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Onikomikosis merupakan suatu penyakit yang disebabkan oleh jamur yang menyerang kuku. Jamur penyakit kuku dapat disebabkan oleh jamur dermatofit, maupun non dermatofit. Jamur golongan dermatofit terdiri dari 3 genus saja yaitu Tricophyton, Microsporum, dan Epidermophyton. Semua genus tersebut memiliki enzim keratinase yang menjadi penentu termasuk jamur dermatofita, dengan penyakit yang diderita biasanya disebut Tinea unguium. Adapun jamur lain yang dapat menyebabkan onikomikosis yang bukan termasuk 3 Genus tersebut, maka dikelompokkan paada jamur non dermatofita. Gejala yang ditimbulkan onikomikosis bervariasi bergantung gejala yang diderita penderita, diantaranya perubahan warna pada lempeng kuku, onikolisis, dan hiperkeratosis subungual yang dapat menyebabkan penebalan lempeng kuku. Prevalensi onikomikosis di Indonesia menunjukkan angka 3,5-4,7%, dan 80-90% diantaranya merupakan kasus onikomikosis yang disebabkan oleh jamur Trichophyton rubrum dan Tricophyton mentagrophytes. Banyaknya kasus onikomikosis tersebut, membuat perlu diadakan kajian dalam penyampaian pencegahan onikomikosis. Dalam jurnal ini dibahas mengenai gembaran klinis serta prosedur diagnosis onikomisis, dan pengobatan yang dilakukan dalam mengurangi infeksi onikomikosis yang dapat dilakukan dengan pengobatan topikal maupun oral. Obat yang biasa digunakan untuk pengobatan onikomikosis diantaranya ciclopirox, eficonazole, dan Amorolfine.

TB is an infectious disease caused by infection with the bacteria Mycobacterium Tuberculosis which can attack the lungs. However, it is not automatically transmitted because transmission depends on several factors such as: body resistance, air circulation conditions, ventilation and contact with people with TB. Based on hospital data in 2024 in the last 3 months, there were 317 cases of pulmonary TB, with 176 cases of patients diagnosed with TB. Treatment can be effective if patients comply with the rules for using drugs prescribed by doctors and from the results of the analysis there is a significant relationship between compliance with taking medication and the rate of recovery of tuberculosis patients. This figure is the third largest case of the disease after type 2 Diabetes Mellitus and Hypertension that occurred at Bhakti Asih Hospital. The purpose of the study was to determine the relationship between stigma and the level of patient compliance in TB treatment at Bhakti Asih Hospital, Ciledug. The research method used was Random Sampling with a sample size of 44 respondents and a measurement method using a questionnaire. The results of the analysis using the chi-square test showed that there was a significant relationship between stigma and compliance with taking pulmonary tuberculosis medication in lung patients at Bhakti Asih Hospital.    

The utilization of electromagnetic fields (EMF) in modern medical technology has become a significant focus of research. This study aims to explore the therapeutic effects of EMF, especially at low frequencies (ELF) and Pulsed Electromagnetic Fields (PEMF), in enhancing the healing of various medical conditions. The method used is a literature study by analyzing various sources from Google Scholar, Science Direct, and PubMed. The results showed that EMF therapy is effective in relieving pain, accelerating tissue healing, and improving the quality of life of patients with musculoskeletal disorders and fractures. Despite the many benefits, it is important to consider the potential health risks of long-term exposure to EMF. This study recommends the development of strict regulations and training for medical personnel to ensure the safe and effective use of EMF.

This study investigates the role of emotional intelligence (EI) in cystic fibrosis (CF) treatment through a comprehensive meta-analysis of 47 studies involving 5,823 CF patients. Results affirm a significant positive correlation between EI and treatment adherence (r = 0.62, p < 0.001), as well as improved quality of life (QoL) for CF patients (β = 0.58, 95% CI [0.49, 0.67]). Regression analysis revealed that EI predicts 37% of the variance in lung function (FEV1) (R² = 0.37, F(1, 5821) = 3421.76, p < 0.001). Furthermore, patients with high EI scores exhibited significantly reduced levels of anxiety (d = -0.79) and depression (d = -0.83) compared to control groups. These findings extend previous research by Salovey et al. (2002) and Ceyhan et al. (2024) by identifying specific EI mechanisms influencing CF treatment outcomes. Unlike Cox et al.'s (2020) study focusing on the general population, our findings specifically demonstrate the effectiveness of EI-based interventions in improving clinical outcomes for CF patients, with an average FEV1 increase of 12% after 6 months of intervention. Lastly, mediation analysis indicated that emotion regulation (β = 0.31, p < 0.001), adaptive health behaviors (β = 0.28, p < 0.001), and utilization of social support (β = 0.22, p < 0.001) mediated the relationship between EI and CF treatment outcomes. These findings underscore the importance of integrating EI training into standard CF care protocols to enhance holistic treatment outcomes.

This meta-analysis investigated the effect of life satisfaction on Sarcoidosis treatment outcomes across 47 studies encompassing 8,932 patients. The findings revealed a significant positive correlation between life satisfaction and treatment success (r = 0.62, p < 0.001). Patients with high life satisfaction scores (>7.5/10) demonstrated a 73% higher likelihood of achieving remission compared to those with low scores (<5/10) (OR = 2.84, 95% CI: 2.31-3.49). Regression analysis indicated that each one-point increase in life satisfaction scores was associated with an 18% reduction in Sarcoidosis relapse rates (β = -0.18, p = 0.002). Treatment adherence and health behaviors were found to mediate the relationship between life satisfaction and Sarcoidosis treatment outcomes, accounting for 42% and 35% of the variance, respectively. Moderator analyses demonstrated stronger effects among patients with disease duration <5 years (p = 0.011) and those with mild to moderate disease severity (p = 0.003). These findings extend the work of Lee et al. (2020) and Martínez-García et al. (2021) by demonstrating a more pronounced effect of life satisfaction on Sarcoidosis treatment compared to other chronic conditions. Notably, contrary to Saketkoo et al (2021) previous study, the effect of life satisfaction remained significant even after controlling for patients' socioeconomic factors (β = 0.41, p < 0.001). These results underscore the crucial role of psychosocial interventions in enhancing Sarcoidosis treatment efficacy, offering new perspectives in the management of this chronic condition.

This meta-analysis examined the relationship between social support and medication adherence among multiple sclerosis (MS) patients through a synthesis of 47 studies (N=12,356). The findings confirmed a significant positive correlation (r=0.42, p<0.001, 95% CI [0.38, 0.46]) with substantial heterogeneity (I²=84.0%). Contrary to Cohen et al.'s (2019) finding that informational support was the strongest predictor, our moderator analyses revealed emotional support as the most robust predictor (β=0.39, p<0.001). Furthermore, this research demonstrated that the effects of social support on MS medication adherence were stronger among women (β=0.18, p=0.023) and patients with longer disease duration (β=0.24, p=0.009), extending Franqueiro et al.'s (2023) findings regarding gender differences in social support effectiveness. Family support showed the largest effect (r=0.48, p<0.001), followed by friends (r=0.40, p<0.001) and healthcare providers (r=0.35, p<0.001). Moreover, mediation modeling revealed a significant role of self-efficacy (indirect effect=0.21, 95% CI [0.17, 0.25]), expanding upon Bandura's (2018) model. Supporting Lavorgna et al.'s (2018) findings, our results confirmed that online social support proved equally effective as offline support (Q=1.87, p=0.171). These findings demonstrated robustness through sensitivity analyses and trim-and-fill procedures, confirming resilience against publication bias (adjusted r=0.39, 95% CI [0.35, 0.43]). The novelty of this research lies in its comprehensive identification of key moderators and underlying mechanisms in the social support-medication adherence relationship and the first empirical testing of an integrated mediation model incorporating social support, self-efficacy, and medication adherence in the MS context.

Background: A malignant tumor known as cervical cancer attacks the female reproductive organs around the vaginal mucosa and the cervical canal mucus, also known as the lower part between the vagina and the uterus. Those diagnosed with cervical cancer must receive a variety of treatments, including chemotherapy, radiation therapy, surgery, or multitherapy. The study evaluated the correlation between treatment and sexual function in patients with cervical cancer at Dr. Kariadi's Hospital in Semarang. This cross-sectional research used consecutive sampling to collect samples from 69 participants from March to April 2024. This study used a questionnaire from the Women's Sexual Function Index. (FSFI). The research results showed that of the 69 respondents, the age group that experienced the most sexual dysfunction was 46-55 years old, with 24 respondents (34.8%), the most common treatment for cervical cancer patients was multitherapy treatment with 49 respondents (71%) , and respondents who experienced sexual dysfunction were 64 respondents (92.8%).The results found a significant correlation between treatment and sexual function in patients diagnosed with cervical cancer. The p-value is 0.004 (p < 0.05), and the correlation coefficient is 0.342, indicating an insignificant correlation. Research suggests that interventions can improve the sexual function of cervical cancer patients.

Fatimah grass (Labisia pumila) is a herbal plant that is widely known in traditional medicine, especially in Southeast Asia. This plant is believed to have various medical properties and has been used to treat various health problems, especially during the birthing process for pregnant women. Clinical studies show the potential of Fatimah Grass in improving women's reproductive health and balancing hormone levels. Although many benefits have been identified, further research is needed to understand the mechanism of action, optimal dosage, and potential side effects. This article aims to summarize the benefits and potential of Fatimah Grass in the medical field and encourage further research for scientific validation and clinical application.

Narcotics and psychotropics are two classes of dangerous drugs that are often abused. The number of users of these two drugs in Indonesia has increased significantly. The purpose of writing this article is to review the use of narcotics and psychotropic substances as a medium of treatment according to Islam. There are several narcotic and psychotropic drugs that can be used medically, including codeine, morphine, methadone, diazepam, alprazolam, methylphenidate, and others. In Islam, narcotics and psychotropic substances are associated with khamr and are absolutely forbidden. However, the use of these two classes of drugs is permitted in emergency conditions.

The community's adoption of Ruqyah Syar'iyyah as an alternative therapy for mental health issues is what spurred this investigation. The research aims to explore the effectiveness of both Ruqyah Syar'iyyah and medical treatment in addressing mental health disorders and to compare the impact on patients. A case study strategy in conjunction with a qualitative technique was used. In-depth interviews with patients suffering from mental health conditions like anxiety, stress, and depression as well as with Ruqyah Syar'iyyah practitioners and medical experts were used to gather data. The findings indicate that Ruqyah Syar'iyyah provides spiritual tranquility, mental fortitude, and increased faith in patients, while medical treatment helps manage symptoms and correct chemical imbalances in the brain. The combination of both approaches yielded significant positive impacts on patients, including reduced symptoms, improved quality of life, and faster recovery. This study concludes that a holistic approach integrating Ruqyah Syar'iyyah and medical treatment can serve as an effective alternative in addressing mental health disorders.

This meta-analysis investigates the relationship between hope and medication adherence in colorectal cancer (CRC) patients. Out of 1,247 identified articles, 18 studies met the inclusion criteria, encompassing 3,562 patients. The findings reveal a significant positive correlation between hope and medication adherence (r = 0.42, 95% CI: 0.35-0.49, p < 0.001), with notable heterogeneity (I² = 76.4%, Q = 72.03, df = 17, p < 0.001). Furthermore, subgroup analyses indicate a stronger effect in patients with advanced-stage cancer (r = 0.49, 95% CI: 0.39-0.58) compared to those in various earlier stages (r = 0.38, 95% CI: 0.30-0.46, Q = 4.12, df = 1, p = 0.04). No significant differences were found regarding the influence of hope on medication adherence based on treatment type or the country of the study. Additionally, this research extends the findings of DiMatteo et al. (2000) concerning the impact of depression on medication nonadherence, emphasizing the importance of positive psychological states. Moreover, the larger effect size observed for self-efficacy and adherence (r = 0.31) reported by Hall et al. (2016) underscores the relative significance of hope in CRC medication adherence. The novelty of this research lies in its comprehensive synthesis of the hope-adherence relationship within the CRC context, clarifying the varied and partial findings of Zhu et al. (2017) and García-Torres et al. (2016). Consequently, these results support the development of hope-based interventions to enhance medication adherence, as Snyder (2002) suggested in the specific context of CRC. Future research should focus on longitudinal analyses and intervention trials to clarify causal relationships and the effectiveness of hope-based approaches in improving CRC medication adherence.

Behçet's disease is a multisystem inflammatory disorder that can significantly impact patients' quality of life. This study conducts a meta-analysis aimed at elucidating the effects of social anxiety on treatment outcomes for Behçet's disease through a comprehensive synthesis of existing literature. Initially, a systematic search was performed across major electronic databases to identify relevant studies published between 2014 and 2024. Out of 1,253 initially identified articles, 18 studies met the inclusion criteria, encompassing 2,487 Behçet's disease patients. The meta-analysis revealed a significant negative correlation between social anxiety levels and treatment adherence for Behçet's disease (r = -0.42, p < 0.001), which was positively associated with disease symptom severity (g = 0.58, 95% CI [0.41, 0.75]). Moderator analysis indicated that the effect of social anxiety on Behçet's treatment outcomes was more pronounced in patients with mucocutaneous manifestations (Q = 7.23, p = 0.007). Additionally, social anxiety showed a strong negative correlation with patients' quality of life in health (r = -0.53, p < 0.001), with the most substantial impact observed in the social functioning domain. Furthermore, thematic analysis of the potential mechanisms underlying the relationship between anxiety and Behçet's treatment outcomes confirmed the mediating roles of patient-doctor communication barriers, increased stigma perception, and avoidance behaviour. These findings underscore the importance of assessing and addressing social anxiety in the comprehensive management of Behçet's disease. The researchers suggest that these findings could have implications for improving patient treatment and quality of life. Finally, the study supports the integration of targeted psychological interventions into standard care protocols for Behçet's disease and emphasizes the need for a biopsychosocial approach to managing this condition. 

This study evaluates the impact of positive emotions on rheumatoid arthritis (RA) treatment outcomes through a meta-analysis of 47 studies (2015-2024) involving 12,384 patients. The primary findings reveal a significant positive correlation between positive emotions and improved RA treatment outcomes (r = 0.42, p < 0.001), with the strongest effects observed in enhanced quality of life (r = 0.51) and physical function (r = 0.45). Patients exhibiting high positive emotions demonstrated greater reductions in pain (d = 0.38), decreased inflammation (d = 0.29), and improved physical function (d = 0.45) compared to control groups. Moreover, moderator analyses uncovered stronger effects among elderly patients (? = 0.012, p = 0.025) and those with longer RA duration (? = 0.018, p = 0.009). Finally, mediational analyses indicated that positive emotions contributed to improved treatment adherence (indirect effect = 0.09, 95% CI [0.05, 0.13]) and increased physical activity (indirect effect = 0.07, 95% CI [0.03, 0.11]) in RA patients. These findings extend Fredrickson's (2001) Broaden-and-Build theory and support Keefe et al.'s (2002) biopsychosocial model. Compared to meta-analyses by Brosseau et al. (2018) and Zhou et al. (2020), this study provides more comprehensive evidence on the role of positive emotions in various RA treatment outcomes. The novelty of this research lies in the analysis of previously unexplored mediating and moderating mechanisms, as well as a comparison of effectiveness with pharmacological interventions (SMD = 0.18, 95% CI [-0.05, 0.41], p = 0.124). These results support the integration of positive emotion-based interventions in RA management and expand upon Strand et al.'s (2019) findings on patient expectations in RA treatment.

This meta-analysis investigates the impact of negative emotions on the effectiveness of endometriosis treatment. Of the 1,245 articles identified, 32 studies (n=4,876 patients) met the inclusion criteria. The results revealed a significant negative correlation between negative emotions and treatment effectiveness (r = -0.38, 95% CI [-0.45, -0.31], p < 0.001). Subgroup analysis further demonstrated a stronger effect on medical treatments (r = -0.43) compared to surgical treatments (r = -0.29, p = 0.02). Additionally, negative emotions were most strongly correlated with pain intensity (r = -0.45), followed by quality of life (r = -0.39), medication adherence (r = -0.33), and patient satisfaction with treatment (r = -0.28, p = 0.02). The meta-analysis of randomized controlled trials (RCTs) (n=8) indicated that psychological interventions could significantly enhance endometriosis treatment outcomes (SMD = 0.58, 95% CI [0.39, 0.77], p < 0.001), with cognitive-behavioural therapy (CBT) being the most effective intervention (SMD = 0.67). Furthermore, the study found that the average age of patients moderates the relationship between negative emotions and endometriosis treatment (β = -0.015, p = 0.03), specifically indicating that the strongest effects of negative emotions are observed in younger patients. Finally, mediation analysis identified that pain perception, medication adherence, and maladaptive coping mechanisms are key mechanisms in the relationship between negative emotions and treatment effectiveness. These findings extend previous research by As-Sanie et al. (2014) and Lagana et al. (2017) by quantifying the impact of negative emotions and validating the effectiveness of psychological interventions as a novel contribution. The researchers advocate for a biopsychosocial approach in endometriosis management to facilitate routine screening for psychological issues and recommend the integration of holistic interventions combining medical and psychological support into standard endometriosis care.

ISPA merupakan penyakit infeksi yang masih menjadi masalah di Indonesia karena kasusnya masih cukup tinggi. Meski pada orang dewasa tidak menimbulkan kesakitan yang parah, namun pada orang tertentu ISPA juga berpotensi meninmbulkan masalah kesehatan yang lebih besar. Berdasarkan permasalahan diatas, pengabdi tertarik mencari alternative solusi untuk mengurangi masalah kesehatan pernafasan pada manusia khususnya warga Desa Sumilir. Pemanfaatan rempah-rempah alami dapat digunakan sebagai solusi pengobatan ISPA pada manusia, seperti jahe, kencur dan bunga telang yang mudah didapatkan. Metode pelaksanaan pengabdian diberikan melalui metode sosialisasi informatif dan praktek langsung. Peserta yang mengikuti kegiatan aktif dalam sosialisasi dibuktikan dari pertanyaan yang diajukan dan warga antusias dalam mengikuti demo pembuatan minuman. Kegiatan ini melibatkan 17 warga Desa Sumilir, yang sebagian besar diikuti oleh Ibu-Ibu. Kegiatan ini sangat bermanfaat dalam pemahaman peningkatan informasi kesehatan pernafasan dan sebagai langkah awal dalam mengurangi gejala ISPA.

This study examines the relationship between life satisfaction and the effectiveness of systemic lupus erythematosus (SLE) treatment through a systematic review and meta-analysis of 32 studies (N=8,746) published between 2018 and 2023. The analysis reveals a moderate negative correlation between life satisfaction and lupus disease activity (r=-0.38, 95% CI: -0.44 to -0.32, p<0.001). More specifically, the data demonstrate a strong positive correlation between life satisfaction and quality of life in the context of health (r=0.52, 95% CI: 0.47-0.57, p<0.001) and a moderate positive correlation with medication adherence (r=0.34, 95% CI: 0.28-0.40, p<0.001). Longitudinal analysis (n=6 studies) shows that early improvements in life satisfaction are significantly predictive of reductions in lupus disease activity (?=-0.24, p<0.001) and enhancements in quality of life (?=0.29, p<0.001) over six months to 2 years. Meta-regression analysis further identifies age (?=0.008, p=0.03) and disease duration (?=0.015, p=0.01) as significant moderators of the effect of life satisfaction on SLE treatment outcomes. These findings extend previous research by Diener and Chan (2011) on well-being and health and by Mok et al. (2019) on depression in SLE by emphasizing the specific role of life satisfaction in SLE management. The novelty of this study lies in its focus on life satisfaction rather than solely negative risk factors, highlighting the potential for life satisfaction-based interventions in the management of SLE. This research supports the integration of life satisfaction assessments and psychosocial interventions into standard SLE care protocols, offering new insights into the psychoimmunological approach to SLE treatment.

Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract that is often accompanied by psychological disorders such as depression. This study aims to analyze the impact of depression on the effectiveness of Crohn's disease treatment through a systematic review and meta-analysis. A literature search was conducted across electronic databases, including PubMed, Scopus, and Web of Science, for studies published in the last five years. Of the 1,247 articles identified, 28 studies met the inclusion criteria. The meta-analysis results indicate that Crohn's disease patients with depression have a lower remission rate (OR = 0.65, 95% CI: 0.54-0.78) and a higher relapse rate (HR = 1.58, 95% CI: 1.32-1.89) compared to patients without depression. Additionally, subgroup analysis reveals that the negative effects of depression are more pronounced in patients receiving biological therapy. These findings underscore the importance of a holistic approach in the management of Crohn's disease, considering the psychological aspects of patients to optimize treatment outcomes.

Lemongrass has many benefits that can be processed into processed ingredients in traditional medicine to overcome diseases, especially to relieve leg pain that attacks children and adults. Lemongrass in Manen Kaleka village is quite abundant because it is easy to grow lemongrass in the area. Lemongrass plants are only widely sold in the Manen Kaleka village market only for cooking ingredients and its economic value can be said to be still low because of the level of processing. One of the measures that have been shown to be effective non-pharmacologically to reduce pain is to warm the affected joint. This lemongrass soak can be used in the treatment of pain and relax tense muscles. Plants that have substances as warmers, anti-inflammatories and can smooth blood flow such as lemongrass. The purpose of this activity is to describe the use of lemongrass decoction in traditional medicine for leg pain at the Manen Kaleka Village Posyandu in 2024, as well as to explore its potential benefits for public health.

Fibromyalgia is a chronic disorder characterized by widespread muscle pain and fatigue, often accompanied by psychological symptoms such as anxiety and depression. Medication adherence is crucial for managing this condition, yet many patients struggle to follow prescribed regimens. This study aims to explore the role of self-efficacy in medication adherence among fibromyalgia patients through a systematic review and meta-analysis. The researcher conducted a literature search in major electronic databases to identify relevant studies published between 2015 and 2023. Out of 1,247 identified articles, 18 studies met the inclusion criteria and were eligible for analysis. The meta-analysis results indicate a significant positive relationship between self-efficacy and medication adherence (r = 0.42, 95% CI [0.35, 0.49], p < 0.001). Moderator analysis revealed that this relationship is stronger among patients receiving self-efficacy-based interventions compared to those receiving standard care. These findings underscore the importance of integrating self-efficacy enhancement strategies into fibromyalgia management to improve medication adherence, ultimately leading to better patient health outcomes.

Hypertension is a Non-Communicable Disease (NCD) characterized by elevated blood pressure above the normal value of 140/90 mmHg. Evaluation of antihypertensive drug use aims to ensure rational and effective medication use in hypertensive patients. Improper medication use can lead to treatment failure. The objective of this study is to evaluate the pattern of antihypertensive treatment among hypertensive outpatients at the Community Health Center (Puskesmas) of Sumberlawang Sub-District, Sragen in 2023. The research was descriptive observational with a cross-sectional study design. Sample selection used purposive sampling based on inclusion and exclusion criteria. The instrument for this study utilized medical records data of hypertensive outpatients at the Community Health Center (Puskesmas) Sumberlawang, Sragen from January to December 2023. Results from the study involving 100 hypertensive patients showed that the majority were female (78%), aged between 51-61 years (40%), with amlodipine being the most frequently used antihypertensive medication (62%), and Calcium Channel Blockers being the most commonly prescribed class of antihypertensive drugs (60%). Evaluation of antihypertensive treatment patterns among 100 patients revealed percentages indicating appropriate indication (100%), patient suitability (100%), correct drug selection (97%), and correct dosage (97%).