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Indonesia is recognized as one of the world’s richest countries in terms of biodiversity, including a wide variety of traditional medicinal plants. One of the lesser-known yet promising local species is matoa (Pometia pinnata J.R. Forst & G. Forst), whose leaves have been traditionally used by local communities to treat various ailments, including diarrhea and seizures. This study aims to investigate the pharmacological effects of matoa leaf extract, with a particular focus on its anticonvulsant activity, while also reviewing its potential chemical constituents as a basis for herbal medicine development. The research was conducted using a combination of literature review and experimental testing on mice (Mus musculus) induced with strychnine to trigger seizures. Key observed parameters included seizure onset time and survival duration (dead time) following the administration of either synthetic drugs or matoa leaf extract. The results demonstrated that the matoa leaf extract exhibited significant anticonvulsant effects, as indicated by prolonged seizure onset and increased survival time in test animals. These pharmacological effects are presumed to be related to the presence of active compounds such as flavonoids, tannins, and alkaloids, which may contribute to the stabilization of the central nervous system. Compared to conventional synthetic anticonvulsants, matoa leaf extract may offer a safer, plant-based alternative with potentially fewer side effects. The findings of this study provide valuable scientific evidence supporting the potential of Pometia pinnata leaves in the development of Indonesian herbal phytopharmaceuticals. Furthermore, they highlight the importance of further research, including preclinical and clinical trials, to validate efficacy, determine optimal dosages, and ensure safety for human use.

Introduction the management of expired drugs is an important part of the hospital's pharmaceutical logistics system to ensure the safety of patients, staff, and to protect the environment. The purpose of this study is to evaluate the implementation of procedures for returning expired drugs to the manufacturer or pharmaceutical company, as well as to examine the expired drug disposal system, particularly the methods of direct disposal to the Final Disposal Site (TPA) and open burning at RSUD Mohammad Natsir Solok. However, the implementation in the field has not been entirely effective. The method used in this study is a qualitative descriptive approach, with data collection techniques including observation, interviews, and documentation. The approach involved several informants who were directly involved in pharmaceutical logistics management in order to obtain in-depth and relevant data. The results of the study show that the hospital has not carried out expired drug destruction using the methods of direct disposal to the TPA or open burning. No clear information or official documentation was found regarding the use of these two methods. Informants stated that even if such methods were used, they occurred in the past and were not formally documented. The conclusion of this study is that open burning and direct disposal to the TPA have not become part of the expired drug management system at RSUD Mohammad Natsir Solok. The recommendation of this research is the development of clear operational procedures and increased staff awareness regarding the importance of safe and standard-compliant pharmaceutical waste managemen

Cough and flu are common health problems experienced by the public, with high prevalence across various age groups. The widespread practice of self-medication in the community highlighted the need for proper education regarding the rational and appropriate selection of medications. This educational activity was conducted at two strategic locations: the Car Free Day (CFD) in Solo and Taman Jaya Wijaya in Mojosongo. The method involved direct socialization, distribution of educational leaflets, and interactive question-and-answer sessions. The education focused on the differences between dry and productive coughs, appropriate medication choices, flu medicine content, and the use of natural remedies such as herbal treatments. A total of 41 participants from diverse backgrounds joined the activity enthusiastically. The results showed an increase in public understanding of cough classifications, medicine components, and the importance of reading drug labels before purchase. The sessions also emphasized the need to match medications with symptoms and advised consulting healthcare professionals if symptoms did not improve within three days. Positive responses from participants indicated that direct education effectively raised awareness and encouraged more rational and safe self-medication practices.

Cough and flu are common health problems experienced by the public, with high prevalence across various age groups. The widespread practice of self-medication in the community highlighted the need for proper education regarding the rational and appropriate selection of medications. This educational activity was conducted at two strategic locations: the Car Free Day (CFD) in Solo and Taman Jaya Wijaya in Mojosongo. The method involved direct socialization, distribution of educational leaflets, and interactive question-and-answer sessions. The education focused on the differences between dry and productive coughs, appropriate medication choices, flu medicine content, and the use of natural remedies such as herbal treatments. A total of 41 participants from diverse backgrounds joined the activity enthusiastically. The results showed an increase in public understanding of cough classifications, medicine components, and the importance of reading drug labels before purchase. The sessions also emphasized the need to match medications with symptoms and advised consulting healthcare professionals if symptoms did not improve within three days. Positive responses from participants indicated that direct education effectively raised awareness and encouraged more rational and safe self-medication practices.

Pain is an unpleasant sensation that can interfere with an individual's quality of life and requires effective management. Synthetic analgesics such as ketorolac, codeine, etoricoxib, and celecoxib are commonly used to relieve pain, but long-term use can cause adverse side effects, including gastrointestinal disturbances, dependence, and cardiovascular risks. Therefore, it is important to find safer, natural alternatives. One promising alternative is the extract of the dragon’s tail leaf (Rhaphidophora pinnata), a plant traditionally used in Indonesian medicine as a pain reliever. This study aims to evaluate and compare the analgesic effects of Rhaphidophora pinnata leaf extract with several synthetic drugs using the writhing test on male mice (Mus musculus). The mice were induced with pain by injecting a 0.5% acetic acid solution. The treatments included ketorolac, codeine, etoricoxib, celecoxib, and Rhaphidophora pinnata leaf extract. The results showed that all treatments, including both synthetic drugs and Rhaphidophora pinnata leaf extract, produced significant analgesic effects compared to the negative control (Na CMC 0.5%). Ketorolac showed the highest effectiveness, followed by codeine, etoricoxib, and celecoxib. Although the Rhaphidophora pinnata leaf extract showed potential as a natural analgesic, its effectiveness varied among individual test animals. Some mice showed a better response to the leaf extract, but overall, the analgesic effect was still lower than that of synthetic drugs. These findings support the use of medicinal plants as a safer alternative to synthetic analgesic drugs. Moreover, this study provides a foundation for further research aimed at isolating active compounds from Rhaphidophora pinnata leaf extract to develop more effective and safer pain-relieving medications.

Hypertension is a condition characterized by elevated blood pressure, where the systolic pressure exceeds 140 mmHg and the diastolic pressure exceeds 90 mmHg. If not properly treated, hypertension can lead to severe complications, increased morbidity, and even mortality. This condition occurs when the heart works harder than usual to pump blood (systolic) and the blood flow returning to the heart (diastolic) also experiences increased pressure. One of the efforts to prevent the progression of hypertension from a primary to a secondary stage is through non-pharmacological treatments. One such treatment includes the use of natural remedies like celery leaves. Celery leaves contain active compounds such as flavonoids and potassium that are believed to help lower blood pressure by relaxing blood vessels and increasing the excretion of sodium through urine.This community service activity was carried out in Purwodadi Village and aimed to increase public awareness, especially among families, regarding hypertension and its non-pharmacological management using natural ingredients that are easy to find and affordable. The method used involved health education through counseling and direct demonstrations of how to prepare and consume celery leaf boiled water. Participants were actively involved in learning how to select, clean, boil, and properly consume the celery leaf water as a herbal drink.The results of the activity showed a significant improvement in community knowledge and understanding related to hypertension and the benefits of using celery leaves as a traditional remedy. It is hoped that after this activity, the local community will be able to independently apply this knowledge and routinely use boiled celery water as a preventive measure to maintain normal blood pressure and reduce the risk of complications. This effort is part of promotive and preventive health services to improve the quality of life and promote a healthy lifestyle at the village level.

Penyakit asam urat (gout) adalah gangguan metabolik yang sering dialami oleh lansia, yang dapat menyebabkan rasa sakit yang hebat, keterbatasan gerakan, serta penurunan kualitas hidup. Penyakit ini terjadi akibat penumpukan kristal asam urat di persendian, yang dapat menyebabkan peradangan dan nyeri yang parah. Faktor risiko utama termasuk pola makan yang kaya purin, obesitas, gangguan ginjal, serta penggunaan obat-obatan tertentu. Namun, banyak lansia yang kurang memahami penyebab, gejala, dan penanganan penyakit ini dengan baik, sehingga kondisi mereka seringkali memburuk. Untuk itu, kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan lansia dalam merawat penyakit asam urat secara mandiri. Program ini diselenggarakan melalui penyuluhan kesehatan yang interaktif, dengan materi yang mencakup etiologi penyakit asam urat, manifestasi klinis, komplikasi yang dapat ditimbulkan, serta berbagai strategi pengelolaan yang efektif. Salah satu aspek penting yang dibahas adalah modifikasi gaya hidup, yang meliputi diet rendah purin, hidrasi yang cukup, serta pentingnya aktivitas fisik. Selain itu, peserta juga diberikan pemahaman mengenai pentingnya kepatuhan terhadap terapi medis yang direkomendasikan oleh tenaga kesehatan. Metode pelaksanaan kegiatan ini meliputi ceramah yang interaktif, sesi tanya jawab, dan distribusi leaflet informatif untuk memperkuat pemahaman peserta. Kegiatan ini dilaksanakan di wilayah RW 05 Srengseng Sawah, Jagakarsa, Jakarta Selatan, yang diikuti oleh sejumlah lansia yang aktif berpartisipasi. Hasil evaluasi menunjukkan adanya peningkatan signifikan dalam pemahaman peserta tentang penyakit asam urat dan bagaimana cara merawatnya. Lansia menunjukkan antusiasme yang tinggi dan mampu mengidentifikasi langkah-langkah praktis yang dapat mereka terapkan dalam kehidupan sehari-hari untuk mengelola kondisi mereka. Melalui kegiatan ini, diharapkan lansia dapat lebih mandiri dalam mengelola asam urat, mengurangi frekuensi serangan, dan meningkatkan kualitas hidup mereka secara keseluruhan.

Silica gel is one of the most commonly used adsorbents in the fractionation of bioactive compounds from medicinal plants. This is due to its ability to separate compounds based on differences in polarity, thus simplifying the purification process of active components. Fractionation itself is a crucial step in phytochemical research, as it aims to obtain active compounds in a purer, standardized form, and ready for further testing, both biologically and pharmacologically. This study aims to review the effectiveness of silica gel in the fractionation of active compounds from various types of medicinal plants. The study was conducted through a systematic literature review method with a qualitative-descriptive approach to 35 scientific articles published in the last five years. The articles analyzed were those that presented primary data on the use of silica gel in the fractionation process of medicinal plants. The results of the study showed that silica gel was proven effective in separating various polar compounds such as flavonoids, alkaloids, and phenolic compounds from crude extracts of medicinal plants. Some studies have even succeeded in isolating pure compounds that have significant biological activities, such as antioxidants, antimicrobials, and anti-inflammatory. The effectiveness of fractionation with silica gel is influenced by several important factors, such as the type and composition of the solvent, the elution technique (gradient or isocratic), and the support of advanced analytical methods such as thin-layer chromatography (TLC) and spectroscopy (UV-Vis, FTIR, and NMR). However, the use of silica gel still has several limitations, including the relatively high solvent requirements and long elution times. From the results of this study, it can be concluded that silica gel has great potential in supporting the fractionation process and isolation of bioactive compounds from medicinal plants. Therefore, optimization of silica gel-based fractionation techniques is important to support research and development of more efficient, standardized, and sustainable phytopharmaceutical products.

Prinsip tujuh benar obat merupakan pedoman penting bagi perawat saat memberikan obat kepada pasien, meliputi benar pasien, benar obat, benar dosis, benar rute, benar waktu, benar dokumentasi, dan benar pendidikan atau informasi kesehatan. Pengetahuan yang baik mengenai prinsip ini sangat penting bagi mahasiswa keperawatan anestesiologi untuk mencegah kesalahan dalam pemberian obat. Penelitian ini bertujuan mengetahui pengaruh edukasi e-pocket book prinsip benar obat terhadap tingkat pengetahuan mahasiswa D4 Keperawatan Anestesiologi Universitas ‘Aisyiyah Yogyakarta. Metode yang digunakan adalah pre-experimental design dengan pendekatan one group pre-test dan post-test dengan sampel 60 mahasiswa angkatan 2023 D4 Keperawatan Anestesiologi yang dipilih secara Simple Random Sampling. Instrumen penelitian berupa kuesioner pengetahuan prinsip benar obat dan analisis data menggunakan uji Wilcoxon. Hasil penelitian menunjukkan adanya pengaruh signifikan edukasi e-pocket book terhadap peningkatan pengetahuan mahasiswa, yang dibuktikan dengan nilai p sebesar 0,000 (p < 0,05). Kesimpulannya, edukasi e-pocket book efektif meningkatkan pengetahuan mahasiswa tentang prinsip tujuh benar obat dan diharapkan dapat membantu saat praktik klinik di rumah sakit.

Pharmacist professionalism is a key component in ensuring the quality of pharmaceutical services, encompassing not only compliance with technical and scientific standards but also a deep commitment to moral and ethical principles. In the Indonesian cultural context, the concept of "medicine as a trust" (obat sebagai amanah) reflects a profound sense of responsibility, where medicine is viewed not merely as a commodity, but as a mandate that must be preserved with integrity and accountability in health care practices. This article conceptually explores the relationship between pharmacist professionalism and the moral value of trust within the framework of the Nusantara constitutional theory. This theory emphasizes the integration of legal, cultural, and moral dimensions in shaping professional conduct in Indonesia. Using a descriptive-critical approach through literature review, this study investigates how trust functions as both a legal expectation and a cultural imperative in the practice of pharmacy. The findings highlight that trust must be internalized as a core value in pharmaceutical services—manifested through ethical decision-making, transparency in drug management, and a commitment to prioritizing patient welfare. Pharmacists are not only required to uphold professional standards, but also to carry out their duties as custodians of public trust. To realize this vision, the integration of the value of trust into pharmacy education, legal regulations, and clinical practice is essential. Educational institutions, professional organizations, and regulatory bodies must work collaboratively to instill this value as part of a pharmacist’s identity. In doing so, the profession can contribute more effectively to building a health care system that is just, culturally grounded, and centered on the well-being of the people.

Hypertension is a condition in which Systolic Blood Pressure (SBP) is greater than 140 mm Hg and Diastolic Blood Pressure (DBP) is greater than 90 mm Hg. This disease is one of the most common chronic diseases and can affect anyone, both young and old. Hypertension is often called a silent killer because it has no major symptoms, so sufferers are often unaware that they have high blood pressure until serious complications occur. This study aims to determine the relationship between medication adherence and the use of complementary therapies in hypertensive patients at Mitra Medika Amplas Hospital. The research design used an analytical survey method with a cross-sectional approach. The population in this study were all hypertensive patients who received treatment at the internal polyclinic of Mitra Medika Amplas Hospital, with a total population of 1,398 people. The sampling technique used was purposive sampling with the Slovin formula, resulting in 94 respondents. Based on the results of the analysis using the chi-square statistical test, the P-Value was obtained at 0.685 or P-Value > 0.005, which indicates that the alternative hypothesis (Ha) is rejected and the null hypothesis (Ho) is accepted. Thus, it can be concluded that there is no significant relationship between medication adherence and the use of complementary therapy in hypertensive patients at Mitra Medika Amplas Hospital. The conclusion of this study shows statistically that there is no relationship between medication adherence and the use of complementary therapy at Mitra Medika Amplas Hospital this year, which indicates the need for more attention in improving patient adherence to recommended treatment. The conclusion of this study statistically shows that there is no relationship of medication adherence in the use of complementary therapy at Mitra Medika Amplas Hospital.

This research is motivated by the rampant circulation of repackaged products that have not been fully supervised. Therefore, it is necessary to analyze the legal protection provided to consumers and the effectiveness of the role of the Food and Drug Supervisory Agency (BPOM) in conducting supervision. The purpose of this study is to determine the legal protection provided to consumers of packaged food products and to determine the extent to which BPOM carries out its role as a supervisory agency in ensuring the safety of these products. This research uses a normative legal approach with a qualitative approach, through literature study and interviews as a complement. The results show that business actors are required to re-register repackaged products in accordance with food safety regulations. This is a preventive measure to ensure that products in circulation are safe for consumption and provide effective legal protection for consumers. The findings also indicate that BPOM supervision still needs strengthening, both in terms of regulations, resources, and community outreach.  

This study explores the use of psychotropic substances, which affect the central nervous system and can alter mental functions, behavior, and individual perception. In the medical context, psychotropics have been widely utilized for treating mental disorders such as depression, anxiety, and schizophrenia. The research emphasizes the importance of understanding the mechanisms of psychotropics to optimize their therapeutic benefits while minimizing the risk of adverse effects. The study employed animal models, specifically rats, using the forced swimming test (FST) to assess the antidepressant and sedative effects of various substances, including Esilgan, Xanax, Zolmia, Syzygium malaccense leaf extract, and lelap (herbal), with NaCMC as a negative control. The results demonstrated varying sedative and antidepressant effects among the substances, with Xanax exhibiting the most significant antidepressant effect, while Syzygium malaccense leaf extract showed potential as a natural sedative agent. The study also underscores the importance of applying the 3R ethical principles (Replacement, Reduction, Refinement) in animal research and highlights the need for alternative methods to reduce reliance on animal testing. These findings are expected to serve as a foundation for developing safer, more effective, and ethical psychotropic therapies for mental disorders in the future.

Abstrak. Osteoporosis is a degenerative bone disease characterized by a decrease in bone mass and strength, particularly in postmenopausal women. Traditional plant-based therapy presents an attractive alternative given the rich local bioactive potential and limited access to pharmacological treatments. One important biochemical indicator in bone regeneration is the level of alkaline phosphatase (ALP). The aim of this study is to evaluate the potential of various Indonesian traditional medicinal plants as bioactive agents in the prevention of osteoporosis, with an emphasis on increasing ALP levels. This method employed a literature search by collecting several scientific articles discussing the anti-osteoporosis activity of traditional medicinal plants through in vitro, in vivo, and clinical observation studies. The results obtained show that traditional medicinal plants such as Turmeric (Curcuma longa), Black pepper (Piper nigrum), Bromelain (Ananas comosus), Papaya (Carica papaya), Japanese knotweed (Reynoutria japonica Houtt.), Veratrum nigrum, Sickle senna (Cassia tora), Red ginger (Zingiber officinale var. rubrum), Clove (Syzygium aromaticum L.), White turmeric (Curcuma zeadoaria), and Celery (Apium graveolens) are capable of reducing the number of osteoclasts and promoting bone formation. These findings consistently demonstrate a positive role in bone health through increased ALP levels. Indonesian traditional medicinal plants hold great potential as evidence-based anti-osteoporosis agents, particularly through enhancing ALP levels and osteoblast activity. This literature review supports the development of local herbal therapy as a promotive and preventive alternative against osteoporosis.

This study proposes a hybrid approach combining Frequent Itemset Mining (FIM) and Algorithms and Genetic Algorithm for product layout optimization with a case study at PT. MPI Pharmacy. The FIM Algorithms is employed to extract association rules from 1,000 beauty product sales transactions, while the Genetic Algorithm is utilized to perform product placement based on these rules generated, with storage space constraints. Implementation results demonstrate that this hybrid approach successfully identifies 18 key association rules (support >15, confidence >80%) and proposes an optimal layout configuration model that reduces customer travel distance by 25 compared to conventional layouts used by MPI Pharmacy. The Genetic Algorithm solves complex rule-based optimization problems for product placement, which are limited by traditional market basket analysis (MBA) approaches that rely solely on association rules. This hybrid sistem not only improves pharmacy operational efficiency at PT MPI (reducing service time by 18) but also increases cross-selling opportunities by 22. Hence, inventory operations management impproved efficiently. The research findings contribute to the field of retail space optimization by effectively integrating association rule mining and evolutionary computation.  

Fever and cough are diseases that often attack humans. Fever and cough are early signs of infection of a disease that attacks the body. This qualitative study was initiated to identify the types of plants, organs used, and local wisdom inherent in the traditional medicine practices of the people of East Java Province in dealing with fever and cough. Data collection was carried out through literature survey methods and journal reviews. Data sourced from articles in the Google Scholar, Google, and ResearchGate databases were then analyzed using a qualitative descriptive approach.The results of the study showed that there were 9 species of plants used for fever and cough medicine, including turmeric (Curcuma domestica), lime (Citrus X aurantiifolia), fennel (Foeniculum vulgare), starfruit (Averrhoa bilimbi L), kencur (Kaempferia galanga), mengkudu (Morinda citrifolia), katuk (Sauropus androgynus (L.) Merr), tapakliman (Elephantopus scaber), lemongrass (Adropogon nardus). The plant has certain content that can cure fever and cough. Fruit, leaves, rhizomes, and roots are parts of the plant organs that are often used by the community.

Stability testing is an important step in the development of pharmaceutical products. This testing must be conducted before the product is manufactured, whether on an industrial or non-industrial scale. Currently, liquid formulations are experiencing rapid development, one of which is suspension. Suspension itself is a liquid formulation that contains undissolved solid particles dispersed in the liquid phase. To assess the stability of suspension, various evaluations are performed such as organoleptic tests, sedimentation volume, redispersion, density, viscosity, particle size distribution, and pH measurement. Based on several studies, temperature is known to affect the stability of drugs, especially in suspension formulations. A study related to diclofenac suspension showed that at a temperature of 4°C, its stability reaches 96.3%, while at temperatures of 40°C and 60°C, there is a significant reduction in content, amounting to 89.58% and 85.17% respectively. Meanwhile, research on folic acid suspension revealed that the drug remains stable at temperatures of 4°C and 25°C, although on day 90 there was an increase in pH. Another study on cefuroxime axetil suspension showed that at a temperature of 20°C, its concentration was 87.68%, while at 5°C, it was higher at 92.35%. This research underscores the importance of considering temperature in the storage and formulation of pharmaceutical suspensions to maintain their effectiveness and stability.

Penelitian ini bertujuan untuk membandingkan stabilitas paracetamol dalam berbagai bentuk sediaan farmasi: tablet, sirup, dan suppositoria. Stabilitas merupakan parameter penting yang memengaruhi keamanan, efektivitas, dan masa simpan suatu produk obat. Desain penelitian yang digunakan adalah eksperimental deskriptif dengan uji stabilitas dipercepat pada sampel yang disimpan dalam suhu dan kelembapan terkendali selama 3 bulan. Parameter stabilitas fisik dan kimia, seperti karakteristik organoleptik, pH, disolusi, dan kadar zat aktif, dievaluasi secara berkala. Hasil menunjukkan bahwa sediaan tablet mempertahankan stabilitas yang lebih baik dibandingkan dengan sirup dan suppositoria, dengan perubahan minimal pada tampilan fisik dan kadar zat aktif. Sediaan sirup cenderung mengalami degradasi pH dan risiko kontaminasi mikroba, sementara suppositoria menunjukkan deformasi ringan dan migrasi zat aktif. Temuan ini menunjukkan bahwa pemilihan bentuk sediaan berperan penting dalam menjamin stabilitas jangka panjang sediaan paracetamol. Penelitian ini memberikan referensi penting bagi perumusan dan penyimpanan sediaan farmasi.

Indonesia is known as a megabiodiversity country with high biological wealth, including a variety of medicinal plants that are traditionally used by various ethnic groups. One of them is the Tengger Tribe in Lumajang Regency, East Java, which until now still maintains traditional medicinal practices based on medicinal plants. This study aims to explore and document the types of medicinal plants used by the Tengger people, the parts of the plants used, the content of active compounds, efficacy, and pharmacological mechanisms of action based on scientific data. The method used is a literature study by searching for scientific articles through Google Scholar and PubMed in the period 2010–2024. The results of the exploration found at least 15 types of medicinal plants that are often used by the Tengger people, including Eucalyptus globulus, Curcuma longa, Zingiber officinale, and Psidium guajava. These plants have active compounds such as eucalyptol, curcumin, gingerol, and quercetin which work through anti-inflammatory, antibacterial, immunomodulatory, and antioxidant mechanisms. Some of them have been tested preclinically and clinically to support their traditional efficacy. This study emphasizes the importance of scientific documentation and validation of local ethnobotanical knowledge as a basis for the development of phytopharmaceuticals and the preservation of traditional Indonesian health culture.

Malaria remains a significant public health issue in Indonesia, particularly in endemic areas such as Keerom Regency, Papua. Efforts to control this disease face challenges due to Plasmodium resistance to synthetic drugs, highlighting the need for safer and more effective alternative treatments. This study aims to identify the secondary metabolite content of several local plants traditionally used as antimalarial remedies. An experimental laboratory study was conducted using phytochemical screening methods. The plants examined included turmeric rhizome (Curcuma longa), meniran leaves (Phyllanthus niruri), papaya leaves (Carica papaya), sambiloto (Andrographis paniculata), and brotowali (Tinospora crispa). Extraction was carried out using the maceration method with 96% ethanol as the solvent. The results showed that all samples contained secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which are known for their antiplasmodial activity. Extract yields ranged from 18% to 24%, with turmeric rhizome showing the highest yield. These findings suggest that local plants from Keerom Regency hold potential as raw materials for the development of herbal antimalarial drugs. This study serves as a preliminary step for further in vitro and in vivo bioactivity testing.