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Degenerative disease is a health condition of an organ or related tissue whose condition can deteriorate over time due to changes in body cells that affect organ function as a whole. The factor is due to unhealthy life changes such as lack of activity and frequent exposure to harmful substances into the body. Degenerative diseases include hypertension, diabetes, cholesterol, cancer, and death. Harmful substances or free radicals can be inhibited by antioxidants. One drug that has antioxidant activity is ascorbic acid (Vitamin C) which functions as an immune booster and is used by the public because it is effective as an antioxidant and health therapy but there are side effects in the form of gastrointestinal. The research aimed to find candidate drug ingredients from compounds contained in black pepper seeds (Piper nigrum L.) as in silico antioxidants. The methods used are molecular docking and molecular dynamics. The results showed BLH19 had better toxicity than the comparator drug and had hydrogen interactions that could be stabilized by the amino acid Gln139. The results of molecular dynamic calculations for BLH19 have an RMSD value of 1.5 Å with a ΔGTotal of -33.50 Kcal/mol. While the comparator drug has an RMSD value of 1.6 Å with ΔGTotal -3.39 Kcal/mol. The results showed that the affinity level of ascorbic acid compared to BLH19 for the 4RP9 receptor was predicted to be a candidate for a new antioxidant drug.

The average coverage of under-five weighing in Indonesia in 2021 is 69.0% of children per month. This number has increased from 2020 of 61.3% of children per month. Health cadres at Posyandu play an important role in efforts to increase public awareness of health as guidance and supervision of promotive and preventive efforts. The achievement of Posyandu goals is inseparable from the behavior of Posyandu cadres. The formation of cadres is an educative approach method, to activate the community in development, especially in the health sector. Posyandu cadres are a very important component for the implementation of Posyandu properly. Objective: To find out the factors related to the service behavior of Posyandu cadres in Sumur Batu Village, Central Jakarta. Research Methods: This type of research is a quantitative study with a cross-sectional research design. The population and sample in this study were all Posyandu cadres in Sumur Batu Village, totaling 72 people. The sample technique used is total sampling. Research results: There is no relationship between attitude (p-value = 0.102) and service behavior of Posyandu cadres, there is a relationship between the support of community leaders (p-value = 0.004) and service behavior of Posyandu cadres, and there is no relationship between family support (p-value = 0.979) with the service behavior of Posyandu cadres in Sumur Batu Village, Central Jakarta in 2023.

Maumere Gymnastic activities within the framework of the healthy living community movement (GERMAS) teluk lada village, sobang-pandeglang sub-district aiim to improve the health of skills in community gymnastic sports in teluk lada village, especially maumere gymanstic which is well known to the community and studied in schools. The purpose of this activity is to improve the skills of students who practice sport and the community in the field of cultural creation gymnastics, especailly maumere gymnastics, considering that this gymnastics has long been known by the community, from tradisional music to movement that are easy for childern to learn and can be enjoyed by young people. All levels of society, and is expected to improve public health in the area to support government activities, namely GERMAS.

Quarantine is a system of preventing the entry, exit, and spread of quarantined animal pests and diseases, as well as supervision and control of food safety and food quality, feed safety and feed quality, Genetic Engineering products, Genetic Resources, Biological Agents, Invasive Foreign Species, Wild Plants and Animals, and Rare Animals that are introduced into, spread from one area to another area, and removed from the territory of the Unitary State of the Republic of Indonesia. To maintain, protect, and improve the quality of animal/livestock resources, animal/livestock health, animal welfare, and the provision of safe, healthy, whole, and halal (ASUH) food of animal origin, as well as maintaining peace or eliminating/preventing public unrest, it is necessary to provide guidance, regulation, control, and supervision of livestock businesses and animal health services. To create a conducive business climate and legal certainty in animal husbandry and animal health, it is necessary to regulate the mechanisms and procedures for licensing livestock and animal health businesses in the regions. The problem faced by the Batam Class I Agricultural Quarantine Center is caused by cows entering Batam Island that do not have an entry permit and are not by Law Number 21 of 2019, which states that every entry or release must be carried out through a designated Place of Entry and Place of Expenditure.

Immunization is the most effective and efficient public health effort in preventing disease and reducing death rates. This study aims to determine the factors that influence the provision of basic immunizations to babies at the PT Pratama Clinic. Hijau Pryan Perdana 2023. The number of samples used was 35 people obtained using total sampling techniques. The data analysis technique uses chi square. The results obtained in this study were that the majority of respondents did not complete basic immunization, 22 people (62.9%), there was a relationship between the age variable with a value of p = 0.004, there was a relationship with the education variable with a value of p = 0.012, there was a relationship with the employment variable with a value of p = 0.036, there is a relationship between the knowledge variable with a value of p = 0.003, there is a relationship between the family support variable with a value of p = 0.010 with the provision of basic immunization. There is a relationship between maternal age, maternal education, maternal employment, maternal knowledge and family support with providing basic immunizations to babies. It is recommended for health services to increase mothers' knowledge about basic immunization for babies through education to increase the completeness of basic immunization for babies.

Covid-19 hit many countries in the world including Indonesia. The Covid-19 outbreak is not only a national problem within a country, but is already a global problem. Covid-19 originated in the Wuhan area of ​​China. The spread of Covid -19, which is so fast and deadly, is transmitted through physical contact through the mouth, eyes and nose. The spread of Covid-19 is out of control, the government invites the public to participate in keeping the spread from spreading by limiting social or physical contact. Community participation is the main key to success in preventing the spread of the Covid-19 outbreak. Social distancing and physical distancing are implemented to cut the chain of spread of the virus.Some people have consciously followed this social restriction mechanism, but some have not participated. This paper examines community participation in preventing the spread of the Covid-19 pandemic in Indonesia. Handling the spread of this virus can be carried out well if the community participates in following the government's advice to always maintain a safe distance from one another, one of which is to stay at home. Covid-19 is an epidemic virus and has the potential for a public health emergency. In the Bangorejo sub-district itself, the government and various local community institutions in dealing with this epidemic have implemented several programs and policies to minimize and prevent the Covid-19 outbreak, but in reality some people do not heed the appeals and directions from the government or social institutions.

Background: Traditional medicine can be used to treat cough in ARI. WHO recommends the use of traditional medicines including herbs in maintaining public health, prevention and treatment of disease, especially for chronic diseases and cancer. Objective: to determine the effect of giving ginger and honey drinks on coughs in toddlers. Method: This type of research is pre-experimental with the research design used is one group pre-test-post test design with a sample of 20 subjects. The instrument used in collecting this data is the respondent's characteristic sheet which contains the name, age, gender along with the observation sheet. Honey ginger therapy intervention was given in the morning and evening for 5 consecutive days with a dose of 1 glass containing 150 ml and 2 teaspoons of pure honey. Result: the results of observations in studies that have been conducted for 5 consecutive days with a frequency of 2x a day obtained a p value of 0.00. Conclusion: There is an Effect of Giving Ginger and Honey Drinks to Ease Coughs in Toddlers.

Hypertension is a condition with blood pressure that exceeds normal limits. If hypertension is not controlled properly, it can cause damage to blood vessels and can even lead to the risk of death. According to the 2018 Riskesdas, it shows that the prevalence of people with high blood pressure is 34.11%. The prevalence of high blood pressure in women is 36.85% higher than that of men, 31.34%. Data obtained from the Sitinjak Health Center, Angkola Barat District, South Tapanuli Regency, the number of hypertension sufferers has increased from 2019-2021. This study aims to determine the risk factors (hereditary, obesity, smoking habits, eating habits, and physical activity) associated with the incidence in adult women in the Working Area of ??the Sitinjak Health Center, Angkola Barat District, South Tapanuli Regency. The type of research used was an analytical design. cross sectional. The population in this study was adult women aged 30-49 years in the Working Area of ??the Sitinjak Health Center, Angkola Barat District, South Tapanuli Regency, as many as 105 people. The sample in this study amounted to 51 people, the sampling technique was this study using a non-probability sampling technique, namely accidental sampling. Data were obtained from the Community Health Center and through interviews using a questionnaire. Methods of data analysis were analyzed univariately, bivariately using Chi-Square test at 95% confidence level (P<0.05) and multivariate test with multiple regression tests. The results showed that hereditary variables, obesity, eating habits were related to the incidence of hypertension. The most dominant variable is eating habits. It is suggested to respondents to change their bad living habits for the better to prevent hypertension and for health workers to conduct health education to the public about how to prevent hypertension, for example by reducing consumption of foods that trigger hypertension.

This research focuses on the issue of organic waste management in Pasar Raya MMTC, which is a major contributor to the increasing amount of waste in Indonesia, especially in the market sector. The objectives of the study were to analyze the level of community participation in organic waste management, identify the constraints faced in organic waste management, and highlight the importance of organic waste management in Pasar Raya MMTC. This research used descriptive method with qualitative descriptive analysis. The results revealed that the low level of community participation in organic waste management in this market is due to the lack of facilities and education on proper waste management to traders and the community. Increased market activity has a significant impact on increasing the volume of organic waste, and without active community participation, waste management is not optimal. This research is expected to have a positive impact on the environment and public health by encouraging community awareness and participation in better organic waste management.

Tuberculosis (TB) is still a major global health problem and is spreading all over the world, including in Indonesia. In recent years, the incidence of TB in Indonesia has continued to increase. Data in East Java also shows that TB is increasing at any time and one of the largest is in Jember. This is caused by various factors, such as the lack of public knowledge about TB, high poverty rates, and lack of access to health services. Therefore, efforts are needed to increase public knowledge about TB and how to prevent its spread. The aim of this program is to provide education related to TB disease prevention among the people of Banjarsengon, Patrang District, Jember, East Java. The target of this program is the general public who are at risk of contracting TB, such as migrant workers, farmers and informal workers. The method used is presentation using actual references and socialization. Socialization can be done through various media, such as leaflets distributed to participants. The socialization material presented included an explanation of TB symptoms, ways of transmission, ways of prevention, and access to health services. Apart from that, educational media is also made, which can be in the form of short videos as an illustration for the participants of this education for prevention and early detection. With increasing public knowledge, it is hoped that it can reduce the incidence of TB among the community in Banjarsengon

Based on population projection data, it is estimated that in 2017 there will be 23.66 million elderly people in Indonesia (9.03%). The number of elderly people is predicted in 2020 (27.08 million), 2025 (33.69 million), 2030 (40.95 million) and 2035 (48.19 million) (Ministry of Health RI, 2017). The prevalence of dementia (per 1000 people) in Indonesia in 2005 was 191.4 incidents, in 2020 it is estimated to be 314.1 incidents, and will increase in 2050 to around 932 incidents. The data obtained in the work area of ​​the Telaga District Public Health Center were 134 elderly, of which 38 had dementia. From the results of interviews obtained from health workers at the puskesmas and families, they said that often the elderly forgot many activities such as bathing, taking medicine and others, so the family had to remind them to take a bath, take medicine and so on. Further interviews conducted by researchers on the elderly, some said that they rarely consume vitamins, especially vitamin D, are lazy to exercise, do light activities or sunbathe every morning which can increase the risk of developing dementia.

Leukemia is a progressive malignant disease of the blood-forming tissues. Leukemia is caused by abnormal growth of white blood cells (leukocytes) in the bone marrow. These cells then spread in the blood circulation. This disease is still a public health problem in the country and in the world, which affects children to adults, leukemia is a cancer with the highest death cases in the world. One of the complementary therapies that can be used to improve the psychological response of cancer patients is music therapy. Music therapy can increase relaxation and reduce anxiety in leukemia patients during the chemotherapy process. Objective : Knowing the results of the application of music therapy to hemodynamics in children with leukemia in the room Flamboyan 9 RSUD Dr. Moewardi surakarta. Method : Methods of data collection in this application is to use the method of interviews, and observation. Findings : After performing music therapy for 1 day, the results were the same for both respondents, that is, children can lower blood pressure and pulse frequency within normal limits. Implication : Music therapy can affect the decrease in hemodynamics in children with leukemia because there are significant changes in hemodynamics from height to decrease.  

In 2019 the total number of tuberculosis cases in North Sumatra was recorded at 99,398 cases, while in 2020 there were 78,698 cases and in 2021 there were 57,247 cases. This study aims to look at the relationship between knowledge, attitudes and family support with the risk of pulmonary TB transmission. This type of research is survey research which is analytic in nature. Cross sectional research design. The sample is pulmonary TB patients in the Working Area of the Kartini Public Health Center, Pematang Siantar City for the period of October 2022 as many as 44 people. Data analysis using chi square. The results of the study concluded that there is a relationship between knowledge, attitudes and family support with the risk of pulmonary TB transmission in the family. The role of health workers and Community Health Centers is as a source of correct information through applicative counseling by giving leaflets to pulmonary TB patients.

The problem faced by the people of Puri Bukit Depok is that there is still a lack of knowledge about the procedures for clean and healthy living behavior, so that the extension education program is the solution. The implementation method of this clean and healthy lifestyle program is through counseling, discussion and field action. Counseling and discussion activities are only 30% of 100% of the program's activities, the rest are direct activities in the field, namely counseling and how to live clean and healthy behaviors carried out by the KKN 64 group and assisted by several representatives from local youth organizations so that this activity can run smoothly. held. The result of this program is increasing public knowledge about how to live a clean and healthy life.

This study discusses the Implementation of Health Insurance Administration Agency Policies at the Durai District Health Center, Karimun Regency. This research refers to the policy implementation model of the Van Metter and Van Horn models, with variables of policy size and objectives, resources, characteristics of implementing agents, attitudes/dispositions of implementers, inter-organizational communication and implementing activities. The data collection techniques are carried out by observation, interviews, and documentation. The data obtained was then analyzed using steps including data collection, data reduction, data presentation, and drawing conclusions. The results showed that the implementation of the Health Social Security Administering Body Program Policy at the Durai District Health Center, Karimun Regency was not optimal and there were still deficiencies that still needed to be corrected. The arrangement of human resources should run optimally so that the program can continue running, there are still gaps in the use of infrastructure in obtaining free health services, and there are still poor people who have not yet received a BPJS card. The Durai Health Center as the executor of the BPJS program is expected to further intensify socialization regarding free h8ealth services, for example by conducting counseling and placing banners so that information about the BPJS program can reach remote villages.

Diabetes mellitus is a frequently encountered degenerative disease. Indonesia, being one of the most populous countries, experiences a notable increase in the global prevalence of diabetes mellitus. Type 2 diabetes mellitus constitutes the most prevalent form, with approximately 90-95% of diabetics falling into this category. Notably, patient compliance in Indonesia falls short of meeting the recommended glycemia target. The root cause of this non-compliance is linked to a lack of understanding among individuals with diabetes mellitus regarding the purpose of therapy, leading to a lack of awareness about potential complications. This research aims to explore the connection between patient characteristics and adherence to medication in Type 2 diabetes mellitus patients at the Tiban Baru Health Center in Batam City. Employing a descriptive correlation approach with a prospective cross-sectional research design, the study utilized purposive sampling, including 92 patients meeting the inclusion criteria. Data collection involved the administration of a compliance questionnaire (MMAS). The study's conclusion reveals a significant association between job characteristics and medication adherence in Type 2 diabetes mellitus patients, evidenced by a p-value of 0.046. Conversely, factors such as gender, age, education, duration of suffering, and comorbidities were not found to be correlated with medication adherence (p-value > 0.05). It is anticipated that healthcare professionals at the Tiban Baru Health Center will impart accurate information to patients, enhancing their awareness of the potential complications associated with diabetes mellitus.

Hypertension or high blood disease is actually a disorder of blood vessels that results in the supply of oxygen and nutrients carried by the blood is hampered to the body tissues in need.hypertension is often called the silent killer dark killer, because it includes diseases that women are declared hypertensive if their blood pressure is 160/95 mmHg. (Nurhaidar, 2010).In addition to hypertension, gout is now also a topic that is very much discussed by women, because most uric acid attacks women, especially the elderly. However, in this day and age it is not only the elderly who can get gout, adults can also get this gout. Irianto in his book entitled Public Health Science said that gout is referred to as a degenerative disease because the incidence rate is related to the degeneration process in old age that takes place according to time and age. (Simamora and Saragih 2019).  Research conducted in the scientific journal Permas shows the results that of the 13 causes of gout, most of the causes are diet and lifestyle. So that those who should be more susceptible to gout are men because their serum uric acid levels are higher than women.(Sulistyoningtyas and Khusnul Dwihestie 2022).Community service activity entitled  "Socialization on the Application of Ergonomic Gymnastics to Reduce Blood Pressure in Kabil Village, Kavling Baru, RT 003 RW 013, Danau Indah Punggur" The activity was welcomed by RW 013 Kavling Baru, Punggur with the hope of getting information about handling hypertension and gout, so as to control and prevent various kinds of disorders of the cardiovascular system in the form of hypertension,  heart, or stroke that can interfere with public health.

Elderly is an age group in humans who have entered the final stages of their life phase. The group that is categorized as elderly will experience a process called the aging process. Indonesia is entering a period of aging population, where there is an increase in life expectancy followed by an increase in the number of elderly people. In Indonesia, there has been an increase in the number of elderly people from 18 million people (7.56%) in 2010 to 25.9 million people (9.7%) in 2019, and can be expected to continue to increase where in 2035 it will be 48.2 million people (15.77%). On the other hand, an increase in the number of elderly people will be a problem if the elderly have health problems. The elderly are a group of people who are susceptible to disease and have different physiological functions from young people, so their treatment pattern becomes more careful. The purpose of this community service activity is to provide outreach and information to the public about the proper and correct use of drugs in Tanjung Pura District, Langkat Regency regarding Provision of Drug and Wise Information on the proper and correct use of drugs. The method of this activity involved the community in Tanjung Pura District, Langkat Regency, namely lectures, distribution of leaflets, and questions and answers. Lectures are presented in the form of power point presentations, distribution of leaflets in the form of brochures followed by a discussion or question and answer session about Wisdom in taking medicine in the elderly. The result of this activity is that in Tanjung Pura District, Langkat Regency understand and are wise in taking drugs, especially in the elderly.

PHBS stands for Clean and Healthy Living Behavior, which is a set of behaviors that are practiced on the basis of awareness as an effort to keep oneself healthy and actively helping the health of the surrounding environment. This activity uses the PAR (Participatory Action Research) research method involving conducting research to define a problem or applying information into action as a solution to a problem that has been defined. In the study of participatory action research there are at least six types of approaches, namely formative, system improvement, problem solving, model analysis, participatory, and critical corporate self. -consciousness). The approach taken in this action study is problem solving and participatory, because they are considered the most relevant to community empowerment efforts. The results of this activity include; conducting PHBS education in households and in public places, conducting morning exercise activities with residents, establishing Integrated Service Posts (Posyandu), and conducting education on the Handwashing Movement and Distribution of Handwashing Tubs

The toddler period is a golden period that determines the rate of growth and development of toddlers both physically, mentally and emotionally. Assessment of nutritional status Assessment of nutritional status of toddlers using standard and measurable parameters can be used as a monitoring item for nutritional problems in toddlers. This study aims to describe the findings based on research data conducted in 2021 on 96 toddlers in the working area of the Ranomuut Public Health Center, Manado City, North Sulawesi Province. Primary anthropometric and age data were collected on toddlers 6-24 months and obtained data that 26% of toddlers have nutritional status in the poor category (<2SD) and 74% of them have nutritional status in the good category (? -2 SD to +2SD). Even though there is no urgency found in the results of this study, the conclusions of the research need to be published, and it is hoped that this can be used as a reference for future research.