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Antimicrobial resistance (AMR) is an age-old biological phenomenon, as evidenced by its evolutionary history and abundance of environmental immunity Antibiotics used by humans contributes to resistance to acquired disease, a public health issue that drives the selection of resistance genes. A.M.R. One of the most important strategies to combat AMR is the search for new antibiotics. During the 1980s, existing products were either enhanced or modified in antibiotics currently on the market. The World Health Organization (WHO) warns of limited new candidates and highly characterizes the current pipeline. After careful analysis of preclinical and therapeutic pipelines, it seems expected that very few new antibiotics will enter the market in the coming years . Most of these candidates do not meet the new standards required to adequately address the growing threat of antimicrobial resistance (AMR).The key principles to cope with the rapidly emerging AMR are diversity and innovation which are done. R&D efforts should address new antibiotic resistance. Although there is promising potential to change the dynamics between the spread of AMR, antibiotic reserves, and meeting new lead standards, we examine the historical context and challenges associated with drug a kills bacteria detection, and various other processes. Let us describe the proposed methods of revitalizing the pipeline.

The purpose of this study was to analyze the factors that influence customer satisfaction at Merpati Urei Faisei Hotel, Waropen Regency, associated with the quality of service and hotel facilities. The population in this study were all customers of Merpati Urei Faisei Hotel, Waropen Regency. This study used a sample of 100 respondents who were and had stayed as customers or guests at Merpati Urei Faisei Hotel in the past year, selected using purposive sampling techniques. The data collection technique used in this study was by distributing questionnaires and data analysis using multiple linear regression analysis techniques with the help of SPSS. The results of the study found that customer satisfaction at Merpati Urei Faisei Hotel, Waropen Regency was positively and significantly influenced by the service quality factor of 0.475, the influence of the hotel facility factor of 0.454. This study is expected to increase insight and knowledge about the quality of service and hotel facilities on customer satisfaction.

The purpose of this study is to ascertain the connection between the Pagar Merbau District Health Center's performance and the leadership style used in decision-making and problem-solving. In 2024, Deli Serdang. This study is cross-sectional and observational. Fifty individuals made up the sample size. A questionnaire is used as a data gathering tool in this study the test known as chi-square is the analysis that is employed. The study room demonstrates that 25 people (50%) are involved in problem-solving using a leadership style that emphasizes involvement. There are 25 individuals (50%) involved in the Making decisions process, which is more educational in character. Bivariate analysis results show that leadership style and health worker performance Community Health Center Pagar Merbau in Regency of Deli Serdang are associated, with a p-value of 0.001 and a related category since the value is greater than 0.05. The findings of the evaluation indicate that health professionals' performance, which includes their presence, teamwork, excellence of the work, professionalism, and knowledge mastery needs to be in harmony with the educational, consultative, participative, and delegative leadership style of the Pagar Merbau Health Center's chief executive. To maximize the performance of all healthcare professionals in problem-solving, The community health center's head should adopt a leadership style That's more adaptable and flexible to different circumstances.

The institution of marriage in Indonesia has long been considered a social and moral milestone. However, in the digital era, shifting gender roles and the rise of social media have significantly transformed how young women perceive marriage. This study aims to explore the perceptions of early adult women (aged 18–25) toward the #MarriageIsScary narrative on TikTok, focusing on content from the account @bobahagia19. The research employs a qualitative descriptive approach using interviews, observations, and content analysis of selected TikTok videos. The findings reveal that the #MarriageIsScary trend represents a collective expression of emotional anxiety, self-awareness, and social critique of traditional marriage norms. Participants perceived marriage as an uncertain institution, often associated with emotional instability, betrayal, and loss of autonomy. Yet, the same discourse also fostered empowerment and solidarity among women, forming what scholars describe as digital sisterhood. The discussion integrates sociological and media theories (Giddens, 1992; Papacharissi, 2015; Banet-Weiser, 2018) to illustrate how digital narratives both reflect and reshape cultural meanings of marriage in contemporary Indonesia. Overall, the study concludes that TikTok functions as a participatory space where young women redefine marital expectations through shared emotions, storytelling, and online community engagement.

PAB Rehandling office workers in the mining sector, these stressors have a greater impact due to the dynamic and often dangerous nature of the work. Office workers responsible for transporting materials and processing associated paperwork are often under pressure to meet strict production targets. This pressure can be exacerbated by a work environment fraught with safety risks, leading to increased levels of anxiety and stress. To determine the correlations of individual stressors (age, gender, and tenure) with occupational stress. Using quantitative methods using a cross sectional design. The sampling technique used was total sampling so that the sample in this study was office workers in the PAB Rehandling section in the Mining Sector, totaling 56 respondents. Data analysis using Spearman test for ordinal data types (age and tenure) and Chi Square test for nominal data types (gender). The study showed that there was a correlation between age with a p-value of 0.032, there was no correlation between gender with a p-value of 0.873, there was a correlation between tenure with a p-value of 0.000. To minimize the high level of stress in PAB Rehandling office workers, it is possible to implement a program to implement stress management in the workplace.

Environmental issues have become an increasingly significant topic in the accountingliterature in recent decades. The public's apprehension regarding the financial andnon-financial performance of companies has been heightened by environmentalissues associated with industrial activities, which has resulted in a heightened demandfor the disclosure and examination of environmental reports, particularly indeveloped countries. Nevertheless, there is a dearth of research in this field indeveloping countries, particularly in the Arab region, including Iraq. Therefore, thispaper aims at investigating the potential impact of disclosure of eco-sustainability infinancial reports on market value and the effect of disclosure of eco-sustainability infinancial reports on market value under the context of company characteristics (size,age, and loss). This paper draws on the data disclosed by companies listed on the IraqStock Exchange. The hypotheses regarding the impact of eco-sustainabilitydisclosure in financial reports on market value regarding company characteristicswere verified by selecting 35 joint stock companies from 2011 to 2022. This paperreached several conclusions. The effect of disclosures regarding eco-sustainability infinancial reports on market value has been revealed. Additionally, the market value of a company is influenced by the disclosure of eco-sustainability in financial reports, asindicated by the quality descriptors of the company, namely age and losses. Thepaper also found out that the disclosure of eco-sustainability in financial reports doesnot affect the market value of the company under the company qualities, as measuredby the company's size.

The purpose of this study is to conduct a literature review of previous research on Good Corporate Governance (GCG) from 2020-2024.GCG refers to the systems and processes that direct and control companies to ensure transparency, accountability, and responsibility in decision making. The implementation of good GCG principles is expected to create a harmonious relationship between management, shareholders, and other stakeholders, so as to improve overall company performance. One aspect that is often studied is the effect of GCG on the company's financial performance. Financial performance, which is measured through various indicators such as profitability, liquidity, and operational efficiency, can be influenced by how well GCG is implemented. This study aims to identify the relationship between GCG implementation and corporate financial performance, and to examine whether better GCG can lead to improved financial performance. The study results show that strong GCG implementation is positively associated with improved financial performance, where companies with good governance tend to have higher profitability and lower financial risk. This research provides an important contribution for companies and stakeholders in designing governance policies that can support the achievement of long-term goals and corporate sustainability.  

Background: Suicidal behavior is the fourth leading cause of death in the world for children and adolescents and is ranked 17th as the leading cause of death throughout life. This study aims to determine the factors associated with suicidal behavior in adolescents. Method: This study was conducted using a systematic literature review method by collecting data through the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) method for studies that study factors associated with suicidal behavior. The literature search strategy that will be used for the study was carried out by accessing the ScienceDirect, PubMed, Scopus database. Results: The results of the study showed that out of 9  research articles (2019-2024), shows that the correlation between depression, anxiety disorders, stress and bullying factors with suicidal behavior in adolescent each has a p-value (<0,001; <0,485; NA; <0,001). Conclusion: Based on the results of the meta-analysis conducted on 9 reseacrch artikels, it was concluded that  there is a significant relationship between depression and bullying and suicidal behavior in adolescents. While the  anxiety disorders and stress factors are considered not to have significant relationship with suicidal behavior.

This study investigates the impact of dual citizenship on political participation and national identity in Indonesia. Despite dual citizenship not being officially recognized under Law No. 12 of 2006 on the Citizenship of the Republic of Indonesia, many Indonesians living abroad encounter this status. This research employs a mixed-methods approach, combining qualitative and quantitative methods, to explore the challenges faced by dual citizens in political engagement and how this status affects their political identity. Findings indicate that individuals with dual citizenship often face legal uncertainties, difficulties in political participation, and conflicts regarding political loyalty. Comparative analysis with countries that recognize dual citizenship, such as the United States and several European Union nations, reveals that acknowledging dual citizenship can facilitate better political participation and reduce identity conflicts. Based on these findings, it is recommended that Indonesia consider reforming its citizenship policies, enhance education on political rights, and strengthen international dialogue to address the challenges associated with dual citizenship.

Employee job satisfaction has become a central issue in the modern business world. Companies that succeed in creating a positive and productive work environment tend to have a competitive advantage. One factor that greatly affects job satisfaction is the quality of human relations. PT Paragon Technology and Innovation, as a leading cosmetics company in Indonesia, strives to create a conducive work environment for its employees. This study aims to analyze the extent to which the application of human relations principles at PT Paragon contributes to increasing employee job satisfaction. Using SWOT analysis, this research will identify the strengths, weaknesses, opportunities, and threats associated with the implementation of human relations in the company and formulate recommendations for future improvements.  

Indonesia is a country that is nicknamed as an archipelagic country which is rich in identity in the form of various cultures, ethnicities, and traditions. Each region has its own characteristics that can be seen in its cultural system, as well as the Dawan Language Speech Guyub raises two problem formulations related to ecolinguistics, namely the grammatical categories of lexicons of subject in Dawan language, the dimensions of the social praxis function of the Ke -an in Dawan Malaka language. Purpose To analyze the grammatical categories of lexicons of pen in Dawan Malaka language. Analyzing the dimensions of the function of the social praxis lexicon Ke-pen-an in Dawan Malaka language. The theory used is ecolinguistic theory and semantic theory. Qualitative research is used in this research. Data collection was carried out by observation, interview and recording methods. Methods and techniques for analyzing data in this study using qualitative data analysis methods, namely making field notes, collecting, sorting, classifying and then categorizing them into three categories, namely noun categories, verb categories and subjective categories. As well as associated with the dimensions of the social praxis function based on the theory used. Study the results of data analysis using deductive and inductive techniques. The results of the research show that the Khazana lexicon of pens in the Dawan Malaka language. There are 50 lexicons for noun categories, 22 lexicons for verb categories, and 50 lexicon   for adjective categories. The 8 (eight) biotic categories of the lexicon are baaf, tauf, nook, sufu, botof, rikuf, poat, pen fua. While the other lexicons from the noun verb category come from the abiotic environment. Relating to the social practical lexicon of pens in the form of Dawan's proverbs. There are 18 personals.

Cigarettes are tobacco products that are used by burning, smoking, or inhaling smoke produced by the plants Nicotiana tabacum, Nicotinia rustica, and other species or their synthesis. The smoke contains nicotine and tar, with or without additions. The goal of this study is to obtain an overview of SMA Negeri 2 Tondano students' understanding of the health risks associated with smoking. This study takes a quantitative approach. The data collection method is questionnaire instrument data. According to the study's findings, the vast majority of students, 93 (75.61%), had a high level of understanding of the consequences of smoking. The remaining 23 pupils (18.70%) were classified as high, 7 students (5.69%) as low, and no children were classified as very low, or 0%.

A culture of innovation is very important to implement in a company to be able to maintain the existence and survival of the company. Successful innovation depends significantly on ability, skills and interpreting a rapidly changing environment. Apart from that, employee involvement also influences success in innovation. Innovation and creativity use the DMAIC (Define, Measure, Analyze, Improve and Control) method which is associated with KAIZEN in Japanese terms, which means "continuous improvement" which emphasizes human effort, morals, communication, training, cooperation, empowerment and self-discipline . The purpose of this research is to find out the strategy carried out by PT. Indolakto Pasuruan in motivating its employees to implement a culture of innovation as well as identifying factors inhibiting its implementation and efforts made to minimize these obstacles. This research uses qualitative research methods and tests the validity of this research data using source triangulation and member checking. From the results of this research, researchers concluded that implementing a culture of innovation in companies can have a positive impact on the company's survival. Research implications - This research makes a contribution to human resource management related to corporate culture.

Budgeting is a crucial element in managing a company’s finances, as it provides clear and structured direction for decision-making and resource allocation. With effective budgeting, a company can optimize the use of its funds, minimize the risk of bankruptcy, and improve overall financial performance. This article aims to discuss the importance of budgeting in financial management, highlighting its role, benefits, and the challenges associated with its implementation.    

Dermatoporosis is a chronic skin fragility syndrome common in the elderly, characterized by thinning of the skin that increases the risk of injury, bruising, and delayed wound healing. Chronic hyperglycemia and poor glycemic control have been reported to be associated with an increased risk of dermatoporosis. This community service activity aims to screen blood sugar levels, HbA1c, and dermatoporosis and educate the elderly using the Plan-Do-Check-Act (PDCA) method at Panti Bina Bhakti, South Tangerang. This activity involved 93 elderly participants aged >65 years. Meanwhile, based on the results of the HbA1C examination, 52 people had moderate glycemic control and 24 people had poor glycemic control. The results of the dermatoporosis examination have not been included. Early intervention through education and monitoring of blood sugar levels can reduce the risk of dermatoporosis, improve the health of the elderly's skin, and reduce the burden of health care.

Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disorder characterized by regurgitation of gastric contents into the esophagus, causing a variety of clinical symptoms such as heartburn, regurgitation, and atypical presentations such as chest pain, chronic cough, and asthma. In the elderly, GERD is very common, often with atypical symptoms and has a higher risk of complications, including esophagitis, Barrett's esophagus, and esophageal cancer. Functional dispepsia, another common gastrointestinal disorder, affects more than 20% of the population and is associated with significant negative impacts on quality of life and health care costs. This community service activity aims to screen for GERD and dispepsia in the elderly population through the Plan-Do-Check-Act (PDCA) approach. The activity was carried out at Panti Bina Bhakti, South Tangerang, involving 93 elderly participants aged over 65 years. The results showed that 64 people (68.82%) had a 50% chance of GERD, 21 people (22.58%) had a 79% chance of GERD, and 6 people (6.45%) had an 89% chance of GERD. Screening for GERD and dispepsia in the elderly is very important for early detection and timely intervention, which can prevent disease progression and reduce the risk of complications.

This study ams to find out more clearly how the process of unloading sugar from the Dancewood SW ship to the truck by PT. PBM Gelora Perkasa Belawan starts from before the unloading process until it is finished. The stevedoring company is a unit of activity carried out at the port, especially the Ujung Baru Belawan port. PT PBM Gelora Perkasa Belawan as a company engaged in the field of stevedoring plays a very important role in the activities at the Ujung Baru Belawan port. Government agency officers related or associated with the activities of ships entering and leaving the port organized by the shipping company are the Belawan Man Harbormaster's office, Port Authority, immigration, PT Pelindo, Customs and Excise. This ams to find out about the process of unloading sugar from the Dancewood SW ship to the truck at PT. PBM Gelora Perkasa Belawan, and also to find out the obstacles found during unloading at the Ujung Baru Belawan port. The method used by the author in completing this paper is Field Research to make it easier for the author to complete this paper and Library Research, the author obtans material or paper materials and books in the library or other reading sources related to the topic of discussion taken.

Investment in marine protection and Fisheries Management Areas (FMAs) is crucial for maintaining the sustainability of the global marine ecosystem. This paper aims to evaluate investment in marine protection and FMAs using Bunaken National Park as a case study. The Cost-Benefit and SWOT analysis approaches are employed to assess the efficiency, effectiveness, and challenges faced in marine protection and fisheries management efforts in this area. Through this review, various costs and benefits of the investment are evaluated, while strengths, weaknesses, opportunities, and threats associated with the implementation of the investment are also identified. The results of this analysis provide insights into the economic feasibility, potential success, and strategies that can be implemented to enhance the sustainability of the marine ecosystem and the welfare of local communities in Bunaken National Park.    

This paper explores the implications of digital surveillance on individual privacy rights, examining the balance between national security and personal freedom. By analyzing laws and regulations on digital monitoring across various countries, the study highlights the challenges and ethical concerns associated with widespread surveillance technologies. The findings emphasize the need for stronger legal frameworks to protect privacy without compromising security.

Work fatigue in the pharmaceutical sector is a condition that needs to be treated. In Indonesia, on average, there are 414 work accidents every day, 27.8% are caused by quite high fatigue, approximately 9.5% or 39 people experience physical disabilities due to exposure to chemical, physical, biological and other hazards. The aim of the research to be conducted is to determine the factors associated with work fatigue in the pharmaceutical sector. This type of research is quantitative research with a cross sectional research design with a sample of 60 respondents. The sampling technique used is simple random sampling. The instruments used were questionnaires and interviews, weight and height weighing tools to determine nutritional status, oymeters to measure workload, and PVT application tools used to measure the level of work fatigue carried out on respondents at PT X. The data analysis used was chi-square test. Univariate results: old age, namely 39 people (65%), obesity nutritional status, namely 30 people (50%), female gender, namely 45 people (75%), no history of disease, 58 people (96.7%), long working period namely 45 people (75%), heavy workload, namely 19 people (31.7%), night shift work, namely 22 people (36.7%), heavy work fatigue, namely 28 people (46.7%). Bivariate analysis shows that there is a relationship with each variable if p<0.05, which from the research shows that the variables age, nutritional status, work period, workload, work shifts have a positive relationship with work fatigue.