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Sleep is a fundamental human need that plays a crucial role in maintaining both physical and mental health. Poor sleep quality can trigger a variety of health problems, ranging from decreased concentration to an increased risk of chronic diseases. The complexity of factors influencing sleep quality—such as stress levels, heart rate, blood pressure, physical activity, and lifestyle—makes its assessment difficult through direct observation alone. Therefore, data mining approaches are increasingly utilized to identify relevant patterns in sleep-related data. This study aims to compare the performance of the C4.5 (Decision Tree) algorithm and the Naïve Bayes algorithm in predicting sleep quality using the Sleep Health and Lifestyle dataset, which contains information from 374 respondents. The research method applied is a quantitative comparative approach employing classification techniques with 10-fold cross-validation to ensure robust evaluation. Model performance is assessed using accuracy, precision, and recall metrics to provide a comprehensive understanding of the effectiveness of each algorithm. The findings indicate that the C4.5 algorithm achieves an accuracy of 96.26% and offers advantages in terms of interpretability through its decision tree visualization, enabling easier understanding of variable relationships. In contrast, the Naïve Bayes algorithm demonstrates superior predictive performance, achieving an accuracy of 98.66% along with consistently high precision and recall across nearly all classes. These results suggest that Naïve Bayes is more effective for predictive tasks involving sleep quality, while C4.5 remains highly valuable when the goal is to interpret variable interactions and decision rules. Overall, this research highlights the potential of data mining techniques in health informatics, particularly in improving the understanding and prediction of sleep quality, which in turn can contribute to better prevention and management of sleep-related health issues.

Water is an essential component in the body that plays a role in various physiological functions, including concentration and learning performance in adolescents. However, teenagers' awareness to consume enough water is still low. This service activity aims to increase the knowledge and awareness of SMP Negeri 1 Kolaka students about the importance of drinking water through health education. The activity method was carried out by interactive counseling using PowerPoint media displayed through an LCD projector and conducted in the school hall on 19 November 2024, attended by 70 students from classes VII to IX. The material was delivered in an engaging manner and was complemented by discussion sessions. The results of the activity showed an increase in student enthusiasm and participation, as well as an awareness to start bringing drinking water to school and reduce the consumption of sugary drinks. This activity proved effective in fostering students' understanding of the importance of adequate hydration for health. The students expressed a greater willingness to incorporate healthier habits, particularly bringing water to school and making informed choices about hydration. Moreover, they became more aware of the negative impacts of sugary drinks. The activity's success highlights the importance of continued support from schools to create a healthy learning environment and to encourage healthy behaviors that can positively impact students' overall health and academic performance.

Work fatigue is a significant issue faced by employees in Indonesia, with approximately 65% experiencing symptoms that reduce their concentration and performance. Excessive workload, particularly mental workload, can result in cognitive strain and decreased productivity. This study aims to measure the level of mental workload experienced by quality control employees at PT Delta Dunia Tekstil I using the NASA Task Load Index (NASA-TLX) method. The research also investigates the relationship between employees’ age, length of service, and perceived mental workload through T-tests and F-tests to provide a more comprehensive analysis. Data were collected from 20 quality control employees who are responsible for monitoring textile production under strict standards. Results from NASA-TLX calculations indicate that the average mental workload falls within the high category, with effort and own performance emerging as the dominant dimensions contributing to mental strain. Correlation analysis shows a negative but not statistically significant relationship between age, length of service, and mental workload, suggesting that other factors play a stronger role in shaping employees’ perceptions. The study further highlights fluctuations in employee attendance and quality performance indicators, emphasizing the importance of workload evaluation. To address these issues, recommendations include adding more operators per machine, which is projected to reduce mental workload scores by approximately 33%. Such measures can optimize task distribution, improve efficiency, and promote employee well-being. Overall, the findings suggest that systematic workload assessments using tools such as NASA-TLX are essential for enhancing productivity and supporting sustainable human resource management in the textile industry.

Companies face a variety of human resources with varying characteristics and abilities, which significantly impact employee performance. The influence of work culture, work morale, and employee performance, including variables such as discipline, mutual respect, individual passion, team spirit, quality, punctuality, workers, salary, promotions, supervision, and coworkers, is crucial in determining how significantly they influence employee job satisfaction at PT RJN. By understanding this relationship, the director or leader of PT RJN can predict employee responses to job satisfaction, maintain it, and improve it so employees feel more comfortable and at ease in their work. The sampling technique in this study used a saturated sampling method, a non-probability sampling method. This research employed a quantitative approach with a concrete data processing methodology. The population consisted of 40 employees in the production, administration, marketing, and distribution departments. The sample used in this study was derived from primary data obtained from 40 respondents from the production department who were still actively working at PT RJN. Data were obtained through questionnaires and observations. From the results of the analysis that has been done, based on the results of partial testing, the job satisfaction of PT RJN employees is positively and significantly influenced by the variables of work culture, work spirit, and employee performance. Based on the results of simultaneous testing, the job satisfaction of PT RJN employees is significantly influenced by the variables of work culture, work spirit, and performance characteristics. significantly influence employee job satisfaction. This is known from the correlation analysis as follows: r value = 0.377 or 37.7% and then the remaining 62.3% comes from various factors outside this concentration and is influenced by other variables not examined in this study.

Liquefied Petroleum Gas (LPG) leakage remains one of the leading causes of fires in both household and industrial environments, highlighting the urgent need for early detection systems that provide fast and accurate warnings. This study aims to design and implement an LPG leakage detection device based on the ESP8266 microcontroller, utilizing the MQ-6 gas sensor and a real-time notification system through Telegram Bot integration. The system operates by reading LPG gas concentration via the MQ-6 sensor, which is then processed by the ESP8266 to automatically activate a buzzer alarm and a DC fan when gas levels exceed the threshold of 200 ppm. Additionally, the system sends instant alert notifications to the user through the Telegram application, allowing remote monitoring of gas conditions. Real-time gas concentration data are also displayed using a 16x2 LCD for direct visualization. System testing was carried out through controlled gas leakage simulations, and the results showed that the device is capable of responding rapidly, with a reaction time of less than 2 seconds after detection, while consistently providing accurate warnings. The integration of Internet of Things (IoT) technology significantly enhances the effectiveness and efficiency of the system, enabling practical and accessible monitoring. Overall, the developed device demonstrates strong potential as an innovative solution to improve safety, minimize fire risks, and raise public awareness regarding the hazards of LPG leakage, making it suitable for practical application in households and small industries.

Cake is a wheat flour-based food product that is popular because of its sweet taste, soft texture, and attractive appearance. This study aims to evaluate the effect of purple sweet potato (Ipomoea batatas) paste substitution on the sensory, chemical, and physical quality of chocolate cake decorated with character pudding. The study was conducted in May–August 2025 at the Makassar Health Laboratory Center and the Chemistry Laboratory of the Pangkep State Agricultural Polytechnic. The study design used a Completely Randomized Design (CRD) with five treatments of purple sweet potato paste concentration (0%, 10%, 20%, 30%, 40%) and two replications. The parameters analyzed included sensory tests (color, aroma, taste, texture, and overall), chemical tests (antioxidant activity, water content, protein, fat, ash, and carbohydrate), and physical tests (expandability and crumb morphology). Data were analyzed using ANOVA and Duncan's further test for parameters with significant differences. The results showed that the addition of purple sweet potato paste had a significant effect (p < 0.05) on sensory and chemical characteristics. Treatment A4 (40% purple sweet potato paste) obtained the highest score in the hedonic test with an average panelist preference level of 4 (like). The best chemical characteristics were also obtained in A4, namely antioxidant content of 25.6%, water content of 32.97%, protein 3.52%, fat 17.19%, ash 1.34%, and carbohydrate 45.05%. Physically, the rise power was not significantly different between treatments, but the crumb morphology showed pore irregularities at high concentrations.

The use of medicinal plants as herbal beverages has long been a part of Indonesian culture. However, the less preferred taste and aroma are obstacles to consumer acceptance. Cat's Whiskers leaves (Orthosiphon aristatus) are known to contain bioactive compounds that act as antioxidants, while Key Lime leaves (Citrus aurantifolia) have a fresh aroma and functional properties that can enhance flavor and health benefits. This study aims to evaluate the effect of adding Key Lime leaves (Citrus aurantifolia) on the chemical characteristics, sensory properties, and effectiveness of brewed Cat's Whiskers (Orthosiphon aristatus) leaf beverages.Five formulations with varying concentrations of Key Lime leaves (0%, 5%, 10%, 15%, and 20%) were tested based on the parameters of moisture content, ash content, pH, solubility, antioxidant activity, and organoleptic tests including color, aroma, taste, and texture. The results showed that the addition of Key Lime leaves significantly improved the chemical quality and sensory acceptability, with the best formulation obtained in treatment P4 (20% Key Lime leaves + 15g Cat's Whiskers), which provided an optimal balance between stability, nutritional content, and organoleptic quality. The addition of Key Lime leaves is recommended as an innovation in the development of functional herbal beverages based on Cat's Whiskers.

Skin that is prone to bacterial infections requires proper care using products containing antibacterial agents. One potential alternative is kaffir lime leaves (Citrus hystrix), which are known to contain antibacterial compounds. This study aimed to evaluate the formulation of liquid soap containing kaffir lime leaf extract and to determine the optimal concentration for inhibiting bacterial growth. An experimental laboratory design was applied, and the antibacterial effectiveness was tested using the disk diffusion method against two test bacteria, namely Staphylococcus aureus and Escherichia coli. Statistical analysis was performed using One-Way ANOVA, followed by Scheffe’s post-hoc test to identify significant differences among treatment groups. The results indicated that the liquid soap containing kaffir lime leaf extract exhibited good physical quality and met standard parameters, including organoleptic evaluation, pH, viscosity, and foam height tests. Antibacterial testing showed that the highest inhibition zone against Staphylococcus aureus was observed at a 15% concentration with a zone diameter of 18.28 mm (strong category), while the highest inhibition zone against Escherichia coli was also at a 15% concentration with a diameter of 19.03 mm (strong category). The One-Way ANOVA results showed a significance value (p < 0.05), indicating a statistically significant difference among treatments for both bacterial species. These findings suggest that liquid soap formulated with kaffir lime leaf extract, particularly at a 15% concentration, has strong antibacterial activity and potential as an effective skin care product. Further studies are recommended to evaluate safety, stability, and long-term effectiveness.

This study aimed to evaluate the effectiveness of liquid organic fertilizer (POC) derived from kirinyuh (Chromolaena odorata) leaves on the growth and yield of potted corn plants. The research was carried out at the Agricultural Development Center (BPP) of Malimbong Balepe’, Tana Toraja District, South Sulawesi Province, located at an altitude of 815 meters above sea level. The experiment was designed using a simple randomized block design (RBD) consisting of four treatments: K0 = control (without treatment), K1 = 20% concentration of kirinyuh leaf POC (200 ml POC + 800 ml water), K2 = 40% concentration of kirinyuh leaf POC (400 ml POC + 600 ml water), and K3 = 60% concentration of kirinyuh leaf POC (600 ml POC + 400 ml water). Parameters observed included plant height at 5 and 7 weeks after planting (WAP), number of leaves at 7 WAP, ear length, ear diameter, and ear weight per plant. The results showed that kirinyuh leaf POC significantly affected the growth and productivity of potted corn plants. Application of POC at 60% concentration (K3) produced the best results, indicated by increased plant height, greater number of leaves, longer ear length, larger ear diameter, and higher ear weight compared to other treatments and control. This finding suggests that kirinyuh leaves, which are often considered as agricultural weeds, have potential as an alternative source of organic fertilizer that is environmentally friendly, low-cost, and effective in improving crop growth and yield. In conclusion, kirinyuh leaf-based liquid organic fertilizer, particularly at a concentration of 60%, demonstrated the highest effectiveness in supporting corn growth and productivity. These results provide practical insights for farmers to utilize locally available organic materials as an alternative to chemical fertilizers in sustainable agricultural practices.

Tofu is a common food made from soybeans. However, because soybeans have limitations in terms of availability, other alternative ingredients such as palm kernel meal (BIS) are needed. The purpose of this study was to determine the best concentration of palm kernel meal added to tofu making so as to reduce dependence on the use of soybeans. The study was designed using a completely randomized design with 1 factorial, namely the concentration of BIS and soybeans. The concentration variations used were: A1 (control, 100% soybean), A2 (25% BIS: 75% soybean), A3 (50% BIS: 50% soybean), and A4 (75% BIS: 25% soybean). The parameters tested were BIS crude fiber, proximate analysis and tofu organoleptic. The results showed that BIS after fermentation experienced a decrease in crude fiber from 27.25 to 18.375%. Based on the proximate analysis, the variation of 75% BIS: 25% soybean is the best concentration with the highest protein content of 45.14%. Likewise, the moisture, ash, fat and carbohydrate content obtained were 79.05; 1.00; 6.20; and 0.96%. The organoleptic showed the level of panelists' liking for color, aroma, texture and taste with the value of panelists' liking level respectively 3.11; 4.09; 3.6 and 3.96 which indicates that this product can be accepted by the community.

Plant Growth Promoting Rhizobacteria (PGPR) is a group of microorganisms that colonize plant roots and play an important role as a biostimulant, biofertilizer, and bioprotectant that can increase plant growth and productivity. This study aims to determine the effectiveness of Tallang bamboo root PGPR on the growth and production of peanut plants (Arachis hypogaea L.) elephant variety. The study was conducted from March 2025 to July 2025 in Lion Tondok Iring Village, North Makale District, Tana Toraja Regency, at an altitude of 828 meters above sea level. The research method used a Randomized Block Design (RBD) with one treatment factor, namely the concentration of Tallang bamboo root PGPR, which consisted of four treatment levels: P0 = without Tallang bamboo root PGPR (control), P1 = 15 ml/L water, P2 = 30 ml/L water, and P3 = 45 ml/L water. The variables observed included the number of pods per plant, fresh weight of pods per plant, dry weight of pods per plant, seed weight per plant, seed weight per plot, seed yield per hectare, and harvest index. The results showed that the application of Tallang bamboo root PGPR at a concentration of 30 ml/L water (P2) had the best effect on all growth and yield parameters, namely the number of pods per plant, fresh weight of pods per plant, dry weight of pods per plant, seed weight per plant, seed weight per plot, seed yield per hectare, and harvest index, compared to the control or other concentration treatments. Thus, it can be concluded that the application of Tallang bamboo root PGPR at a concentration of 30 ml/L water is the most effective dose to increase the growth and production of Gajah variety peanut plants.

This study aims to determine the level of problematic smartphone use (PSU) and revenge sleep procrastination (RBP) among MTs/SMP students in District X, while also examining the relationship between the two variables. The problem of excessive smartphone use among adolescents is increasingly important to study because it can impact sleep quality, learning concentration, and mental health. This research approach uses a quantitative correlational method with data collection through a bold questionnaire (Google Form). The research sample consisted of 103 MTs/SMP students in District X who were selected using an incidental sampling technique. The RBP variable measurement scale was developed by the researcher with reference to aspects proposed by Kroese et al. (2014). Meanwhile, the PSU Scale was developed based on dimensions formulated by Foerster et al. (2015), including withdrawal, desire, loss of control, dependence on peers, and negative life consequences. The results of the correlation analysis showed that PSU had a very strong positive relationship with RBP (r = 0.833) and was statistically significant (p < 0.000). This means that the higher a person's tendency to experience problematic smartphone use, the greater the likelihood of revenge bedtime delay. Among the dimensions of PSU, withdrawal showed the highest correlation with RBP (r = 0.831). This was followed by negative life consequences (r = 0.778), craving (r = 0.577), loss of control (r = 0.489), and dependence on peers (r = 0.333). Overall, this study concludes that PSU plays a significant role in increasing RBP trends among students. These findings highlight the urgent need for awareness and intervention programs to reduce excessive smartphone use among adolescents. Therefore, the results of this study are expected to serve as a reference for schools and parents in designing strategies to prevent the negative impacts of smartphone use on adolescents.

Fermentation of seluang fish (Rasbora spp.) pekasam is a traditional method for extending shelf life and enhancing flavor, typically produced through spontaneous fermentation dominated by lactic acid bacteria (LAB). However, uncontrolled production processes lead to significant variability in product quality. This research aims to optimize the fermentation process of seluang fish pekasam through a series of controlled microbiology-based experimental practicums. The experiments were designed to investigate the impact of two main parameters: (1) the use of a LAB starter culture isolated from high-quality pekasam, and (2) the control of incubation temperature (e.g., at 25°C and 30°C). During the fermentation period, samples were periodically analyzed to measure changes in physicochemical parameters, including pH, moisture content, and salt concentration. Microbiological analysis was performed to count the populations of LAB and other spoilage microbes. The results showed that the use of a LAB starter culture significantly accelerated the pH drop within the first 24 hours, reaching a critical pH below 4.5, which effectively inhibited the growth of pathogenic microbes. Furthermore, the optimal raw material ratio and controlled incubation temperature resulted in pekasam with a firmer texture and a more balanced sour-savory taste, differing significantly from spontaneously fermented products. Organoleptic tests confirmed panelists' preference for the product made with the optimal treatment. The conclusion of this study is that optimization through microbiology-based experimental practicums is key to the standardization and improvement of the quality and food safety of pekasam products.

This study aimed to develop a simple acid-base reaction-based screening method for distinguishing between GMO (Genetically Modified Organism) and non-GMO soybeans as a practical alternative to expensive and expensive molecular methods. Twenty GMO soybean samples, 20 non-GMO samples, and three mixtures with ratios of 10%, 25%, and 50% were analyzed using 0.01–0.1 N HCl and 0.1 N NaOH solutions. Observation parameters included color change, pH, and absorbance using a UV-Vis spectrophotometer. The results showed that at a concentration of 0.01 N HCl, the color difference was most pronounced. The GMO sample solution showed a red color, while the non-GMO sample solution showed a green color. At higher concentrations, the differences became more subtle or difficult to distinguish. Validation using a PCR assay as the gold standard yielded sensitivity, specificity, and accuracy of >95%, indicating the reliability of this method as an initial screening technique. This physicochemical approach is considered effective for rapid, inexpensive, and easily implemented screening in food industry laboratories, particularly for monitoring non-GMO soybean raw materials and preventing food fraud. Therefore, this acid-base method has the potential to be a practical alternative solution for industry and education in detecting indications of GMOs before further confirmation with molecular methods.

Burns can cause infection, hinder healing, and increase the risk of long-term complications. Staphylococcus aureus and Pseudomonas aeruginosa often infect burn wounds in general, infections are treated with antibiotics, but continued use of antibiotics can cause bacterial resistance. Binahong leaves (Anredera cordifolia) have potential as a substitute for antibiotics because of their antibacterial properties from active compounds such as alkaloids, polyphenols, tannins, saponins and ascorbic acid. This research aims to activate the antibacterial ability of binahong leaf ethanol extract against S. aureus and P. aeruginosa. This research uses an experimental method with a control group design using diffusion and dilution methods at varying concentrations. Statistical analysis of the inhibition zone showed that there was a significance difference of <0.05 between treatment groups. In the solid diluted method, S. aureus obtained an MIC value of 10.5% and a MBC of 11.5%, whereas P. aeruginosa had an MIC of 14.5% and a MBC of 15%. The results showed that the ethanol extract of binahong leaves was more sensitive to S. aureus than P. aeruginosa.  

Psychological fatigue is a common condition experienced by nursing students due to heavy academic workload, clinical practice demands, and emotional pressure during the learning process. This condition may negatively affect concentration, learning motivation, and overall mental health. One non-pharmacological intervention strategy proven effective in reducing stress and psychological fatigue is Progressive Muscle Relaxation (PMR) based on Jacobson’s technique. In this community service program, PMR was combined with instrumental music to provide a more optimal relaxation effect and to be easily applied by students independently. The purpose of this activity was to provide education, training, and hands-on experience for students in practicing Self-Guided PMR combined with instrumental music as a preventive and promotive effort for mental health. The program was carried out on Thursday, August 14, 2025, involving 15 nursing students as participants. The stages of implementation included delivering material on PMR concepts and mental health, demonstrating Jacobson’s technique, independent practice of PMR with instrumental music, and a reflection session to explore participants’ experiences. The evaluation results indicated that most students reported feeling calmer, more relaxed, experiencing reduced muscle tension, and decreased symptoms of psychological fatigue after the intervention. In addition, students stated that this technique was easy to practice independently, making it a potential simple strategy to maintain mental health throughout their nursing studies. In conclusion, the implementation of Self-Guided PMR based on Jacobson’s technique combined with instrumental music was effective in reducing psychological fatigue among nursing students and in increasing awareness of the importance of independent relaxation practice as part of maintaining mental and physical balance.

This research aims to analyze the role of morning exercise activities on the health and physical fitness of fifth-grade students at SD Negeri 48 Pagar alam. Morning exercise as a routine physical activity in the school environment potentially provides significant benefits to the physical development and health of elementary school-aged children. The research method used is descriptive qualitative with an observational approach. The research subjects were 28 fifth-grade students of SD Negeri 48 Pagar alam, located in Rimba Candi Village, Candi Jaya Sub-district, Dempo Tengah District. Data collection was carried out through participatory observation, structured interviews with teachers and students, and physical fitness measurements using the Indonesian Physical Fitness Test (TKJI) for children aged 10-12 years. The results showed a significant improvement in components of students' physical fitness including cardiorespiratory endurance, muscle strength, flexibility, and balance after the implementation of routine morning exercise programs for one semester. Additionally, it was identified that morning exercise activities contributed to increased learning concentration, discipline, and school enthusiasm. Several factors supporting the success of this program include support from the school, availability of adequate facilities, and active participation of teachers as role models. Meanwhile, inhibiting factors include unpredictable weather conditions, student tardiness, and limited variation in exercise movements. This research concludes that morning exercise plays a strategic role in improving the health and physical fitness of fifth-grade students at SD Negeri 48 Pagaralam, thus it is recommended to be established as a sustainable program with the development of movement variations and provision of competent instructors.

Acid mine drainage (AMD) is one of the major environmental problems arising from coal mining activities. AMD is formed through the oxidation of sulfide minerals, resulting in acidic water with high concentrations of dissolved heavy metals. This condition is characterized by elevated levels of Fe, Mn, and total suspended solids (TSS), which, if left untreated, can pollute nearby water bodies, damage aquatic ecosystems, and pose risks to human health. Therefore, effective, eco-friendly, and low-cost treatment methods are needed to minimize the negative impacts of AMD. This study aims to investigate the effect of activated carbon derived from sugarcane bagasse as an adsorbent for reducing Fe, Mn, and TSS levels in AMD at the sump of PT Alreksa Bara Mitra. The selection of sugarcane bagasse is based on its abundance as an agro-industrial waste and its high lignocellulosic content, making it a potential raw material for activated carbon. The research involved the preparation of activated carbon through carbonization and activation processes, followed by its application to AMD samples with variations in adsorbent dosage and contact time. Laboratory analyses were conducted to measure the concentrations of Fe, Mn, and TSS before and after treatment. The results showed that sugarcane bagasse-based activated carbon significantly reduced Fe, Mn, and TSS concentrations. The highest removal efficiencies were achieved under optimum conditions, reaching 93.14% for Fe, 95.05% for Mn, and 85.04% for TSS. These findings demonstrate that activated carbon from sugarcane bagasse has a strong adsorption capacity for dissolved metals and suspended solids in AMD. In conclusion, sugarcane bagasse-derived activated carbon has potential as an environmentally friendly and cost-effective alternative for AMD treatment, while simultaneously providing added value to agro-industrial waste. This research is expected to serve as a reference for the development of more sustainable mine wastewater treatment methods.

Anxiety is a common phenomenon that is a universal cause of poor academic performance among students worldwide. Anxiety can also have an impact on student learning. Bold learning carried out during the Covid-19 pandemic caused anxiety or pressure for some students which could result in confusion, decrease the ability to direct attention, decrease memory, and interfere with students' concentration. The purpose of this study was to describe the level of anxiety in the pre-clinical group of FK Unpatti, age, gender, place of residence, consuming alcoholic beverages. This research is a descriptive study using a cross-sectional approach which was conducted in September 2021. The number of respondents collected was 535 respondents based on total sampling. The analysis used is univariate analysis. The data obtained using the Hamilton Rating Scale for Anxiety (HRS-A) questionnaire. The results of this study were obtained mostly in unhurried conditions based on the batch of 2020 (32.8%), class of 2019 (22.5%), class of 2018 (26.2%) and class of 2017 (18.5%). Based on age, namely at 17 years (1.2%), at 18 years (37.9%), at 19-20 years (28.3%), at 21 years (25.1%) and at 22 years ( 7.5%). Based on gender male (26.9%) and female (73.1%). Based on the place of residence with parents (50.8%) and not with parents (49.2%). Based on consuming alcoholic beverages (2.8%) and not consuming alcoholic beverages (97.2%). Research shows that there are variations in the level of anxiety in pre-clinical students of FK Unpatti who take courageous learning.

Dyslipidemia is a health problem characterized by impaired fat metabolism in the body, characterized by changes in blood lipid levels, either increasing or decreasing. This condition is generally seen through increased levels of total cholesterol, low-density lipoprotein (LDL), triglycerides, and decreased levels of high-density lipoprotein (HDL). This imbalance in the lipid profile, if persisted over the long term, has the potential to accelerate the formation of atherosclerotic plaque on artery walls, which can lead to cardiovascular disease. This study aims to determine the effectiveness of papaya leaf (Carica papaya L.) ethanol extract microcapsules in reducing cholesterol levels in white rats induced by a high-fat diet. The high-fat diet is formulated from a mixture of beef fat, eggs, and lard to increase cholesterol levels in a controlled manner. After the induction phase, the rats were divided into six treatment groups: a negative control group, a positive control group (simvastatin 0.36 mg), and three treatment groups with doses of papaya leaf ethanol extract microcapsules of 0.25%, 0.50%, and 0.75%. The treatment was given orally for 14 consecutive days. Total cholesterol levels were measured before and after treatment to evaluate the effectiveness of the intervention. The results showed that administration of papaya leaf extract microcapsules significantly reduced cholesterol levels. The 0.50% dose provided the most optimal effect, with a reduction reaching 77 mg/dL, greater than the simvastatin group. However, increasing the dose to 0.75% did not show a significant additional reduction effect, indicating an optimal dose-response point. Therefore, the 0.50% concentration can be considered the most effective dose and has the potential to be developed as an alternative natural cholesterol-lowering therapy. These findings also strengthen the potential use of papaya leaves as a bioactive source to support efforts to prevent and control dyslipidemia.