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One cardiovascular condition known as venous thromboembolism (VTE) is believed to be brought on by hormonal medications like oral contraceptives. Women taking oral contraceptives are more likely to develop VTE over the age of 40 due to a genetic predisposition that can trigger the risk from the cytochrome gene. One of the genes associated with VTE and contraception is the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Methods: A quality assessment of the method and risk was conducted using The Joanna Briggs Institute (JBI) Instrument after a number of articles collected from Scopus, Crossref, Ebsco, Pubmed, Science Direct, and Google Scholar were selected by the inclusion criteria. Results:Articles or journals on the JBI instrument showed good quality in the number of 10 research particles. From the results of the journal analysis, several cytochrome genes were obtained, namely the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Conclusion: Several types of cytochrome genes that affect oral use as well as VTE. The cytochrome CYP2C19 gene may decrease the effects of clopidogrel. The use of CYP3A4 gene-inducing drugs should be considered at the same time as contraception and it is advisable to use other drug alternatives. Concomitant use of CYP1A2 gene-inducing drugs with contraception should be avoided because they may decrease the contraceptive effect. The use of cyclosporine drugs needs to be monitored because cyclosporine can increase estrogen levels in the liver.

One cardiovascular condition known as venous thromboembolism (VTE) is believed to be brought on by hormonal medications like oral contraceptives. Women taking oral contraceptives are more likely to develop VTE over the age of 40 due to a genetic predisposition that can trigger the risk from the cytochrome gene. One of the genes associated with VTE and contraception is the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Methods: A quality assessment of the method and risk was conducted using The Joanna Briggs Institute (JBI) Instrument after a number of articles collected from Scopus, Crossref, Ebsco, Pubmed, Science Direct, and Google Scholar were selected by the inclusion criteria. Results:Articles or journals on the JBI instrument showed good quality in the number of 10 research particles. From the results of the journal analysis, several cytochrome genes were obtained, namely the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Conclusion: Several types of cytochrome genes that affect oral use as well as VTE. The cytochrome CYP2C19 gene may decrease the effects of clopidogrel. The use of CYP3A4 gene-inducing drugs should be considered at the same time as contraception and it is advisable to use other drug alternatives. Concomitant use of CYP1A2 gene-inducing drugs with contraception should be avoided because they may decrease the contraceptive effect. The use of cyclosporine drugs needs to be monitored because cyclosporine can increase estrogen levels in the liver.

Traditional medicine is currently developing rapidly, especially those based on plants. Active plant compounds are the main basis for the development of new drugs, which after further research, can be commercialized and used in pharmaceutical treatment. This review was conducted to identify the pharmacological effects of active drug compounds isolated from medicinal plants by conducting a literature study. The results of the literature review contained 37 articles that met the inclusion criteria. Until now, there are several active drug compounds from plants that are sold commercially in the form of modern drugs. Some of the pharmacological effects found are cardiac glycosides, anticholinergics, antiplatelets, analgesics, anticancer, sympathomimetics and antimalarials. This search shows that natural materials are still used as a potential source of active drug compounds, thus encouraging research to find new active compounds from medicinal plants to overcome diseases in the future.

Dengue fever, malaria, and other mosquito-borne diseases remain significant health problems and challenges in various regions, especially in rural areas. Dengue fever (DBD) is caused by the dengue virus types 1-4, which are transmitted through the bites of Aedes aegypti and Aedes albopictus mosquitoes. The majority of the residents of Karya Mukti Village work as rubber tappers. They usually start their activities early in the morning or even before dawn. However, mosquitoes are most active in the morning and late afternoon, making the local community highly vulnerable to mosquito bites. To address this issue, the people of Karya Mukti Village still widely use mosquito repellents available on the market, which contain harmful chemicals that pose risks to both health and the environment if used over the long term. Therefore, this community service initiative aims to conduct outreach and hands-on training on the use of citronella (Cymbopogon nardus) as a natural mosquito repellent alternative. This program is carried out using a socialization and product-making approach through participatory engagement, where Dasawisma (women's community groups) are encouraged to identify their needs and challenges, as well as appropriate solutions to address them. By involving Dasawisma members in the learning and production process of natural mosquito repellents, it is hoped that they will gain better knowledge and skills in making natural mosquito repellents.

Gout arthritis (gout) is a disease that occurs suddenly and repeatedly, characterized by the formation of monosodium uric acid crystal deposits that attack the joints, due to high levels of uric acid in the blood (hyperuricemia). The aim of this activity is to be able to understand gouty arthritis and the practice of making non-pharmacological drugs from pineapple juice and honey to reduce uric acid levels in the body. This health education can increase the knowledge of Purwodadi village residents to do their best to treat gout arthritis using traditional medicine. Health education for residents can increase knowledge and skills in using simple traditional medicines

Law Number 35 of 2009 concerning Narcotics in Indonesia provides a strong legal basis for regulating the use of narcotics in the medical field. This regulation aims to ensure that the use of narcotics is carried out safely, in a controlled manner and in accordance with the interests of health services. This research aims to analyze legal aspects related to the use of illegal drugs in the medical field, identify challenges in implementing regulations, and provide policy recommendations to overcome existing obstacles. The research method used is normative juridical, with a legal approach and literature studies from various legal and health journals. The research results show that although regulations have been prepared comprehensively, their implementation in the field faces obstacles, such as complicated bureaucracy, lack of education for medical personnel, and social stigma against narcotics use. This hampers patient access to treatment, especially for palliative therapy needs and chronic pain management. The conclusions of this research emphasize the need for strategic steps to increase understanding of medical personnel, simplify administrative procedures, and educate the public to reduce stigma. Thus, existing regulations can be implemented optimally to support public health goals without ignoring aspects of supervision. It is hoped that this recommendation can strengthen the legal system and health services in Indonesia, so that patients' rights to health can be fulfilled more effectively.

Hydroponic Cultivation and Family Medicinal Plants (TOGA) is an innovation that supports food security. The Community Service Program in Getas Village, Kendal Regency, Central Java, aims to improve agricultural land use through sustainable management and development of medicinal plants. The target of this program is for farmer groups and youth organizations. These activities include counseling, establishment of hydroponic houses, training, mentoring, monitoring, collaboration between the government and educational institutions, and evaluation and feedback. This program has succeeded in achieving several achievements, namely increasing knowledge, increasing skills, increasing production, and changing behavior.

Cancer therapy has undergone remarkable advancements in recent decades, driven by innovations in gene therapy, cell-based therapy, and the development of anti-cancer drugs from natural products. Gene therapy offers the possibility of correcting genetic mutations that cause cancer, while cell-based therapies, such as CAR-T cell therapy, provide personalized and effective solutions. Additionally, the exploration of natural compounds continues to be a promising approach in anti-cancer drug development. This paper discusses recent progress in these three fields, highlighting their potential, challenges, and implications for future clinical applications.

Drug interactions can occur when drugs are administered simultaneously with other drugs, both pharmacologically and clinically. This study aims to identify drug interactions that occur in prescriptions with patients experiencing endocrine system disorders for the period July 2024 at Hospital X, Bandung City. Endocrine disorders, involving hormonal dysfunction such as that of the thyroid, adrenals, or pancreas, can affect the pharmacokinetics and pharmacodynamics of drugs, thereby increasing the risk of interactions. This research method involved randomly collecting two prescriptions per day, with a total of 60 recipes analyzed. The results of the assessment showed that there were 15 potential drug interactions with a percentage of 25%, consisting of one minor interaction (6.67%), 15 moderate interactions (93.33%), and no major interactions were found.

Through Presidential Regulation No. 82 of 2018, concerning Health Insurance in article 48, one of the benefits of promotive preventive services is health history screening services. Health history screening abbreviated as SRK is a preventive effort that can detect participants with a potential risk of diabetes, hypertension, kidney failure and coronary heart disease. This SRK filling activity is very beneficial for JKN participants, one of which is that they can find out the potential risk of disease as early as possible for themselves and their family members. Some people still have minimal knowledge about the Mobile JKN application, there are several obstacles in the community, especially the elderly who experience either a lack of smartphones or a lack of understanding of how to use the Mobile JKN application, so these obstacles are the main problems that occur in the Marpoyan Damai area, especially in the Jl. nurul. The aim of the activity is to increase the public's insight and knowledge regarding how to use and benefit the Mobile JKN application in health history screening. In this case, the service team will provide education and assistance with health screening through the BPJS application as an effort to prevent disease. The location for this activity will be carried out in one of the neighborhoods in Pekanbaru City, namely the RT 01 RW 21 Tangkerang Tengah neighborhood, Pekanbaru City. The aim is that after this community service is carried out, it can improve the level of public health through health screening in the application and also increase the knowledge of the community in the area regarding the use of family medicinal plants (herbal medicine)

Keluarga Jaya Pharmacy is a shop that provides various types of medicines and medical devices where the transaction process is still done traditionally, recording the stock of medicines and medical devices also still uses excel files. Of course, because of this, the transaction process to recording the stock of goods becomes longer and less accurate. Inaccurate and incomplete data on medicines and medical devices often causes medicines that are approaching their expiration date not to be detected as soon as possible. Therefore, the author decided to build a web-based drug stock inventory application at the Keluarga Jaya pharmacy. This system will be able to solve the problems that are currently still being experienced at the Keluaga Jaya pharmacy. The drug stock inventory system that the author built in this study is modeled into a class diagram and also a use case diagram. The results of the study are a web-based drug stock recording system at the Keluarga Jaya pharmacy that has features for logging in, managing master data, managing sales, managing returns, managing reports and logging out.

The introduction and use of traditional medicine is an alternative step to carry out natural and effective treatment. Traditional medicine has great potential to improve people's health. Not many people use herbs for medicinal purposes, so the community service activity team aims to increase knowledge about Traditional Medicine (Herbal Medicine), especially for teenagers. Currently, teenagers prefer to use modern medicine, so their knowledge and experience regarding traditional medicine are still very lacking. Knowledge about herbal medicine is important for teenagers because it can help them use traditional medicine appropriately. Good knowledge of herbal medicine can also help prevent traditional medicine that can heal from becoming dangerous. The activity method is carried out using education through counseling about the introduction and use of traditional medicine (Herbal Medicine), which is carried out for students at Ummul Quro Al-Hamidiyah Foundation Middle School, Masjid Kyai Muara Ogan Street, Kertapati Palembang. This activity was held on December 19, 2024, with 50 participants from Ummul Quro Al-Hamidiyah Foundation Middle School students. The activity results stated that students understood the counseling about using traditional medicine (Herbal Medicine) well.

Diabetes is a chronic disease in the form of a metabolic disorder characterized by blood sugar levels that exceed normal limits and one of them is Diabetes Mellitus Type II. Effective education to improve self-management in Type II Diabetes Mellitus sufferers. Non-compliance with Diabetes Mellitus treatment is currently still a quite important problem in the management of Diabetes Mellitus patients. To find out and analyze the effect of education on the level of compliance with medication and diet in Type II Diabetes Mellitus Patients at the Bintan Regency Regional Hospital. The research used Pre-experimental, with a One Group Pretest Posttest research design by analyzing the effect of providing education on the level of compliance with taking medication and diet in Type II Diabetes Mellitus Patients at the Bintan Regency Hospital. The results of the analysis of the Wilcoxon signed ranks test, the level of compliance with taking medication and dietary behavior after being given education was better than before being given education with a significance value of P < 0.0001, less than 0.05, meaning that there was a significant influence before and after being given education on the level of compliance. taking medicine and diet. For future researchers, the problem of patient education should be deepened so that patients understand more about the disease they are suffering from.

Patented drugs are a type of drug that has just been discovered and has a certain patent period based on its type. This drug is designed to provide convenience through innovations such as practical packaging, better taste, and syrup that is not bitter due to the use of micro particles. Technologies such as slow-release tablets or sugar coatings also reduce side effects in the stomach, making them safer to use. In addition, this innovation can overcome other obstacles, such as avoiding alcohol solvents that are not in accordance with some religious beliefs. On the other hand, generic drugs still meet pharmacopoeial requirements and have gone through a good drug manufacturing process (CPOB), with strict supervision from the Food and Drug Supervisory Agency (BPOM). This study aims to determine the level of knowledge of the people of Sukorejo Village about patented and generic drugs. The type of research used is descriptive, using a questionnaire as a data collection tool. The sample consisted of 100 people selected through a simple random sampling technique, where each element of the population has an equal chance of being selected. Percentage analysis was used to evaluate the results of the study. The data shows that 49% of respondents have good knowledge of patented and generic drugs, while 23% have sufficient knowledge. These results indicate that the majority of the community already understands the differences between the two types of drugs.

Bioprinting 3D merupakan suatu teknologi transformatif dalam konstruksi rekayasa jaringan dan prototipe organ untuk meniru karakteristik jaringan alami yang digunakan dalam pengobatan regeneratif. Secara bioetika, organ tiruan 3D melibatkan analisis dan evaluasi tentang implikasi moral, sosial, dan hukum dari penggunaan teknologi. Metode yang digunakan dalam penelitian ini adalah systematic literature review dengan menyajikan gambaran yang komprehensif tentang pengembangan dan pemanfaatan teknologi organ tiruan 3D (bioprinting) dalam perspektif bioetika dan hukum islam. Hasil menunjukkan bahwa bioprinting 3D memiliki pengaplikasian yang sangat beragam, diantaranya dalam bidang medis contohnya model untuk studi penyakit dan uji obat, pengobatan regeneratif, pembentukan organoid dan jaringan khusus, dan masih banyak lagi. Aspek bioetika mengenai bioprinting 3D masih menimbulkan tantangan yang perlu dipertimbangkan. Masalah bioetika seperti sumber atau asal bahan yang digunakan dalam bioprinting masih menjadi permasalahan. Penggunaan sel punca embrionik masih kontroversial, karena melibatkan penghancuran embrio manusia, sehingga menimbulkan pertanyaan moral dan etika mengenai nilai dan kesucian hidup manusia. Dalam perspektif Islam, berdasarkan analisis dari Al-Quran, hadits, dan beberapa fatwa, produksi organ tubuh melalui metode cetak 3D disarankan untuk dikategorikan sebagai perubahan ciptaan Tuhan yang dibolehkan karena tujuannya untuk mengobati dan menyelamatkan nyawa atau khusus untuk penggunaan proses transplantasi organ.

Circulating drugs without a distribution permit is a criminal act, where the drugs being distributed are not necessarily relevant to their composition and manufacture. This means that the safety, efficacy and benefits of drugs being traded are not guaranteed. Then the perpetrators of distributing drugs without a distribution permit will be punished and subject to criminal penalties. In this case Law no. 17 of 2023 concerning Health regulates criminal provisions for perpetrators of distributing drugs without a distribution permit with a prison sentence of 12 years and a fine of five billion rupiah, but the criminal sanctions imposed by the judge in decision case number 111/pid.B/2013/PN/ are reduced. Mtr does not provide a deterrent effect for perpetrators. The problems in this research are: first, what is the responsibility for perpetrators of criminal acts of distributing drugs without a distribution permit? Second, what are the judge's considerations in handing down a decision regarding the distribution of drugs without a distribution permit in case number 111/pid.B/2013/PN/Mtr?The results of this research are to show that the form of responsibility of the defendant is in accordance with the elements of responsibility, because the actions carried out by the defendant contained an element of intentional error and the judge sentenced the defendant to 10 months' imprisonment, which according to the author was not appropriate because the sentence This will not have a deterrent effect on the perpetrator.

Gastritis atau yang biasa disebut dengan maag ialah kondisi dimana lapisan dinding lambung (mukosa lambung) mengalami inflamasi atau peradangan Persentase dari angka kejadian gastritis di Indonesia menurut WHO adalah 40,8%. Angka kejadian gastritis pada beberapa daerah di Indonesia cukup tinggi dengan prevalensi 274,396 kasus dari 238,452,952 jiwa penduduk. Studi di Indonesia menyatakan 550 pasien yang melakukan pemeriksaan endoskopi, 44,7% diantaranya memiliki gastritis akut. Selain disebabkan oleh bakteri helicobacter pylori, gastritis ini juga bisa diakibatkan dari penyakit lain yaitu penggunaan obat NSAID (Nonsteroidal anti- inflammatory drug) seperti aspirin dan ibuprofen, konsumsi alkohol yang berlebihan, penggunaan kokain, stress fisik, dan merokok. Kegiatan Pengabdian kepada Masyarat (PkM) ini bertujuan untuk mengedukasi masyarakat dalam menambah pengetahuan terkait pola makan sehat untuk penderita gastritis. Metode yang digunakan dalam menganalisis data hasil kegiatan ini menggunakan metode kuantitatif untuk melihat peningkatan pengetahuan masyarakat. Sampel atau responden dalam kegiatan ini merupakan perwakilan warga di kelurahan durensawit yang diambil menggunakan Accidental Sampling dengan jumlah responden sebanyak 34 responden. Pengambilan data dilakukan menggunakan kuesioner pola makan sehat untuk penderita gastritis. Hasil pengolahan data menunjukkan bahwa sebelum kegiatan penyuluhan dilakukan sebanyak 12% responden  berpengetahuan baik, 21% responden berpengetahuan cukup sebanyak dan sebanyak 67% responden  berpengetahuan kurang. Setelah kegiatan penyuluhan dilakukan sebanyak 62% responden  berpengetahuan baik, 23% responden berpengetahuan cukup sebanyak dan sebanyak 15% responden  berpengetahuan kurang.  Berdasarkan hasil tersebut dapat disimpulkan bahwa penyuluhan yang dilakukan mampu meningkatkan pengetahuan peserta mengenai pola makan sehat untuk penderita gastritis.

Drug abuse is a serious issue that affects public health, social dynamics, and the economy in various regions. In areas with limited roles of the National Narcotics Agency (BNN) and Guidance and Counseling (BK), preventive strategies are often suboptimal, creating gaps in mitigation efforts. This study aims to identify the gaps in drug prevention strategies in such areas, focusing on causal factors, challenges, and opportunities for improvement. The methods employed include literature reviews and interviews with community members and relevant stakeholders. The results indicate that the lack of human resources, limited access to education, and low public awareness are the primary challenges. Recommended strategies include empowering local communities, enhancing educational institutions' roles, and fostering cross-sector collaboration to strengthen prevention efforts in regions where the roles of BNN and BK are constrained.

Dismenore adalah nyeri pada abdomen yang dirasakan sesaat sebelum atau pada saat menstruasi dan mengganggu aktifitas sehari-hari, bahkan sering kali mengharuskan penderita beristirahat dan meninggalkan aktifitasnya selama berjam-jam akibat nyeri haid. Latihan fisik dan olahraga akan mengakibatkan pelepasan endoprin, suatu substansi yang diproduksi oleh otak yang ambang rasa nyeri (Prawirohardjo, 2008). Glycine Max L atau sering disebut dengan kedelai merupakan salah satu tanaman jenis kacang-kacangan yang dapat membantu menurunkan nyeri haid. Mengkonsumsi makanan yang terbuat dari kacang kedelai dapat membantu merangsang produksi hormon estrogen saat menstruasi dan mengurangi peradangan serta nyeri menstruasi. Studi Pendahuluan di Trenclass SMA Muhammadiyah Wonosobo dengan wawancara secara langsung kepada 10 santriwati dengan hasil sebagian besar mengalami dismenore dengan skala nyeri ringan 4 snatriwati, skala nyeri sedang 6 santriwati. Ketika sedang dismenore dari 10 orang yang diwawancarai secara langsung mengalami gejala seperti mual, hilang nafsu makan, pusing, pinggang terasa sakit dan ada beberapa santriwati yang sampai tidak bisa menjalani aktivitas sehari-harinya. Penanganan yang biasa diberikan adalah 4 santriwati dengan kompres air hangat dan 6 santriwati lainnya menggunakan obat Pereda nyeri dengan jenis ibuprofen. 

Medicinal plants are plants that are known to contain beneficial compounds that can prevent, alleviate, or cure diseases. Knowledge about medicinal plants has different characteristics depending on the region. This study aims to document the knowledge of residents of the Legok Hayam Cultural Village, Girimekar Village, Bandung Regency about traditional medicinal plants. The ethnobotanical research method was conducted from September 2024 using semi-structured interviews and observations with measurement parameters of Species Use Value (SUV), Family Use Value (FUV), and Fidelity Level (FL). The research sample used a random sampling technique with a total of 25 respondents. The results identified 25 medicinal plants belonging to 15 families, traditional medicinal plants are often obtained by planting in the yard. The most frequently used medicinal plants are ginger, turmeric, binahong and kencur based on their highest utility value. The Zingiberaceae family has the largest contribution to use. In addition, binahong, kencur, katuk, and ginger plants are widely used to treat certain diseases.