeutic method that has long been recognized in Thibbun Nabawi and continues to be used as a complementary therapy in contemporary healthcare. Along with the development of scientific research, cupping therapy has increasingly been examined from a medical perspective, highlighting the need for an integrative review that combines medical evidence and Islamic perspectives. This study aims to examine cupping therapy from both medical and Islamic perspectives based on a literature review. This study employed a qualitative approach using a literature review design. Data were collected from national and international scientific articles published between 2019 and 2025 through indexed databases, including Scopus, PubMed, Google Scholar, and Garuda. The review was complemented by Islamic sources such as the Qur’an, Hadith, and scholarly works on Thibbun Nabawi. Data were analyzed using descriptive qualitative analysis by categorizing findings into medical benefits and religious foundations of cupping therapy. The literature review indicates that cupping therapy has potential medical benefits, including pain reduction, blood pressure control, and improvement of metabolic parameters such as blood glucose and cholesterol levels. From an Islamic perspective, cupping therapy is regarded as part of Thibbun Nabawi and is recommended as a form of human effort to maintain health, while ultimate healing is believed to come from Allah SWT. Cupping therapy demonstrates strong relevance from both medical and religious perspectives. Integrating cupping therapy with modern medical principles and Islamic values may provide a holistic health approach that supports promotive, preventive, and curative healthcare services within complementary medicine.

Tuberculosis (TB) is a chronic, infectious disease caused by the bacterium Mycobacterium tuberculosis. Primary infection occurs upon first exposure to bacillary tuberculosis, which often occurs in childhood, hence the term "childhood TB." The diagnosis of TB is usually made through a history that includes complaints of persistent cough, weight loss, fever, and weakness, along with a chest X-ray that shows typical abnormalities of pulmonary TB. In this case, a 21-month-old girl presented with a worsening, persistent cough accompanied by weight loss. The patient's mother reported that her child frequently had fevers and appeared weak. After a physical examination and supporting tests, the patient was diagnosed with TB. The patient was given pharmacological therapy in the form of anti-tuberculosis drugs (OAT), and parents were educated about the importance of adherence to TB treatment as prescribed by the doctor. Furthermore, providing a balanced, nutritious diet is recommended to support successful treatment.

This study aims to determine the relationship between low self-acceptance and the level of self-efficacy in prisoners, as well as its implications on social life after prisoners are released from punishment. The systematic review method  is used with the SPIDER approach to formulate research questions and select relevant articles. The search was conducted through the Publish or Perish, Google Scholar, and Scopus databases with keywords related to self-acceptance, self-efficacy, and inmates. Of the 100 articles identified, 13 studies met the inclusion criteria. The results of the review showed that low self-acceptance was consistently negatively associated with self-efficacy in prisoners, which had an impact on low self-confidence to face social challenges, reintegration, and overcome societal stigma. Psychological factors such as guilt, anxiety, depression, and insecurity can exacerbate low self-acceptance, especially in female inmates. In addition, social support from family, the environment, and psychological interventions have been shown to play an important role in improving self-acceptance and self-efficacy. Interventions such as expressive art therapy, psychoeducation, counseling, skills training, and religious activities have shown effectiveness in improving psychological well-being. These findings underscore the importance of systematic efforts to improve self-acceptance and self-efficacy to support the successful social reintegration of prisoners.

Viral hepatitis is a systemic disease that primarily affects the liver and is characterized by a necroinflammatory process that plays a significant role in clinical and laboratory manifestations. Chronic hepatitis is defined as liver inflammation lasting more than six months, with persistent elevations in aminotransferases and characteristic histological features, and carries a risk of progression to cirrhosis and hepatocellular carcinoma. Chronic hepatitis C virus infection occurs due to an ineffective host immune response to the virus, allowing the infection to persist. The innate immune system, particularly type I interferon, plays a key role in the initial defense mechanisms against viral replication. Various antiviral therapies, such as interferon, nucleoside analogs, and nucleotide analogs, are currently available, which have been shown to reduce viral load and inhibit disease progression. Appropriate therapy is expected to prevent long-term complications in patients with chronic hepatitis.

Health anxiety is a psychological condition characterized by excessive and persistent worry about having or developing a serious illness despite the absence of objective medical evidence. Among adolescents, health anxiety often manifests through recurrent somatic complaints that lead to repeated visits to primary health care services. This study aims to describe the dynamics of health anxiety in an adolescent and to examine the early response to a cognitive behavioral therapy (CBT) intervention delivered in a primary health care setting. This research employed a clinical case study design with a descriptive qualitative approach supported by quantitative assessment data. The participant was an adolescent presenting with recurrent physical complaints without identifiable medical pathology. Data were collected through clinical interviews, behavioral observation, and standardized psychological instruments, namely the Short Health Anxiety Inventory (HAI-18) and the Patient Health Questionnaire-15 (PHQ-15). Quantitative analysis focused on pre- and post-intervention score comparison, calculation of change scores, and the Reliable Change Index to evaluate individual-level change. The findings revealed a high level of health anxiety accompanied by low severity of somatic symptoms, indicating that psychological distress was primarily driven by maladaptive cognitive interpretations rather than physical pathology. Following the CBT intervention, a reduction in health anxiety scores was observed, reflecting an early improvement, although the change did not reach statistical significance based on the Reliable Change Index. These results suggest that CBT may produce meaningful early changes in health anxiety when implemented in primary health care settings, even with brief intervention formats. The study highlights the importance of early psychological assessment and intervention for adolescents with recurrent somatic complaints and supports the integration of mental health services within primary health care. However, findings should be interpreted cautiously due to the single-case design, and further research with larger samples and longitudinal follow-up is recommended

Non-hemorrhagic stroke occurs due to blockage of blood flow to the brain by a thrombus or embolus. The blockage results in focal neurological disorders that affect the musculoskeletal system, namely weakness in the extremities, which gives rise to nursing problems of impaired physical mobility. To overcome the problem of impaired physical mobility, rubber ball grip exercises (ball squeezing) are given. These exercises have been shown to increase muscle strength, prevent joint stiffness, and improve blood circulation. This scientific paper was conducted to determine the description of nursing care for non-hemorrhagic stroke patients with nursing problems of impaired physical mobility. During the meeting, the nurse provided rubber ball grip exercises (ball squeezing) for 10-15 minutes for 3 times in 24 hours. Evaluation of these actions showed that the patient who initially experienced weakness in the upper extremities with muscle strength 2-3 and after being given rubber ball grip exercises (ball squeezing), the problem of impaired physical mobility was resolved, as evidenced by the patient being able to perform therapy, the extremities feeling slightly lighter, and muscle strength 4. Therefore, it is recommended that non-hemorrhagic stroke patients be given rubber ball grip exercises (ball squeezing) to overcome impaired physical mobility.

Hypertension is a public health problem that requires educational approaches and nonpharmacological interventions. This community service activity aimed to improve knowledge and support community-based hypertension management through health education, hypertension exercise, and cucumber juice therapy in RT 03 RW 08 Lenteng Agung, South Jakarta. The activity was conducted in three stages. The preparation stage included site selection, door-to-door screening of individuals with hypertension, which identified 32 hypertensive residents, obtaining informed consent, and preparing the instruments. The implementation stage consisted of hypertension education with pre-test and post-test knowledge assessments, as well as demonstrations of hypertension exercise and cucumber juice preparation involving 29 participants. Participants were encouraged to perform the exercise and consume cucumber juice regularly for seven days at home. The evaluation stage assessed changes in blood pressure after the intervention. The results showed improved knowledge and reduced blood pressure in most participants. This activity was effective in supporting hypertension management in the community.