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Vitamin A Deficiency (VAD) and iron deficiency anemia (IDA) are global nutritional issues affecting children, particularly in developing countries. The interaction between these two conditions can lead to a more complex condition known as Vitamin A Deficiency Anemia (VADA). This study aims to review the molecular relationship between Vitamin A deficiency and iron metabolism leading to VADA, as well as its impact on children's health. The methodology used in this article is a literature review of various clinical studies, epidemiological research, and relevant molecular experiments. The results show that VADA is primarily a functional iron deficiency, where iron absorption is impaired despite overall body iron levels not being critically low. This mechanism involves the regulation of hepcidin, redistribution of iron, and its effects on erythropoiesis. Additionally, therapy with Vitamin A supplementation has been shown to increase erythropoietin and hemoglobin production in children with dual deficiencies. The implications of these findings highlight the need for more integrated therapeutic strategies that consider both Vitamin A and iron status simultaneously. Further research is needed to understand the molecular mechanisms more deeply involved in this interaction and to develop more effective therapies for children with VADA.

Anemia is a medical condition characterized by a lower-than-normal number of red blood cells or hemoglobin levels in the blood. This results in a reduced ability of the blood to carry oxygen throughout the body. Consequently, individuals with anemia may experience various symptoms such as fatigue, dizziness, and shortness of breath. The main causes of anemia are generally due to a lack of knowledge about this condition and deficiencies in nutrients such as iron.The purpose of this study is to determine the level of knowledge among ninth-grade female students regarding the prevention of anemia and their ability to prevent it. This study uses a descriptive research method, focusing on describing the level of knowledge of ninth-grade female students about the prevention of anemia.The study uses the Total Sampling method as the sampling technique, which means that all members of the population are included as respondents. Therefore, the number of respondents in this study is equal to the total population of female students, which are 54 individuals. Data collection is conducted using a closed-ended questionnaire consisting of 20 items covering indicators such as the definition of anemia, its etiology, signs and symptoms, treatment, and prevention.The results of the study show that knowledge regarding the definition of anemia is in the good category for 35 respondents (64.8%), knowledge about etiology is in the fair category for 35 respondents (64.8%), knowledge of signs and symptoms was in the fair category for 45 respondents (83.3%), knowledge about treatment is in the good category for 33 respondents (61.1%), and knowledge of prevention is in the fair category for 32 respondents (59.3%).It is hoped that by increasing the knowledge of ninth-grade female students about the prevention of anemia, schools and health workers can work together to carry out regular health education.

Hemoglobin examination constitutes an essential procedure in clinical diagnosis, with the SLS-hemoglobin method serving as a non-toxic alternative to cyanmethemoglobin. However, the limited availability of sulfolyser has prompted investigations into the use of soap solutions, which also contain sodium lauryl sulfate (SLS), as a potential substitute. This study employed a quasi-experimental design with a posttest-only control group on 24 blood samples, comparing the standard sulfolyser reagent with three types of commercial soaps. The analysis revealed significant differences in hemoglobin levels across groups (p < 0.001), with dishwashing soap yielding values most comparable to the control, albeit still statistically lower. These findings confirm that soap solutions are capable of lysing erythrocytes and forming hemoglobin complexes, though variations in product composition constrain the consistency of results. Practically, soap demonstrates potential as a more accessible and cost-effective alternative reagent; however, its application requires concentration standardization to ensure diagnostic validity.

Anemia in pregnancy is a major health problem that increases maternal and fetal morbidity and mortality, thus requiring prompt and appropriate management. This study aimed to describe nursing care for Mrs. D, a 19-year-old primigravida with anemia in the Nusa Indah Ward of RSUD dr. Soeselo, Tegal Regency. The method used was a case report with data collected through interviews, direct observation, and medical record review during hospitalization from January 13–15, 2025. Assessment results showed a hemoglobin level of 6.5 g/dL with clinical signs of pallor, cold extremities, tachycardia, and complaints of dizziness and weakness. The nursing diagnoses established were ineffective peripheral perfusion and risk for nutritional deficit. Interventions included monitoring vital signs, providing nutritional education, administering iron and folic acid supplements, and collaborating on blood transfusion. Evaluation indicated both subjective and objective improvement, and the nursing problems were resolved. In conclusion, comprehensive and collaborative nursing care contributed to the improvement of the patient’s condition with pregnancy-related anemia.

Pregnancy is a unique natural condition because although it is not a disease, it often causes complications due to various anatomical and physiological changes in the mother's body. Pregnant women who suffer from anemia can have an impact on the fetus, such as premature birth, the risk of low birth weight (LBW), fetal abnormalities, and increased risk of fetal distress. In general, the causes of anemia in pregnancy are iron deficiency and acute bleeding or even the interaction of both. The purpose of this study was to determine the difference in the effectiveness of giving red spinach juice and Ambon bananas on Hb levels in pregnant women in the third trimester. The design used in this study was a quantitative inferential study including the pre-experimental type with two group pretest-posttest. Based on the time of data collection, it included the cross-sectional type, sourced from primary and secondary data. An assessment of the difference in increasing HB levels was carried out before and after treatment (Pretest and Postest two Group Design). Data analysis consisted of univariate and bivariate analysis. The results of the analysis showed an effect in giving red spinach juice and Ambon bananas. It is hoped that the Health Center will facilitate health workers (midwives) in providing information on providing guava juice with red spinach leaf juice as an alternative for preventing and managing anemia during pregnancy in the Health Center's work area.    

Anemia is a global health problem with a high prevalence among adolescents, especially girls, due to increased iron requirements, rapid growth, and menstruation. This condition impacts health, concentration, and quality of life. Hemoglobin, as an indicator of anemia, plays a crucial role in oxygen transport, so adolescents' understanding of its function is crucial. This activity aims to increase adolescents' understanding of the role of hemoglobin and anemia prevention through health education at SMK Negeri 10 Garut. The method used was a participatory approach through an initial questionnaire, material delivery, discussion, and post-education evaluation. The results showed an increase in students' knowledge about anemia and hemoglobin. This education effectively increases adolescents' awareness and motivation to improve their diets, so it needs to be implemented continuously with the support of schools, parents, and health workers.

Working memory capacity is a crucial aspect of cognitive function that plays a significant role in supporting students' learning processes. Working memory functions as a temporary storage system that allows individuals to store and manipulate information quickly. In an educational context, optimal working memory capacity can improve students' ability to understand, process, and remember information presented during the teaching and learning process. Several factors known to influence working memory capacity include breakfast habits, nutritional status, body fat percentage, and hemoglobin (Hb) levels. These factors are closely related to students' daily nutritional intake and healthy lifestyle. This Community Service (PkM) activity, with the topic "Healthy Food and Lifestyle to Increase Working Memory Capacity," aimed to increase students' understanding and awareness of the importance of a healthy diet and an active lifestyle in supporting cognitive function, particularly working memory. This activity was held in July 2024 at MTs (Madrasah Tsanawiyah) Al Fatah, Natar District, Lampung Regency. The implementation method was interactive nutrition education, covering the importance of a nutritious breakfast, consuming a balanced diet, physical activity, and general health care. Based on the results of evaluations conducted before and after the activity, there was an increase in the average knowledge scores of female students, as well as a significant difference in their understanding of the concepts of healthy eating and a lifestyle that supports working memory function. These findings indicate that nutrition education interventions have significant potential to improve the quality of learning by enhancing students' cognitive aspects. This activity is expected to become a model that can be implemented sustainably in other school settings.

Thalassemia is a genetic disorder characterized by impaired hemoglobin synthesis. This disease is caused by mutations in the globin gene, leading to disrupted production of globin chains. As a result, the red blood cells produced are dysfunctional and have a shorter lifespan, causing anemia. This condition requires proper medical management, including blood transfusions and other treatments. One way to detect and monitor the progression of thalassemia is by using biochemical markers that can identify changes in the patient’s body. Therefore, the aim of this systematic literature review is to identify biochemical markers that can be used for the diagnosis and monitoring of thalassemia. The literature used in this study includes articles on human thalassemia research published in the last 10 years. Literature searches were conducted in several academic databases using relevant keywords such as “biochemical markers for thalassemia,” “diagnosis of thalassemia,” and “thalassemia monitoring.” Based on the search results, several biochemical markers related to thalassemia were identified, including hepcidin, ferritin, and lipid profile. Ferritin plays a role in monitoring iron levels, which are often elevated in thalassemia patients, while hepcidin regulates iron homeostasis in the body. Additionally, other components involved in thalassemia diagnosis and monitoring include Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), and hemoglobin levels. The findings of this systematic literature review are expected to provide a comprehensive overview of biochemical markers that can be used in the diagnosis and monitoring of thalassemia. By identifying relevant markers, it is hoped that more accurate and effective diagnostic methods will be developed in the future, leading to better monitoring of thalassemia patients.

Background: Anemia during pregnancy remains a major public health concern in Indonesia, contributing to increased maternal and fetal morbidity. Iron supplementation often faces challenges in compliance and side effects, prompting the need for natural alternatives. Natural honey has been shown to help increase hemoglobin levels due to its iron, folate, and antioxidant content. Objective: This community service aimed to educate pregnant women on the benefits and utilization of natural honey as a complementary strategy to prevent anemia. Method: The activity was conducted at PMB CH Mala in Palembang City using health education sessions, demonstrations, and distribution of printed educational materials. Participants' knowledge and hemoglobin levels were assessed pre- and post-intervention using a questionnaire and digital hemoglobinometer. The intervention lasted for 2 weeks, with honey consumption recommended at 2 tablespoons daily. Results: There was a notable improvement in participants' knowledge about anemia and the role of honey. Preliminary observations also showed a slight increase in hemoglobin levels among pregnant women who regularly consumed honey during the intervention period. Conclusion: Educational intervention on the use of natural honey proved effective in improving knowledge and potentially supporting anemia prevention among pregnant women. Further studies are recommended to evaluate long-term outcomes and larger-scale implementation.

Chronic Kidney Disease (CKD) is a major global health issue that can lead to serious complications and long-term medical care. This study aims to identify key clinical factors associated with CKD status using binary logistic regression analysis. The dataset, obtained from Kaggle, contains 400 patient records with various clinical and demographic attributes. The dependent variable is CKD status (positive or negative), while the independent variables include age, blood pressure, hemoglobin level, urine albumin level, and serum creatinine. Initial analysis involved descriptive statistics and multicollinearity checks, followed by model estimation and evaluation using likelihood ratio and Wald tests. The final model identified four significant predictors: blood pressure, hemoglobin, urine albumin, and serum creatinine. The model achieved a high classification accuracy of 95.50% and an Area Under the ROC Curve (AUC) of 98.78%, indicating excellent predictive performance. These results highlight the importance of these clinical indicators in early CKD detection and support their use in risk assessment models for kidney disease screening Keywords: Chronic Kidney Disease, Binary Logistic Regression, Likelihood Ratio Test, Wald Test, Classification Accuracy

Iron-deficiency anemia during pregnancy remains a major public health concern in developing countries. This study aims to evaluate the effectiveness of iron and folic acid supplementation, known as iron tablets, in reducing the risk of anemia among pregnant women. A descriptive qualitative literature review method was employed by analyzing nine eligible studies published between 2013 and 2023. Articles were selected from databases including Google Scholar, PubMed, and ScienceDirect using specific keywords. The findings suggest that regular consumption of iron tablets, particularly starting in the second trimester and meeting the minimum recommended dose of 90 tablets, is effective in improving hemoglobin levels and lowering anemia prevalence. However, compliance remains a significant challenge, influenced by side effects, maternal knowledge, and social support. The review highlights the need for behavior-based interventions and family involvement to enhance adherence. The implication of this review supports the integration of targeted health education and follow-up strategies within antenatal care services to reduce anemia-related risks in pregnancy.

Type 2 diabetes mellitus (T2DM), hypertension, anemia, nephrotic syndrome, and urinary tract infection (UTI) are interrelated clinical conditions frequently encountered in patients with chronic kidney disease (CKD). This case report presents a 33-year-old woman who was admitted with complaints of generalized weakness, accompanied by headache, generalized edema, and pruritus. Laboratory findings revealed hyperglycemia (>300 mg/dL), elevated blood pressure (210/120 mmHg), increased urea and creatinine levels, 2+ proteinuria, and microcytic hypochromic anemia (hemoglobin ranging from 7.9 to 9.9 g/dL). Urinalysis showed leukocyturia, hyaline casts, and bacteriuria. The patient was diagnosed with uncontrolled T2DM, hypertensive urgency, microcytic hypochromic anemia, nephrotic syndrome, and UTI. Management included basal-bolus insulin regimen, combined antihypertensive therapy, packed red cell transfusions, and supportive treatments. Throughout the hospitalization, improvements were observed in hemoglobin levels and blood pressure, although subjective symptoms such as fatigue and headache remained fluctuating. This case highlights the importance of comprehensive and multidisciplinary management in patients with complex multisystem chronic conditions to prevent complications and improve clinical outcomes.

Iron deficiency anemia (ADB) is anemia that arises due to reduced iron supply for erythropoiesis, due to empty iron stores (depleted iron stores) which ultimately results in reduced hemoglobin formation. This study aims to determine the effect of giving blood supplement tablets on HB levels in female students suffering from anemia at SMAN 1 Tambakboyo, Tuban Regency. The research design used a pre-experiment using a one group pre test post test approach, with a total sampling technique on a population of 34 female students suffering from anemia in class X and analyzed using the Wilcoxon test. The instruments in this research were Standard Operating Procedures (SOP), hemoglobin level observation sheets and Easy Touch GCU brand hemoglobin measuring equipment. The results of the study showed that the average HB level before 10.17 g/dl and after 15.46 g/dl given blood supplement tablets was normal. The results of the Wilcoxon test obtained a significant value of p=0.000 (p<0.05), which means that there was a significant difference in the HB levels of class X female students before and after being given blood supplement tablets. Health workers, especially in school health offices, should provide blood supplement tablets at the right time so that female students can take the blood supplement tablets regularly and finish them.

Anemia during pregnancy is a significant health issue that contributes to the incidence of low-birth-weight (LBW) babies. At the Bere-Bere Community Health Center, the prevalence of LBW is 15%, higher than the national average, and the prevalence of anemia in pregnant women is 30%. This study aimed to analyze the relationship between hemoglobin (Hb) levels in pregnant women and the incidence of LBW at the center. A cross-sectional design was used with 30 pregnant women selected via purposive sampling. Hb levels were categorized into anemia (Hb <11 g/dL) and normal (Hb ≥11 g/dL), while birth weight was categorized into LBW (<2500 grams) and normal (≥2500 grams). Data analysis was performed using univariate and bivariate analysis with the Chi-Square test. Results showed that 43.3% of pregnant women experienced anemia and 33.3% of babies had LBW. Of the 13 anemic mothers, 61.5% gave birth to LBW babies, while only 11.8% of mothers with normal Hb levels had LBW babies. The Chi-Square test revealed a significant relationship (p = 0.004, p < 0.05) between maternal Hb levels and LBW incidence. In conclusion, maternal anemia is significantly associated with LBW, highlighting the need for interventions such as iron supplementation, nutrition education, and regular check-ups to prevent anemia and reduce LBW rates.

The third trimester of pregnancy is a critical period with increased risks of obstetric complications, necessitating adequate knowledge of pregnancy danger signs. The Pregnant Women's Class (Kelas Bumil) is a preventive and educational initiative in antenatal care designed to enhance knowledge and preparedness among pregnant women. This study aimed to assess the impact of the Pregnant Women's Class on the knowledge of pregnancy danger signs and changes in hemoglobin levels among third-trimester pregnant women. Using a quasi-experimental pretest-posttest design, the study involved 30 pregnant women selected through purposive sampling. Knowledge was assessed via structured questionnaires before and after attending the class, while hemoglobin levels were measured at both intervals. Univariate and bivariate analyses were conducted, with the Wilcoxon test used for comparing pre- and post-intervention data (p < 0.05). Results revealed a significant increase in knowledge levels, with most women showing good knowledge after the intervention. Hemoglobin levels also improved significantly (p = 0.001). These findings demonstrate that the Pregnant Women's Class effectively enhances both cognitive knowledge and health status in pregnant women. In conclusion, strengthening and sustaining the Pregnant Women's Class should be a continuous part of integrated antenatal care to improve maternal health outcomes.

Hemoglobin and hematocrit examinations serve as important early indicators of hematological status, reflecting the blood’s capacity to transport oxygen. A decrease in these two parameters leads to anemia, which is often undetected due to minimal early symptoms and low awareness to undergo examinations. This activity was carried out using the Plan-Do-Check-Act (PDCA) approach, by examining hemoglobin and hematocrit levels in adult participants. Capillary blood samples were analyzed using a portable device at the examination location. Education was delivered through leaflets regarding the importance of iron, vitamin B12, and folate intake to support erythrocyte formation. The examination was attended by 104 participants, the majority of whom were women. The average hemoglobin was recorded as approaching the lower limit of normal values, while hematocrit levels showed wide variations. More than half of the participants were classified as having anemia. This high proportion of anemia highlights the urgent need for targeted nutritional education. Hemoglobin and hematocrit screening proves effective as an early detection tool for hematological disorders. Education that is linked to laboratory findings should be prioritized to promote improved dietary patterns, particularly the consumption of iron-rich foods, vitamin B12, and folate, in order to prevent erythropoietic dysfunction and long-term health complications.

Anemia is a common nutritional problem that occurs in vulnerable groups such as pregnant women and teenage girls. One of its main causes is iron deficiency, which can be exacerbated by low vitamin C intake. Red guava (Psidium guajava L.) is a local fruit that is rich in vitamin C and has the potential to improve iron absorption, thus supporting an increase in hemoglobin levels. This study aims to review the effectiveness of red guava in increasing hemoglobin as an effort to prevent anemia. This study uses a literature review design on five experimental research articles published in the last 10 years. The study results show that the consumption of red guava, whether consumed alone or in combination, can significantly increase hemoglobin levels in pregnant women and adolescent girls with anemia. The vitamin C content in red guava plays a role in enhancing the bioavailability of iron needed for hemoglobin formation. Thus, red guava has the potential to be used as part of a locally based food nutrition intervention that is effective, affordable, and applicable in the effort to prevent anemia.

Anemia is a medical condition characterized by a decrease in the number of red blood cells (erythrocytes) or hemoglobin (Hb) levels in the blood which results in impaired oxygen transport to body tissues. Mild anemia is more common and is asymptomatic and does not require treatment. Anemia can have a negative impact on endurance, productivity, and is high risk during pregnancy because it can affect fetal growth and development, increase the risk of pregnancy and childbirth complications, and even maternal and child death. The Community Service (PKM) activity carried out at the Asisi Church, Tebet District aims to increase public awareness of the importance of early detection of anemia through hemoglobin and hematocrit screening activities. This activity uses the Plan-Do-Check-Act (PDCA) approach which includes capillary blood tests with Point-of-Care Testing (POCT) tools and education about symptoms, risk factors, and prevention of anemia. Of the 68 participants involved, 40 people (58.82%) were identified as having anemia, while 28 people (41.18%) had normal hemoglobin levels. These results emphasize the importance of early anemia screening to prevent long-term complications and build public awareness of the importance of maintaining optimal hemoglobin levels to support ongoing health and quality of life.   Keywords: Anemia, Early Detection, Hemoglobin, Hematocrit, Screening

Anemia is a common health issue among adolescent girls, primarily due to increased iron demands during growth and menstruation. This literature study aims to synthesize existing research on complementary therapies for managing anemia in this population. The study employed a literature review design with a systematic search of scientific articles published between 2018 and 2025. Data were collected from multiple electronic databases, including PubMed and Google Scholar, using keywords such as "anemia," "adolescent girls," "complementary therapy," "iron deficiency," "herbal medicine," and "nutritional intervention." Only peer-reviewed articles, clinical trials, systematic reviews, and meta-analyses published in English were included. The review found that natural interventions like Moringa oleifera leaf extract, beetroot juice, dates with lime juice, and educational programs are effective, affordable, and culturally acceptable for improving hemoglobin levels and anemia prevention. However, many studies have limitations such as small sample sizes and short intervention durations. Future research should focus on more rigorous designs with larger samples and longer follow-ups. Combining nutritional supplementation with health education offers a promising holistic approach to managing anemia in adolescent girls.

Anemia is a common complication in cancer patients, especially in advanced stages, which affects quality of life and response to therapy. This study aims to analyze the relationship between cancer stage and hemoglobin (Hb) levels in female patients undergoing chemotherapy. This quantitative study used a cross-sectional design and involved 54 female cancer patients at the H. Adam Malik General Hospital Polyclinic, Medan. The sampling technique used convenience sampling. Data were analyzed using the Spearman's rho test to determine the relationship between cancer stage and Hb levels. The majority of respondents were in stage 3 (48.1%) and stage 4 (37.0%), with 63% experiencing moderate anemia (Hb 8–10 g/dL). The results of the Spearman test showed a significant positive correlation between cancer stage and Hb levels (r = 0.683; p = 0.000), indicating that the more advanced the cancer stage, the lower the hemoglobin levels tend to be. It was concluded that there was a significant relationship between cancer stage and hemoglobin levels in female patients. These results emphasize the importance of monitoring Hb levels in clinical management and nursing care of cancer patients, especially in advanced stages.