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This study aims to: 1) to determine the description of the science abilities of children in group B before treatment with the guided inquiry method at Pembina Bungi State Kindergarten, 2) To determine the description of the development of science abilities of children in group B using the guided inquiry method at Pembina Bungi State Kindergarten. The research technique is an experiment with the design of this study One Groups Pretest-Posttest Design. Data collection techniques used in the study are observation, testing and documentation. The subjects of this study were 10 children divided by the study conducted pretest and posttest. The results of this study indicate that 1) the science abilities of children in group B1 with the guided inquiry method have the highest achievement of developing very well at 79% and the lowest value of 58%, and the average value is 71.3%. 2) the results of the posttest of the science abilities of children in group B1, the highest achievement developed very well at 92%, the lowest achievement developed according to expectations at 71%, and the average was 84.6%. This shows the influence of students' science abilities when given the guided inquiry method in group B at Pembina Bungi State Kindergarten, Baubau City. Overall, the study concludes that the guided inquiry method is effective in improving early childhood science learning outcomes, particularly in enhancing curiosity, critical thinking, and problem-solving skills in the classroom context.

Acid mine drainage (AMD) is one of the major environmental problems arising from coal mining activities. AMD is formed through the oxidation of sulfide minerals, resulting in acidic water with high concentrations of dissolved heavy metals. This condition is characterized by elevated levels of Fe, Mn, and total suspended solids (TSS), which, if left untreated, can pollute nearby water bodies, damage aquatic ecosystems, and pose risks to human health. Therefore, effective, eco-friendly, and low-cost treatment methods are needed to minimize the negative impacts of AMD. This study aims to investigate the effect of activated carbon derived from sugarcane bagasse as an adsorbent for reducing Fe, Mn, and TSS levels in AMD at the sump of PT Alreksa Bara Mitra. The selection of sugarcane bagasse is based on its abundance as an agro-industrial waste and its high lignocellulosic content, making it a potential raw material for activated carbon. The research involved the preparation of activated carbon through carbonization and activation processes, followed by its application to AMD samples with variations in adsorbent dosage and contact time. Laboratory analyses were conducted to measure the concentrations of Fe, Mn, and TSS before and after treatment. The results showed that sugarcane bagasse-based activated carbon significantly reduced Fe, Mn, and TSS concentrations. The highest removal efficiencies were achieved under optimum conditions, reaching 93.14% for Fe, 95.05% for Mn, and 85.04% for TSS. These findings demonstrate that activated carbon from sugarcane bagasse has a strong adsorption capacity for dissolved metals and suspended solids in AMD. In conclusion, sugarcane bagasse-derived activated carbon has potential as an environmentally friendly and cost-effective alternative for AMD treatment, while simultaneously providing added value to agro-industrial waste. This research is expected to serve as a reference for the development of more sustainable mine wastewater treatment methods.

Malaria is a global health problem, particularly in tropical countries like Indonesia. Papua has 374 endemic districts/cities, with the highest number of malaria cases, with 14,586 cases, and Jayapura Regency in 2024 with 50,529 patients and 6,213 relapses. The high number of cases is due to the geographical conditions that favor mosquito breeding and the dormant state in the body. If treatment is not carried out correctly and thoroughly, it can lead to malaria relapse. The purpose of this study was to determine factors associated with relapse in malaria patients in the Harapan Community Health Center (Puskesmas) area, Jayapura Regency. This research was an analytical study with a cross-sectional design. Data collection was conducted using a questionnaire. A total of 88 respondents were recruited using simple accidental sampling. The data obtained were statistically analyzed using chi-square and binary logistic regression. Based on the analysis, it was found that factors that were not related to recurrence in malaria patients in the Harapan Community Health Center, Jayapura Regency were age (p-value 1.000 > α 0.05), gender (p-value 0.855 > α 0.05), and education (p-value 0.124 > α 0.05). Factors related to recurrence in malaria patients in the Harapan Community Health Center, Jayapura Regency were occupation (p-value 0.032 or p < α 0.05), nutritional status (p-value 0.000 < α 0.05), and medication adherence (p-value 0.000 < α 0.05). Medication adherence was the dominant factor in recurrence in malaria patients at the Harapan Community Health Center (p-value 0.000 < 0.05). Malaria patients who do not comply with taking their medication cause the malaria parasite to become dormant in the body which can at any time cause malaria relapses and resistance to malaria drugs.

Urological examinations using Multi Slice Computed Tomography (MSCT) often require the use of diuretic agents to enhance the visualization of the urinary tract system. However, the use of synthetic pharmacological agents may sometimes lead to undesirable side effects. The aim of this study was to evaluate the effectiveness of ginger extract (Zingiber officinale) as a natural diuretic alternative in MSCT urological examinations. This research utilized an experimental design, comparing two groups: one that was given ginger extract before the examination and another control group that did not receive any additional treatment. Key parameters observed included the degree of urinary tract distension, MSCT image quality, and the smoothness of contrast media excretion. The results indicated that the administration of ginger extract significantly increased the degree of ureteral and urinary bladder distension, leading to improved image visualization quality compared to the control group. These findings suggest that ginger extract can serve as a promising natural diuretic alternative for MSCT urological examinations. However, further studies with larger sample sizes are necessary to confirm the validity and reproducibility of these results. Ginger extract offers an innovative and potentially safer approach to improving the effectiveness of MSCT scans without the side effects associated with synthetic diuretics.

Taro flour (Colocasia esculenta L. Schott) is a local food ingredient with significant potential to be developed as an alternative carbohydrate source. Its high starch content, dietary fiber, and functional properties make taro flour a promising candidate for use in various food formulations. Moreover, the widespread availability of taro in tropical regions supports its sustainable utilization. However, the development and application of taro flour face several challenges, such as high levels of antinutritional compounds (particularly oxalates), variability in characteristics among cultivars, limited processing technology, and low consumer acceptance. Therefore, innovation in processing techniques is needed, including pre-treatment methods to reduce antinutrient content, starch modification to enhance functionality, and composite formulation with other food ingredients to expand product applications. This article aims to establish a comprehensive conceptual framework for the innovative development of taro flour, focusing on processing technology, functional value, and commercialization potential. Through this approach, the development of taro-based products is expected to increase added value, support local food diversification, and strengthen national food security.

. Indonesian National Police (Polri) members are state officials who play a strategic role in maintaining security, order, law enforcement, and providing protection, care, and service to the community. As civil servants of the Indonesian National Police (POLRI), Polri members are required to be in excellent health to optimally carry out their duties and responsibilities. One of the challenges faced is adherence to medication, especially for Polri members undergoing medical treatment. Medication adherence is a crucial factor in successful treatment, and one determinant that can influence adherence is family support. This study aims to describe the relationship between medication adherence and family support among Polri members undergoing treatment at the Papua Regional Police Medical and Health Unit. The research method used is descriptive quantitative, namely research that focuses on describing social phenomena through numerical data obtained from measurements and analyzed statistically. This study does not aim to test hypotheses, but rather to explain the characteristics and trends that emerge from the data obtained. The results show that of the 24 respondents with high medication adherence, 17 (70.8%) received high family support. These findings confirm that family support significantly contributes to the level of compliance of Indonesian National Police (Polri) members with their medication. Therefore, the role of the family needs to be given greater attention in efforts to improve the success of treatment, particularly among Polri members. The study concluded that the better the family support received, the higher the level of medication compliance, which ultimately positively impacts the health of Polri members.  

This research is motivated by students' low basic table tennis skills, particularly in the technical aspects of holding the racket, hitting the ball, and maintaining proper body position. This condition results in low student learning outcomes in physical education subjects, so learning media that can support the learning process more effectively are needed. One alternative media that can be used is tutorial media, because it has the advantage of presenting movements visually, systematically, and can be repeated according to student needs. The method used in this study was an experiment with a one-group pretest-posttest design. The research subjects were 20 fifth-grade students of Begawat 01 State Elementary School, selected using a total sampling technique. The research instruments included a practical test of basic table tennis skills, observation, and documentation. Data on student learning outcomes before and after the treatment were then analyzed to determine differences in ability. The results showed a significant increase in basic table tennis skills after the use of tutorial media. Students were able to improve their racket holding techniques, adjust their body position, and become more skilled at hitting the ball. In addition, the use of tutorial media also had an impact on increasing student learning motivation and participation in practical activities. The clearly displayed visualization of movements helped students understand the steps of basic techniques more quickly and effectively. The conclusion of this study is that tutorial media is proven to be effective in improving the table tennis learning outcomes of fifth grade students at Begawat 01 State Elementary School. The implications of this study emphasize the importance of utilizing innovative learning media to support the physical education learning process, so that learning objectives can be achieved more optimally.

Dysmenorrhea, or menstrual pain, is a common gynecological problem among adolescent girls and often interferes with their daily activities, school performance, and overall quality of life. Conventional pharmacological treatments such as nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used but may cause side effects with long-term consumption. Therefore, safe and natural alternatives are needed to manage menstrual pain effectively. Carrot juice, which is rich in beta-carotene, vitamin E, and other antioxidants, has been reported to possess anti-inflammatory and analgesic properties that could potentially reduce the severity of dysmenorrhea. This study aimed to determine the effect of carrot juice on reducing menstrual pain in female students at SMAN 1 Trimurjo. A pre-experimental study with a one-group pretest–posttest design was conducted involving 27 students who experienced dysmenorrhea. Pain intensity was assessed before and after the intervention using the Numeric Rating Scale (NRS). Data were analyzed using the Wilcoxon signed-rank test. The results showed that before the intervention, the majority of respondents (85.2%) reported moderate pain, while after consuming carrot juice, 92.6% reported mild pain and 7.4% reported no pain. Statistical analysis revealed a significant difference in pain levels before and after the intervention (p = 0.000, p < 0.05). These findings indicate that carrot juice is effective in reducing dysmenorrhea intensity among adolescent girls. As a safe, affordable, and easy-to-implement non-pharmacological therapy, carrot juice has the potential to be recommended as a complementary approach to menstrual pain management, especially for adolescents who seek natural remedies. Further research with larger samples and control groups is recommended to strengthen the evidence and explore the long-term benefits of carrot juice in menstrual health.

Well water is still one of the main sources of daily water supply for the residents of the Candi Muaro Jambi area. The dependence on well water makes it vital for consumption, cooking, and other domestic activities. However, with the increasing human activity, the development of tourist areas, and environmental changes in the surrounding area, the quality of the well water is at risk of being affected. This study aims to evaluate the feasibility of well water from an environmental and health perspective based on physical, chemical, and biological parameters, referring to the clean water quality standards set by the Ministry of Health of the Republic of Indonesia. The research employs a descriptive quantitative method, with well water samples taken from several points around the residential areas in the Candi Muaro Jambi region. The analyzed parameters include temperature, color, odor, turbidity, pH, nitrate content, metal content (Fe and Mn), and the presence of coliform bacteria. Laboratory test results show that most of the well water samples still meet the established physical and chemical standards, but some wells were found to have coliform levels exceeding the recommended threshold. This condition indicates contamination, most likely from domestic waste, particularly from household sanitation systems that are not ideally located relative to the wells. While the well water in the study area is generally still suitable for daily use, it is recommended that the community performs simple water treatment, such as boiling or filtration, before direct consumption. These measures are crucial to reduce contamination risks and ensure the water's quality for safe consumption and health.

Passing is a fundamental skill that is crucial in soccer because it plays a role in maintaining ball possession, controlling tempo, and creating scoring opportunities. However, in practice, many young players still struggle to pass correctly, both in terms of foot technique, strength, and accuracy of the ball's direction. Technological advancements in the world of sports offer various learning alternatives, one of which is through video feedback. This technology allows players to review their movements, making it easier to identify technical errors and make systematic improvements. Therefore, this study was conducted to determine the effect of video feedback on improving passing skills in young players. This study used an experimental method with a one-group pretest-posttest design. The subjects were 20 SSB Merpati Cerih U-14 players selected using a total sampling technique. The research instrument was a passing skills test administered before and after treatment. The test data were analyzed using descriptive and inferential statistics to measure the difference in average passing skill scores before and after the video feedback application. The results showed a significant improvement in passing ability after players received video feedback training. Players were able to correct technical errors, such as body position, leg swing, and pass direction. Visualizing movements directly through video recordings helps players more quickly identify weaknesses and correct them in subsequent training sessions. In conclusion, the application of video feedback technology has proven effective in improving basic passing skills in SSB Merpati Cerih U-14 players. This approach makes the learning process more interactive, motivates players, and optimizes training results. The application of similar technology is highly relevant to support achievement development in youth soccer.

Myofascial pain syndrome (MPS) is a condition characterized by muscle or fascia pain, involving sensory, motor, or autonomic functions, linked to myofascial trigger points (MTrPs). Motor symptoms can include muscle weakness, limited movement, and stiffness. Sensory symptoms may involve tenderness, referred pain, hyperalgesia, or allodynia, while autonomic symptoms include sweating, changes in skin temperature, and salivation. MPS occurs due to increased sympathetic nervous system activity, which worsens pain. Physical therapy is vital in improving movement and function, with Active Exercise Therapy being a recommended treatment. MPS affects 36% of 431 patients, with pain intensity often developing within a week, and in Indonesia, it reaches 40% within a year. MPS is more common in females than males. Active Exercise Therapy, which can be performed at home or work, is essential for preventing MPS. On July 31, 2025, a community service activity was held at RT VIII Tanjung Mas Village, Semarang Utara, with 29 participants. The event included blood pressure checks, blood sugar tests, BMI measurements, and counseling on the importance of exercise therapy to prevent muscle fatigue, particularly in the neck area. The therapy, focusing on improving tendon and ligament strength and muscle strength, helps maintain joint stability and increase the range of motion. Strength training includes isotonic exercises and progressive resistance training, tailored to each individual's needs. The event provided education on managing muscle pain and fatigue through targeted exercise routines and home programs. These initiatives emphasize muscle recovery, physical health, and overall wellness, ensuring participants can manage and prevent MPS effectively. The event highlighted the critical role of regular physical activity in improving quality of life and preventing long-term musculoskeletal pain.

Limited knowledge and utilization of digital technology in the fisheries and plantation sectors remains a major obstacle for the people of Samo Village, South Halmahera Regency, the majority of whom work as fishermen and farmers. This results in low productivity, limited access to information, and less than optimal development of micro-enterprises based on local potential. This community service activity aims to introduce and train the use of Fishbrain, Plantix, and ChatGPT applications relevant to local community needs. The activity implementation method includes three main stages: the preparation phase, which involves coordination with village officials and the development of training materials; the implementation phase, which involves socialization and hands-on training; and the evaluation phase, which involves discussions, reflections, and Q&A sessions with participants. The results of the activity demonstrated a significant increase in participants' understanding and skills in utilizing digital technology. The Fishbrain application has been proven to assist fishermen in determining more potential fishing locations based on global community data, while Plantix is ​​useful in detecting plant diseases, providing treatment recommendations, and increasing crop yields. Meanwhile, ChatGPT is used by the community as a virtual assistant to support information searches, innovation ideas, product marketing strategies, and digital-based small business planning. The participants' enthusiasm was evident in their active involvement throughout the training, their eagerness to try the applications independently, and their ability to repeat the three applications' core functions. In conclusion, this training activity not only broadened the community's digital knowledge and skills but also encouraged a shift in mindset toward utilizing technology as a means to improve well-being. With the knowledge gained, the Samo Village community is expected to be more adaptive to technological developments, enabling the sustainable development of the fisheries, plantations, and local micro-enterprises sectors.

This study aims to explain the effectiveness of using ChatGPT version 3.5 on advanced writing production in Tendances A2, Unit 7, Learning 2, with the topic “Demander une autorisation” (Requesting Permission) for fourth-semester students of the French Language Education Program at Unimed. The issue addressed in this study is the lack of students' mastery of vocabulary and sentence structure, as well as the fact that ChatGPT has never been used as a learning medium in the advanced writing course. This issue is reflected in the students’ pre-test score, which was 32—still below the minimum passing score (KKM) of 75. The method employed in this research is an experimental method using a one-group pre-test and post-test design. The sampling technique used is purposive sampling. The study population consisted of all 17 students from Class B of the 2023 academic year. To analyze the effectiveness of the media used, several stages were carried out: pre-test, treatment, and post-test. 

This study aims to determine the effect of the Course Review Horay learning model on students' comprehension ability in response text material at SMP Negeri 4 Gunungsitoli Idanoi. This learning model is an active and fun strategy that combines game elements with learning activities, so it is expected to increase student engagement and understanding of the material. The study used a quasi-experimental approach with a Non-Equivalent Control Group Design. The research procedure included three stages, namely (1) implementing a pre-test to measure students' initial abilities, (2) providing treatment by applying the Course Review Horay model in the experimental class and conventional learning in the control class, and (3) implementing a post-test to determine the increase in students' comprehension abilities. The study population was all seventh grade students consisting of two classes, namely VII-A and VII-B, each consisting of 20 students, so that the total number of participants was 40 people. Sampling used a saturated sampling technique because the entire population was sampled. The independent variable in the study was the application of the Course Review Horay learning model, while the dependent variable was student learning outcomes in the response text material. The results of data analysis showed a significant difference between student learning outcomes in the experimental class and the control class. Based on the hypothesis test, the t-value was 12.006, with a significance (2-tailed) <0.001, which is smaller than 0.05. 

This study is aim to find out the significant effect of using grammar racing game to the students’ grammar score (simple present tense)  and the students’ interest toward grammar racing as media in teaching grammar for the Students of Elementary School Education Teacher Program In University of Palangka Raya. The study includes in Quantitative Paradigm with Experimental Design. The researcher designed the Lesson Plan, conducted the treatment and observed the students’ score by pretest and posttest. The population of study was at the first semester students which consisted of three classes. The researcher chose 1A as sample. The sample was determined using purposive sampling technique. After getting the data that were from pretest and posttest, the researcher analyzed the data using ttest formula to test the hypothesis stated based on the result of analysis, it was found that the value of tobserved = 8.677 and the ttable =2.03. It showed that the tobserved was higher than the ttable and to answer the second alternative hypotheses research used questionnaire there are 94 % of 43 students of 1A was interest toward grammar racing game as media in teaching grammar. The result of testing hypothesis determined that the Alternative Hypothesis (Ha) stating that there was significant effect of using grammar racing game toward student’s grammar score of Elementary School Education Teacher Program was accepted and Ho stating that there was no significant effect of using grammar racing toward student’s grammar score was rejected.

Coffee is a leading commodity in Indonesia's agricultural sector, possessing high economic value and providing a livelihood for many farmers. However, coffee plant productivity often declines significantly due to various diseases affecting the leaves, stems, and berries. This situation is exacerbated by the lack of knowledge among most farmers in recognizing early disease symptoms, resulting in delayed treatment. Consequently, crop losses are unavoidable. Based on these challenges, this study aims to design and build an expert system capable of diagnosing coffee plant diseases quickly, precisely, and accurately using the Bayesian Theorem method. This method was chosen because it can calculate the probability of a disease occurring based on observed symptoms in plants. The Bayesian approach allows the system to provide more reliable diagnostic results by updating the probability values ​​as new evidence is introduced. The developed expert system is web-based, making it easily accessible to users, both farmers and other interested parties. Users simply select the symptoms observed in coffee plants, and the system will then provide a diagnostic result in the form of possible diseases and their probability levels. Test results indicate that the system is capable of providing fairly accurate diagnostic results and can be used as a basis for farmers in making initial decisions regarding coffee plant disease management. With this expert system, farmers are expected to improve their ability to detect coffee plant diseases early, thereby maintaining crop productivity. This expert system is expected to be an effective decision support tool for farmers to reduce crop losses and improve agricultural sustainability.

Auditory hallucinations are one of the main symptoms experienced by patients with schizophrenia. Non-pharmacological interventions, such as spiritual therapy, serve as important alternatives to support treatment. One increasingly used method is the recitation of Qur’anic verses (murottal therapy), which provides psychological and spiritual calming effects.  To determine the impact of murottal audio therapy of Surah Ar-Rahman on the intensity of auditory hallucinations in patients with schizophrenia at Gramesia Nursing Home, Cirebon.  This scientific paper is presented in the form of a nursing care report focusing on the application of murottal audio therapy using Surah Ar-Rahman as an intervention.  Before the therapy, the patient experienced moderate auditory hallucinations, accompanied by intense emotional reactions and difficulty controlling behavior. After undergoing murottal audio therapy, there was a decrease in hallucination intensity and improvement in the patient’s emotional condition. Murottal audio therapy of Surah Ar-Rahman is effective as a non-pharmacological approach to reduce auditory hallucinations and support psychological recovery in patients with schizophrenia. Following the intervention, patients reported a significant decrease in the intensity of their hallucinations. Emotional reactions were notably less intense, and patients displayed improved emotional regulation and greater behavioral control. The results suggest that murottal audio therapy using Surah Ar-Rahman is an effective non-pharmacological intervention that not only reduces the intensity of auditory hallucinations but also plays a supportive role in the psychological recovery of patients with schizophrenia. The findings emphasize the importance of integrating spiritual therapies into comprehensive treatment plans, as they offer a holistic approach to managing schizophrenia. This intervention can complement traditional pharmacological treatments, providing patients with a sense of spiritual calm and emotional stability, which can enhance their overall mental health and well-being.

Cassava tapai is a traditional Indonesian food product produced through the fermentation of cassava (Manihot esculenta) with the help of microorganisms, particularly the yeast Saccharomyces cerevisiae. This product not only has cultural and economic value but also contains bioactive compounds with health benefits, such as probiotics and fermentation metabolites. However, the quality of cassava tapai is significantly influenced by process factors, particularly incubation time. This study aimed to analyze microbial growth and changes in the chemical properties of cassava tapai with varying fermentation times. The study was conducted using an experimental design with fermentation times of 24, 48, and 72 hours at room temperature. The main parameters observed included the number of microbial colonies (cfu/g), pH changes, and alcohol content produced during the fermentation process. The results showed that microbial growth increased significantly, peaking at 48 hours, with the highest colony count compared to other treatments. After 72 hours, the number of colonies decreased, likely due to ethanol accumulation and decreased substrate availability, which reduced microbial activity. The pH value tended to decrease with increasing fermentation time, reflecting the formation of organic acids during the process. Meanwhile, the alcohol content showed an increasing trend from the beginning to the end of fermentation, although the growth rate was relatively slower at 72 hours. These findings confirm that varying incubation length significantly influences microbial dynamics and chemical changes in cassava tapai. The optimal fermentation time is around 48 hours, as this is the phase where the balance between microbial growth, alcohol formation, and sensory characteristics is maintained. The results of this study can serve as a basis for developing standards for cassava tapai production at both household and industrial scales, while also strengthening efforts to preserve traditional foods with a modern scientific approach.

Elevated blood cholesterol levels are known to be a major risk factor for cardiovascular disease. Hypercholesterolemia can trigger atherosclerosis, which in turn increases the risk of coronary heart disease and stroke. One approach to managing cholesterol levels is through the use of natural ingredients with antihyperlipidemic activity. White turmeric (Curcuma zedoaria Rosc) is an herbal plant long used in traditional medicine and contains bioactive compounds such as curcuminoids and essential oils. These compounds are reported to have antioxidant and anti-inflammatory activities, as well as potential as agents for lowering blood lipid levels. Herbal-based therapies are increasingly considered as safe alternatives to synthetic drugs in managing hyperlipidemia. This study aims to evaluate the effectiveness of a microencapsulated preparation of white turmeric ethanol extract in reducing total cholesterol levels in male rats (Rattus norvegicus) induced by a high-fat diet. The study was conducted experimentally using 25 rats divided into six treatment groups. The groups consisted of normal controls, negative controls, positive controls using simvastatin, and three treatment groups given white turmeric extract microcapsules at concentrations of 0.25%, 0.50%, and 0.75%. The microencapsulation technique was applied to improve the stability and bioavailability of the turmeric extract. Cholesterol levels were measured before and after treatment. The results showed that the treatment group with the 0.25% concentration produced the most significant cholesterol reduction, from 110 mg/dL to 59 mg/dL. These findings indicate that even at a relatively low concentration, microencapsulated turmeric extract can significantly reduce cholesterol levels in vivo. Therefore, it can be concluded that white turmeric extract in microcapsule form is effective in lowering total cholesterol levels, especially at the 0.25% dose. This suggests that Curcuma zedoaria microcapsules hold promise as a natural therapeutic option for managing hypercholesterolemia and reducing cardiovascular risk.  

Dyslipidemia is a health problem characterized by impaired fat metabolism in the body, characterized by changes in blood lipid levels, either increasing or decreasing. This condition is generally seen through increased levels of total cholesterol, low-density lipoprotein (LDL), triglycerides, and decreased levels of high-density lipoprotein (HDL). This imbalance in the lipid profile, if persisted over the long term, has the potential to accelerate the formation of atherosclerotic plaque on artery walls, which can lead to cardiovascular disease. This study aims to determine the effectiveness of papaya leaf (Carica papaya L.) ethanol extract microcapsules in reducing cholesterol levels in white rats induced by a high-fat diet. The high-fat diet is formulated from a mixture of beef fat, eggs, and lard to increase cholesterol levels in a controlled manner. After the induction phase, the rats were divided into six treatment groups: a negative control group, a positive control group (simvastatin 0.36 mg), and three treatment groups with doses of papaya leaf ethanol extract microcapsules of 0.25%, 0.50%, and 0.75%. The treatment was given orally for 14 consecutive days. Total cholesterol levels were measured before and after treatment to evaluate the effectiveness of the intervention. The results showed that administration of papaya leaf extract microcapsules significantly reduced cholesterol levels. The 0.50% dose provided the most optimal effect, with a reduction reaching 77 mg/dL, greater than the simvastatin group. However, increasing the dose to 0.75% did not show a significant additional reduction effect, indicating an optimal dose-response point. Therefore, the 0.50% concentration can be considered the most effective dose and has the potential to be developed as an alternative natural cholesterol-lowering therapy. These findings also strengthen the potential use of papaya leaves as a bioactive source to support efforts to prevent and control dyslipidemia.