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Osteoarthritis is a progressive degenerative joint disease characterized by cartilage damage, chronic inflammation, and functional limitation. Current treatments mainly focus on symptom relief and mechanical correction, with limited ability to restore the biological environment of the joint. Recently, mesenchymal stem cell derived secretome has emerged as a promising cell free regenerative therapy with anti-inflammatory and tissue-repair potential. This study aimed to systematically review the role of mesenchymal stem cell secretome in osteoarthritis management, both as an intra-articular therapy and as an adjuvant following surgical intervention. A literature review was conducted on relevant preclinical and early clinical studies published over the past decade. The selected articles were analyzed to evaluate therapeutic mechanisms and clinical implications. The findings indicate that intra articular administration of secretome reduces inflammatory mediators, suppresses catabolic enzyme activity, and improves cartilage integrity in various osteoarthritis models. Early clinical evidence also suggests improvements in pain and joint function, especially in patients with mild to moderate disease. Furthermore, secretome shows potential as an adjuvant therapy after surgery by supporting biological recovery of joint tissues. Overall, mesenchymal stem cell secretome represents a promising component of a multimodal strategy for osteoarthritis management, although further clinical trials are required to confirm its efficacy and safety.

PT. XYZ faces administrative challenges in implementing the Contractor Safety Management System (CSMS), which has been managed manually from risk assessment and pre-qualification to contractor selection resulting in validation delays, document duplication, and limited monitoring. This study aims to: (1) identify the constraints of the manual CSMS at PT. XYZ; (2) design an electronic-CSMS (e-CSMS) application tailored to internal user needs; (3) analyze the contribution of e-CSMS to document management effectiveness; and (4) evaluate the design's alignment with the Occupational Health and Safety Management System (SMK3) principles as per Government Regulation No. 50 of 2012. The method employed is Research and Development (preliminary stage) using a descriptive qualitative approach through interviews, observations, and document studies. The design results include: (i) a unified digital form integrating procurement data input, risk assessment entries (severity and probability), and document upload and assessment for pre-qualification/selection in a single workflow; (ii) a monitoring dashboard with filtering and export functions; and (iii) internal access settings within PT. XYZ's HSSE portal. Functionally, this design addresses the main bottlenecks of the manual process by creating a more concise, structured, and documented verification workflow, thereby making document management more efficient and traceable. In terms of compliance, e-CSMS supports the implementation of SMK3 elements in the administrative domain of policy establishment, planning, and execution of OHS plans through consistent recording and verification mechanisms. Development recommendations include expansion to field implementation phases, automation of risk-level calculations, and an option for preliminary data entry by contractors with final verification remaining with the internal team.

Nephrotic syndrome (NS) is a kidney disorder characterized by massive proteinuria, hypoalbuminemia, edema, and hypercholesterolemia, most commonly occurring in children. This disease can be caused by various conditions, such as minimal change disease, FSGS, or lupus nephritis. This case report discusses a 16-year-old boy who experienced nephrotic syndrome with symptoms of swelling throughout his body, accompanied by decreased appetite and a productive cough. The patient presented with complaints of swelling throughout his body that began 7 days after hospitalization and was accompanied by coughing and shortness of breath. A physical examination revealed massive edema, abdominal hypertympany, and shifting dullness. Laboratory tests revealed proteinuria, hypoalbuminemia, and decreased serum albumin. Other supporting tests confirmed nephrotic syndrome. The patient received medication therapy including diuretics, corticosteroids in the form of methylprednisolone, and albumin. Nephrotic syndrome in children can develop gradually and requires management that includes steroids, diuretics, and close monitoring of kidney function and electrolytes. Early detection and appropriate treatment can help improve the patient's prognosis.

Hemangioma is the most common benign vascular tumor in infancy and is generally characterized by a proliferative phase followed by spontaneous involution. Although most cases resolve without intervention, treatment is required when hemangiomas cause functional impairment, ulceration, or life-threatening complications. Lingual hemangioma is a rare presentation and may result in significant feeding difficulties and airway compromise, requiring prompt and multidisciplinary management. This study aims to report the comprehensive management of a refractory lingual hemangioma in an infant, emphasizing diagnostic evaluation, therapeutic strategy, and nutritional support. A six-month-old female infant presented with a lingual hemangioma associated with progressive feeding difficulties. Prior to initiating therapy, a thorough diagnostic workup was performed, including echocardiography to assess cardiac function, magnetic resonance imaging (MRI) to evaluate lesion extent, and computed tomography angiography (CT-angiography) to delineate vascular anatomy. The patient initially received oral propranolol as first-line therapy; however, due to an inadequate response, combination chemotherapy with Bleomycin–Vincristine (BV) was initiated. To minimize the risk of toxicity, a 50% dose reduction was applied. Clinical evaluation demonstrated a favorable therapeutic response, with a reduction in lesion size and improvement in feeding ability after 10 weeks of treatment. No severe adverse effects were observed during the treatment period. To ensure adequate nutritional intake and support growth, enteral nutrition via a nasogastric tube (NGT) was provided throughout the course of therapy. This case highlights the importance of comprehensive diagnostic assessment, individualized treatment planning, and close monitoring in refractory hemangioma. In addition, optimal nutritional support plays a crucial role in overall patient outcomes. A multidisciplinary approach is essential for the successful management of complex infantile hemangiomas with functional complications.

This study examines the role of the General Affairs (GA) Division in ensuring the effectiveness of administrative processes and facility management at PT. Panorama Indah Permai (Saloka Theme Park). The research was conducted during an internship program from September to December 2025, during which the researcher was directly involved in daily operational activities. Using a descriptive qualitative method, data were obtained through direct observation, administrative document analysis, and informal interviews with GA personnel. The results show that the GA Division functions as a critical support unit responsible for logistics management, documentation control, meeting room preparation, and operational vehicle administration. Several challenges were identified, including inconsistencies in documentation, high workload during peak operations, and limited digital integration. Despite these challenges, the GA Division plays a central role in coordinating with other departments to maintain workflow continuity. This study reinforces the relevance of operations management, office administration, facility management, and organizational communication theories in practical workplace settings. The findings imply that improving digital administrative systems, enhancing coordination mechanisms, and standardizing procedures could significantly strengthen GA performance and overall organizational efficiency.

This study aims to analyze the effectiveness of the internal control system in the Personnel Division of PT Sendang Derma Pesona in supporting effective, efficient, and well-governed human resource management. The background of this research is based on the importance of internal control systems in preventing administrative errors, reducing the risk of fraud, and ensuring compliance with labor regulations, particularly in personnel and payroll functions. This study employs a descriptive qualitative approach using an operational audit method. Data were collected through questionnaires, interviews, and document observation covering recruitment procedures, personnel data management, employee transfers, authorization processes, as well as payroll and bank reconciliation procedures. The results indicate that, in general, the internal control system in the Personnel Division has been implemented adequately, as reflected by complete personnel documentation and multi-level authorization in decision-making processes. However, several weaknesses were identified, including the lack of proper segregation of duties between payroll preparation and salary payment, the absence of regular bank reconciliation, and the continued use of manual personnel archive management. These weaknesses indicate that the internal control system still needs to be strengthened to minimize the risk of errors and improve the efficiency of personnel administration. The findings of this study are expected to provide practical implications for management in improving internal control policies and procedures to support better corporate governance and sustainable organizational performance.

Administration is an activity that must be managed effectively to support public service quality, and one of the main keys to achieving a good administrative system is the utilization of information technology, which is currently developing rapidly. Administrative activities at the Wendewa Barat village hall are still carried out using conventional and ineffective methods, particularly in population data recording, which relies on manual bookkeeping. This approach is time-consuming, labor-intensive, prone to errors, and incurs higher operational costs. Therefore, an integrated system is needed to manage administrative activities more efficiently, accurately, and systematically. This research aims to develop a web-based population administration system to improve administrative performance at the Wendewa Barat village office. The system development employs the waterfall method, which consists of several stages, including requirements analysis, system design, implementation, system testing, and maintenance. The system is built using the PHP programming language with the CodeIgniter framework and utilizes a MySQL database for data management. Additionally, jQuery is applied in several system functions to enhance system interactivity, effectiveness, and user interface attractiveness.

The Ciliwung River Basin is a strategic watershed with significant ecological, social, and economic functions, yet it is increasingly threatened by land use change, rapid urbanization, and water pollution, particularly in the Jakarta metropolitan area. This study aims to assess the water quality condition of the Ciliwung River based on real time monitoring data from the ONLIMO system and to examine spatial and temporal variations in water quality status along the middle and downstream segments. A descriptive quantitative approach was applied using secondary data obtained from three ONLIMO monitoring stations, namely Masjid Istiqlal, Pintu Air Manggarai, and Kelapa Dua Srengseng Sawah, during the period of 6–12 May 2025. The analyzed parameters included temperature, dissolved oxygen, Biochemical Oxygen Demand, nitrate, ammonia, and other relevant physicochemical indicators. The results indicate that the water quality of the Ciliwung River generally falls within lightly to moderately polluted categories, with higher pollution levels observed in the middle segment of the river. Critical parameters influencing pollution status include Biochemical Oxygen Demand, nitrate, ammonia, and consistently low dissolved oxygen levels. These findings demonstrate that pollution in the Ciliwung River is persistent and cumulative, highlighting the urgency of integrated watershed management, strengthening real time water quality monitoring, and enhancing cross sector collaboration to support effective pollution control and sustainable river restoration.

Academic productivity is a vital indicator of student success in higher education, but it is often hampered by the complexity of tasks, transitions in the learning environment, and digital distractions that trigger procrastination. This phenomenon demands a high degree of adaptability so that students do not become trapped in physical and mental exhaustion due to unmanaged workloads. Therefore, this study aims to analyze in depth the causal relationship between time management skills and academic productivity, as well as investigate their role in mitigating academic stress levels in students. The research method applied is a literature review with a qualitative-descriptive approach. The research data was sourced from secondary data in the form of 21 reputable scientific articles (national and international journals) published between 2020 and 2025. The data analysis process was carried out through the stages of data reduction, synthesis of findings, and narrative conclusion drawing to systematically map the relationship between variables. The results and discussion of the study show that time management has a significant positive correlation with improved learning achievement. Specific indicators such as daily schedule planning, priority setting, and self-regulation have been empirically proven to increase task completion efficiency and Grade Point Average (GPA) achievement. Conversely, poor time management was identified as a major predictor of cognitive overload and exhaustion, especially among students with dense curricula such as engineering majors. This study concludes that mastery of time management is not merely a scheduling tool, but a fundamental cognitive strategy that functions as a coping mechanism to maintain mental health and achieve an optimal study-life balance.

Background: Zinc Oxide Eugenol (ZOE) is the most widely used root canal filling material in primary teeth. Its sedative effect on the pulp and its ability to effectively seal the root canal contribute to the success of pulpectomy procedures. One of the main advantages of ZOE is its slow resorption rate, which allows it to maintain its integrity over time while the primary tooth remains functional. Purpose: ZOE is used to treat reversible pulpitis. Case: An 8-year-old boy came to Soelastri Dental and Oral Hospital complaining of a cavity in his lower left molar that was sensitive to cold. Case Management: The results of clinical and radiographic examinations indicated that the treatment performed in this case was a pulpotomy using ZOE material and a final restoration with SSC. Conclusion: The pulpotomy treatment was evaluated successfully, and the tooth was restored with a stainless steel crown.

The background of this research is based on the enormous potential of zakat, infaq, shadaqah, and waqf (ZISWAF) as Islamic social finance instruments which, if managed optimally and sustainably, can play a significant role in reducing poverty and promoting comprehensive economic independence among communities amid the ongoing challenges of social inequality. The purpose of this study is to explain the strategic function of ZISWAF in strengthening the community’s economy while emphasizing the urgency of professional, transparent, and targeted management for the improvement of public welfare at large. The research method used was library research, evaluating various literature sources such as books, scientific journals, and relevant previous research reports. The collected data was then analyzed using a qualitative descriptive approach to provide an in-depth understanding of the mechanism of economic empowerment through ZISWAF. Research findings show that ZISWAF plays a crucial role in improving economic welfare through a paradigm shift from consumptive assistance to productive assistance programs. Management oriented towards sustainability and transparency has proven effective in promoting economic ind ependence among low-income communities and significantly reducing poverty rates. The implication of this study confirm that strengthening regulations, digitizing management, and improving public literacy regarding ZISWAF are essential. Management institutions must continue to improve their accountability in order to increase public trust, so that ZISWAF can become a key development in the future.

Postoperative pain is a common clinical condition experienced by patients after surgical procedures and may hinder the recovery process if not properly managed. In addition to pharmacological therapy, safe and effective non-pharmacological interventions are needed, one of which is early mobilization. This study aimed to analyze the effect of early mobilization on pain reduction in postoperative surgical patients. A scoping review method was conducted based on the Arksey and O’Malley framework. Literature searches were performed using ScienceDirect, PubMed, and Google Scholar databases with a PICO strategy, including articles published within the last five years. From a total of 167,948 identified articles, 10 studies met the inclusion criteria and were included in the analysis. The results showed that early mobilization performed gradually and according to patients’ clinical conditions had a significant effect on reducing postoperative pain intensity. In addition, early mobilization was associated with improved comfort, enhanced functional recovery, and faster postoperative rehabilitation without increasing the risk of complications. Although variations were found in the timing and type of mobilization across studies, overall evidence supports that early mobilization is safe and effective. In conclusion, early mobilization can be recommended as an evidence-based nursing intervention for postoperative pain management.

Curriculum management is a strategic component of Islamic education because it plays an important role in achieving educational objectives and internalizing Islamic values within the learning process. Nevertheless, in practice, many schools continue to face managerial challenges in implementing the curriculum effectively. This study aims to evaluate curriculum management at MTs Persis 23 Cirengit based on the core functions of Islamic Educational Management, namely Planning, Organizing, Actuating, and Controlling (POAC). The research employed a qualitative approach using a case study design. Data were collected through in-depth interviews, direct observation, and document analysis, and were analyzed using an interactive analysis model. The findings reveal that the POAC functions have been formally applied but have not yet operated as an integrated managerial cycle oriented toward continuous quality improvement. Curriculum planning remains largely procedural, organizing is not sufficiently participatory, implementation depends heavily on individual teacher capacity, and supervision is mostly administrative with limited follow-up actions.

Educator certificates are official documents that play a crucial role for teachers, as they serve as legal proof of professional competence and are required for various administrative purposes, such as professional allowance applications, promotion, transfer, and institutional accreditation. Along with the increasing number of educators in Indonesia, the volume of educator certificate data managed by educational institutions has also grown significantly. However, certificate management is still largely conducted in a conventional manner, functioning merely as digital or physical archives without an effective search mechanism, resulting in inefficiencies and difficulties in retrieving relevant documents. Therefore, an information retrieval approach is needed to support fast and accurate document searching. This study aims to analyze and implement an information retrieval system for educator certificates using the Cosine Similarity method. The research data consist of educator certificate documents, including professional educator certificates, training certificates, and competency certificates. The retrieval process involves text preprocessing, term weighting using TF-IDF, and similarity measurement using Cosine Similarity. The results show that document d1 (Professional Mathematics Educator Certificate) has the highest similarity value to the query “educator certificate,” as it contains all query terms with relatively high TF-IDF weights. Document d3 ranks second due to partial term similarity, while document d2 has the lowest similarity value because it shares only one common term with the query. These findings indicate that the Cosine Similarity method is effective in ranking educator certificate documents based on their content relevance in an objective and measurable manner. The proposed system can improve the efficiency and accuracy of educator certificate document management and retrieval in educational institutions.

This study investigates the role of Information Technology (IT) governance in enhancing risk management performance and ensuring regulatory compliance within multinational digital enterprises. As digital transformation continues to reshape the global business landscape, organizations face increasing challenges in managing technological risks and complying with complex regulatory requirements across various jurisdictions. The study adopts a quantitative approach, using a survey methodology to collect data from senior IT and compliance managers in multinational digital enterprises. The survey focuses on how IT governance frameworks, such as COBIT 2019 and ISO 27000, are utilized to align IT strategies with business objectives, mitigate risks, and maintain regulatory compliance. The findings indicate that organizations with well-established IT governance structures are better positioned to proactively identify and mitigate risks, ensuring greater consistency in meeting regulatory requirements. These organizations demonstrate improved risk management effectiveness, especially concerning cybersecurity, data privacy, and compliance with global regulations like GDPR. In contrast, organizations with ad hoc or decentralized governance structures struggle with fragmented risk management and compliance efforts. The study further highlights the importance of integrating IT governance frameworks with internal audit functions, specifically the Chief Audit Executive (CAE), to enhance cybersecurity resilience and ensure compliance with global standards. This research contributes to the literature by providing empirical evidence on the integration of IT governance, risk management, and regulatory compliance in multinational enterprises. It also highlights the need for a structured and systematic approach to IT governance to improve organizational performance in managing risks and ensuring consistent regulatory adherence. The study offers practical insights for organizations looking to optimize their IT governance structures in the face of rapid digital transformation.

The use of Information Systems and Information Technology (IS/IT) is a crucial factor in improving the efficiency and accuracy of retail sector operations. PT XYZ, a retail-level staple goods provider, has implemented IS/IT to support sales recording, inventory management, security, and operational reporting. This study aims to assess the effectiveness, efficiency, security, and compliance of the information system used. The audit was conducted through observation, interviews, document review, and system testing, referring to the COBIT framework and the ISO/IEC 27001 standard. The audit results indicated that the system supported core operational functions, but weaknesses remained, including insufficient system documentation, limited access controls, and suboptimal data security and backup mechanisms. Furthermore, reliance on manual procedures has the potential to lead to errors and slow down service delivery. Therefore, system improvements, strengthening security controls, developing standard operating procedures, and enhancing the competency of human resources and IT infrastructure are needed. This audit is expected to support improved service quality and secure, effective, and sustainable IT governance at PT XYZ.

This study investigates the role of Enterprise Information Systems (EIS) in driving innovation within organizations. The research employs a mixed-method approach, combining survey-based structural analysis and in-depth organizational case studies to explore how different EIS capabilities influence organizational innovation. The study focuses on four key EIS capabilities: functional capabilities such as workforce management and customer value creation; technological capabilities including ERP systems and real-time analytics; dynamic capabilities, especially organizational learning; and collaborative innovation through external partnerships. The survey results reveal that EIS capabilities, particularly data analytics and integration, significantly enhance organizational agility, decision-making, and innovation outcomes. In-depth case studies provide detailed insights into how these capabilities are applied in real-world organizational settings, illustrating their impact on process and service innovation. The findings indicate that the effective integration of EIS across organizational functions, along with improved access to data, contributes to operational efficiency and innovation success. However, challenges such as integration issues, resistance to change, and lack of skilled personnel were also identified as barriers to successful EIS adoption. The study contributes to the literature by offering a comprehensive understanding of how EIS capabilities drive innovation and highlighting the importance of organizational culture and leadership in the adoption process. The research provides practical recommendations for organizations to leverage EIS for fostering innovation, such as focusing on EIS integration, overcoming organizational barriers, and ensuring leadership engagement. Finally, the study suggests future research directions, including the refinement of multi-method approaches and the need for longitudinal studies to better understand the long-term impact of EIS on innovation outcomes.

Postoperative pain is a common physiological response following surgical procedures, and its suboptimal management can have physiological and psychological effects, including sleep disturbances, decreased functional capacity, increased anxiety, and deterioration in quality of life. This scoping review aims to describe the empirical evidence regarding the effectiveness of music therapy in reducing the intensity of postoperative pain in surgical patients. A systematic search was conducted through four major databases (ScienceDirect, PubMed, Neliti, and Google Scholar) using Boolean operators and keywords such as ‘postoperative pain,’ ‘music therapy,’ and ‘pain scale.’ Inclusion criteria included articles published in the last decade, in English or Indonesian, and available in full text format. In accordance with PRISMA-ScR guidelines, this review analysed 10 articles. The synthesis of results showed that music therapy consistently reduced pain intensity, anxiety, and analgesic requirements through mechanisms such as increased endorphin secretion, decreased stress hormone levels, and activation of the gate control theory. Typically administered for 15–30 minutes, music therapy is a safe, cost-effective, and patient-acceptable non-pharmacological modality. This intervention is recommended as an adjunct component in perioperative pain management in nursing practice, although further standardised research is needed to improve consistency.

The Special Dental and Oral Hospital of South Sumatra Province has an official WordPress-based website (https://rsgigimulut.co.id/) that functions as a medium for information dissemination, communication, and public services to the community. This website is expected to provide accurate, up-to-date, and easily accessible information for users. However, in practice, the website management staff still face challenges and limitations in independently managing and updating the content, resulting in the suboptimal utilization of the website’s potential. This community service activity aims to provide website management training for the staff by utilizing the WordPress Content Management Sistem (CMS) so that they are able to manage the website effectively and sustainably. The training was conducted on August 11, 2025, in the third-floor meeting room of the Special Dental and Oral Hospital of South Sumatra Province, involving two website management staff members. The implementation methods included lectures, demonstrations, and hands-on practice covering the introduction to the WordPress interface, page layout customization, the addition of new posts and pages, menu creation and management, as well as tips on content management and website maintenance. The results of the training indicate an improvement in participants’ understanding and skills in independently managing the website, which has a positive impact on enhancing the quality of public information presentation and strengthening the hospital’s digital services.

This study aims to develop a Student Progress Assessment Information System for PAUD Laskar Pelangi as a solution to various problems that arise in the academic data management process, which was previously carried out manually. The management of student grades, student data, class data, and subject data often encountered obstacles such as delays, recording errors, difficulty in searching for data, and inaccuracies in report preparation. To overcome these issues, a web-based information system was developed to manage all data in an integrated and more efficient manner. The system development method used the Website Development Life Cycle approach, and the application was implemented using the PHP programming language. The system is designed to enable the admin to manage student data, class data, subject data, grades, and automatically generate student grade reports. Database implementation was carried out to ensure that data is stored properly and can be accessed easily. Functional testing was conducted to ensure that all features operate according to user needs. The results of the study show that the developed information system is capable of improving administrative efficiency, accelerating the grade processing workflow, minimizing recording errors, and generating student grade reports quickly and accurately. Therefore, this system provides significant benefits for PAUD Laskar Pelangi in improving the effectiveness of academic administrative management and can be further developed according to the school's needs.