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Drug-resistant tuberculosis (TB) is an escalating global health issue, particularly with the rise of multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), which complicate treatment and control efforts. Resistance to both first-line and second-line drugs weakens the effectiveness of standard WHO-recommended therapies, while alternative drugs can cause severe side effects and reduce patient adherence. This study aims to explore the integration of bioinformatics and pharmacogenomics in supporting personalized TB treatment to improve therapeutic success and reduce the risk of further resistance. The research employed a laboratory-based experimental design with a bioinformatics approach, involving TB patients with clinical evidence of drug resistance. Clinical samples were analyzed through whole genome sequencing to identify gene mutations associated with resistance, followed by pharmacogenomic mapping to predict pharmacological responses based on patients’ genetic variations. The results revealed several specific gene mutations consistently linked to resistance and produced individualized therapeutic recommendations that were more targeted than standard protocols. Effectiveness evaluation demonstrated that genome-based personalized therapy yielded higher treatment success rates, faster recovery times, and lower rates of subsequent resistance. These findings highlight the significant potential of precision medicine in TB management, particularly for resistant cases that are difficult to treat with conventional approaches. In conclusion, the integration of bioinformatics and pharmacogenomics plays an essential role in strengthening TB treatment strategies through a personalized, adaptive, effective, and sustainable approach. Nevertheless, its implementation still faces challenges such as high costs, limited infrastructure, and the need for clear regulations regarding the use of patients’ genomic data.

The advancement of Industry 4.0 demands production systems to operate more efficiently, adaptively, and securely in facing global challenges. One promising technology that addresses these needs is the Digital Twin (DT), a digital representation of physical systems that enables integration between the real and virtual environments. Through DT, production processes can be modeled, monitored, and tested in real time, allowing for evaluation and optimization before implementation in actual systems. This study aims to explore the effectiveness of DT in modeling automated industrial systems, particularly in relation to improving production efficiency, quality control, energy savings, and operational safety. The research employed an experimental approach based on simulation within a robotic production line consisting of machines, sensors, actuators, and conveyors. The research stages included identifying system components and workflows, developing a DT model that integrates physical and virtual layers with Internet of Things–based data connectivity, and conducting simulations representing diverse operational scenarios. The findings indicate that DT implementation enhances operational efficiency, reduces production errors, and optimizes energy utilization. Furthermore, DT proves effective in strengthening safety aspects by enabling early detection of potential disruptions and providing preventive recommendations before significant impacts occur. Compared to conventional simulations, DT offers a more realistic, adaptive, and relevant approach to the needs of modern industry. The implications of this study highlight DT’s strong potential to become a new standard in the development and control of automation-based production systems, driving the creation of smarter, more efficient, and sustainable industries.

This qualitative study aims to explore the impact of financial literacy on human capital development within micro, small, and medium enterprises (MSMEs). The research utilizes a descriptive qualitative approach to delve into the intricate relationship between financial literacy and human capital enhancement. Sampling technique employed purposive sampling to select MSMEs owners and employees who possess varying degrees of financial literacy. Data analysis involves thematic analysis, allowing for the identification of recurring patterns and themes within the collected data. The findings underscore the pivotal role of financial literacy in fostering human capital development within MSMEs, highlighting its significance in promoting entrepreneurial success, enhancing decision-making processes, and facilitating business growth. This study contributes to the existing body of knowledge by providing insights into the mechanisms through which financial literacy influences human capital development within the context of MSMEs.

It is necessary to take action because the speaking abilities of the youngsters at Baitul Hikmah Early Childhood Education have declined. The purpose of this study is to enhance young children's speaking skills in early childhood education by using role-playing exercises. The John Elliot model of classroom action research is applied in this study methodology. Teachers, parents, and kids in Baitul Hikmah 1 Early Childhood Education are the subjects of this study. There are nine males and eleven girls among the twenty children. Data for this study were gathered through observation, interviews, and documentation. The researcher observed the children at Baitul Hikmah Early Childhood Education 1 and their speaking ability. Both quantitative and qualitative analysis were employed to analyze the data for this study. The study's findings demonstrate that playing activities can help Baitul Hikmah 1 Early Childhood Education students' speaking abilities.

This study aims to determine the partial significant effect of work environment on employee work discipline, to determine the partial significant effect of organizational commitment on employee work discipline, to determine the simultaneous significant effect of work environment and organizational commitment on employee work discipline at the Department of Population and Registration Bima Regency civil servant. The population in this study were 120 employees consisting of 35 civil servants, 21 honorary employees and 64 non-permanent employees. The sample in this study were 35 civil servants using purposive sampling technique. Data collection techniques include observation, interviews, questionnaires, documentation. Data analysis techniques used validity test, reliability test, multiple linear regression test, classic assumption test, multiple correlation coefficient test, coefficient of determination, t test and f test with the help of SPSS version 22 for windows. The results showed that there was a partial positive and significant effect of the work environment on employee work discipline, there was no partial positive and significant effect of organizational commitment on employee work discipline, there was a positive and significant simultaneous effect of work environment and organizational commitment on employee work discipline in Department of Population and Civil Registration of Bima Regency.

The purpose of this study is to find out whether there is an influence of self-efficacy, career development and self-esteem on the performance of Yamaha Panorama in Bengkulu City. The method used in this research is distributing questionnaires. This research is a quantitative approach research. The research population was Yamaha Panorama employees in Bengkulu City, 35 samples were selected to represent Yamaha Panorama in Bengkulu City. The analytical tool used in this study uses SPSS 23. The data analysis method used is multiple linear regression. The results showed that (1) Self Efficacy has a significant effect on Yamaha Panorama Employee Performance, (2) Career Development has no significant effect on Yamaha Panorama Employee Performance, (3) Self Esteem has a significant effect on Yamaha Panorama Employee Performance, (4) Self Efficacy, Career Development and Self Esteem have a simultaneous effect on Yamaha Panorama Employee Performance.

Executive Information Systems (ISE) have become an integral part of modern corporate management, providing executives with relevant and immediate information to support decision making. This journal discusses the implementation of the Executive Information System in the employee payroll process using the Microsoft Visual Studio 2010 development environment and SQL Server database. This research includes the design, development and implementation of an Executive Information System application for the employee payroll department. The system development methodology focuses on requirements analysis, application design, coding, testing, and implementation. Microsoft Visual Studio 2010 is used as the primary development environment, providing powerful tools for building intuitive and efficient user interfaces. SQL Server database is used as an integrated and secure data storage. This application is designed to manage payroll information, including employee personal data, salary history, salary deductions and bonuses. The advantages of this system include the ability to provide real-time information to executives, increase the efficiency of human resource management, and support faster and more accurate decision making in the context of employee payroll.

The problem is that people with disabilities are always considered not to be independent and are often seen as lacking performance in companies. This greatly influences employees with disabilities in adapting to the work environment. Apart from that, the problem raised is the quality of performance of employees who are considered to have committed fraud. The aim of this research is to look at the quality of performance of accountants with disabilities found in literary works. The research method used is the hermeneutical method. The method used is to understand the text and the problem to be able to understand and know the strengths and weaknesses of the text. This research uses data from the literary work used entitled Love Risk Management by Helen Tanuwan. Theories in research are incongruent. The results of this research show that the main character has hearing problems but there are conditions imposed by his former boss so that the main character must be responsible for the bad credit of one of his customers.    

Theme is a fundamental idea that unifies a tale, song, or literary work, making it simple to comprehend and enjoy. The theme serves as a concept, element, descriptor, and attribute. A song without a theme will be dry, unclear, and unlived. This research is aimed to (1) find out the main themes Keshi tries to show through his songs in Bandaids mini album; (2) find out the kinds of themes in Bandaids mini album by Keshi; (3) explain how the song lyrics in Bandaids mini album contribute to poetry teaching. This research using characters, plots, and setting as part of the intrinsic approach. Reads the song lyrics, listen the song, understand the lyrics, taking notes, conducting a thorough analysis, and organizing the data are the methods and approaches to collect data or can be called documentation and observation data collection. Gill’s theory used to discuss the main themes and kinds of themes in the song lyrics; the approach and method of data analysis used are descriptive qualitative with secondary data and three stream (1) data reduction; (2) data display; (3) drawing conclusion. In Gill’s theory (1995), the researcher used three ways to identify main themes, there are the title was selected by the writer of the song to convey a key message to the audience about the music; the characters' interests in moral and psychological development are reflected in how they develop, alter, and come to their own conclusions; repeating symbol or one that is employed at a crucial period might communicate a song's major topic. The result of the data showed 5 are indicated as the main themes and 5 are indicated as kinds of themes, namely love; heartbreak; depression; sadness; loneliness.

The purpose of this study is to determine whether there is an influence between recruitment, training and career development on employee performance at CV. New Source. This study uses a quantitative approach with a questionnaire in obtaining data from respondents, totaling 39 employees, and the entire population is used as a sample. Statistical analysis method using SPSS V.24 software. Tests in this study used validity, reliability, normality test, heteroscedasticity test, multicollinearity test, T test, F test, and the coefficient of determination. Based on the results of the research that has been done, it can be concluded that recruitment, training and career development simultaneously have a significant positive effect on employee performance. Partially, the recruitment variable has a significant positive effect on employee performance. The training variable has a positive and significant effect on employee performance. Career development variable has a significant positive effect on employee performance.

The psychological and emotional state that a person feels in relation to their job is called job satisfaction. It indicates how satisfied, happy, and content a person is with their work environment. Positive feelings about the job itself, the work environment, relationships with coworkers, pay, promotions, recognition, and other elements of the job can be part of job satisfaction.    The method used in this research is descriptive qualitative research method which requires identifying and analyzing the problems found. Data collection techniques through observation, interviews and documentation. The purpose of this study was to analyze and determine employee job satisfaction that occurs at PT Digivla Indonesia.      The results of pre-research data on 20 employees show that 30% of employees are not satisfied with their jobs and 50% are satisfied with their jobs at PT.Digivla Indonesia. The results of the interview show that job satisfaction affects employee performance, this is supported by the Company's efforts to increase job satisfaction and a supportive environment is one of the factors in employee job satisfaction.

This research aims to determine and analyze the influence of Training, Work Discipline and Competency on Performance through Job Satisfaction, both partially and simultaneously. This research uses a quantitative approach with descriptive analysis. The data analysis technique used in this research is filling out a questionnaire. In this study, researchers used a questionnaire with a Likert scale which was distributed to 120 respondents or employees. Analysis tools use Partial Least Square Software (Smartpls 4.0). The calculation results show that: (1) the training variable has a positive and significant effect on employee performance; (2) the discipline variable has a positive and significant effect on employee performance; (3) the competency variable has a positive and significant effect on employee performance.

WiFi networks are very crucial in today's corporate industry. Because the WiFi network contains the internet which acts as a data transfer and communication route to support the company's operations. PT. Bukit Baiduri Energi (PT. BBE) as a company operating in the coal mining sector relies heavily on the internet to carry out company operations. Every day there is always an exchange of data and communication from employees to monitor the process of carrying out existing tasks and work, in responding to problems faced during the internship at PT. Bukit Baiduri Energi, our team takes the right steps to find the optimal solution. The first step taken was to identify the company's needs and formulate the idea of ​​creating a web company profile as a Mikrotik Hotspot captive portal. The website development process involves utilizing HTML, CSS, and JavaScript to create an attractive appearance and ensure functionality. The results of the project during the internship were to create a web company profile as a captive portal for PT Mikrotik Hotspot. Bukit Baiduri Energy. During the internship period at PT BBE, our team succeeded in completing the captive login hotspot project on Mikrotik devices by changing the design of the hotspot login portal and adding a brief company profile page. This project provides important benefits for companies in improving the security of their Wi-Fi networks and introducing the company to users through profile pages. The result is a positive step in supporting the growth and image of companies in the coal mining sector.

Occupational accidents are considered a risk that is difficult to avoid in production or work activities. Protection of rights can ensure the working life not to consider itself in a hazardous work environment, even if accidents at work are inevitable. The research uses implementation assessment elements: programs or policies, target groups, and implementers. The aim of this study is to find out how the implementation of worker rights protection is related to employment accidents at BPJS Employment. The research method used is qualitative, with a library study approach. As for the results obtained in this study, i.e. in creating social security related to work accidents as an attempt to protect workers or workers, the program or policy implemented is JKK (Work Accident Insurance) with the target group of workers and workers and implementers of the BPJS Employment. This research could draw the conclusion that the implementation of social security efforts related to work accidents is not optimal because there are still problems in these activities, such as delays, and companies do not do what should be done by the company.

The purpose of this study was to determine the effect of locus of control and perceptions of organizational support on employee performance with employee engagement and proactive work behavior as intervention variables in DP3AP2KB Central Java Province. This study uses a quantitative descriptive which describes the condition of the facts with the data collected from a questionnaire based on direct observation of the Central Java Province DP3AP2KB. The population in the study included all DP3AP2KB Central Java Province workers, totaling 101 workers and the analysis technique used was multiple linear regression analysis, using SPSS Version 24, and it was found that locus of control had the strongest influence on improving employee performance. Perceived organizational support will also improve employee performance through proactive behavior of employees, because perceived organizational support is found to be unable to directly influence employee performance.

This service activity aims to create contextually-oriented learning and teaching materials for Grade 9 students on the topic of inheritance. The purpose of this activity is to support MGMP teachers in Bogor district. The teaching methods employed during this training activity include lectures, discussions, guidance and hands-on instruction, as well as virtual consultation sessions through Zoom meetings and WhatsApp groups. Lectures and discussions were utilized to present objective information on the concept of crosses, including real-world examples and innovative applications for creating case study-based LKPD. Guidance and training methods, including Zoom meetings and online groups, were employed to finalize and improve knowledge transfer from lectures and discussions. Design abilities of innovative LKPD concepts were improved through training and mentoring on the concept of crossover. The average score before the training was 43, while the posttest score increased to 73. Based on the success indicators of implementing PkM activities for the development of innovative worksheet learning, it was discovered that all participants achieved success in designing LKPD based on case studies. The efficacy of training activities can be gauged by evaluating participant feedback on the usefulness of said activities, grouped into four categories. The results indicate that 73% of participants found the training activities to be "very useful," while the remaining 27% found them "useful."

This paper discusses one of the theological streams within Islam, namely Maturidiyyah, which is divided into Maturidiyyah Samarkand and Maturidiyyah Bukhara. As a reaction to Mu'tazilah, Maturidiyyah, like Asy'ariyyah, is a sect of Ahl al-Sunnah wa al-Jama'ah. This study delineates how the theological thought of al-Maturidi emerged, the background factors, developments after the death of al-Maturidi, the Maturidiyyah thought methodology, and the portrayal of modern Maturidiyyah thought. A qualitative descriptive method is employed with a literature review approach to the Maturidiyyah theological and kalam thought. Rooted in Abu Mansur al-Maturidi, this stream uses rational and verbal evidence to counter Mu'tazilah, Jahmiyyah, and other streams. The evolution of Maturidiyyah is divided into stages of establishment, formation, organization and the foundation of beliefs, as well as expansion and dissemination. Maturidiyyah thought encompasses the obligation to know God, acknowledgment of good and evil, the wisdom and purpose of God's actions, the attributes of Allah, seeing Allah on Judgment Day, and views on major sinners. Modern Maturidiyyah thought emphasizes individual freedom in interpreting and practicing Islamic teachings, active engagement in interfaith dialogue, and maintaining a balance between reason and revelation to uphold the relevance of Islam in the modern era.

The focus of this research is, 1) how business management at CV Antique Production to improve consumer satisfaction in the Islamic Perspective of Islam. 2) What are the constraints on printing business management at CV Antique Production in improving consumer satisfaction in the Islamic Emergency Perspective. 3) What are the solutions of the constraints on printing business management on CV antique production in improving consumer satisfaction in the Islamic Emergency Perspective. This research uses descriptive approach with the type of qualitative research. The data source obtained is primary and secondary data. Data collection techniques with observation, interview and documentation. Data analysis techniques use data reduction, data presentation, and concludes. This research is the management of printing business done by CV. Antique Production To improve consumer satisfaction in the Islamic economic perspective is to implement management functions or management in Islam well. The management function consists of: the implementation (planning), organizing), implementation (actuating), and control (controlling). Constraint business management facing by CV. Antique Production To improve consumer satisfaction include internal constraints that is lack of employees when many demand and delay of product raw material supplies, and external constraints are of unclear consumers with product details of the product and competitor or competitors. Solutions to overcome constraints on printing business management by CV. Antique Production To improve consumer satisfaction includes the solution of internal constraints that adds employees with freelance systems, adding more than one supplyer and check periodically inventory of product raw materials while solutions for external constraints are providing conservation sessions of the booking and consuming businesses by opening product gallery and developing its employee skills.

North Sumatra Regional Main Unit Baitul Mal Foundation, which is part of a State-Owned Enterprise, Collects zakat funds collected from the income of PLN employees. This research aims to investigate the process of collecting and distributing zakat carried out by the North Sumatra Regional Main Unit State Electricity Company Baitul Maal Foundation. This research uses a qualitative approach with a case study design, data is collected through observation, interviews and documentation. The North Sumatra Regional Main Unit Baitul Mal Foundation is the object and source of research data. The research results show that zakat funds are obtained from employee salaries and processed by the amil before being distributed to mustahik in the form of vouchers.  

This study aims to examine the Influence of Accountability, Transparency, and Human Resource Quality on Employee Performance (A Study in the Villages of Langsa Lama Sub-District, Langsa City). The sample selection in this research utilized purposive sampling, with a total of 75 respondents. Data collection was carried out through the distribution of questionnaires. The obtained data were analyzed using the Statistical Product and Service Solutions (SPSS) program. The analytical methods employed in this study included validity testing, classical assumption testing, and multiple linear regression analysis. The research results indicate that accountability significantly influences employee performance, as evidenced by the t-sig value of 0.000 < 0.05. Transparency does not have a significant impact on employee performance, with a t-sig value of 0.130 > 0.05. Human Resource Quality significantly affects employee performance, as indicated by the t-sig value of 0.007 < 0.05. Simultaneously, accountability, transparency, and human resource quality collectively have a significant influence on employee performance, as demonstrated by the results of the F-test with a significance value of 0.000 < 0.05.